Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Long-chain fatty acid transport protein 1

Gene

Slc27a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of Fatp1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi246 – 25712AMPBy similarityAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism, Lipid transport, Transport

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain fatty acid transport protein 1 (EC:6.2.1.-)
Short name:
FATP-1
Short name:
Fatty acid transport protein 1
Alternative name(s):
Solute carrier family 27 member 1
Gene namesi
Name:Slc27a1
Synonyms:Fatp, Fatp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620927. Slc27a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1313ExtracellularSequence analysisAdd
BLAST
Transmembranei14 – 3421HelicalSequence analysisAdd
BLAST
Topological domaini35 – 646612CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • caveola Source: RGD
  • endomembrane system Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • intracellular membrane-bounded organelle Source: RGD
  • mitochondrion Source: RGD
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 646646Long-chain fatty acid transport protein 1PRO_0000193203Add
BLAST

Proteomic databases

PaxDbiP97849.
PRIDEiP97849.

PTM databases

iPTMnetiP97849.
PhosphoSiteiP97849.

Interactioni

Subunit structurei

Self-associates. May function as a homodimer (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024659.

Structurei

3D structure databases

ProteinModelPortaliP97849.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni191 – 475285Sufficient for oligomerizationBy similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1179. Eukaryota.
ENOG410XQ8T. LUCA.
HOGENOMiHOG000044189.
HOVERGENiHBG005642.
InParanoidiP97849.
PhylomeDBiP97849.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR030308. FATP1.
[Graphical view]
PANTHERiPTHR24096:SF148. PTHR24096:SF148. 1 hit.
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97849-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTPGAGTAS VASLGLLWLL GLPWTWSAAA AFGVYVGSGG WRFLRIVCKT
60 70 80 90 100
ARRDLFGLSV LIRVRLELRR HRRAGDTIPR IFQAVAQRQP ERLALVDASS
110 120 130 140 150
GICWTFAQLD TYSNAVANLF LQLGFAPGDV VAVFLEGRPE FVGLWLGLAK
160 170 180 190 200
AGVVAALLNV NLRREPLAFC LGTSAAKALI YGGEMAAAVA EVSEQLGKSL
210 220 230 240 250
LKFCSGDLGP ESVLPDTQLL DPMLAEAPTT PLAQAPGKGM DDRLFYIYTS
260 270 280 290 300
GTTGLPKAAI VVHSRYYRIA AFGHHSYSMR ANDVLYDCLP LYHSAGNIMG
310 320 330 340 350
VGQCIIYGLT VVLRKKFSAS RFWDDCVKYN CTVVQYIGEI CRYLLRQPVR
360 370 380 390 400
DVERRHRVRL AVGNGLRPAI WEEFTQGFGV RQIGEFYGAT ECNCSIANMD
410 420 430 440 450
GKVGSCGFNS RILTHVYPIR LVKVNEDTME PLRDSQGLCI PCQPGEPGLL
460 470 480 490 500
VGQINQQDPL RRFDGYVSDS ATNKKIAHSV FRKGDSAYLS GDVLVMDELG
510 520 530 540 550
YMYFRDRSGD TFRWRGENVS TTEVEAVLSR LLGQTDVAVY GVAVPGVEGK
560 570 580 590 600
SGMAAIADPH NQLDPNSMYQ ELQKVLASYA QPIFLRLLPQ VDTTGTFKIQ
610 620 630 640
KTRLQREGFD PRQTSDRLFF LDLKQGRYLP LDERVHARIC AGDFSL
Length:646
Mass (Da):71,283
Last modified:May 1, 1997 - v1
Checksum:iC450CF174CC2EB87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89529 mRNA. Translation: AAC53424.1.
UniGeneiRn.1047.

Genome annotation databases

UCSCiRGD:620927. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89529 mRNA. Translation: AAC53424.1.
UniGeneiRn.1047.

3D structure databases

ProteinModelPortaliP97849.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024659.

PTM databases

iPTMnetiP97849.
PhosphoSiteiP97849.

Proteomic databases

PaxDbiP97849.
PRIDEiP97849.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:620927. rat.

Organism-specific databases

RGDi620927. Slc27a1.

Phylogenomic databases

eggNOGiKOG1179. Eukaryota.
ENOG410XQ8T. LUCA.
HOGENOMiHOG000044189.
HOVERGENiHBG005642.
InParanoidiP97849.
PhylomeDBiP97849.

Miscellaneous databases

PROiP97849.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR030308. FATP1.
[Graphical view]
PANTHERiPTHR24096:SF148. PTHR24096:SF148. 1 hit.
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS27A1_RAT
AccessioniPrimary (citable) accession number: P97849
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.