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Protein

Contactin-associated protein 1

Gene

Cntnap1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction. In association with contactin may have a role in the signaling between axons and myelinating glial cells.

GO - Molecular functioni

  • SH3 domain binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-associated protein 1
Short name:
Caspr
Short name:
Caspr1
Alternative name(s):
Neurexin IV
Neurexin-4
Paranodin
p190
Gene namesi
Name:Cntnap1
Synonyms:Caspr, Nrxn4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi70902. Cntnap1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 1284ExtracellularSequence analysisAdd BLAST1264
Transmembranei1285 – 1305HelicalSequence analysisAdd BLAST21
Topological domaini1306 – 1381CytoplasmicSequence analysisAdd BLAST76

GO - Cellular componenti

  • axon Source: RGD
  • integral component of membrane Source: RGD
  • myelin sheath Source: Ensembl
  • paranode region of axon Source: BHF-UCL
  • voltage-gated potassium channel complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001950521 – 1381Contactin-associated protein 1Add BLAST1361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 169By similarity
Glycosylationi121N-linked (GlcNAc...)Sequence analysis1
Glycosylationi129N-linked (GlcNAc...)Sequence analysis1
Glycosylationi277N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi324 ↔ 356By similarity
Glycosylationi421N-linked (GlcNAc...)Sequence analysis1
Glycosylationi500N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi507 ↔ 539By similarity
Glycosylationi519N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi545 ↔ 556By similarity
Disulfide bondi550 ↔ 565By similarity
Disulfide bondi567 ↔ 577By similarity
Glycosylationi598N-linked (GlcNAc...)Sequence analysis1
Glycosylationi654N-linked (GlcNAc...)Sequence analysis1
Glycosylationi665N-linked (GlcNAc...)Sequence analysis1
Glycosylationi764N-linked (GlcNAc...)Sequence analysis1
Glycosylationi805N-linked (GlcNAc...)Sequence analysis1
Glycosylationi844N-linked (GlcNAc...)Sequence analysis1
Glycosylationi861N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi931 ↔ 958By similarity
Glycosylationi949N-linked (GlcNAc...)Sequence analysis1
Glycosylationi957N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi962 ↔ 975By similarity
Disulfide bondi969 ↔ 984By similarity
Disulfide bondi986 ↔ 996By similarity
Glycosylationi1079N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1148N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1210 ↔ 1251By similarity
Modified residuei1380PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP97846.
PRIDEiP97846.

PTM databases

iPTMnetiP97846.
PhosphoSitePlusiP97846.
UniCarbKBiP97846.

Expressioni

Tissue specificityi

Predominantly expressed in brain. In myelinated nerve fibers of the CNS predominantly found in paranodal axoglial junctions. In unmyelinated nerve fibers of the CNS diffusely distributed along the entire surface. Weak expression is detected in ovary, pancreas, colon, lung, heart, intestine and testis.1 Publication

Developmental stagei

Detected on postnatal day 7 in cerebellum. Follows a caudorostral progession according to the myelination process. Appears to redistribute from the internode to the paranodal region during myelin compaction and maturation. Expression reaches maximal levels between days 14 and 18 and remains at the same levels until adulthood.

Gene expression databases

BgeeiENSRNOG00000020277.
GenevisibleiP97846. RN.

Interactioni

Subunit structurei

Interacts with contactin in cis form.1 Publication

GO - Molecular functioni

  • SH3 domain binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027505.

Structurei

3D structure databases

ProteinModelPortaliP97846.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 169F5/8 type CPROSITE-ProRule annotationAdd BLAST144
Domaini204 – 356Laminin G-like 1PROSITE-ProRule annotationAdd BLAST153
Domaini390 – 539Laminin G-like 2PROSITE-ProRule annotationAdd BLAST150
Domaini544 – 576EGF-like 1PROSITE-ProRule annotationAdd BLAST33
Domaini577 – 796Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST220
Domaini814 – 958Laminin G-like 3PROSITE-ProRule annotationAdd BLAST145
Domaini962 – 996EGF-like 2PROSITE-ProRule annotationAdd BLAST35
Domaini1089 – 1251Laminin G-like 4PROSITE-ProRule annotationAdd BLAST163

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1329 – 1366SH3-bindingSequence analysisAdd BLAST38

Sequence similaritiesi

Belongs to the neurexin family.Curated
Contains 2 EGF-like domains.PROSITE-ProRule annotation
Contains 1 F5/8 type C domain.PROSITE-ProRule annotation
Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation
Contains 4 laminin G-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, SH3-binding, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3516. Eukaryota.
ENOG410XPHG. LUCA.
GeneTreeiENSGT00760000118991.
HOGENOMiHOG000230964.
HOVERGENiHBG057718.
InParanoidiP97846.
KOiK07379.
OMAiRHDLHYH.
OrthoDBiEOG091G00LF.
PhylomeDBiP97846.

