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P97840

- LEG9_RAT

UniProt

P97840 - LEG9_RAT

Protein

Galectin-9

Gene

Lgals9

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    Binds galactosides. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death By similarity. May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion. Highly selective to the anion urate.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei47 – 471Beta-galactoside 1By similarity
    Binding sitei60 – 601Beta-galactoside 1By similarity
    Binding sitei64 – 641Beta-galactoside 1By similarity
    Binding sitei74 – 741Beta-galactoside 1By similarity
    Binding sitei266 – 2661Beta-galactoside 2By similarity
    Binding sitei270 – 2701Beta-galactoside 2By similarity
    Binding sitei280 – 2801Beta-galactoside 2By similarity

    GO - Molecular functioni

    1. carbohydrate binding Source: UniProtKB

    GO - Biological processi

    1. ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Lectin

    Protein family/group databases

    TCDBi9.B.9.1.1. the urate transporter (uat) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Galectin-9
    Short name:
    Gal-9
    Alternative name(s):
    36 kDa beta-galactoside-binding lectin
    Urate transporter/channel
    Short name:
    UAT
    Gene namesi
    Name:Lgals9
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi3005. Lgals9.

    Subcellular locationi

    Cytoplasm By similarity. Secreted By similarity
    Note: May also be secreted by a non-classical secretory pathway.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 354354Galectin-9PRO_0000076948Add
    BLAST

    Proteomic databases

    PaxDbiP97840.
    PRIDEiP97840.

    Expressioni

    Tissue specificityi

    The isoform Long is expressed exclusively in the small intestine.

    Gene expression databases

    GenevestigatoriP97840.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000017042.

    Structurei

    3D structure databases

    ProteinModelPortaliP97840.
    SMRiP97840. Positions 1-147.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini17 – 147131Galectin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini226 – 354129Galectin 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni81 – 877Beta-galactoside binding 1By similarity
    Regioni286 – 2927Beta-galactoside binding 2By similarity

    Domaini

    Contains two homologous but distinct carbohydrate-binding domains.

    Sequence similaritiesi

    Contains 2 galectin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG264430.
    HOGENOMiHOG000290194.
    HOVERGENiHBG002412.
    InParanoidiP97840.
    KOiK10093.
    PhylomeDBiP97840.

    Family and domain databases

    Gene3Di2.60.120.200. 2 hits.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001079. Galectin_CRD.
    [Graphical view]
    PfamiPF00337. Gal-bind_lectin. 2 hits.
    [Graphical view]
    SMARTiSM00908. Gal-bind_lectin. 2 hits.
    SM00276. GLECT. 2 hits.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 2 hits.
    PROSITEiPS51304. GALECTIN. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform Long (identifier: P97840-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAFFSTQPPY MNPVIPFTGI IQGGLQNGLQ ITLQGTVHPF PNRIAVNFQT    50
    GFSGNDIAFH FNPRFEEGGY VVCNTKQNGK WGPEERKMQM PFQKGMPFEL 100
    CFLVQRSEFK VMVNKNFFVQ YSHRVPYHLV DTISVSGCLH LSFINFQNST 150
    AAPVQPVFST MQFSQPVQFP RMPKGRKQRT QGFQPALQAP VAQTIIHTVH 200
    SIPGQMLSTP GIPPMAYPTP AYTIPFFTSI PNGFYPSKSI NISGVVLPDA 250
    KRFHINLRCG GDIAFHLNPR FNEKVVVRNT QINNSWGPEE RSLPGRMPFN 300
    RGQSFSVWIL CEGHCFKVAV DGQHICEYYH RLKNLPDINT LEVAGDIQLT 350
    HVQT 354
    Length:354
    Mass (Da):39,946
    Last modified:July 15, 1998 - v2
    Checksum:i6574F960B2EAF37C
    GO
    Isoform Short (identifier: P97840-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         148-179: Missing.

    Show »
    Length:322
    Mass (Da):36,317
    Checksum:i3268B472A91EECCA
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei148 – 17932Missing in isoform Short. 2 PublicationsVSP_003098Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U59462 mRNA. Translation: AAB51192.1.
    U72741 mRNA. Translation: AAB68592.1.
    U67958 mRNA. Translation: AAB48591.1.
    RefSeqiNP_037109.1. NM_012977.1.
    UniGeneiRn.10706.

    Genome annotation databases

    GeneIDi25476.
    KEGGirno:25476.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U59462 mRNA. Translation: AAB51192.1 .
    U72741 mRNA. Translation: AAB68592.1 .
    U67958 mRNA. Translation: AAB48591.1 .
    RefSeqi NP_037109.1. NM_012977.1.
    UniGenei Rn.10706.

    3D structure databases

    ProteinModelPortali P97840.
    SMRi P97840. Positions 1-147.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000017042.

    Protein family/group databases

    TCDBi 9.B.9.1.1. the urate transporter (uat) family.

    Proteomic databases

    PaxDbi P97840.
    PRIDEi P97840.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 25476.
    KEGGi rno:25476.

    Organism-specific databases

    CTDi 3965.
    RGDi 3005. Lgals9.

    Phylogenomic databases

    eggNOGi NOG264430.
    HOGENOMi HOG000290194.
    HOVERGENi HBG002412.
    InParanoidi P97840.
    KOi K10093.
    PhylomeDBi P97840.

    Miscellaneous databases

    NextBioi 606793.
    PROi P97840.

    Gene expression databases

    Genevestigatori P97840.

    Family and domain databases

    Gene3Di 2.60.120.200. 2 hits.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001079. Galectin_CRD.
    [Graphical view ]
    Pfami PF00337. Gal-bind_lectin. 2 hits.
    [Graphical view ]
    SMARTi SM00908. Gal-bind_lectin. 2 hits.
    SM00276. GLECT. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 2 hits.
    PROSITEi PS51304. GALECTIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of galectin-9, a novel beta-galactoside-binding mammalian lectin."
      Wada J., Kanwar Y.S.
      J. Biol. Chem. 272:6078-6086(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
      Strain: Sprague-Dawley.
      Tissue: Kidney and Small intestine.
    2. "Molecular cloning and functional reconstitution of a urate transporter/channel."
      Leal-Pinto E., Tao W., Rappaport J., Richardson M., Knorr B.A., Abramson R.G.
      J. Biol. Chem. 272:617-625(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
      Strain: Sprague-Dawley.
      Tissue: Kidney.

    Entry informationi

    Entry nameiLEG9_RAT
    AccessioniPrimary (citable) accession number: P97840
    Secondary accession number(s): O08588, O35866
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The LGALS9-like proteins are encoded by a duplicated regions on chromosome 17; there are at least 3 genes coding for galectin-9-like proteins.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3