P97844 (RGS1_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Regulator of G-protein signaling 1
Short name=RGS1

Gene names

Name:

Rgs1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	162 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form By similarity.
Tissue specificity	Expressed in multiple tissues.
Post-translational modification	Could be phosphorylated. Might be functionally regulated by protein kinase(s) By similarity.
Sequence similarities	Contains 1 RGS domain.

Ontologies

Keywords
Molecular function	Signal transduction inhibitor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	termination of G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from Biological aspect of Ancestor. Source: RefGenome plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	GTPase activator activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 162	162	Regulator of G-protein signaling 1		PRO_0000204177
Regions
	Domain	38 – 153	116	RGS

Sequences

	Sequence		Length	Mass (Da)
	P97844 [UniParc]. Last modified December 20, 2005. Version 2. Checksum: D2541C3AFA93F930	FASTA	162	18,836
	10 20 30 40 50 60 MDMKAYLRSM IPHLESGMKS SKSKDILSAE EVMQWSQSLE KLLANQMGQN VFGKFLKSEF 70 80 90 100 110 120 SEENIEFWLA CEDYKKTETD LLHNKAEHIY KAFVHSDAVK QINIDFHTRE STAKKIKTPT 130 140 150 160 PTCFDEAQKV IYALMEKDSY PRFLKSNIYL NLLNDLQANT LK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thymus.
[2]	"The rat RGS1 gene is expressed in multiple tissues." Greenwood M.T., Guo Y., Hussain S.N.A. Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 44-124.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC098681 mRNA. Translation: AAH98681.1. U77698 mRNA. Translation: AAB48300.1.
IPI	IPI00358927.
RefSeq	NP_062209.1. NM_019336.1.
UniGene	Rn.14787.
3D structure databases
ProteinModelPortal	P97844.
SMR	P97844. Positions 24-157.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-191648.
Proteomic databases
PaxDb	P97844.
PRIDE	P97844.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000005251; ENSRNOP00000005251; ENSRNOG00000003895.
GeneID	54289.
KEGG	rno:54289.
UCSC	RGD:3561. rat.
Organism-specific databases
CTD	5996.
RGD	3561. Rgs1.
Phylogenomic databases
eggNOG	NOG312555.
GeneTree	ENSGT00700000104212.
HOGENOM	HOG000233512.
HOVERGEN	HBG013233.
InParanoid	P97844.
KO	K16449.
OrthoDB	EOG42822Z.
Gene expression databases
Genevestigator	P97844.
GermOnline	ENSRNOG00000003895. Rattus norvegicus.
Family and domain databases
Gene3D	1.10.196.10. 2 hits.
InterPro	IPR000342. Regulat_G_prot_signal. IPR024066. Regulat_G_prot_signal_dom1. IPR016137. Regulat_G_prot_signal_superfam. [Graphical view]
Pfam	PF00615. RGS. 1 hit. [Graphical view]
PRINTS	PR01301. RGSPROTEIN.
SMART	SM00315. RGS. 1 hit. [Graphical view]
SUPFAM	SSF48097. Regulat_G_prot_signal_superfam. 1 hit.
PROSITE	PS50132. RGS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	610888.

Entry information

Entry name

RGS1_RAT

Accession

Primary (citable) accession number: P97844
Secondary accession number(s): Q4KM99

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	December 20, 2005
Last modified:	May 29, 2013
This is version 82 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program