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P97840

- LEG9_RAT

UniProt

P97840 - LEG9_RAT

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Protein

Galectin-9

Gene

Lgals9

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Binds galactosides. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death (By similarity). May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion. Highly selective to the anion urate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei47 – 471Beta-galactoside 1By similarity
Binding sitei60 – 601Beta-galactoside 1By similarity
Binding sitei64 – 641Beta-galactoside 1By similarity
Binding sitei74 – 741Beta-galactoside 1By similarity
Binding sitei266 – 2661Beta-galactoside 2By similarity
Binding sitei270 – 2701Beta-galactoside 2By similarity
Binding sitei280 – 2801Beta-galactoside 2By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB

GO - Biological processi

  1. ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Lectin

Protein family/group databases

TCDBi9.B.9.1.1. the urate transporter (uat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-9
Short name:
Gal-9
Alternative name(s):
36 kDa beta-galactoside-binding lectin
Urate transporter/channel
Short name:
UAT
Gene namesi
Name:Lgals9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3005. Lgals9.

Subcellular locationi

Cytoplasm By similarity. Secreted By similarity
Note: May also be secreted by a non-classical secretory pathway.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Galectin-9PRO_0000076948Add
BLAST

Proteomic databases

PaxDbiP97840.
PRIDEiP97840.

Expressioni

Tissue specificityi

The isoform Long is expressed exclusively in the small intestine.

Gene expression databases

GenevestigatoriP97840.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017042.

Structurei

3D structure databases

ProteinModelPortaliP97840.
SMRiP97840. Positions 1-147.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 147131Galectin 1PROSITE-ProRule annotationAdd
BLAST
Domaini226 – 354129Galectin 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni81 – 877Beta-galactoside binding 1By similarity
Regioni286 – 2927Beta-galactoside binding 2By similarity

Domaini

Contains two homologous but distinct carbohydrate-binding domains.

Sequence similaritiesi

Contains 2 galectin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG264430.
HOGENOMiHOG000290194.
HOVERGENiHBG002412.
InParanoidiP97840.
KOiK10093.
PhylomeDBiP97840.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS51304. GALECTIN. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform Long (identifier: P97840-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFFSTQPPY MNPVIPFTGI IQGGLQNGLQ ITLQGTVHPF PNRIAVNFQT
60 70 80 90 100
GFSGNDIAFH FNPRFEEGGY VVCNTKQNGK WGPEERKMQM PFQKGMPFEL
110 120 130 140 150
CFLVQRSEFK VMVNKNFFVQ YSHRVPYHLV DTISVSGCLH LSFINFQNST
160 170 180 190 200
AAPVQPVFST MQFSQPVQFP RMPKGRKQRT QGFQPALQAP VAQTIIHTVH
210 220 230 240 250
SIPGQMLSTP GIPPMAYPTP AYTIPFFTSI PNGFYPSKSI NISGVVLPDA
260 270 280 290 300
KRFHINLRCG GDIAFHLNPR FNEKVVVRNT QINNSWGPEE RSLPGRMPFN
310 320 330 340 350
RGQSFSVWIL CEGHCFKVAV DGQHICEYYH RLKNLPDINT LEVAGDIQLT

HVQT
Length:354
Mass (Da):39,946
Last modified:July 15, 1998 - v2
Checksum:i6574F960B2EAF37C
GO
Isoform Short (identifier: P97840-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-179: Missing.

Show »
Length:322
Mass (Da):36,317
Checksum:i3268B472A91EECCA
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei148 – 17932Missing in isoform Short. 2 PublicationsVSP_003098Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59462 mRNA. Translation: AAB51192.1.
U72741 mRNA. Translation: AAB68592.1.
U67958 mRNA. Translation: AAB48591.1.
RefSeqiNP_037109.1. NM_012977.1.
UniGeneiRn.10706.

Genome annotation databases

GeneIDi25476.
KEGGirno:25476.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59462 mRNA. Translation: AAB51192.1 .
U72741 mRNA. Translation: AAB68592.1 .
U67958 mRNA. Translation: AAB48591.1 .
RefSeqi NP_037109.1. NM_012977.1.
UniGenei Rn.10706.

3D structure databases

ProteinModelPortali P97840.
SMRi P97840. Positions 1-147.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000017042.

Protein family/group databases

TCDBi 9.B.9.1.1. the urate transporter (uat) family.

Proteomic databases

PaxDbi P97840.
PRIDEi P97840.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 25476.
KEGGi rno:25476.

Organism-specific databases

CTDi 3965.
RGDi 3005. Lgals9.

Phylogenomic databases

eggNOGi NOG264430.
HOGENOMi HOG000290194.
HOVERGENi HBG002412.
InParanoidi P97840.
KOi K10093.
PhylomeDBi P97840.

Miscellaneous databases

NextBioi 606793.
PROi P97840.

Gene expression databases

Genevestigatori P97840.

Family and domain databases

Gene3Di 2.60.120.200. 2 hits.
InterProi IPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view ]
Pfami PF00337. Gal-bind_lectin. 2 hits.
[Graphical view ]
SMARTi SM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 2 hits.
PROSITEi PS51304. GALECTIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification and characterization of galectin-9, a novel beta-galactoside-binding mammalian lectin."
    Wada J., Kanwar Y.S.
    J. Biol. Chem. 272:6078-6086(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
    Strain: Sprague-Dawley.
    Tissue: Kidney and Small intestine.
  2. "Molecular cloning and functional reconstitution of a urate transporter/channel."
    Leal-Pinto E., Tao W., Rappaport J., Richardson M., Knorr B.A., Abramson R.G.
    J. Biol. Chem. 272:617-625(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
    Strain: Sprague-Dawley.
    Tissue: Kidney.

Entry informationi

Entry nameiLEG9_RAT
AccessioniPrimary (citable) accession number: P97840
Secondary accession number(s): O08588, O35866
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: October 29, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The LGALS9-like proteins are encoded by a duplicated regions on chromosome 17; there are at least 3 genes coding for galectin-9-like proteins.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3