Disks large-associated protein 1 - Rattus norvegicus (Rat)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Disks large-associated protein 1
Short name=DAP-1

Alternative name(s):
Guanylate kinase-associated protein
Short name=rGKAP
PSD-95/SAP90-binding protein 1
SAP90/PSD-95-associated protein 1
Short name=SAPAP1

Gene names

Name:	Dlgap1
Synonyms:	Gkap

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	992 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Part of the postsynaptic scaffold in neuronal cells.
Subunit structure	Interacts with guanylate kinase-like domain of DLG1, DLG2, DLG3, DLG4 and AIP1. Interacts with the PDZ domain of SHANK1, SHANK2 and SHANK3. Found in a complex with DLG4 and SHANK1, SHANK2 or SHANK3. Found in a complex with DLG4 and BEGAIN. Interacts with DYL2 and LRFN1. Ref.1 Ref.4 Ref.5 Ref.6 Ref.7 Ref.8 Ref.9 Ref.10
Subcellular location	Cell membrane; Peripheral membrane protein. Cell junction › synapse › postsynaptic cell membrane › postsynaptic density. Cell junction › synapse. Note: Found in postsynaptic density of neuronal cells.
Tissue specificity	Expressed in brain and testis.
Developmental stage	Highest level of isoform 1 in the brain of newborn rats. Increasing levels of isoforms 2, 3, 4, and 5 in the brain of newborn rats from birth to 6 weeks of postnatal development. Increasing but low level of isoform 6 is expressed in the brain from 2 to 6 weeks of postnatal development. Ref.2
Sequence similarities	Belongs to the SAPAP family.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
Coding sequence diversity	Alternative splicing
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aggresome assembly Inferred from mutant phenotype. Source: BHF-UCL cell-cell signaling Inferred from electronic annotation. Source: InterPro protein localization to synapse Inferred from mutant phenotype. Source: BHF-UCL regulation of proteasomal protein catabolic process Inferred from mutant phenotype. Source: BHF-UCL
Cellular component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell postsynaptic density Inferred from electronic annotation. Source: UniProtKB-SubCell postsynaptic membrane Inferred from direct assay Ref.1. Source: RGD
Molecular function	protein domain specific binding Inferred from direct assay Ref.1. Source: RGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Dlg4	P31016	5	EBI-80901,EBI-375655
Shank1	Q9WV48	3	EBI-80901,EBI-80909

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P97836-1) Also known as: SAPAP1; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P97836-4) Also known as: GKAP C; 2A; The sequence of this isoform differs from the canonical sequence as follows: 1-298: Missing. 299-325: QKASVNMDQAVVKSEACQQERSCQYLQ → MIDLFKAEWVSSVCVQVSRNGRTDQVW

Isoform 3 (identifier: P97836-5) Also known as: GKAP A; GKAP1a; The sequence of this isoform differs from the canonical sequence as follows: 1-298: Missing. 299-325: QKASVNMDQAVVKSEACQQERSCQYLQ → MIDLFKAEWVSSVCVQVSRNGRTDQVW 547-574: Missing.

Isoform 4 (identifier: P97836-6) Also known as: GKAP B; 2C; The sequence of this isoform differs from the canonical sequence as follows: 1-298: Missing. 299-325: QKASVNMDQAVVKSEACQQERSCQYLQ → MIDLFKAEWVSSVCVQVSRNGRTDQVW 537-546: Missing.

Isoform 5 (identifier: P97836-7) Also known as: 2B; The sequence of this isoform differs from the canonical sequence as follows: 1-298: Missing. 299-324: QKASVNMDQAVVKSEACQQERSCQYL → MIDLFKAEWVSSVCVQVSRNGRTD

Isoform 6 (identifier: P97836-8) Also known as: 2D; The sequence of this isoform differs from the canonical sequence as follows: 1-298: Missing. 299-325: QKASVNMDQAVVKSEACQQERSCQYLQ → MNLIFHKDILFGVSATK

