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Protein

Disks large-associated protein 4

Gene

Dlgap4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.

GO - Molecular functioni

  • protein domain specific binding Source: RGD

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Disks large-associated protein 4
Short name:
DAP-4
Alternative name(s):
PSD-95/SAP90-binding protein 4
SAP90/PSD-95-associated protein 4
Short name:
SAPAP-4
Gene namesi
Name:Dlgap4
Synonyms:Dap4, Sapap4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708350. Dlgap4.

Subcellular locationi

GO - Cellular componenti

  • dendrite Source: RGD
  • neuronal cell body Source: RGD
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 992992Disks large-associated protein 4PRO_0000174298Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei206 – 2061PhosphoserineCombined sources
Modified residuei207 – 2071PhosphoserineCombined sources
Modified residuei377 – 3771PhosphoserineCombined sources
Modified residuei380 – 3801PhosphoserineCombined sources
Modified residuei384 – 3841PhosphoserineBy similarity
Modified residuei388 – 3881PhosphoserineBy similarity
Modified residuei405 – 4051PhosphoserineCombined sources
Modified residuei415 – 4151PhosphoserineCombined sources
Modified residuei421 – 4211PhosphoserineCombined sources
Modified residuei580 – 5801PhosphoserineBy similarity
Modified residuei581 – 5811PhosphoserineBy similarity
Modified residuei609 – 6091PhosphoserineBy similarity
Modified residuei611 – 6111PhosphoserineBy similarity
Modified residuei665 – 6651PhosphoserineBy similarity
Modified residuei744 – 7441PhosphoserineBy similarity
Modified residuei915 – 9151PhosphothreonineCombined sources
Modified residuei973 – 9731PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP97839.
PRIDEiP97839.

PTM databases

iPTMnetiP97839.
PhosphoSiteiP97839.

Expressioni

Tissue specificityi

Expressed in brain.

Interactioni

Subunit structurei

Interacts with DLG1 and DLG4/PSD-95.By similarity

GO - Molecular functioni

  • protein domain specific binding Source: RGD

Protein-protein interaction databases

IntActiP97839. 5 interactions.
MINTiMINT-1796252.
STRINGi10116.ENSRNOP00000034166.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi266 – 2738Poly-Pro

Sequence similaritiesi

Belongs to the SAPAP family.Curated

Phylogenomic databases

eggNOGiKOG3971. Eukaryota.
ENOG4111JKV. LUCA.
HOGENOMiHOG000015346.
HOVERGENiHBG018957.
InParanoidiP97839.
PhylomeDBiP97839.

Family and domain databases

InterProiIPR030527. DLGAP4.
IPR005026. SAPAP.
[Graphical view]
PANTHERiPTHR12353:SF19. PTHR12353:SF19. 2 hits.
PfamiPF03359. GKAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97839-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGLGDSRPR HLSDSLDPPH EPLFAGPDRN PYLLSPTEAF AREARFPGQN
60 70 80 90 100
TLPGDGLFPL NNQLPPPSST FPRIHYNSHF EVPEESPFPS HAQATKINRL
110 120 130 140 150
PANLLDQFEK QLPIHRDGFS TLQFPRGEAK ARGESPGRIR HLVHSVQRLF
160 170 180 190 200
FTKAPSMEGT TGKVGGNGGK KGVLEDGKGR RAKSKERAKA GEPKRRSRSN
210 220 230 240 250
ISGWWSSDDN LDGEGGAFRS GPASGLMTLG RQPERTQPRY FMHAYNTISG
260 270 280 290 300
HMLKTTKNTT TELTAPPPPP APPATCPSLG VGTDTNYVKR GSWSTLTLSH
310 320 330 340 350
AHEVCQKTSA TLDKSLLKSK SCHQGLAYHY LQVPGGGGEW STTLLSPRDM
360 370 380 390 400
DSTAEGPIPC RRMRSGSYIK AMGDEDSDES GGGSPKPSPK TAARRQSYLR
410 420 430 440 450
ATQQSLGEQS NPRRSLDRLD SVDMPLPSKY PSWEEDYNPI SDSLNDSGCI
460 470 480 490 500
SQVFGQASLI PQLFGHDQQV READLSDQYE AACESACSEA ESTAAEALDL
510 520 530 540 550
SLPSYFRSRS HSYLRAIQAG CSQEEDSVSL QSLSPPPSTG SLSNSRTLPS
560 570 580 590 600
SSCLVAYKKT PPPVPPRTTS KPFISVTVQS STESAQDTYL DSQDHKSEVT
610 620 630 640 650
SQSGLSNSSD SLDSSTRPPS VTRGGITPGP EAPEPPPKHA ALKSEHGTLT
660 670 680 690 700
SSESHSEAVP KRKLSSIGIQ VDCIQPVPKE EPSPATKFQS IGVQVEDDWR
710 720 730 740 750
SSAPSHSMSS RRDTDSDTQD ANDSSCKSSE RSLPDCTSHP NSISIDAGPR
760 770 780 790 800
QAPKIAQIKR NLSYGDNSDP ALEASSLPPP DPWMETSSSS PAEPAQPGAC
810 820 830 840 850
RRDGYWFLKL LQAETERLEG WCCQMDKETK ENNLSEEVLG KVLSAVGSAQ
860 870 880 890 900
LLMSQKFQQF RGICEQNLNP DANPRPTAQD LAGFWDLLQL SIEDISMKFD
910 920 930 940 950
ELYHLKANSW QLVETPEKRK EEKKPPPPVP KKPAKSKAAV SRDKASDAGD
960 970 980 990
KQRQEARKRL LAAKRAASVR QNSATESADS IEIYVPEAQT RL
Length:992
Mass (Da):108,035
Last modified:May 1, 1997 - v1
Checksum:i8875B67C3FD71F04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67140 mRNA. Translation: AAB48590.1.
RefSeqiNP_775168.1. NM_173145.1.
UniGeneiRn.11279.

Genome annotation databases

GeneIDi286930.
KEGGirno:286930.
UCSCiRGD:708350. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67140 mRNA. Translation: AAB48590.1.
RefSeqiNP_775168.1. NM_173145.1.
UniGeneiRn.11279.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP97839. 5 interactions.
MINTiMINT-1796252.
STRINGi10116.ENSRNOP00000034166.

PTM databases

iPTMnetiP97839.
PhosphoSiteiP97839.

Proteomic databases

PaxDbiP97839.
PRIDEiP97839.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi286930.
KEGGirno:286930.
UCSCiRGD:708350. rat.

Organism-specific databases

CTDi22839.
RGDi708350. Dlgap4.

Phylogenomic databases

eggNOGiKOG3971. Eukaryota.
ENOG4111JKV. LUCA.
HOGENOMiHOG000015346.
HOVERGENiHBG018957.
InParanoidiP97839.
PhylomeDBiP97839.

Miscellaneous databases

PROiP97839.

Family and domain databases

InterProiIPR030527. DLGAP4.
IPR005026. SAPAP.
[Graphical view]
PANTHERiPTHR12353:SF19. PTHR12353:SF19. 2 hits.
PfamiPF03359. GKAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density."
    Takeuchi M., Hata Y., Hirao K., Toyoda A., Irie M., Takai Y.
    J. Biol. Chem. 272:11943-11951(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-206; SER-207; SER-377; SER-380; SER-405; SER-415; SER-421; THR-915 AND SER-973, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDLGP4_RAT
AccessioniPrimary (citable) accession number: P97839
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 1997
Last modified: July 6, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.