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Protein

Regulator of G-protein signaling 1

Gene

Rgs1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors. Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation, Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 1
Short name:
RGS1
Gene namesi
Name:Rgs1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi3561. Rgs1.

Subcellular locationi

  • Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
  • Cytoplasmcytosol By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Regulator of G-protein signaling 1PRO_0000204177Add
BLAST

Proteomic databases

PaxDbiP97844.
PRIDEiP97844.

Expressioni

Tissue specificityi

Expressed in multiple tissues.1 Publication

Gene expression databases

BgeeiENSRNOG00000003895.
GenevisibleiP97844. RN.

Interactioni

Subunit structurei

Interacts with GNAI1 and GNAQ.By similarity

Protein-protein interaction databases

MINTiMINT-191648.
STRINGi10116.ENSRNOP00000005251.

Structurei

3D structure databases

ProteinModelPortaliP97844.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini85 – 200116RGSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiP97844.
KOiK16449.
OMAiKIYKAFV.
OrthoDBiEOG091G0BDG.
TreeFamiTF315837.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR016137. RGS.
IPR030409. RGS1.
IPR024066. RGS_subdom1.
[Graphical view]
PANTHERiPTHR10845:SF34. PTHR10845:SF34. 1 hit.
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P97844-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRAAAISMPR LNKMPGMFFS ASPKDSKEPS HSLLDDNKQK KRPKTFGMDM
60 70 80 90 100
KAYLRSMIPH LESGMKSSKS KDILSAEEVM QWSQSLEKLL ANQMGQNVFG
110 120 130 140 150
KFLKSEFSEE NIEFWLACED YKKTETDLLH NKAEHIYKAF VHSDAVKQIN
160 170 180 190 200
IDFHTRESTA KKIKTPTPTC FDEAQKVIYA LMEKDSYPRF LKSNIYLNLL

NDLQANTLK
Length:209
Mass (Da):24,096
Last modified:February 17, 2016 - v3
Checksum:i939CCD55ADB06432
GO
Isoform 2 (identifier: P97844-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.

Show »
Length:162
Mass (Da):18,836
Checksum:iD2541C3AFA93F930
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4747Missing in isoform 2. VSP_058127Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07021216 Genomic DNA. No translation available.
CH473958 Genomic DNA. Translation: EDM09598.1.
BC098681 mRNA. Translation: AAH98681.1.
U77698 mRNA. Translation: AAB48300.1.
RefSeqiNP_062209.1. NM_019336.1. [P97844-2]
XP_006250036.1. XM_006249974.2. [P97844-1]
UniGeneiRn.14787.

Genome annotation databases

EnsembliENSRNOT00000005251; ENSRNOP00000005251; ENSRNOG00000003895. [P97844-1]
GeneIDi54289.
KEGGirno:54289.
UCSCiRGD:3561. rat. [P97844-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07021216 Genomic DNA. No translation available.
CH473958 Genomic DNA. Translation: EDM09598.1.
BC098681 mRNA. Translation: AAH98681.1.
U77698 mRNA. Translation: AAB48300.1.
RefSeqiNP_062209.1. NM_019336.1. [P97844-2]
XP_006250036.1. XM_006249974.2. [P97844-1]
UniGeneiRn.14787.

3D structure databases

ProteinModelPortaliP97844.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-191648.
STRINGi10116.ENSRNOP00000005251.

Proteomic databases

PaxDbiP97844.
PRIDEiP97844.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005251; ENSRNOP00000005251; ENSRNOG00000003895. [P97844-1]
GeneIDi54289.
KEGGirno:54289.
UCSCiRGD:3561. rat. [P97844-1]

Organism-specific databases

CTDi5996.
RGDi3561. Rgs1.

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiP97844.
KOiK16449.
OMAiKIYKAFV.
OrthoDBiEOG091G0BDG.
TreeFamiTF315837.

Miscellaneous databases

PROiP97844.

Gene expression databases

BgeeiENSRNOG00000003895.
GenevisibleiP97844. RN.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR016137. RGS.
IPR030409. RGS1.
IPR024066. RGS_subdom1.
[Graphical view]
PANTHERiPTHR10845:SF34. PTHR10845:SF34. 1 hit.
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRGS1_RAT
AccessioniPrimary (citable) accession number: P97844
Secondary accession number(s): A0A0H2UHC4, Q4KM99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 17, 2016
Last modified: September 7, 2016
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.