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Protein

Homeobox protein unc-4 homolog

Gene

Uncx

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi109 – 168HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein unc-4 homolog
Alternative name(s):
Homeobox protein Uncx4.1
Paired-type homeodomain transcription factor 1
Gene namesi
Name:Uncx
Synonyms:Phd1, Uncx4.1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69361 Uncx

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003346261 – 530Homeobox protein unc-4 homologAdd BLAST530

Proteomic databases

PaxDbiP97830
PRIDEiP97830

Expressioni

Tissue specificityi

Expressed in a narrow layer adjacent to the ventricular zone of the dorsal spinal cord, preceding overt neuronal differentiation.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001730

Structurei

3D structure databases

ProteinModelPortaliP97830
SMRiP97830
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi242 – 245Poly-Gly4
Compositional biasi248 – 522Pro-richAdd BLAST275
Compositional biasi408 – 482Ala-richAdd BLAST75

Sequence similaritiesi

Belongs to the paired homeobox family. Unc-4 subfamily.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
HOGENOMiHOG000154780
HOVERGENiHBG096185
InParanoidiP97830
KOiK09328
PhylomeDBiP97830

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P97830-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDGRLLEHP HAQFGGSLGG VVGFPYPLGH HHVYELAGHQ LQSAAAAAAA
60 70 80 90 100
ASVPFSIDGL LSGSCAAAAA SVVNPTPLLP AACGVAGESQ PFKLADSGDP
110 120 130 140 150
DKESPGCKRR RTRTNFTGWQ LEELEKAFNE SHYPDVFMRE ALAVRLDLVE
160 170 180 190 200
SRVQVWFQNR RAKWRKKENT KKGPGRPAHN SHPTTCSGEP MDPEEIARKE
210 220 230 240 250
LEKMEKKKRK HEKKLLKSQS RHLHSPGGLS LHSAPSSDSD SGGGGLSPEP
260 270 280 290 300
PEPPPPTASA KGPGAHGSGI AGSAPVPPGE PPAPGTCDPA FYPSQRSGAG
310 320 330 340 350
SQPRLGRPAD KDTVPCGPGA ASTAGLPKAS PFSVESLLSD SPPRRKATPA
360 370 380 390 400
NTAATAGLDF TPGLPCAPRT LIGKGHFLLY PITQPLGFLV PQAALKGGAG
410 420 430 440 450
PELVPKDAPP APPAPPAPPA QASFGAFPGP VGAADPAFAR RSPEVVASPG
460 470 480 490 500
PPAPASFRGL AAAAAESGAG DCADAGTVCP AAPPPPPLET SPGPGPRAPS
510 520 530
PPGEPATCGA AEPGAATGSS PPEGEEVDMD
Length:530
Mass (Da):53,880
Last modified:May 1, 1997 - v1
Checksum:iF5D5C0BD87ECF792
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87748 mRNA Translation: BAA13452.1
RefSeqiNP_058875.1, NM_017179.1
UniGeneiRn.10710

Genome annotation databases

GeneIDi29375
KEGGirno:29375
UCSCiRGD:69361 rat

Similar proteinsi

Entry informationi

Entry nameiUNC4_RAT
AccessioniPrimary (citable) accession number: P97830
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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