Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Disks large-associated protein 2

Gene

Dlgap2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.

GO - Molecular functioni

  • guanylate kinase activity Source: RGD
  • protein domain specific binding Source: RGD

GO - Biological processi

  • neuron-neuron synaptic transmission Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Disks large-associated protein 2
Short name:
DAP-2
Alternative name(s):
PSD-95/SAP90-binding protein 2
SAP90/PSD-95-associated protein 2
Short name:
SAPAP2
Gene namesi
Name:Dlgap2
Synonyms:Dap2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620224. Dlgap2.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • dendrite Source: RGD
  • neurofilament Source: UniProtKB
  • postsynaptic density Source: UniProtKB-SubCell
  • postsynaptic membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001742931 – 1059Disks large-associated protein 2Add BLAST1059

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei302PhosphoserineCombined sources1
Modified residuei308PhosphoserineCombined sources1
Modified residuei390PhosphoserineCombined sources1
Modified residuei456PhosphoserineBy similarity1
Modified residuei667PhosphoserineBy similarity1
Modified residuei670PhosphoserineCombined sources1
Modified residuei673PhosphoserineCombined sources1
Modified residuei720PhosphoserineBy similarity1
Modified residuei743PhosphothreonineCombined sources1
Modified residuei745PhosphoserineCombined sources1
Modified residuei776PhosphoserineBy similarity1
Modified residuei811PhosphoserineBy similarity1
Modified residuei983PhosphoserineCombined sources1
Modified residuei1012PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP97837.
PRIDEiP97837.

PTM databases

iPTMnetiP97837.
PhosphoSitePlusiP97837.
SwissPalmiP97837.

Expressioni

Tissue specificityi

Expressed in various brain areas.2 Publications

Interactioni

Subunit structurei

Interacts with DLG4/PSD-95.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Dlg4P310162EBI-81025,EBI-375655

GO - Molecular functioni

  • protein domain specific binding Source: RGD

Protein-protein interaction databases

BioGridi250564. 5 interactors.
IntActiP97837. 7 interactors.
MINTiMINT-1796202.
STRINGi10116.ENSRNOP00000054654.

Family & Domainsi

Sequence similaritiesi

Belongs to the SAPAP family.Curated

Phylogenomic databases

eggNOGiKOG3971. Eukaryota.
ENOG4111JKV. LUCA.
HOGENOMiHOG000015346.
HOVERGENiHBG018957.
InParanoidiP97837.
PhylomeDBiP97837.

Family and domain databases

InterProiIPR030525. DLGAP2.
IPR005026. SAPAP.
[Graphical view]
PANTHERiPTHR12353:SF3. PTHR12353:SF3. 1 hit.
PfamiPF03359. GKAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97837-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTAQVLPGI LQKHCCILPD RNTESQCTLC GEPEEEEGGD LAQPGLSFPG
60 70 80 90 100
PAEEDIDQQY SWSPTQHFSE ERYSPAPRNM KGLTGSRNQP QLCVGHTCGL
110 120 130 140 150
SPTDECEHPH DHVRHGPDVR QPYLLSPAES CPMDHHRCSP RSSVHSECMM
160 170 180 190 200
MPVMLGDHVS SSTFPRMHYS SHYDTRDDCA TSHASTKVNR IPANLLDQFE
210 220 230 240 250
KQLPLHRDGF HTLQYHRASA ATEQRNESPG RIRHLVHSVQ KLFTKSHSLE
260 270 280 290 300
GSSKSNINGT KSEGRMDDHH QSHLSKHSKR SKSKERKPES KHKSGMSSWW
310 320 330 340 350
SSDDNLDSDS TYRTPSVAHR HHMDHIPHCY PEALQSPFGD LSLKTSKSNS
360 370 380 390 400
DVKCSACEGL ALTPDTRYMK RSSWSTLTVS QAKEAYRKSS LNLDKPLVHP
410 420 430 440 450
EIKPSLQPCH YLQVPQDDWG AYPTGGKEEE IPCRRMRSGS YIKAMGDEES
460 470 480 490 500
GESDSSPKTS PTVALRPEPL LKSIIQRPLG DHQTQSYLQA ATEVPVGHSL
510 520 530 540 550
DPSVNYNSPK FRSRNQSYMR AVSTLSQASC VSQMSEAEVN GQFESVCESV
560 570 580 590 600
FSEVESQAMD ALDLPGCFRT RSHSYLRAIQ AGYSQDDECI PVMTPSNMTS
610 620 630 640 650
TIRSTAAVSY TNYKKTPPPV PPRTTSKPLI SVTAQSSTES TQDAYQDSRA
660 670 680 690 700
QRMSPWPQDS RGGLYNSMDS LDSNKAMNLA LESAAAQRHA ADTQSSSTRS
710 720 730 740 750
IDKAVLVSKA EELLKSRCSS IGVQDSEFPD HQPYPRSDVE TATDSDTESR
760 770 780 790 800
GLREYHSVGV QVEDEKRHGR FKRSNSVTAA VQADLELEGF PGHVSMEDKG
810 820 830 840 850
LQFGSSFQRH SEPSTPTQYG ALRTVRTQGL FSYREDYRTQ VDTSTLPPPD
860 870 880 890 900
PWLEPSLDTV ETGRMSPCRR DGSWFLKLLH TETKKMEGWC KEMEREAEEN
910 920 930 940 950
DLSEEILGKI RSAVGSAQLL MSQKFQQFYW LCQQNMDPSA MPRPTSQDLA
960 970 980 990 1000
GYWDMLQLSV EDVSMKFDEL HQLKLNDWKI MESPERKEER KIPPPIPKKP
1010 1020 1030 1040 1050
PKGKFPITRE KSLDLPDRQR QEARRRLMAA KRAASFRQNS ATERADSIEI

YIPEAQTRL
Length:1,059
Mass (Da):118,978
Last modified:July 19, 2005 - v3
Checksum:i8AB2A3667AD79434
GO

Sequence cautioni

The sequence AAB48588 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67138 mRNA. Translation: AAB48588.1. Different initiation.
RefSeqiNP_446353.2. NM_053901.1.
UniGeneiRn.10705.

Genome annotation databases

GeneIDi116681.
KEGGirno:116681.
UCSCiRGD:620224. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67138 mRNA. Translation: AAB48588.1. Different initiation.
RefSeqiNP_446353.2. NM_053901.1.
UniGeneiRn.10705.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250564. 5 interactors.
IntActiP97837. 7 interactors.
MINTiMINT-1796202.
STRINGi10116.ENSRNOP00000054654.

PTM databases

iPTMnetiP97837.
PhosphoSitePlusiP97837.
SwissPalmiP97837.

Proteomic databases

PaxDbiP97837.
PRIDEiP97837.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi116681.
KEGGirno:116681.
UCSCiRGD:620224. rat.

Organism-specific databases

CTDi9228.
RGDi620224. Dlgap2.

Phylogenomic databases

eggNOGiKOG3971. Eukaryota.
ENOG4111JKV. LUCA.
HOGENOMiHOG000015346.
HOVERGENiHBG018957.
InParanoidiP97837.
PhylomeDBiP97837.

Miscellaneous databases

PROiP97837.

Family and domain databases

InterProiIPR030525. DLGAP2.
IPR005026. SAPAP.
[Graphical view]
PANTHERiPTHR12353:SF3. PTHR12353:SF3. 1 hit.
PfamiPF03359. GKAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDLGP2_RAT
AccessioniPrimary (citable) accession number: P97837
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: July 19, 2005
Last modified: November 2, 2016
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.