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Protein

Twist-related protein 2

Gene

Twist2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism (By similarity). Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Twist-related protein 2
Gene namesi
Name:Twist2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi621286. Twist2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation
  • Cytoplasm By similarity

  • Note: Mainly nuclear during embryonic development. Cytoplasmic in adult tissues (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001274911 – 160Twist-related protein 2Add BLAST160

Proteomic databases

PaxDbiP97831.

PTM databases

PhosphoSitePlusiP97831.

Expressioni

Gene expression databases

BgeeiENSRNOG00000020355.
GenevisibleiP97831. RN.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with TCF3/E12. Also interacts with MEF2C (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027597.

Structurei

3D structure databases

ProteinModelPortaliP97831.
SMRiP97831.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 117bHLHPROSITE-ProRule annotationAdd BLAST52

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4447. Eukaryota.
ENOG4111QFU. LUCA.
GeneTreeiENSGT00760000119097.
HOGENOMiHOG000261629.
HOVERGENiHBG019071.
InParanoidiP97831.
KOiK09069.
OMAiDNKMSSC.
OrthoDBiEOG091G07PB.
PhylomeDBiP97831.
TreeFamiTF315153.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97831-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEGSSSPVS PVDSLGTSEE ELERQPKRFG RKRRYSKKSS EDGSPTPGKR
60 70 80 90 100
GKKGSPSAQS FEELQSQRIL ANVRERQRTQ SLNEAFAALR KIIPTLPSDK
110 120 130 140 150
LSKIQTLKLA ARYIDFLYQV LQSDEMDNKM TSCSYVAHER LSYAFSVWRM
160
EGAWSMSASH
Length:160
Mass (Da):18,124
Last modified:May 1, 1999 - v2
Checksum:i8F44750916940C0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08139 mRNA. Translation: CAA69333.1.
RefSeqiNP_067723.1. NM_021691.2.
UniGeneiRn.16279.

Genome annotation databases

EnsembliENSRNOT00000027597; ENSRNOP00000027597; ENSRNOG00000020355.
GeneIDi59327.
KEGGirno:59327.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08139 mRNA. Translation: CAA69333.1.
RefSeqiNP_067723.1. NM_021691.2.
UniGeneiRn.16279.

3D structure databases

ProteinModelPortaliP97831.
SMRiP97831.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027597.

PTM databases

PhosphoSitePlusiP97831.

Proteomic databases

PaxDbiP97831.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027597; ENSRNOP00000027597; ENSRNOG00000020355.
GeneIDi59327.
KEGGirno:59327.

Organism-specific databases

CTDi117581.
RGDi621286. Twist2.

Phylogenomic databases

eggNOGiKOG4447. Eukaryota.
ENOG4111QFU. LUCA.
GeneTreeiENSGT00760000119097.
HOGENOMiHOG000261629.
HOVERGENiHBG019071.
InParanoidiP97831.
KOiK09069.
OMAiDNKMSSC.
OrthoDBiEOG091G07PB.
PhylomeDBiP97831.
TreeFamiTF315153.

Miscellaneous databases

PROiP97831.

Gene expression databases

BgeeiENSRNOG00000020355.
GenevisibleiP97831. RN.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTWST2_RAT
AccessioniPrimary (citable) accession number: P97831
Secondary accession number(s): Q60981
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.