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P97844 (RGS1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Regulator of G-protein signaling 1

Short name=RGS1
Gene names
Name:Rgs1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length162 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form By similarity.

Tissue specificity

Expressed in multiple tissues.

Post-translational modification

Could be phosphorylated. Might be functionally regulated by protein kinase(s) By similarity.

Sequence similarities

Contains 1 RGS domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 162162Regulator of G-protein signaling 1
PRO_0000204177

Regions

Domain38 – 153116RGS

Sequences

Sequence LengthMass (Da)Tools
P97844 [UniParc].

Last modified December 20, 2005. Version 2.
Checksum: D2541C3AFA93F930

FASTA16218,836
        10         20         30         40         50         60 
MDMKAYLRSM IPHLESGMKS SKSKDILSAE EVMQWSQSLE KLLANQMGQN VFGKFLKSEF 

        70         80         90        100        110        120 
SEENIEFWLA CEDYKKTETD LLHNKAEHIY KAFVHSDAVK QINIDFHTRE STAKKIKTPT 

       130        140        150        160 
PTCFDEAQKV IYALMEKDSY PRFLKSNIYL NLLNDLQANT LK 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thymus.
[2]"The rat RGS1 gene is expressed in multiple tissues."
Greenwood M.T., Guo Y., Hussain S.N.A.
Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 44-124.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC098681 mRNA. Translation: AAH98681.1.
U77698 mRNA. Translation: AAB48300.1.
RefSeqNP_062209.1. NM_019336.1.
UniGeneRn.14787.

3D structure databases

ProteinModelPortalP97844.
SMRP97844. Positions 24-157.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-191648.
STRING10116.ENSRNOP00000005251.

Proteomic databases

PaxDbP97844.
PRIDEP97844.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000005251; ENSRNOP00000005251; ENSRNOG00000003895.
GeneID54289.
KEGGrno:54289.
UCSCRGD:3561. rat.

Organism-specific databases

CTD5996.
RGD3561. Rgs1.

Phylogenomic databases

eggNOGNOG312555.
GeneTreeENSGT00750000117371.
HOGENOMHOG000233512.
HOVERGENHBG013233.
InParanoidP97844.
KOK16449.
OMAEVIQWSQ.
OrthoDBEOG7VHSZ5.
PhylomeDBP97844.
TreeFamTF315837.

Gene expression databases

GenevestigatorP97844.

Family and domain databases

Gene3D1.10.196.10. 2 hits.
InterProIPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamPF00615. RGS. 1 hit.
[Graphical view]
PRINTSPR01301. RGSPROTEIN.
SMARTSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMSSF48097. SSF48097. 1 hit.
PROSITEPS50132. RGS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio610888.
PROP97844.

Entry information

Entry nameRGS1_RAT
AccessionPrimary (citable) accession number: P97844
Secondary accession number(s): Q4KM99
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 20, 2005
Last modified: May 14, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families