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Protein

Steroidogenic acute regulatory protein, mitochondrial

Gene

Star

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity).By similarity

Pathwayi: cholesterol metabolism

This protein is involved in the pathway cholesterol metabolism, which is part of Steroid metabolism.
View all proteins of this organism that are known to be involved in the pathway cholesterol metabolism and in Steroid metabolism.

GO - Molecular functioni

  • cholesterol binding Source: Ensembl
  • cholesterol transporter activity Source: RGD

GO - Biological processi

  • bile acid biosynthetic process Source: RGD
  • biphenyl metabolic process Source: RGD
  • brain development Source: RGD
  • cellular response to alkaloid Source: RGD
  • cellular response to antibiotic Source: RGD
  • cellular response to cadmium ion Source: RGD
  • cellular response to cAMP Source: RGD
  • cellular response to dexamethasone stimulus Source: RGD
  • cellular response to epinephrine stimulus Source: RGD
  • cellular response to fibroblast growth factor stimulus Source: RGD
  • cellular response to follicle-stimulating hormone stimulus Source: RGD
  • cellular response to glucose stimulus Source: RGD
  • cellular response to gonadotropin stimulus Source: RGD
  • cellular response to growth hormone stimulus Source: RGD
  • cellular response to insulin stimulus Source: RGD
  • cellular response to interferon-alpha Source: RGD
  • cellular response to interferon-gamma Source: RGD
  • cellular response to lipopolysaccharide Source: RGD
  • cellular response to luteinizing hormone stimulus Source: RGD
  • cellular response to metal ion Source: RGD
  • cellular response to organic cyclic compound Source: RGD
  • cellular response to transforming growth factor beta stimulus Source: RGD
  • cholesterol metabolic process Source: UniProtKB-UniPathway
  • circadian rhythm Source: RGD
  • circadian sleep/wake cycle, REM sleep Source: RGD
  • dibenzo-p-dioxin metabolic process Source: RGD
  • diterpenoid metabolic process Source: RGD
  • estrogen biosynthetic process Source: RGD
  • glucocorticoid metabolic process Source: Ensembl
  • insecticide metabolic process Source: RGD
  • intracellular cholesterol transport Source: RGD
  • male gonad development Source: RGD
  • negative regulation of neuron apoptotic process Source: RGD
  • organic acid metabolic process Source: RGD
  • phenol-containing compound metabolic process Source: RGD
  • phthalate metabolic process Source: RGD
  • positive regulation of gene expression Source: RGD
  • positive regulation of neurogenesis Source: RGD
  • regulation of neuronal synaptic plasticity Source: RGD
  • regulation of steroid biosynthetic process Source: Ensembl
  • response to activity Source: RGD
  • response to antibiotic Source: RGD
  • response to corticosterone Source: RGD
  • response to drug Source: RGD
  • response to estrogen Source: RGD
  • response to ethanol Source: RGD
  • response to fungicide Source: RGD
  • response to gonadotropin Source: RGD
  • response to herbicide Source: RGD
  • response to hydrogen peroxide Source: RGD
  • response to insecticide Source: RGD
  • response to ionizing radiation Source: RGD
  • response to lead ion Source: RGD
  • response to leptin Source: RGD
  • response to nicotine Source: RGD
  • response to nutrient Source: RGD
  • response to nutrient levels Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to organic substance Source: RGD
  • response to peptide hormone Source: RGD
  • response to steroid hormone Source: RGD
  • response to toxic substance Source: RGD
  • steroid biosynthetic process Source: RGD
  • testosterone biosynthetic process Source: RGD
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Steroidogenesis, Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiR-RNO-196108. Pregnenolone biosynthesis.
UniPathwayiUPA00296.

Names & Taxonomyi

Protein namesi
Recommended name:
Steroidogenic acute regulatory protein, mitochondrial
Short name:
StAR
Alternative name(s):
START domain-containing protein 1
Short name:
StARD1
Gene namesi
Name:Star
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi3770. Star.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: RGD
  • mitochondrial crista Source: RGD
  • mitochondrial intermembrane space Source: RGD
  • neuronal cell body Source: RGD
  • neuron projection Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 6262MitochondrionBy similarityAdd
BLAST
Chaini63 – 284222Steroidogenic acute regulatory protein, mitochondrialPRO_0000033320Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei56 – 561Phosphoserine; by PKABy similarity
Modified residuei194 – 1941Phosphoserine; by PKABy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP97826.
PRIDEiP97826.

PTM databases

iPTMnetiP97826.
PhosphoSiteiP97826.

Expressioni

Gene expression databases

BgeeiENSRNOG00000015052.
GenevisibleiP97826. RN.

Interactioni

Subunit structurei

May interact with TSPO.By similarity

Protein-protein interaction databases

BioGridi247588. 1 interaction.
STRINGi10116.ENSRNOP00000020606.

