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Protein

Disks large-associated protein 3

Gene

Dlgap3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.

GO - Molecular functioni

  • PDZ domain binding Source: BHF-UCL
  • protein complex scaffold activity Source: BHF-UCL
  • protein domain specific binding Source: RGD
  • scaffold protein binding Source: BHF-UCL

GO - Biological processi

  • protein complex assembly Source: BHF-UCL
  • signaling Source: InterPro

Names & Taxonomyi

Protein namesi
Recommended name:
Disks large-associated protein 3
Short name:
DAP-3
Alternative name(s):
PSD-95/SAP90-binding protein 3
SAP90/PSD-95-associated protein 3
Short name:
SAPAP3
Gene namesi
Name:Dlgap3
Synonyms:Dap3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708349. Dlgap3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001742961 – 977Disks large-associated protein 3Add BLAST977

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei58PhosphoserineBy similarity1
Modified residuei404PhosphoserineBy similarity1
Modified residuei407PhosphoserineBy similarity1
Modified residuei410PhosphoserineBy similarity1
Modified residuei414PhosphoserineBy similarity1
Modified residuei641PhosphoserineBy similarity1
Modified residuei643PhosphoserineBy similarity1
Modified residuei930PhosphoserineCombined sources1
Modified residuei933PhosphoserineCombined sources1
Modified residuei965PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP97838.
PRIDEiP97838.

PTM databases

iPTMnetiP97838.
PhosphoSitePlusiP97838.

Expressioni

Tissue specificityi

Expressed in most brain regions.2 Publications

Interactioni

Subunit structurei

Interacts with DLG1 and DLG4/PSD-95.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
GraspQ8R4T53EBI-375673,EBI-7361884

GO - Molecular functioni

  • PDZ domain binding Source: BHF-UCL
  • protein complex scaffold activity Source: BHF-UCL
  • protein domain specific binding Source: RGD
  • scaffold protein binding Source: BHF-UCL

Protein-protein interaction databases

IntActiP97838. 6 interactors.
MINTiMINT-1790577.
STRINGi10116.ENSRNOP00000019214.

Structurei

3D structure databases

SMRiP97838.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi222 – 233Poly-HisAdd BLAST12

Sequence similaritiesi

Belongs to the SAPAP family.Curated

Phylogenomic databases

eggNOGiKOG3971. Eukaryota.
ENOG4111JKV. LUCA.
HOGENOMiHOG000015346.
HOVERGENiHBG018957.
InParanoidiP97838.
PhylomeDBiP97838.

Family and domain databases

InterProiView protein in InterPro
IPR030526. DLGAP3.
IPR005026. SAPAP.
PANTHERiPTHR12353:SF28. PTHR12353:SF28. 1 hit.
PfamiView protein in Pfam
PF03359. GKAP. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P97838-1) [UniParc]FASTAAdd to basket
Also known as: SAPAP3+

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGYHGDRGS HPRPARFADQ QHMDVGPAAR APYLLGSREA FSTEPRFCAP
60 70 80 90 100
RAGLGHLSPE GPLSLSEGPS SVGPEGGPGG VGAGGSSSTF PRMYPGQGPF
110 120 130 140 150
DTCEDCVGHP QGKGATRLLP TFLDQFEKQL PVQQDGFHTL PYQRGPAGPG
160 170 180 190 200
PGPGSGAAPE ARSESPSRIR HLVHSVQKLF AKSHSLEAPG KRDYNGPKAE
210 220 230 240 250
GRSSSGGDSY SGPGSGGPPT SHHHHHHHHH HHHQSRHGKR SKSKDRKGDG
260 270 280 290 300
RHQTKATGWW SSDDNLDSDS GFLGGRPPGE PGGPFCLDAP DGSYRDLSFK
310 320 330 340 350
GRSGGSEGRC LACTGMSMSL DGQSVKRSAW HTMMVSQGRD GYPGAGPGKG
360 370 380 390 400
LLGPETKAKA RTYHYLQVPQ DDWGGYPTGG KDGEIPCRRM RSGSYIKAMG
410 420 430 440 450
DEESGDSDGS PKTSPKALAR RFASRRSSSV DTARINCCVP PRIHPRSSIP
460 470 480 490 500
GYSRSLTTGQ LSEEFNQQLE AVCGSVFGEL ESQAVDALDL PGCFRMRSHS
510 520 530 540 550
YLRAIQAGCS QDDDCLPLLA APASVSGRPG SSFNFRKAPP PIPPGSQAPP
560 570 580 590 600
RISITAQSST DSAHESFTAA EGPARRCSSA DGLDGPTMGA RTLELAPVPP
610 620 630 640 650
RASPKPPTLI IKTIPGREEL RSLARQRKWR PSIGVQVETI SDSDTENRSR
660 670 680 690 700
REFHSIGVQV EEDKRRARFK RSNSVTAGVQ ADLELEGLAG LATVATEDKA
710 720 730 740 750
LQFGRPFQRQ ASEPQPGPRA PTYSVFRTVH TQGQWAYREG YPLPYEPPAT
760 770 780 790 800
DGSPGPPPVP APGPGSGRRD SWMERGSRSL PDSGRTSPCP RDGEWFIKML
810 820 830 840 850
RAEVEKLEHW CQQMEREAED YELPEEILEK IRSAVGSTQL LLSQKVQQFF
860 870 880 890 900
RLCQQSLDPT AFPVPTFQDL AGFWDLLQLS IEDVTLKFLE LQQLKANSWK
910 920 930 940 950
LLEPKEEKKV PPPIPKKPSR GRGVPVKERS LDSVDRQRQE ARKRLLAAKR
960 970
AASFRHSSAT ESADSIEIYI PEAQTRL
Length:977
Mass (Da):105,990
Last modified:July 19, 2005 - v2
Checksum:iAD65DB11E1D4F723
GO
Isoform 2 (identifier: P97838-2) [UniParc]FASTAAdd to basket
Also known as: SAPAP3-

The sequence of this isoform differs from the canonical sequence as follows:
     858-868: Missing.

Show »
Length:966
Mass (Da):104,789
Checksum:i4FE546B0E496AA5C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti77G → S in AAB48589 (PubMed:9115257).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014818858 – 868Missing in isoform 2. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67139 mRNA. Translation: AAB48589.1.
AY530298 mRNA. Translation: AAS90634.1.
AY530299 mRNA. Translation: AAS90635.1.
UniGeneiRn.22954.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDLGP3_RAT
AccessioniPrimary (citable) accession number: P97838
Secondary accession number(s): Q6QQA8, Q6QQA9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: July 19, 2005
Last modified: September 27, 2017
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families