P97839 (DLGP4_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Disks large-associated protein 4
Short name=DAP-4

Alternative name(s):
PSD-95/SAP90-binding protein 4
SAP90/PSD-95-associated protein 4
Short name=SAPAP-4

Gene names

Name:	Dlgap4
Synonyms:	Dap4, Sapap4

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	992 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.
Subunit structure	Interacts with DLG1 and DLG4/PSD-95 By similarity.
Subcellular location	Membrane; Peripheral membrane protein By similarity.
Tissue specificity	Expressed in brain.
Sequence similarities	Belongs to the SAPAP family.

Ontologies

Keywords
Cellular component	Membrane
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell-cell signaling Inferred from electronic annotation. Source: InterPro
Cellular_component	dendrite Inferred from direct assay Ref.1. Source: RGD neuronal cell body Inferred from direct assay Ref.1. Source: RGD plasma membrane Inferred from direct assay Ref.1. Source: RGD
Molecular_function	protein domain specific binding Inferred from direct assay Ref.1. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 992	992	Disks large-associated protein 4		PRO_0000174298
Regions
	Compositional bias	266 – 273	8	Poly-Pro
Amino acid modifications
	Modified residue	367	1	Phosphoserine By similarity
	Modified residue	377	1	Phosphoserine By similarity
	Modified residue	397	1	Phosphoserine By similarity
	Modified residue	421	1	Phosphoserine By similarity
	Modified residue	512	1	Phosphoserine By similarity
	Modified residue	665	1	Phosphoserine By similarity
	Modified residue	915	1	Phosphothreonine By similarity
	Modified residue	973	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P97839 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 8875B67C3FD71F04	FASTA	992	108,035
	10 20 30 40 50 60 MKGLGDSRPR HLSDSLDPPH EPLFAGPDRN PYLLSPTEAF AREARFPGQN TLPGDGLFPL 70 80 90 100 110 120 NNQLPPPSST FPRIHYNSHF EVPEESPFPS HAQATKINRL PANLLDQFEK QLPIHRDGFS 130 140 150 160 170 180 TLQFPRGEAK ARGESPGRIR HLVHSVQRLF FTKAPSMEGT TGKVGGNGGK KGVLEDGKGR 190 200 210 220 230 240 RAKSKERAKA GEPKRRSRSN ISGWWSSDDN LDGEGGAFRS GPASGLMTLG RQPERTQPRY 250 260 270 280 290 300 FMHAYNTISG HMLKTTKNTT TELTAPPPPP APPATCPSLG VGTDTNYVKR GSWSTLTLSH 310 320 330 340 350 360 AHEVCQKTSA TLDKSLLKSK SCHQGLAYHY LQVPGGGGEW STTLLSPRDM DSTAEGPIPC 370 380 390 400 410 420 RRMRSGSYIK AMGDEDSDES GGGSPKPSPK TAARRQSYLR ATQQSLGEQS NPRRSLDRLD 430 440 450 460 470 480 SVDMPLPSKY PSWEEDYNPI SDSLNDSGCI SQVFGQASLI PQLFGHDQQV READLSDQYE 490 500 510 520 530 540 AACESACSEA ESTAAEALDL SLPSYFRSRS HSYLRAIQAG CSQEEDSVSL QSLSPPPSTG 550 560 570 580 590 600 SLSNSRTLPS SSCLVAYKKT PPPVPPRTTS KPFISVTVQS STESAQDTYL DSQDHKSEVT 610 620 630 640 650 660 SQSGLSNSSD SLDSSTRPPS VTRGGITPGP EAPEPPPKHA ALKSEHGTLT SSESHSEAVP 670 680 690 700 710 720 KRKLSSIGIQ VDCIQPVPKE EPSPATKFQS IGVQVEDDWR SSAPSHSMSS RRDTDSDTQD 730 740 750 760 770 780 ANDSSCKSSE RSLPDCTSHP NSISIDAGPR QAPKIAQIKR NLSYGDNSDP ALEASSLPPP 790 800 810 820 830 840 DPWMETSSSS PAEPAQPGAC RRDGYWFLKL LQAETERLEG WCCQMDKETK ENNLSEEVLG 850 860 870 880 890 900 KVLSAVGSAQ LLMSQKFQQF RGICEQNLNP DANPRPTAQD LAGFWDLLQL SIEDISMKFD 910 920 930 940 950 960 ELYHLKANSW QLVETPEKRK EEKKPPPPVP KKPAKSKAAV SRDKASDAGD KQRQEARKRL 970 980 990 LAAKRAASVR QNSATESADS IEIYVPEAQT RL

References

[1]	"SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density." Takeuchi M., Hata Y., Hirao K., Toyoda A., Irie M., Takai Y. J. Biol. Chem. 272:11943-11951(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U67140 mRNA. Translation: AAB48590.1.
IPI	IPI00208650.
RefSeq	NP_775168.1. NM_173145.1.
UniGene	Rn.11279.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P97839. 4 interactions.
STRING	10116.ENSRNOP00000034166.
PTM databases
PhosphoSite	P97839.
Proteomic databases
PaxDb	P97839.
PRIDE	P97839.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	286930.
KEGG	rno:286930.
UCSC	RGD:708350. rat.
Organism-specific databases
CTD	22839.
RGD	708350. Dlgap4.
Phylogenomic databases
eggNOG	NOG331770.
HOGENOM	HOG000015346.
HOVERGEN	HBG018957.
InParanoid	P97839.
OrthoDB	EOG4ZCT3Z.
Gene expression databases
ArrayExpress	P97839.
Genevestigator	P97839.
GermOnline	ENSRNOG00000020225. Rattus norvegicus.
Family and domain databases
InterPro	IPR005026. GKAP. [Graphical view]
Pfam	PF03359. GKAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	625100.

Entry information

Entry name

DLGP4_RAT

Accession

Primary (citable) accession number: P97839

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	May 1, 1997
Last modified:	April 3, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program