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Protein

Galectin-9

Gene

Lgals9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds galactosides. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death (By similarity). May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion. Highly selective to the anion urate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei47 – 471Beta-galactoside 1By similarity
Binding sitei60 – 601Beta-galactoside 1By similarity
Binding sitei64 – 641Beta-galactoside 1By similarity
Binding sitei74 – 741Beta-galactoside 1By similarity
Binding sitei266 – 2661Beta-galactoside 2By similarity
Binding sitei270 – 2701Beta-galactoside 2By similarity
Binding sitei280 – 2801Beta-galactoside 2By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Lectin

Protein family/group databases

TCDBi9.B.9.1.1. the urate transporter (uat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-9
Short name:
Gal-9
Alternative name(s):
36 kDa beta-galactoside-binding lectin
Urate transporter/channel
Short name:
UAT
Gene namesi
Name:Lgals9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3005. Lgals9.

Subcellular locationi

  • Cytoplasm By similarity
  • Secreted By similarity

  • Note: May also be secreted by a non-classical secretory pathway.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Galectin-9PRO_0000076948Add
BLAST

Proteomic databases

PaxDbiP97840.
PRIDEiP97840.

Expressioni

Tissue specificityi

The isoform Long is expressed exclusively in the small intestine.

Gene expression databases

GenevisibleiP97840. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017042.

Structurei

3D structure databases

ProteinModelPortaliP97840.
SMRiP97840. Positions 1-147.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 147131Galectin 1PROSITE-ProRule annotationAdd
BLAST
Domaini226 – 354129Galectin 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni81 – 877Beta-galactoside binding 1By similarity
Regioni286 – 2927Beta-galactoside binding 2By similarity

Domaini

Contains two homologous but distinct carbohydrate-binding domains.

Sequence similaritiesi

Contains 2 galectin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG264430.
HOGENOMiHOG000290194.
HOVERGENiHBG002412.
InParanoidiP97840.
KOiK10093.
PhylomeDBiP97840.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS51304. GALECTIN. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.

Isoform Long (identifier: P97840-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFFSTQPPY MNPVIPFTGI IQGGLQNGLQ ITLQGTVHPF PNRIAVNFQT
60 70 80 90 100
GFSGNDIAFH FNPRFEEGGY VVCNTKQNGK WGPEERKMQM PFQKGMPFEL
110 120 130 140 150
CFLVQRSEFK VMVNKNFFVQ YSHRVPYHLV DTISVSGCLH LSFINFQNST
160 170 180 190 200
AAPVQPVFST MQFSQPVQFP RMPKGRKQRT QGFQPALQAP VAQTIIHTVH
210 220 230 240 250
SIPGQMLSTP GIPPMAYPTP AYTIPFFTSI PNGFYPSKSI NISGVVLPDA
260 270 280 290 300
KRFHINLRCG GDIAFHLNPR FNEKVVVRNT QINNSWGPEE RSLPGRMPFN
310 320 330 340 350
RGQSFSVWIL CEGHCFKVAV DGQHICEYYH RLKNLPDINT LEVAGDIQLT

HVQT
Length:354
Mass (Da):39,946
Last modified:July 15, 1998 - v2
Checksum:i6574F960B2EAF37C
GO
Isoform Short (identifier: P97840-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-179: Missing.

Show »
Length:322
Mass (Da):36,317
Checksum:i3268B472A91EECCA
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei148 – 17932Missing in isoform Short. 2 PublicationsVSP_003098Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59462 mRNA. Translation: AAB51192.1.
U72741 mRNA. Translation: AAB68592.1.
U67958 mRNA. Translation: AAB48591.1.
RefSeqiNP_037109.1. NM_012977.1.
UniGeneiRn.10706.

Genome annotation databases

GeneIDi25476.
KEGGirno:25476.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59462 mRNA. Translation: AAB51192.1.
U72741 mRNA. Translation: AAB68592.1.
U67958 mRNA. Translation: AAB48591.1.
RefSeqiNP_037109.1. NM_012977.1.
UniGeneiRn.10706.

3D structure databases

ProteinModelPortaliP97840.
SMRiP97840. Positions 1-147.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017042.

Protein family/group databases

TCDBi9.B.9.1.1. the urate transporter (uat) family.

Proteomic databases

PaxDbiP97840.
PRIDEiP97840.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25476.
KEGGirno:25476.

Organism-specific databases

CTDi3965.
RGDi3005. Lgals9.

Phylogenomic databases

eggNOGiNOG264430.
HOGENOMiHOG000290194.
HOVERGENiHBG002412.
InParanoidiP97840.
KOiK10093.
PhylomeDBiP97840.

Miscellaneous databases

NextBioi606793.
PROiP97840.

Gene expression databases

GenevisibleiP97840. RN.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS51304. GALECTIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification and characterization of galectin-9, a novel beta-galactoside-binding mammalian lectin."
    Wada J., Kanwar Y.S.
    J. Biol. Chem. 272:6078-6086(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
    Strain: Sprague-Dawley.
    Tissue: Kidney and Small intestine.
  2. "Molecular cloning and functional reconstitution of a urate transporter/channel."
    Leal-Pinto E., Tao W., Rappaport J., Richardson M., Knorr B.A., Abramson R.G.
    J. Biol. Chem. 272:617-625(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
    Strain: Sprague-Dawley.
    Tissue: Kidney.

Entry informationi

Entry nameiLEG9_RAT
AccessioniPrimary (citable) accession number: P97840
Secondary accession number(s): O08588, O35866
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: June 24, 2015
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The LGALS9-like proteins are encoded by a duplicated regions on chromosome 17; there are at least 3 genes coding for galectin-9-like proteins.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.