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 992

992

Disks large-associated protein 1

PRO_0000174290

Regions

Region

665 – 676

12

Interaction with DYL2

Region

687 – 698

12

Interaction with DYL2

Motif

990 – 992

3

PDZ-binding

Amino acid modifications

Modified residue

123

1

Phosphotyrosine By similarity

Modified residue

134

1

Phosphoserine By similarity

Modified residue

352

1

Phosphoserine By similarity

Modified residue

362

1

Phosphoserine By similarity

Modified residue

389

1

Phosphoserine By similarity

Modified residue

412

1

Phosphoserine By similarity

Modified residue

421

1

Phosphoserine By similarity

Modified residue

436

1

Phosphothreonine By similarity

Modified residue

437

1

Phosphoserine By similarity

Modified residue

446

1

Phosphoserine By similarity

Modified residue

499

1

Phosphoserine By similarity

Modified residue

509

1

Phosphoserine By similarity

Modified residue

516

1

Phosphoserine By similarity

Modified residue

947

1

Phosphoserine By similarity

Natural variations

Alternative sequence

1 – 298

298

Missing in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6.

VSP_015415

Alternative sequence

299 – 325

27

QKASV…CQYLQ → MIDLFKAEWVSSVCVQVSRN GRTDQVW in isoform 2, isoform 3 and isoform 4.

VSP_015416

Alternative sequence

299 – 325

27

QKASV…CQYLQ → MNLIFHKDILFGVSATK in isoform 6.

VSP_015417

Alternative sequence

299 – 324

26

QKASV…SCQYL → MIDLFKAEWVSSVCVQVSRN GRTD in isoform 5.

VSP_015418

Alternative sequence

537 – 546

10

Missing in isoform 4.

VSP_015419

Alternative sequence

547 – 574

28

Missing in isoform 3.

