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Protein

COP9 signalosome complex subunit 1

Gene

Gps1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
COP9 signalosome complex subunit 1
Short name:
SGN1
Short name:
Signalosome subunit 1
Alternative name(s):
G protein pathway suppressor 1
Short name:
GPS-1
JAB1-containing signalosome subunit 1
MFH protein
Gene namesi
Name:Gps1
Synonyms:Cops1, Csn1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621532. Gps1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Signalosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 471471COP9 signalosome complex subunit 1PRO_0000120961Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei448 – 4481PhosphoserineBy similarity
Modified residuei454 – 4541PhosphoserineCombined sources
Modified residuei459 – 4591PhosphothreonineBy similarity
Modified residuei463 – 4631PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP97834.
PRIDEiP97834.

PTM databases

iPTMnetiP97834.
PhosphoSiteiP97834.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in testis.1 Publication

Interactioni

Subunit structurei

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS2, COPS3, COPS4 and COPS5. Interacts directly with inositol kinase ITPK1. Interacts with CAPN8 (By similarity).By similarity

Protein-protein interaction databases

BioGridi250638. 1 interaction.
STRINGi10116.ENSRNOP00000066704.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini240 – 408169PCIAdd
BLAST

Domaini

The PCI domain is necessary and sufficient for the interactions with other CSN subunits of the complex. Mediates the interaction with CAPN8 (By similarity).By similarity
The N-terminal part (1-196), which is not required for deneddylating activity and CSN complex formation, is nevertheless essential for other aspects of CSN complex function, such as repression of c-fos/FOS expression.By similarity

Sequence similaritiesi

Belongs to the CSN1 family.Curated
Contains 1 PCI domain.Curated

Phylogenomic databases

eggNOGiKOG0686. Eukaryota.
ENOG410XRXI. LUCA.
HOVERGENiHBG030722.
InParanoidiP97834.
KOiK12175.
OrthoDBiEOG7VX8VS.
PhylomeDBiP97834.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.25.40.10. 2 hits.
InterProiIPR033008. CSN1.
IPR000717. PCI_dom.
IPR019585. Rpn7/CSN1.
IPR011990. TPR-like_helical_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR14145:SF2. PTHR14145:SF2. 1 hit.
PfamiPF01399. PCI. 1 hit.
PF10602. RPN7. 1 hit.
[Graphical view]
SMARTiSM00088. PINT. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.

Sequencei

Sequence statusi: Complete.

P97834-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQIDVDPQED PQNAPDVNYV VENPTLDLEQ YAASYSGLMR IERLQFIADR
60 70 80 90 100
CPPLRVEALK MALSFVQRTF NVDMYEEIHR KLSEATRELQ NAPDAIPESG
110 120 130 140 150
VEPPPLDTAW VEATRKKALL KLEKLDTDLK NYKGNSIKES IRRGHDDLGD
160 170 180 190 200
HYLDCGDLSN ALKCYSRARD YCTSAKHVIN MCLNVIKVSV YLQNWSHVLS
210 220 230 240 250
YVSKAESTPE IAEQRGERDS QTQAILTKLK CAAGLAELAA RKYKQAAKCF
260 270 280 290 300
LLASFDHCDF PELLSPSNVA VYGGLCALAT FDRQELQRNV ISSSSFKLFL
310 320 330 340 350
ELEPQVRDII FKFYESKYAS CLKMLDEMKD NLLLDMYLAP HVRTLYTQIR
360 370 380 390 400
NRALIQYFSP YVSADMHKMA AAFNTTVAAL EDELTQVILE GLINARIDSH
410 420 430 440 450
SKILYARDVD QRSTTFEKSL LMGKEFQRRA KAMILRAAVL RNQIHVKSPP
460 470
REGSQGELTP ANSQSRMSTN M
Length:471
Mass (Da):53,428
Last modified:May 1, 1997 - v1
Checksum:iED919C9A9F3C8711
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti387 – 3871V → L in AAH61746 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87885 mRNA. Translation: CAA61139.1.
BC061746 mRNA. Translation: AAH61746.1.
PIRiS57449.
RefSeqiNP_001257868.1. NM_001270939.1.
NP_446421.3. NM_053969.3.
UniGeneiRn.16873.

Genome annotation databases

GeneIDi117039.
KEGGirno:117039.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87885 mRNA. Translation: CAA61139.1.
BC061746 mRNA. Translation: AAH61746.1.
PIRiS57449.
RefSeqiNP_001257868.1. NM_001270939.1.
NP_446421.3. NM_053969.3.
UniGeneiRn.16873.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250638. 1 interaction.
STRINGi10116.ENSRNOP00000066704.

PTM databases

iPTMnetiP97834.
PhosphoSiteiP97834.

Proteomic databases

PaxDbiP97834.
PRIDEiP97834.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi117039.
KEGGirno:117039.

Organism-specific databases

CTDi2873.
RGDi621532. Gps1.

Phylogenomic databases

eggNOGiKOG0686. Eukaryota.
ENOG410XRXI. LUCA.
HOVERGENiHBG030722.
InParanoidiP97834.
KOiK12175.
OrthoDBiEOG7VX8VS.
PhylomeDBiP97834.

Miscellaneous databases

PROiP97834.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.25.40.10. 2 hits.
InterProiIPR033008. CSN1.
IPR000717. PCI_dom.
IPR019585. Rpn7/CSN1.
IPR011990. TPR-like_helical_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR14145:SF2. PTHR14145:SF2. 1 hit.
PfamiPF01399. PCI. 1 hit.
PF10602. RPN7. 1 hit.
[Graphical view]
SMARTiSM00088. PINT. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A fusca gene homologue in mammalian tissues: developmental regulation in the rat testes."
    Nitz B., Ivell R., Hartung S., Middendorff R., Olcese J.
    Mol. Cell. Endocrinol. 144:131-138(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Wistar.
    Tissue: Pineal gland.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  3. Lubec G., Kang S.U., Lubec S.
    Submitted (SEP-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 125-130 AND 134-143, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  4. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-454 AND SER-463, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCSN1_RAT
AccessioniPrimary (citable) accession number: P97834
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: June 8, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.