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Protein

Regulator of G-protein signaling 1

Gene

Rgs1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 1
Short name:
RGS1
Gene namesi
Name:Rgs1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi3561. Rgs1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 162162Regulator of G-protein signaling 1PRO_0000204177Add
BLAST

Post-translational modificationi

Could be phosphorylated. Might be functionally regulated by protein kinase(s) (By similarity).By similarity

Proteomic databases

PaxDbiP97844.
PRIDEiP97844.

Expressioni

Tissue specificityi

Expressed in multiple tissues.

Gene expression databases

GenevisibleiP97844. RN.

Interactioni

Protein-protein interaction databases

MINTiMINT-191648.
STRINGi10116.ENSRNOP00000005251.

Structurei

3D structure databases

ProteinModelPortaliP97844.
SMRiP97844. Positions 24-157.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 153116RGSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG312555.
GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiP97844.
KOiK16449.
OMAiKIYKAFV.
OrthoDBiEOG7VHSZ5.
PhylomeDBiP97844.
TreeFamiTF315837.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR016137. RGS.
IPR030409. RGS1.
IPR024066. RGS_subdom1.
[Graphical view]
PANTHERiPTHR10845:SF34. PTHR10845:SF34. 1 hit.
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97844-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDMKAYLRSM IPHLESGMKS SKSKDILSAE EVMQWSQSLE KLLANQMGQN
60 70 80 90 100
VFGKFLKSEF SEENIEFWLA CEDYKKTETD LLHNKAEHIY KAFVHSDAVK
110 120 130 140 150
QINIDFHTRE STAKKIKTPT PTCFDEAQKV IYALMEKDSY PRFLKSNIYL
160
NLLNDLQANT LK
Length:162
Mass (Da):18,836
Last modified:December 20, 2005 - v2
Checksum:iD2541C3AFA93F930
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098681 mRNA. Translation: AAH98681.1.
U77698 mRNA. Translation: AAB48300.1.
RefSeqiNP_062209.1. NM_019336.1.
UniGeneiRn.14787.

Genome annotation databases

EnsembliENSRNOT00000005251; ENSRNOP00000005251; ENSRNOG00000003895.
GeneIDi54289.
KEGGirno:54289.
UCSCiRGD:3561. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098681 mRNA. Translation: AAH98681.1.
U77698 mRNA. Translation: AAB48300.1.
RefSeqiNP_062209.1. NM_019336.1.
UniGeneiRn.14787.

3D structure databases

ProteinModelPortaliP97844.
SMRiP97844. Positions 24-157.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-191648.
STRINGi10116.ENSRNOP00000005251.

Proteomic databases

PaxDbiP97844.
PRIDEiP97844.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005251; ENSRNOP00000005251; ENSRNOG00000003895.
GeneIDi54289.
KEGGirno:54289.
UCSCiRGD:3561. rat.

Organism-specific databases

CTDi5996.
RGDi3561. Rgs1.

Phylogenomic databases

eggNOGiNOG312555.
GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiP97844.
KOiK16449.
OMAiKIYKAFV.
OrthoDBiEOG7VHSZ5.
PhylomeDBiP97844.
TreeFamiTF315837.

Miscellaneous databases

NextBioi610888.
PROiP97844.

Gene expression databases

GenevisibleiP97844. RN.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR016137. RGS.
IPR030409. RGS1.
IPR024066. RGS_subdom1.
[Graphical view]
PANTHERiPTHR10845:SF34. PTHR10845:SF34. 1 hit.
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  2. "The rat RGS1 gene is expressed in multiple tissues."
    Greenwood M.T., Guo Y., Hussain S.N.A.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 44-124.

Entry informationi

Entry nameiRGS1_RAT
AccessioniPrimary (citable) accession number: P97844
Secondary accession number(s): Q4KM99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 20, 2005
Last modified: June 24, 2015
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.