VSP_015420

Experimental info

Mutagenesis

990

1

T → A: Abolishes interaction with SHANK1. Ref.7

Mutagenesis

991

1

R → D: Abolishes interaction with SHANK1. Ref.7

Mutagenesis

992

1

L → A: Abolishes interaction with SHANK1. Ref.7

Sequence conflict

636

1

S → T Ref.1

Sequence conflict

636

1

S → T Ref.2

Sequences

Sequence		Length	Mass (Da)
Isoform 1 (SAPAP1) [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 44BAF9BC0C14C099 Show »	FASTA	992	110,178
10 20 30 40 50 60 MKGLSGSRSH HHGITCESAC DSLSHHSDHK PYLLSPVDHH PADHPYYTQR NSFQAECVGP 70 80 90 100 110 120 FSDPLASSTF PRRHYTSQQE LKDESALVPR TLATKANRLP TNLLDQFERQ LPLSRDGYHT 130 140 150 160 170 180 LQYKRTAVEH RSDSPGRIRH LVHSVQKLFT KSHSLEGASK GGVNGGKASP DGSQTVRYGK 190 200 210 220 230 240 RSKSKERRSE PKARSNASNA SPTSPSWWSS DDNLDGDMCL YHTPSGVMTM GRCPDRSVSQ 250 260 270 280 290 300 YFMGAYNTIS EQAVKASRSN NDVKCSTCAN LPVTLDAPLL KKSAWSSTLT VSRAREVYQK 310 320 330 340 350 360 ASVNMDQAVV KSEACQQERS CQYLQVPQDE WTGYTPRGKD DEIPCRRMRS GSYIKAMGDE 370 380 390 400 410 420 DSGDSDTSPK PSPKVAARRE SYLKATQPSL TELTTLKISN EHSPKLQIRS HSYLRAVSEV 430 440 450 460 470 480 SINRSLDSLD PAGLLTSPKF RSRNESYMRA MSTISQVSEM EVNGQFESVC ESVFSELESQ 490 500 510 520 530 540 AVEALDLPMP GCFRMRSHSY VRAIEKGCSQ DDECVSLRSS SPPRTTTTVR TIQSSTGVIK 550 560 570 580 590 600 LSSAVEVSSC ITTYKKTPPP VPPRTTTKPF ISITAQSSTE SAQDAYMDGQ GQRGDMISQS 610 620 630 640 650 660 GLSNSTESLD SMKALTAAIE AANAQIHGPA SQHMGSNAAA VTTTTTIATV TTEDRKKDFK 670 680 690 700 710 720 KNRCLSIGIQ VDDAEESEKM AESKTSSKFQ SVGVQVEEEK CFRRFTRSNS VTTAVQADLD 730 740 750 760 770 780 FHDNLENSLE SIEDNSCPGP MARQFSRDAS TSTVSIQGSG NHYHACAADD DFDTDFDPSI 790 800 810 820 830 840 LPPPDPWIDS ITEDPLEAVQ RSVCHRDGHW FLKLLQAERD RMEGWCKQME REERENNLPE 850 860 870 880 890 900 DILGKIRTAV GSAQLLMAQK FYQFRELCEE NLNPNAHPRP TSQDLAGFWD MLQLSIENIS 910 920 930 940 950 960 MKFDELHQLK ANNWKQMDPL DKKERRAPPP VPKKPAKGPA PLIRERSLES SQRQEARKRL 970 980 990 MAAKRAASVR QNSATESAES IEIYIPEAQT RL « Hide
Isoform 2 (GKAP C) (2A) [UniParc]. Checksum: 2263D659AD1F6627 Show »	FASTA	694	77,263
10 20 30 40 50 60 MIDLFKAEWV SSVCVQVSRN GRTDQVWVPQ DEWTGYTPRG KDDEIPCRRM RSGSYIKAMG 70 80 90 100 110 120 DEDSGDSDTS PKPSPKVAAR RESYLKATQP SLTELTTLKI SNEHSPKLQI RSHSYLRAVS 130 140 150 160 170 180 EVSINRSLDS LDPAGLLTSP KFRSRNESYM RAMSTISQVS EMEVNGQFES VCESVFSELE 190 200 210 220 230 240 SQAVEALDLP MPGCFRMRSH SYVRAIEKGC SQDDECVSLR SSSPPRTTTT VRTIQSSTGV 250 260 270 280 290 300 IKLSSAVEVS SCITTYKKTP PPVPPRTTTK PFISITAQSS TESAQDAYMD GQGQRGDMIS 310 320 