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P97821

- CATC_MOUSE

UniProt

P97821 - CATC_MOUSE

Protein

Dipeptidyl peptidase 1

Gene

Ctsc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function.

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro.

    Cofactori

    Binds 1 chloride ion per heavy chain.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei257 – 2571By similarity
    Binding sitei301 – 3011ChlorideBy similarity
    Binding sitei303 – 3031Chloride; via amide nitrogenBy similarity
    Binding sitei346 – 3461ChlorideBy similarity
    Active sitei404 – 4041By similarity
    Active sitei426 – 4261By similarity

    GO - Molecular functioni

    1. chloride ion binding Source: Ensembl
    2. cysteine-type peptidase activity Source: UniProtKB-KW
    3. peptidase activator activity involved in apoptotic process Source: MGI
    4. serine-type endopeptidase activity Source: UniProtKB

    GO - Biological processi

    1. aging Source: Ensembl
    2. apoptotic process Source: GOC
    3. positive regulation of apoptotic signaling pathway Source: MGI
    4. proteolysis Source: UniProtKB
    5. response to organic substance Source: Ensembl
    6. T cell mediated cytotoxicity Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Ligandi

    Chloride

    Protein family/group databases

    MEROPSiC01.070.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dipeptidyl peptidase 1 (EC:3.4.14.1)
    Alternative name(s):
    Cathepsin C
    Cathepsin J
    Dipeptidyl peptidase I
    Short name:
    DPP-I
    Short name:
    DPPI
    Dipeptidyl transferase
    Cleaved into the following 3 chains:
    Alternative name(s):
    Dipeptidyl peptidase I exclusion domain chain
    Alternative name(s):
    Dipeptidyl peptidase I heavy chain
    Alternative name(s):
    Dipeptidyl peptidase I light chain
    Gene namesi
    Name:Ctsc
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:109553. Ctsc.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: Ensembl
    2. Golgi apparatus Source: Ensembl
    3. lysosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Lysosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 134110Dipeptidyl peptidase 1 exclusion domain chainBy similarityPRO_0000026346Add
    BLAST
    Propeptidei135 – 23096By similarityPRO_0000026347Add
    BLAST
    Chaini231 – 393163Dipeptidyl peptidase 1 heavy chainPRO_0000026348Add
    BLAST
    Chaini394 – 46269Dipeptidyl peptidase 1 light chainPRO_0000026349Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi30 ↔ 118By similarity
    Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi54 ↔ 136By similarity
    Disulfide bondi254 ↔ 297By similarity
    Glycosylationi275 – 2751N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi290 ↔ 330By similarity
    Disulfide bondi320 ↔ 336By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    MaxQBiP97821.
    PaxDbiP97821.
    PRIDEiP97821.

    PTM databases

    PhosphoSiteiP97821.

    Expressioni

    Tissue specificityi

    Broadly distributed, but higher levels found in lung, liver, kidney and spleen. Lower levels found in testis and brain.

    Gene expression databases

    ArrayExpressiP97821.
    BgeeiP97821.
    CleanExiMM_CTSC.
    GenevestigatoriP97821.

    Interactioni

    Subunit structurei

    Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.By similarity

    Protein-protein interaction databases

    IntActiP97821. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP97821.
    SMRiP97821. Positions 25-144, 174-462.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4870.
    HOGENOMiHOG000068022.
    HOVERGENiHBG005248.
    InParanoidiP97821.
    KOiK01275.
    OMAiYDDFLHY.
    OrthoDBiEOG74R1QK.
    PhylomeDBiP97821.
    TreeFamiTF313225.

