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P97844

- RGS1_RAT

UniProt

P97844 - RGS1_RAT

Protein

Regulator of G-protein signaling 1

Gene

Rgs1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.By similarity

    GO - Molecular functioni

    1. GTPase activator activity Source: RefGenome

    GO - Biological processi

    1. positive regulation of GTPase activity Source: GOC
    2. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of G-protein signaling 1
    Short name:
    RGS1
    Gene namesi
    Name:Rgs1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 13

    Organism-specific databases

    RGDi3561. Rgs1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. plasma membrane Source: RefGenome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 162162Regulator of G-protein signaling 1PRO_0000204177Add
    BLAST

    Post-translational modificationi

    Could be phosphorylated. Might be functionally regulated by protein kinase(s) By similarity.By similarity

    Proteomic databases

    PaxDbiP97844.
    PRIDEiP97844.

    Expressioni

    Tissue specificityi

    Expressed in multiple tissues.

    Gene expression databases

    GenevestigatoriP97844.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-191648.
    STRINGi10116.ENSRNOP00000005251.

    Structurei

    3D structure databases

    ProteinModelPortaliP97844.
    SMRiP97844. Positions 24-157.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini38 – 153116RGSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG312555.
    GeneTreeiENSGT00750000117371.
    HOGENOMiHOG000233512.
    HOVERGENiHBG013233.
    InParanoidiP97844.
    KOiK16449.
    OMAiEVIQWSQ.
    OrthoDBiEOG7VHSZ5.
    PhylomeDBiP97844.
    TreeFamiTF315837.

    Family and domain databases

    Gene3Di1.10.196.10. 2 hits.
    InterProiIPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view]
    PfamiPF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    PROSITEiPS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P97844-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDMKAYLRSM IPHLESGMKS SKSKDILSAE EVMQWSQSLE KLLANQMGQN    50
    VFGKFLKSEF SEENIEFWLA CEDYKKTETD LLHNKAEHIY KAFVHSDAVK 100
    QINIDFHTRE STAKKIKTPT PTCFDEAQKV IYALMEKDSY PRFLKSNIYL 150
    NLLNDLQANT LK 162
    Length:162
    Mass (Da):18,836
    Last modified:December 20, 2005 - v2
    Checksum:iD2541C3AFA93F930
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC098681 mRNA. Translation: AAH98681.1.
    U77698 mRNA. Translation: AAB48300.1.
    RefSeqiNP_062209.1. NM_019336.1.
    UniGeneiRn.14787.

    Genome annotation databases

    EnsembliENSRNOT00000005251; ENSRNOP00000005251; ENSRNOG00000003895.
    GeneIDi54289.
    KEGGirno:54289.
    UCSCiRGD:3561. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC098681 mRNA. Translation: AAH98681.1 .
    U77698 mRNA. Translation: AAB48300.1 .
    RefSeqi NP_062209.1. NM_019336.1.
    UniGenei Rn.14787.

    3D structure databases

    ProteinModelPortali P97844.
    SMRi P97844. Positions 24-157.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-191648.
    STRINGi 10116.ENSRNOP00000005251.

    Proteomic databases

    PaxDbi P97844.
    PRIDEi P97844.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000005251 ; ENSRNOP00000005251 ; ENSRNOG00000003895 .
    GeneIDi 54289.
    KEGGi rno:54289.
    UCSCi RGD:3561. rat.

    Organism-specific databases

    CTDi 5996.
    RGDi 3561. Rgs1.

    Phylogenomic databases

    eggNOGi NOG312555.
    GeneTreei ENSGT00750000117371.
    HOGENOMi HOG000233512.
    HOVERGENi HBG013233.
    InParanoidi P97844.
    KOi K16449.
    OMAi EVIQWSQ.
    OrthoDBi EOG7VHSZ5.
    PhylomeDBi P97844.
    TreeFami TF315837.

    Miscellaneous databases

    NextBioi 610888.
    PROi P97844.

    Gene expression databases

    Genevestigatori P97844.

    Family and domain databases

    Gene3Di 1.10.196.10. 2 hits.
    InterProi IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view ]
    Pfami PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    PROSITEi PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thymus.
    2. "The rat RGS1 gene is expressed in multiple tissues."
      Greenwood M.T., Guo Y., Hussain S.N.A.
      Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 44-124.

    Entry informationi

    Entry nameiRGS1_RAT
    AccessioniPrimary (citable) accession number: P97844
    Secondary accession number(s): Q4KM99
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3