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P97844

- RGS1_RAT

UniProt

P97844 - RGS1_RAT

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Protein

Regulator of G-protein signaling 1

Gene

Rgs1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.By similarity

GO - Molecular functioni

  1. GTPase activator activity Source: RefGenome

GO - Biological processi

  1. positive regulation of GTPase activity Source: GOC
  2. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 1
Short name:
RGS1
Gene namesi
Name:Rgs1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi3561. Rgs1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. plasma membrane Source: RefGenome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 162162Regulator of G-protein signaling 1PRO_0000204177Add
BLAST

Post-translational modificationi

Could be phosphorylated. Might be functionally regulated by protein kinase(s) By similarity.By similarity

Proteomic databases

PaxDbiP97844.
PRIDEiP97844.

Expressioni

Tissue specificityi

Expressed in multiple tissues.

Gene expression databases

GenevestigatoriP97844.

Interactioni

Protein-protein interaction databases

MINTiMINT-191648.
STRINGi10116.ENSRNOP00000005251.

Structurei

3D structure databases

ProteinModelPortaliP97844.
SMRiP97844. Positions 24-157.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 153116RGSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG312555.
GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiP97844.
KOiK16449.
OMAiEVIQWSQ.
OrthoDBiEOG7VHSZ5.
PhylomeDBiP97844.
TreeFamiTF315837.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97844-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDMKAYLRSM IPHLESGMKS SKSKDILSAE EVMQWSQSLE KLLANQMGQN
60 70 80 90 100
VFGKFLKSEF SEENIEFWLA CEDYKKTETD LLHNKAEHIY KAFVHSDAVK
110 120 130 140 150
QINIDFHTRE STAKKIKTPT PTCFDEAQKV IYALMEKDSY PRFLKSNIYL
160
NLLNDLQANT LK
Length:162
Mass (Da):18,836
Last modified:December 20, 2005 - v2
Checksum:iD2541C3AFA93F930
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC098681 mRNA. Translation: AAH98681.1.
U77698 mRNA. Translation: AAB48300.1.
RefSeqiNP_062209.1. NM_019336.1.
UniGeneiRn.14787.

Genome annotation databases

EnsembliENSRNOT00000005251; ENSRNOP00000005251; ENSRNOG00000003895.
GeneIDi54289.
KEGGirno:54289.
UCSCiRGD:3561. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC098681 mRNA. Translation: AAH98681.1 .
U77698 mRNA. Translation: AAB48300.1 .
RefSeqi NP_062209.1. NM_019336.1.
UniGenei Rn.14787.

3D structure databases

ProteinModelPortali P97844.
SMRi P97844. Positions 24-157.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-191648.
STRINGi 10116.ENSRNOP00000005251.

Proteomic databases

PaxDbi P97844.
PRIDEi P97844.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000005251 ; ENSRNOP00000005251 ; ENSRNOG00000003895 .
GeneIDi 54289.
KEGGi rno:54289.
UCSCi RGD:3561. rat.

Organism-specific databases

CTDi 5996.
RGDi 3561. Rgs1.

Phylogenomic databases

eggNOGi NOG312555.
GeneTreei ENSGT00760000118903.
HOGENOMi HOG000233512.
HOVERGENi HBG013233.
InParanoidi P97844.
KOi K16449.
OMAi EVIQWSQ.
OrthoDBi EOG7VHSZ5.
PhylomeDBi P97844.
TreeFami TF315837.

Miscellaneous databases

NextBioi 610888.
PROi P97844.

Gene expression databases

Genevestigatori P97844.

Family and domain databases

Gene3Di 1.10.196.10. 2 hits.
InterProi IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view ]
Pfami PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SMARTi SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
PROSITEi PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  2. "The rat RGS1 gene is expressed in multiple tissues."
    Greenwood M.T., Guo Y., Hussain S.N.A.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 44-124.

Entry informationi

Entry nameiRGS1_RAT
AccessioniPrimary (citable) accession number: P97844
Secondary accession number(s): Q4KM99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 20, 2005
Last modified: October 29, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3