330 340 350 360 QSGLSNSTES LDSMKALTAA IEAANAQIHG PASQHMGSNA AAVTTTTTIA TVTTEDRKKD 370 380 390 400 410 420 FKKNRCLSIG IQVDDAEESE KMAESKTSSK FQSVGVQVEE EKCFRRFTRS NSVTTAVQAD 430 440 450 460 470 480 LDFHDNLENS LESIEDNSCP GPMARQFSRD ASTSTVSIQG SGNHYHACAA DDDFDTDFDP 490 500 510 520 530 540 SILPPPDPWI DSITEDPLEA VQRSVCHRDG HWFLKLLQAE RDRMEGWCKQ MEREERENNL 550 560 570 580 590 600 PEDILGKIRT AVGSAQLLMA QKFYQFRELC EENLNPNAHP RPTSQDLAGF WDMLQLSIEN 610 620 630 640 650 660 ISMKFDELHQ LKANNWKQMD PLDKKERRAP PPVPKKPAKG PAPLIRERSL ESSQRQEARK 670 680 690 RLMAAKRAAS VRQNSATESA ESIEIYIPEA QTRL « Hide
Isoform 3 (GKAP A) (GKAP1a) [UniParc]. Checksum: F027510C20BC2290 Show »	FASTA	666	74,220
10 20 30 40 50 60 MIDLFKAEWV SSVCVQVSRN GRTDQVWVPQ DEWTGYTPRG KDDEIPCRRM RSGSYIKAMG 70 80 90 100 110 120 DEDSGDSDTS PKPSPKVAAR RESYLKATQP SLTELTTLKI SNEHSPKLQI RSHSYLRAVS 130 140 150 160 170 180 EVSINRSLDS LDPAGLLTSP KFRSRNESYM RAMSTISQVS EMEVNGQFES VCESVFSELE 190 200 210 220 230 240 SQAVEALDLP MPGCFRMRSH SYVRAIEKGC SQDDECVSLR SSSPPRTTTT VRTIQSSTGV 250 260 270 280 290 300 IKLSSAVEAQ SSTESAQDAY MDGQGQRGDM ISQSGLSNST ESLDSMKALT AAIEAANAQI 310 320 330 340 350 360 HGPASQHMGS NAAAVTTTTT IATVTTEDRK KDFKKNRCLS IGIQVDDAEE SEKMAESKTS 370 380 390 400 410 420 SKFQSVGVQV EEEKCFRRFT RSNSVTTAVQ ADLDFHDNLE NSLESIEDNS CPGPMARQFS 430 440 450 460 470 480 RDASTSTVSI QGSGNHYHAC AADDDFDTDF DPSILPPPDP WIDSITEDPL EAVQRSVCHR 490 500 510 520 530 540 DGHWFLKLLQ AERDRMEGWC KQMEREEREN NLPEDILGKI RTAVGSAQLL MAQKFYQFRE 550 560 570 580 590 600 LCEENLNPNA HPRPTSQDLA GFWDMLQLSI ENISMKFDEL HQLKANNWKQ MDPLDKKERR 610 620 630 640 650 660 APPPVPKKPA KGPAPLIRER SLESSQRQEA RKRLMAAKRA ASVRQNSATE SAESIEIYIP EAQTRL « Hide
Isoform 4 (GKAP B) (2C) [UniParc]. Checksum: C37FA0BA715BAF66 Show »	FASTA	684	76,279
10 20 30 40 50 60 MIDLFKAEWV SSVCVQVSRN GRTDQVWVPQ DEWTGYTPRG KDDEIPCRRM RSGSYIKAMG 70 80 90 100 110 120 DEDSGDSDTS PKPSPKVAAR RESYLKATQP SLTELTTLKI SNEHSPKLQI RSHSYLRAVS 130 140 150 160 170 180 EVSINRSLDS LDPAGLLTSP KFRSRNESYM RAMSTISQVS EMEVNGQFES VCESVFSELE 190 200 210 220 230 240 SQAVEALDLP MPGCFRMRSH SYVRAIEKGC SQDDECVSLR SSSPPRTTTT VRTIQSSTVS 250 260 270 280 290 300 SCITTYKKTP PPVPPRTTTK PFISITAQSS TESAQDAYMD GQGQRGDMIS QSGLSNSTES 310 320 330 340 350 360 LDSMKALTAA IEAANAQIHG PASQHMGSNA AAVTTTTTIA TVTTEDRKKD FKKNRCLSIG 370 380 390 400 410 420 IQVDDAEESE KMAESKTSSK FQSVGVQVEE EKCFRRFTRS NSVTTAVQAD LDFHDNLENS 430 440 450 460 470 480 LESIEDNSCP GPMARQFSRD ASTSTVSIQG SGNHYHACAA DDDFDTDFDP SILPPPDPWI 490 500 510 520 530 540 DSITEDPLEA VQRSVCHRDG HWFLKLLQAE RDRMEGWCKQ MEREERENNL PEDILGKIRT 550 560 570 580 590 600 AVGSAQLLMA QKFYQFRELC EENLNPNAHP RPTSQDLAGF WDMLQLSIEN ISMKFDELHQ 610 620 630 640 650 660 LKANNWKQMD PLDKKERRAP PPVPKKPAKG PAPLIRERSL ESSQRQEARK RLMAAKRAAS 670 680 VRQNSATESA ESIEIYIPEA QTRL « Hide
