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P97840 (LEG9_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Galectin-9

Short name=Gal-9
Alternative name(s):
36 kDa beta-galactoside-binding lectin
Urate transporter/channel
Short name=UAT
Gene names
Name:Lgals9
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds galactosides. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death By similarity. May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion. Highly selective to the anion urate.

Subcellular location

Cytoplasm By similarity. Secreted By similarity. Note: May also be secreted by a non-classical secretory pathway By similarity.

Tissue specificity

The isoform Long is expressed exclusively in the small intestine.

Domain

Contains two homologous but distinct carbohydrate-binding domains.

Miscellaneous

The LGALS9-like proteins are encoded by a duplicated regions on chromosome 17; there are at least 3 genes coding for galectin-9-like proteins.

Sequence similarities

Contains 2 galectin domains.

Ontologies

Keywords
   Biological processIon transport
Transport
   Cellular componentCytoplasm
Secreted
   Coding sequence diversityAlternative splicing
   DomainRepeat
   LigandLectin
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_procession transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncarbohydrate binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.
Isoform Long (identifier: P97840-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Short (identifier: P97840-2)

The sequence of this isoform differs from the canonical sequence as follows:
     148-179: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 354354Galectin-9
PRO_0000076948

Regions

Domain17 – 147131Galectin 1
Domain226 – 354129Galectin 2
Region81 – 877Beta-galactoside binding 1 By similarity
Region286 – 2927Beta-galactoside binding 2 By similarity

Sites

Binding site471Beta-galactoside 1 By similarity
Binding site601Beta-galactoside 1 By similarity
Binding site641Beta-galactoside 1 By similarity
Binding site741Beta-galactoside 1 By similarity
Binding site2661Beta-galactoside 2 By similarity
Binding site2701Beta-galactoside 2 By similarity
Binding site2801Beta-galactoside 2 By similarity

Natural variations

Alternative sequence148 – 17932Missing in isoform Short.
VSP_003098

Sequences

Sequence LengthMass (Da)Tools
Isoform Long [UniParc].

Last modified July 15, 1998. Version 2.
Checksum: 6574F960B2EAF37C

FASTA35439,946
        10         20         30         40         50         60 
MAFFSTQPPY MNPVIPFTGI IQGGLQNGLQ ITLQGTVHPF PNRIAVNFQT GFSGNDIAFH 

        70         80         90        100        110        120 
FNPRFEEGGY VVCNTKQNGK WGPEERKMQM PFQKGMPFEL CFLVQRSEFK VMVNKNFFVQ 

       130        140        150        160        170        180 
YSHRVPYHLV DTISVSGCLH LSFINFQNST AAPVQPVFST MQFSQPVQFP RMPKGRKQRT 

       190        200        210        220        230        240 
QGFQPALQAP VAQTIIHTVH SIPGQMLSTP GIPPMAYPTP AYTIPFFTSI PNGFYPSKSI 

       250        260        270        280        290        300 
NISGVVLPDA KRFHINLRCG GDIAFHLNPR FNEKVVVRNT QINNSWGPEE RSLPGRMPFN 

       310        320        330        340        350 
RGQSFSVWIL CEGHCFKVAV DGQHICEYYH RLKNLPDINT LEVAGDIQLT HVQT 

« Hide

Isoform Short [UniParc].

Checksum: 3268B472A91EECCA
Show »

FASTA32236,317

References

[1]"Identification and characterization of galectin-9, a novel beta-galactoside-binding mammalian lectin."
Wada J., Kanwar Y.S.
J. Biol. Chem. 272:6078-6086(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
Strain: Sprague-Dawley.
Tissue: Kidney and Small intestine.
[2]"Molecular cloning and functional reconstitution of a urate transporter/channel."
Leal-Pinto E., Tao W., Rappaport J., Richardson M., Knorr B.A., Abramson R.G.
J. Biol. Chem. 272:617-625(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
Strain: Sprague-Dawley.
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U59462 mRNA. Translation: AAB51192.1.
U72741 mRNA. Translation: AAB68592.1.
U67958 mRNA. Translation: AAB48591.1.
RefSeqNP_037109.1. NM_012977.1.
UniGeneRn.10706.

3D structure databases

ProteinModelPortalP97840.
SMRP97840. Positions 1-147.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000017042.

Protein family/group databases

TCDB9.B.9.1.1. the urate transporter (uat) family.

Proteomic databases

PaxDbP97840.
PRIDEP97840.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID25476.
KEGGrno:25476.

Organism-specific databases

CTD3965.
RGD3005. Lgals9.

Phylogenomic databases

eggNOGNOG264430.
HOGENOMHOG000290194.
HOVERGENHBG002412.
InParanoidP97840.
KOK10093.
PhylomeDBP97840.

Gene expression databases

GenevestigatorP97840.

Family and domain databases

Gene3D2.60.120.200. 2 hits.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001079. Galectin_CRD.
[Graphical view]
PfamPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view]
SUPFAMSSF49899. SSF49899. 2 hits.
PROSITEPS51304. GALECTIN. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio606793.
PROP97840.

Entry information

Entry nameLEG9_RAT
AccessionPrimary (citable) accession number: P97840
Secondary accession number(s): O08588, O35866
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: April 16, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families