P97837 (DLGP2_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Disks large-associated protein 2
Short name=DAP-2

Alternative name(s):
PSD-95/SAP90-binding protein 2
SAP90/PSD-95-associated protein 2
Short name=SAPAP2

Gene names

Name:	Dlgap2
Synonyms:	Dap2

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	1059 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.
Subunit structure	Interacts with DLG4/PSD-95. Ref.1
Subcellular location	Cell membrane; Peripheral membrane protein. Cell junction › synapse › postsynaptic cell membrane › postsynaptic density. Cell junction › synapse. Note: Postsynaptic density of neuronal cells. Ref.1
Tissue specificity	Expressed in various brain areas. Ref.1 Ref.3
Sequence similarities	Belongs to the SAPAP family.
Sequence caution	The sequence AAB48588.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	neuron-neuron synaptic transmission Non-traceable author statement. Source: UniProtKB
Cellular component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW neurofilament Non-traceable author statement. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell postsynaptic density Inferred from electronic annotation. Source: UniProtKB-SubCell postsynaptic membrane Non-traceable author statement. Source: RGD
Molecular function	guanylate kinase activity Non-traceable author statement. Source: RGD protein domain specific binding Inferred from direct assay Ref.1. Source: RGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Dlg4	P31016	2	EBI-81025,EBI-375655

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1059	1059	Disks large-associated protein 2		PRO_0000174293
Amino acid modifications
	Modified residue	228	1	Phosphoserine By similarity
	Modified residue	312	1	Phosphotyrosine By similarity
	Modified residue	440	1	Phosphoserine By similarity
	Modified residue	450	1	Phosphoserine By similarity
	Modified residue	453	1	Phosphoserine By similarity
	Modified residue	574	1	Phosphoserine By similarity
	Modified residue	745	1	Phosphoserine By similarity
	Modified residue	1012	1	Phosphoserine By similarity
	Modified residue	1040	1	Phosphoserine By similarity
	Modified residue	1047	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P97837 [UniParc]. Last modified July 19, 2005. Version 3. Checksum: 8AB2A3667AD79434	FASTA	1,059	118,978
	10 20 30 40 50 60 MGTAQVLPGI LQKHCCILPD RNTESQCTLC GEPEEEEGGD LAQPGLSFPG PAEEDIDQQY 70 80 90 100 110 120 SWSPTQHFSE ERYSPAPRNM KGLTGSRNQP QLCVGHTCGL SPTDECEHPH DHVRHGPDVR 130 140 150 160 170 180 QPYLLSPAES CPMDHHRCSP RSSVHSECMM MPVMLGDHVS SSTFPRMHYS SHYDTRDDCA 190 200 210 220 230 240 TSHASTKVNR IPANLLDQFE KQLPLHRDGF HTLQYHRASA ATEQRNESPG RIRHLVHSVQ 250 260 270 280 290 300 KLFTKSHSLE GSSKSNINGT KSEGRMDDHH QSHLSKHSKR SKSKERKPES KHKSGMSSWW 310 320 330 340 350 360 SSDDNLDSDS TYRTPSVAHR HHMDHIPHCY PEALQSPFGD LSLKTSKSNS DVKCSACEGL 370 380 390 400 410 420 ALTPDTRYMK RSSWSTLTVS QAKEAYRKSS LNLDKPLVHP EIKPSLQPCH YLQVPQDDWG 430 440 450 460 470 480 AYPTGGKEEE IPCRRMRSGS YIKAMGDEES GESDSSPKTS PTVALRPEPL LKSIIQRPLG 490 500 510 520 530 540 DHQTQSYLQA ATEVPVGHSL DPSVNYNSPK FRSRNQSYMR AVSTLSQASC VSQMSEAEVN 550 560 570 580 590 600 GQFESVCESV FSEVESQAMD ALDLPGCFRT RSHSYLRAIQ AGYSQDDECI PVMTPSNMTS 610 620 630 640 650 660 TIRSTAAVSY TNYKKTPPPV PPRTTSKPLI SVTAQSSTES TQDAYQDSRA QRMSPWPQDS 670 680 690 700 710 720 RGGLYNSMDS LDSNKAMNLA LESAAAQRHA ADTQSSSTRS IDKAVLVSKA EELLKSRCSS 730 740 750 760 770 780 IGVQDSEFPD HQPYPRSDVE TATDSDTESR GLREYHSVGV QVEDEKRHGR FKRSNSVTAA 790 800 810 820 830 840 VQADLELEGF PGHVSMEDKG LQFGSSFQRH SEPSTPTQYG ALRTVRTQGL FSYREDYRTQ 850 860 870 880 890 900 VDTSTLPPPD PWLEPSLDTV ETGRMSPCRR DGSWFLKLLH TETKKMEGWC KEMEREAEEN 910 920 930 940 950 960 DLSEEILGKI RSAVGSAQLL MSQKFQQFYW LCQQNMDPSA MPRPTSQDLA GYWDMLQLSV 970 980 990 1000 1010 1020 EDVSMKFDEL HQLKLNDWKI MESPERKEER KIPPPIPKKP PKGKFPITRE KSLDLPDRQR 1030 1040 1050 QEARRRLMAA KRAASFRQNS ATERADSIEI YIPEAQTRL

References

[1]	"SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density." Takeuchi M., Hata Y., Hirao K., Toyoda A., Irie M., Takai Y. J. Biol. Chem. 272:11943-11951(1997) [PubMed: 9115257] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH DLG4. Tissue: Brain.
[2]	Lubec G., Kang S.U., Lubec S. Submitted (SEP-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 234-241 AND 710-715, MASS SPECTROMETRY. Strain: Sprague-Dawley. Tissue: Brain.
[3]	"Distinct spatiotemporal expression of SAPAP transcripts in the developing rat brain: a novel dendritically localized mRNA." Kindler S., Rehbein M., Classen B., Richter D., Boeckers T.M. Brain Res. Mol. Brain Res. 126:14-21(2004) [PubMed: 15207911] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U67138 mRNA. Translation: AAB48588.1. Different initiation.
IPI	IPI00208648.
RefSeq	NP_446353.2. NM_053901.1.
UniGene	Rn.10705.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P97837. 6 interactions.
STRING	P97837.
PTM databases
PhosphoSite	P97837.
Proteomic databases
PRIDE	P97837.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	116681.
KEGG	rno:116681.
UCSC	NM_053901. rat.
Organism-specific databases
CTD	9228.
RGD	620224. Dlgap2.
Phylogenomic databases
eggNOG	roNOG12240.
GeneTree	ENSGT00550000074473.
HOVERGEN	HBG018957.
InParanoid	P97837.
OrthoDB	EOG4DBTD4.
Gene expression databases
ArrayExpress	P97837.
Genevestigator	P97837.
GermOnline	ENSRNOG00000012573. Rattus norvegicus.
Family and domain databases
InterPro	IPR005026. GKAP. [Graphical view]
Pfam	PF03359. GKAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	619524.

Entry information

Entry name

DLGP2_RAT

Accession

Primary (citable) accession number: P97837

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	July 19, 2005
Last modified:	November 16, 2011
This is version 81 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program