Isoform 5 (2B) [UniParc]. Checksum: 7180180258ADEF72 Show »	FASTA	692	76,978
10 20 30 40 50 60 MIDLFKAEWV SSVCVQVSRN GRTDQVPQDE WTGYTPRGKD DEIPCRRMRS GSYIKAMGDE 70 80 90 100 110 120 DSGDSDTSPK PSPKVAARRE SYLKATQPSL TELTTLKISN EHSPKLQIRS HSYLRAVSEV 130 140 150 160 170 180 SINRSLDSLD PAGLLTSPKF RSRNESYMRA MSTISQVSEM EVNGQFESVC ESVFSELESQ 190 200 210 220 230 240 AVEALDLPMP GCFRMRSHSY VRAIEKGCSQ DDECVSLRSS SPPRTTTTVR TIQSSTGVIK 250 260 270 280 290 300 LSSAVEVSSC ITTYKKTPPP VPPRTTTKPF ISITAQSSTE SAQDAYMDGQ GQRGDMISQS 310 320 330 340 350 360 GLSNSTESLD SMKALTAAIE AANAQIHGPA SQHMGSNAAA VTTTTTIATV TTEDRKKDFK 370 380 390 400 410 420 KNRCLSIGIQ VDDAEESEKM AESKTSSKFQ SVGVQVEEEK CFRRFTRSNS VTTAVQADLD 430 440 450 460 470 480 FHDNLENSLE SIEDNSCPGP MARQFSRDAS TSTVSIQGSG NHYHACAADD DFDTDFDPSI 490 500 510 520 530 540 LPPPDPWIDS ITEDPLEAVQ RSVCHRDGHW FLKLLQAERD RMEGWCKQME REERENNLPE 550 560 570 580 590 600 DILGKIRTAV GSAQLLMAQK FYQFRELCEE NLNPNAHPRP TSQDLAGFWD MLQLSIENIS 610 620 630 640 650 660 MKFDELHQLK ANNWKQMDPL DKKERRAPPP VPKKPAKGPA PLIRERSLES SQRQEARKRL 670 680 690 MAAKRAASVR QNSATESAES IEIYIPEAQT RL « Hide
Isoform 6 (2D) [UniParc]. Checksum: 991D69B760948790 Show »	FASTA	684	76,043
10 20 30 40 50 60 MNLIFHKDIL FGVSATKVPQ DEWTGYTPRG KDDEIPCRRM RSGSYIKAMG DEDSGDSDTS 70 80 90 100 110 120 PKPSPKVAAR RESYLKATQP SLTELTTLKI SNEHSPKLQI RSHSYLRAVS EVSINRSLDS 130 140 150 160 170 180 LDPAGLLTSP KFRSRNESYM RAMSTISQVS EMEVNGQFES VCESVFSELE SQAVEALDLP 190 200 210 220 230 240 MPGCFRMRSH SYVRAIEKGC SQDDECVSLR SSSPPRTTTT VRTIQSSTGV IKLSSAVEVS 250 260 270 280 290 300 SCITTYKKTP PPVPPRTTTK PFISITAQSS TESAQDAYMD GQGQRGDMIS QSGLSNSTES 310 320 330 340 350 360 LDSMKALTAA IEAANAQIHG PASQHMGSNA AAVTTTTTIA TVTTEDRKKD FKKNRCLSIG 370 380 390 400 410 420 IQVDDAEESE KMAESKTSSK FQSVGVQVEE EKCFRRFTRS NSVTTAVQAD LDFHDNLENS 430 440 450 460 470 480 LESIEDNSCP GPMARQFSRD ASTSTVSIQG SGNHYHACAA DDDFDTDFDP SILPPPDPWI 490 500 510 520 530 540 DSITEDPLEA VQRSVCHRDG HWFLKLLQAE RDRMEGWCKQ MEREERENNL PEDILGKIRT 550 560 570 580 590 600 AVGSAQLLMA QKFYQFRELC EENLNPNAHP RPTSQDLAGF WDMLQLSIEN ISMKFDELHQ 610 620 630 640 650 660 LKANNWKQMD PLDKKERRAP PPVPKKPAKG PAPLIRERSL ESSQRQEARK RLMAAKRAAS 670 680 VRQNSATESA ESIEIYIPEA QTRL « Hide