Structurei

3D structure databases

ProteinModelPortaliP97826.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini66 – 279214STARTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 START domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3845. Eukaryota.
ENOG41100B5. LUCA.
GeneTreeiENSGT00530000063139.
HOGENOMiHOG000142452.
HOVERGENiHBG010529.
InParanoidiP97826.
KOiK16931.
OMAiATFKLCA.
OrthoDBiEOG091G06RM.
PhylomeDBiP97826.
TreeFamiTF313869.

Family and domain databases

CDDicd08905. START_STARD1-like. 1 hit.
Gene3Di3.30.530.20. 1 hit.
InterProiIPR029866. StAR.
IPR000799. StAR-like.
IPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PANTHERiPTHR12136:SF9. PTHR12136:SF9. 1 hit.
PfamiPF01852. START. 1 hit.
[Graphical view]
PRINTSiPR00978. STARPROTEIN.
SMARTiSM00234. START. 1 hit.
[Graphical view]
PROSITEiPS50848. START. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLATFKLCA GSSYRHMRNM KGLRHQAVLA IGQELNRRAL GDPSPGWMGQ
60 70 80 90 100
VRRRSSLLGS QLEATLYSDQ ELSYIQQGEE AMQKALGILN NQEGWKKESQ
110 120 130 140 150
QENGDEVLSK VVPGVGKVFR LEVLLDQPMD RLYEELVDRM EAMGEWNPNV
160 170 180 190 200
KEIKVLKKIG KDTVITHELA AAAAGNLVGP RDFVSVRCTK RRGSTCVLAG
210 220 230 240 250
MATHFGEMPE QSGVIRAEHG PTCMVLHPLA GSPSKTKLTW LLSIDLKGWL
260 270 280
PKTIINQVLS QTQIEFASHL RKRLESSPAS EAQC
Length:284
Mass (Da):31,501
Last modified:May 1, 1997 - v1
Checksum:i439C41B971EE8270
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 77MLLATFK → MIWFSTAVLIGLYVFERFPT SMIGVGLFTNLVYFGLLQTF PFIMLTSPNFILSCGLVVVN HYLAFQFFAEEYYPFSEVLA YFTFC in AAB41674 (PubMed:9015355).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001349 mRNA. Translation: BAA19245.1.
U76419 mRNA. Translation: AAB41674.1.
AF044081 mRNA. Translation: AAC02528.1.
AB006007 mRNA. Translation: BAA34737.1.
BC088859 mRNA. Translation: AAH88859.1.
RefSeqiNP_113746.1. NM_031558.3.
UniGeneiRn.11399.

Genome annotation databases

EnsembliENSRNOT00000020606; ENSRNOP00000020606; ENSRNOG00000015052.
GeneIDi25557.
KEGGirno:25557.
UCSCiRGD:3770. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001349 mRNA. Translation: BAA19245.1.
U76419 mRNA. Translation: AAB41674.1.
AF044081 mRNA. Translation: AAC02528.1.
AB006007 mRNA. Translation: BAA34737.1.
BC088859 mRNA. Translation: AAH88859.1.
RefSeqiNP_113746.1. NM_031558.3.
UniGeneiRn.11399.

3D structure databases

ProteinModelPortaliP97826.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247588. 1 interaction.
STRINGi10116.ENSRNOP00000020606.

PTM databases

iPTMnetiP97826.
PhosphoSiteiP97826.

Proteomic databases

PaxDbiP97826.
PRIDEiP97826.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020606; ENSRNOP00000020606; ENSRNOG00000015052.
GeneIDi25557.
KEGGirno:25557.
UCSCiRGD:3770. rat.

Organism-specific databases

CTDi6770.
RGDi3770. Star.

Phylogenomic databases

eggNOGiKOG3845. Eukaryota.
ENOG41100B5. LUCA.
GeneTreeiENSGT00530000063139.
HOGENOMiHOG000142452.
HOVERGENiHBG010529.
InParanoidiP97826.
KOiK16931.
OMAiATFKLCA.
OrthoDBiEOG091G06RM.
PhylomeDBiP97826.
TreeFamiTF313869.

Enzyme and pathway databases

UniPathwayiUPA00296.
ReactomeiR-RNO-196108. Pregnenolone biosynthesis.

Miscellaneous databases

PROiP97826.

Gene expression databases

BgeeiENSRNOG00000015052.
GenevisibleiP97826. RN.

Family and domain databases

CDDicd08905. START_STARD1-like. 1 hit.
Gene3Di3.30.530.20. 1 hit.
InterProiIPR029866. StAR.
IPR000799. StAR-like.
IPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PANTHERiPTHR12136:SF9. PTHR12136:SF9. 1 hit.
PfamiPF01852. START. 1 hit.
[Graphical view]
PRINTSiPR00978. STARPROTEIN.
SMARTiSM00234. START. 1 hit.
[Graphical view]
PROSITEiPS50848. START. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTAR_RAT
AccessioniPrimary (citable) accession number: P97826
Secondary accession number(s): P97628
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: September 7, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.