Family and domain databases

Gene3Di2.60.120.200. 5 hits.
2.60.120.260. 1 hit.
3.90.215.10. 1 hit.
InterProiIPR028872. Caspr1.
IPR013320. ConA-like_dom.
IPR000742. EGF-like_dom.
IPR000421. FA58C.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR008979. Galactose-bd-like.
IPR001791. Laminin_G.
IPR003585. Neurexin-like.
[Graphical view]
PANTHERiPTHR10127:SF4. PTHR10127:SF4. 2 hits.
PfamiPF00754. F5_F8_type_C. 1 hit.
PF02210. Laminin_G_2. 4 hits.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00231. FA58C. 1 hit.
SM00282. LamG. 4 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF49899. SSF49899. 5 hits.
SSF56496. SSF56496. 1 hit.
PROSITEiPS50026. EGF_3. 2 hits.
PS01285. FA58C_1. 1 hit.
PS01286. FA58C_2. 1 hit.
PS50022. FA58C_3. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50025. LAM_G_DOMAIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97846-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSLRLFSIL LAAVVSGAQG WGYYGCNEEL VGPLYARSLG ASSYYGLFTT
60 70 80 90 100
ARFARLHGIS GWSPRIGDPN PWLQIDLMKK HRIRAVATQG AFNSWDWVTR
110 120 130 140 150
YMLLYGDRVD SWTPFYQQGH NATFFGNVND SAVVRHDLHY HFTARYIRIV
160 170 180 190 200
PLAWNPRGKI GLRLGIYGCP YTSNILYFDG DDAISYRFQR GASQSLWDVF
210 220 230 240 250
AFSFKTEEKD GLLLHTEGSQ GDYVTLELQG AHLLLHMSLG SSPIQPRPGH
260 270 280 290 300
TTVSAGGVLN DLSWHYVRVD RYGREANLTL DGYVHRFVLN GDFERLNLEN
310 320 330 340 350
EIFIGGLVGA ARKNLAYRHN FRGCIENVIY NRINIAEMAV QRHSRITFEG
360 370 380 390 400
NVAFRCLDPV PHPINFGGPH NFVQVPGFPR RGRLAVSFRF RTWDLTGLLL
410 420 430 440 450
FSRLGDGLGH VELMLSEGQV NVSIAQTGRK KLQFAAGYRL NDGFWHEVNF
460 470 480 490 500
VAQENHAVIS IDDVEGAEVR VSYPLLIRTG TSYFFGGCPK PASRWGCHSN
510 520 530 540 550
QTAFHGCMEL LKVDGQLVNL TLVEFRKLGY FAEVLFDTCG ITDRCSPNMC
560 570 580 590 600
EHDGRCYQSW DDFICYCELT GYKGVTCHEP LYKESCEAYR LSGKYSGNYT
610 620 630 640 650
IDPDGSGPLK PFVVYCDIRE NRAWTVVRHD RLWTTRVTGS SMDRPFLGAI
660 670 680 690 700
QYWNASWEEV SALANASQHC EQWIEFSCYN SRLLNTAGGY PYSFWIGRNE
710 720 730 740 750
EQHFYWGGSQ PGIQRCACGL DQSCIDPALH CNCDADQPQW RTDKGLLTFV
760 770 780 790 800
DHLPVTQVVI GDTNRSSSEA QFFLRPLRCY GDRNSWNTIS FRTGAALRFP
810 820 830 840 850
PIRANHSLDV SFYFRTSAPS GVFLENMGGP FCQWRRPYVR VELNTSRDVV
860 870 880 890 900
FAFDIGNGDE NLTVHSDDFE FNDDEWHLVR AEINVKQARL RVDHRPWVLR
910 920 930 940 950
PMPLQTYIWL EYDQPLYVGS AELKRRPFVG CLRAMRLNGV TLNLEGRANA
960 970 980 990 1000
SEGTFPNCTG HCTHPRFPCF HGGRCVERYS YYTCDCDLTA FDGPYCNHDI
1010 1020 1030 1040 1050
GGFFETGTWM RYNLQSALRS AAQEFSHMLS RPVPGYEPGY IPGYDTPGYV
1060 1070 1080 1090 1100
PGYHGPGYRL PDYPRPGRPV PGYRGPVYNV TGEEVSFSFS TSSAPAVLLY
1110 1120 1130 1140 1150
VSSFVRDYMA VLIKEDGTLQ LRYQLGTSPY VYQLTTRPVT DGQPHSVNIT
1160 1170 1180 1190 1200
RVYRNLFIQV DYFPLTEQKF SLLVDSQLDS PKALYLGRVM ETGVIDPEIQ
1210 1220 1230 1240 1250
RYNTPGFSGC LSGVRFNNVA PLKTHFRTPR PMTAELAEAM RVQGELSESN
1260 1270 1280 1290 1300
CGAMPRLVSE VPPELDPWYL PPDFPYYHDD GWIAILLGFL VAFLLLGLVG
1310 1320 1330 1340 1350
MLVLFYLQNH RYKGSYHTNE PKATHDSHPG GKAPLPPSGP AQAPAPTPAP
1360 1370 1380
TQVPTPAPAP ASGPGPRDQN LPQILEESRS E
Length:1,381
Mass (Da):155,868
Last modified:May 1, 1997 - v1
Checksum:iBC1CE83DB57C1BA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U87224 mRNA. Translation: AAB48482.1.
AF000114 mRNA. Translation: AAC53342.1.
PIRiT31083.
RefSeqiNP_114450.1. NM_032061.2.
UniGeneiRn.88654.

Genome annotation databases

EnsembliENSRNOT00000027505; ENSRNOP00000027505; ENSRNOG00000020277.
GeneIDi84008.
KEGGirno:84008.
UCSCiRGD:70902. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U87224 mRNA. Translation: AAB48482.1.
AF000114 mRNA. Translation: AAC53342.1.
PIRiT31083.
RefSeqiNP_114450.1. NM_032061.2.
UniGeneiRn.88654.

3D structure databases

ProteinModelPortaliP97846.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027505.

PTM databases

iPTMnetiP97846.
PhosphoSitePlusiP97846.
UniCarbKBiP97846.

Proteomic databases

PaxDbiP97846.
PRIDEiP97846.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027505; ENSRNOP00000027505; ENSRNOG00000020277.
GeneIDi84008.
KEGGirno:84008.
UCSCiRGD:70902. rat.

Organism-specific databases

CTDi8506.
RGDi70902. Cntnap1.

Phylogenomic databases

eggNOGiKOG3516. Eukaryota.
ENOG410XPHG. LUCA.
GeneTreeiENSGT00760000118991.
HOGENOMiHOG000230964.
HOVERGENiHBG057718.
InParanoidiP97846.
KOiK07379.
OMAiRHDLHYH.
OrthoDBiEOG091G00LF.
PhylomeDBiP97846.

Miscellaneous databases

PROiP97846.

Gene expression databases

BgeeiENSRNOG00000020277.
GenevisibleiP97846. RN.

Family and domain databases

Gene3Di2.60.120.200. 5 hits.
2.60.120.260. 1 hit.
3.90.215.10. 1 hit.
InterProiIPR028872. Caspr1.
IPR013320. ConA-like_dom.
IPR000742. EGF-like_dom.
IPR000421. FA58C.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR008979. Galactose-bd-like.
IPR001791. Laminin_G.
IPR003585. Neurexin-like.
[Graphical view]
PANTHERiPTHR10127:SF4. PTHR10127:SF4. 2 hits.
PfamiPF00754. F5_F8_type_C. 1 hit.
PF02210. Laminin_G_2. 4 hits.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00231. FA58C. 1 hit.
SM00282. LamG. 4 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF49899. SSF49899. 5 hits.
SSF56496. SSF56496. 1 hit.
PROSITEiPS50026. EGF_3. 2 hits.
PS01285. FA58C_1. 1 hit.
PS01286. FA58C_2. 1 hit.
PS50022. FA58C_3. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50025. LAM_G_DOMAIN. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNTP1_RAT
AccessioniPrimary (citable) accession number: P97846
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: May 1, 1997
Last modified: November 2, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.