References

[1]	"GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules." Kim E., Naisbitt S., Hsueh Y.-P., Rao A., Rothschild A., Craig A.M., Sheng M. J. Cell Biol. 136:669-678(1997) [PubMed: 9024696] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4), INTERACTION WITH DLG1; DLG2; DLG3 AND DLG4. Tissue: Brain.
[2]	"Differential expression of isoforms of PSD-95 binding protein (GKAP/SAPAP1) during rat brain development." Kawashima N., Takamiya K., Sun J., Kitabatake A., Sobue K. FEBS Lett. 418:301-304(1997) [PubMed: 9428732] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 4; 5 AND 6), DEVELOPMENTAL STAGE.
[3]	"SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density." Takeuchi M., Hata Y., Hirao K., Toyoda A., Irie M., Takai Y. J. Biol. Chem. 272:11943-11951(1997) [PubMed: 9115257] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[4]	"BEGAIN (brain-enriched guanylate kinase-associated protein), a novel neuronal PSD-95/SAP90-binding protein." Deguchi M., Hata Y., Takeuchi M., Ide N., Hirao K., Yao I., Irie M., Toyoda A., Takai Y. J. Biol. Chem. 273:26269-26272(1998) [PubMed: 9756850] [Abstract] Cited for: INTERACTION WITH BEGAIN AND DLG4.
[5]	"Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family." Boeckers T.M., Winter C., Smalla K.-H., Kreutz M.R., Bockmann J., Seidenbecher C., Garner C.C., Gundelfinger E.D. Biochem. Biophys. Res. Commun. 264:247-252(1999) [PubMed: 10527873] [Abstract] Cited for: INTERACTION WITH DLG4 AND SHANK PROTEINS.
[6]	"Synamon, a novel neuronal protein interacting with synapse-associated protein 90/postsynaptic density-95-associated protein." Yao I., Hata Y., Hirao K., Deguchi M., Ide N., Takeuchi M., Takai Y. J. Biol. Chem. 274:27463-27466(1999) [PubMed: 10488079] [Abstract] Cited for: INTERACTION WITH DLG4 AND SHANK1. Tissue: Brain.
[7]	"Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin." Naisbitt S., Kim E., Tu J.C., Xiao B., Sala C., Valtschanoff J., Weinberg R.J., Worley P.F., Sheng M. Neuron 23:569-582(1999) [PubMed: 10433268] [Abstract] Cited for: INTERACTION WITH SHANK PROTEINS, MUTAGENESIS OF THR-990; ARG-991 AND LEU-992.
[8]	"A novel multiple PDZ domain-containing molecule interacting with N-methyl-d-aspartate receptors and neuronal cell adhesion proteins." Hirao K., Hata Y., Ide N., Takeuchi M., Irie M., Yao I., Deguchi M., Toyoda A., Suedhof T.C., Takai Y. J. Biol. Chem. 273:21105-21110(1998) [PubMed: 9694864] [Abstract] Cited for: INTERACTION WITH AIP1.
[9]	"Proteomic identification of brain proteins that interact with dynein light chain LC8." Navarro-Lerida I., Martinez Moreno M., Roncal F., Gavilanes F., Albar J.P., Rodriguez-Crespo I. Proteomics 4:339-346(2004) [PubMed: 14760703] [Abstract] Cited for: INTERACTION WITH DYL2.
[10]	"SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses." Ko J., Kim S., Chung H.S., Kim K., Han K., Kim H., Jun H., Kaang B.-K., Kim E. Neuron 50:233-245(2006) [PubMed: 16630835] [Abstract] Cited for: INTERACTION WITH LRFN1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U67987 mRNA. Translation: AAC53054.1. AB003594 mRNA. Translation: BAA24265.1. U67137 mRNA. Translation: AAB48587.1.
IPI	IPI00208647. IPI00231500. IPI00231501. IPI00650111. IPI00650122. IPI00650130.
PIR	T00025.
RefSeq	NP_075235.2. NM_022946.2.
UniGene	Rn.90059.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P97836. 8 interactions.
MINT	MINT-101502.
STRING	P97836.
PTM databases
PhosphoSite	P97836.
Proteomic databases
PRIDE	P97836.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000047288; ENSRNOP00000044028; ENSRNOG00000016196.
GeneID	65040.
KEGG	rno:65040.
UCSC	NM_022946. rat.
Organism-specific databases
CTD	9229.
RGD	620223. Dlgap1.
Phylogenomic databases
eggNOG	roNOG13060.
GeneTree	ENSGT00550000074473.
HOVERGEN	HBG018957.
InParanoid	P97836.
OrthoDB	EOG4TB49Q.
Gene expression databases
ArrayExpress	P97836.
Genevestigator	P97836.
GermOnline	ENSRNOG00000016196. Rattus norvegicus.
Family and domain databases
InterPro	IPR005026. GKAP. [Graphical view]
KO	K15008.
Pfam	PF03359. GKAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	613856.

Entry information

Entry name

DLGP1_RAT

Accession

Primary (citable) accession number: P97836
Secondary accession number(s): O54773, P97841

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	May 1, 1997
Last modified:	November 16, 2011
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents