ID   DLGP2_RAT               Reviewed;        1059 AA.
AC   P97837;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 3.
DT   16-JUN-2009, entry version 62.
DE   RecName: Full=Disks large-associated protein 2;
DE            Short=DAP-2;
DE   AltName: Full=SAP90/PSD-95-associated protein 2;
DE            Short=SAPAP2;
DE   AltName: Full=PSD-95/SAP90-binding protein 2;
GN   Name=Dlgap2; Synonyms=Dap2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION,
RP   AND INTERACTION WITH DLG4.
RC   TISSUE=Brain;
RX   MEDLINE=97277335; PubMed=9115257; DOI=10.1074/jbc.272.18.11943;
RA   Takeuchi M., Hata Y., Hirao K., Toyoda A., Irie M., Takai Y.;
RT   "SAPAPs. A family of PSD-95/SAP90-associated proteins localized at
RT   postsynaptic density.";
RL   J. Biol. Chem. 272:11943-11951(1997).
RN   [2]
RP   PROTEIN SEQUENCE OF 234-241 AND 710-715, AND MASS SPECTROMETRY.
RC   STRAIN=Sprague-Dawley; TISSUE=Brain;
RA   Lubec G., Kang S.U., Lubec S.;
RL   Submitted (SEP-2007) to UniProtKB.
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=15207911; DOI=10.1016/j.molbrainres.2004.03.014;
RA   Kindler S., Rehbein M., Classen B., Richter D., Boeckers T.M.;
RT   "Distinct spatiotemporal expression of SAPAP transcripts in the
RT   developing rat brain: a novel dendritically localized mRNA.";
RL   Brain Res. Mol. Brain Res. 126:14-21(2004).
CC   -!- FUNCTION: May play a role in the molecular organization of
CC       synapses and neuronal cell signaling. Could be an adapter protein
CC       linking ion channel to the subsynaptic cytoskeleton. May induce
CC       enrichment of PSD-95/SAP90 at the plasma membrane.
CC   -!- SUBUNIT: Interacts with DLG4/PSD-95.
CC   -!- INTERACTION:
CC       P31016:Dlg4; NbExp=1; IntAct=EBI-81025, EBI-375655;
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein.
CC       Cell junction, synapse, postsynaptic cell membrane, postsynaptic
CC       density. Cell junction, synapse. Note=Postsynaptic density of
CC       neuronal cells.
CC   -!- TISSUE SPECIFICITY: Expressed in various brain areas.
CC   -!- SIMILARITY: Belongs to the SAPAP family.
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DR   EMBL; U67138; AAB48588.1; ALT_INIT; mRNA.
DR   IPI; IPI00208648; -.
DR   RefSeq; NP_446353.1; -.
DR   UniGene; Rn.10705; -.
DR   IntAct; P97837; 6.
DR   PhosphoSite; P97837; -.
DR   Ensembl; ENSRNOG00000012573; Rattus norvegicus.
DR   GeneID; 116681; -.
DR   KEGG; rno:116681; -.
DR   RGD; 620224; Dlgap2.
DR   HOVERGEN; P97837; -.
DR   NextBio; 619524; -.
DR   ArrayExpress; P97837; -.
DR   GermOnline; ENSRNOG00000012573; Rattus norvegicus.
DR   GO; GO:0030054; C:cell junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0030425; C:dendrite; IDA:RGD.
DR   GO; GO:0005883; C:neurofilament; NAS:UniProtKB.
DR   GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR   GO; GO:0045211; C:postsynaptic membrane; NAS:RGD.
DR   GO; GO:0004385; F:guanylate kinase activity; NAS:RGD.
DR   GO; GO:0019904; F:protein domain specific binding; IDA:RGD.
DR   GO; GO:0007270; P:nerve-nerve synaptic transmission; NAS:UniProtKB.
DR   InterPro; IPR005026; GKAP.
DR   Pfam; PF03359; GKAP; 1.
PE   1: Evidence at protein level;
KW   Cell junction; Cell membrane; Direct protein sequencing; Membrane;
KW   Phosphoprotein; Postsynaptic cell membrane; Synapse.
FT   CHAIN         1   1059       Disks large-associated protein 2.
FT                                /FTId=PRO_0000174293.
FT   MOD_RES     228    228       Phosphoserine (By similarity).
FT   MOD_RES     312    312       Phosphotyrosine (By similarity).
FT   MOD_RES     440    440       Phosphoserine (By similarity).
FT   MOD_RES     450    450       Phosphoserine (By similarity).
FT   MOD_RES     453    453       Phosphoserine (By similarity).
FT   MOD_RES     574    574       Phosphoserine (By similarity).
FT   MOD_RES     745    745       Phosphoserine (By similarity).
FT   MOD_RES    1012   1012       Phosphoserine (By similarity).
FT   MOD_RES    1040   1040       Phosphoserine (By similarity).
FT   MOD_RES    1047   1047       Phosphoserine (By similarity).
SQ   SEQUENCE   1059 AA;  118978 MW;  8AB2A3667AD79434 CRC64;
     MGTAQVLPGI LQKHCCILPD RNTESQCTLC GEPEEEEGGD LAQPGLSFPG PAEEDIDQQY
     SWSPTQHFSE ERYSPAPRNM KGLTGSRNQP QLCVGHTCGL SPTDECEHPH DHVRHGPDVR
     QPYLLSPAES CPMDHHRCSP RSSVHSECMM MPVMLGDHVS SSTFPRMHYS SHYDTRDDCA
     TSHASTKVNR IPANLLDQFE KQLPLHRDGF HTLQYHRASA ATEQRNESPG RIRHLVHSVQ
     KLFTKSHSLE GSSKSNINGT KSEGRMDDHH QSHLSKHSKR SKSKERKPES KHKSGMSSWW
     SSDDNLDSDS TYRTPSVAHR HHMDHIPHCY PEALQSPFGD LSLKTSKSNS DVKCSACEGL
     ALTPDTRYMK RSSWSTLTVS QAKEAYRKSS LNLDKPLVHP EIKPSLQPCH YLQVPQDDWG
     AYPTGGKEEE IPCRRMRSGS YIKAMGDEES GESDSSPKTS PTVALRPEPL LKSIIQRPLG
     DHQTQSYLQA ATEVPVGHSL DPSVNYNSPK FRSRNQSYMR AVSTLSQASC VSQMSEAEVN
     GQFESVCESV FSEVESQAMD ALDLPGCFRT RSHSYLRAIQ AGYSQDDECI PVMTPSNMTS
     TIRSTAAVSY TNYKKTPPPV PPRTTSKPLI SVTAQSSTES TQDAYQDSRA QRMSPWPQDS
     RGGLYNSMDS LDSNKAMNLA LESAAAQRHA ADTQSSSTRS IDKAVLVSKA EELLKSRCSS
     IGVQDSEFPD HQPYPRSDVE TATDSDTESR GLREYHSVGV QVEDEKRHGR FKRSNSVTAA
     VQADLELEGF PGHVSMEDKG LQFGSSFQRH SEPSTPTQYG ALRTVRTQGL FSYREDYRTQ
     VDTSTLPPPD PWLEPSLDTV ETGRMSPCRR DGSWFLKLLH TETKKMEGWC KEMEREAEEN
     DLSEEILGKI RSAVGSAQLL MSQKFQQFYW LCQQNMDPSA MPRPTSQDLA GYWDMLQLSV
     EDVSMKFDEL HQLKLNDWKI MESPERKEER KIPPPIPKKP PKGKFPITRE KSLDLPDRQR
     QEARRRLMAA KRAASFRQNS ATERADSIEI YIPEAQTRL
//