    Family and domain databases

    Gene3Di2.40.128.80. 1 hit.
    InterProiIPR014882. CathepsinC_exc.
    IPR025661. Pept_asp_AS.
    IPR000169. Pept_cys_AS.
    IPR025660. Pept_his_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    [Graphical view]
    PANTHERiPTHR12411. PTHR12411. 1 hit.
    PfamiPF08773. CathepsinC_exc. 1 hit.
    PF00112. Peptidase_C1. 1 hit.
    [Graphical view]
    PRINTSiPR00705. PAPAIN.
    SMARTiSM00645. Pept_C1. 1 hit.
    [Graphical view]
    SUPFAMiSSF75001. SSF75001. 1 hit.
    PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    PS00639. THIOL_PROTEASE_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P97821-1 [UniParc]FASTAAdd to Basket

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    MGPWTHSLRA VLLLVLLGVC TVRSDTPANC TYPDLLGTWV FQVGPRSSRS    50
    DINCSVMEAT EEKVVVHLKK LDTAYDELGN SGHFTLIYNQ GFEIVLNDYK 100
    WFAFFKYEVR GHTAISYCHE TMTGWVHDVL GRNWACFVGK KVESHIEKVN 150
    MNAAHLGGLQ ERYSERLYTH NHNFVKAINT VQKSWTATAY KEYEKMSLRD 200
    LIRRSGHSQR IPRPKPAPMT DEIQQQILNL PESWDWRNVQ GVNYVSPVRN 250
    QESCGSCYSF ASMGMLEARI RILTNNSQTP ILSPQEVVSC SPYAQGCDGG 300
    FPYLIAGKYA QDFGVVEESC FPYTAKDSPC KPRENCLRYY SSDYYYVGGF 350
    YGGCNEALMK LELVKHGPMA VAFEVHDDFL HYHSGIYHHT GLSDPFNPFE 400
    LTNHAVLLVG YGRDPVTGIE YWIIKNSWGS NWGESGYFRI RRGTDECAIE 450
    SIAVAAIPIP KL 462
    Length:462
    Mass (Da):52,376
    Last modified:May 1, 1997 - v1
    Checksum:i56574B38D7DF4710
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U89269 mRNA. Translation: AAB49457.1.
    U74683 mRNA. Translation: AAB58400.3.
    BC067063 mRNA. Translation: AAH67063.1.
    CCDSiCCDS21438.1.
    RefSeqiNP_034112.3. NM_009982.4.
    UniGeneiMm.322945.

    Genome annotation databases

    EnsembliENSMUST00000032779; ENSMUSP00000032779; ENSMUSG00000030560.
    GeneIDi13032.
    KEGGimmu:13032.
    UCSCiuc009ifu.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U89269 mRNA. Translation: AAB49457.1 .
    U74683 mRNA. Translation: AAB58400.3 .
    BC067063 mRNA. Translation: AAH67063.1 .
    CCDSi CCDS21438.1.
    RefSeqi NP_034112.3. NM_009982.4.
    UniGenei Mm.322945.

    3D structure databases

    ProteinModelPortali P97821.
    SMRi P97821. Positions 25-144, 174-462.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P97821. 1 interaction.

    Chemistry

    BindingDBi P97821.
    ChEMBLi CHEMBL3454.

    Protein family/group databases

    MEROPSi C01.070.

    PTM databases

    PhosphoSitei P97821.

    Proteomic databases

    MaxQBi P97821.
    PaxDbi P97821.
    PRIDEi P97821.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032779 ; ENSMUSP00000032779 ; ENSMUSG00000030560 .
    GeneIDi 13032.
    KEGGi mmu:13032.
    UCSCi uc009ifu.2. mouse.

    Organism-specific databases

    CTDi 1075.
    MGIi MGI:109553. Ctsc.

    Phylogenomic databases

    eggNOGi COG4870.
    HOGENOMi HOG000068022.
    HOVERGENi HBG005248.
    InParanoidi P97821.
    KOi K01275.
    OMAi YDDFLHY.
    OrthoDBi EOG74R1QK.
    PhylomeDBi P97821.
    TreeFami TF313225.

    Miscellaneous databases

    ChiTaRSi CTSC. mouse.
    NextBioi 282904.
    PROi P97821.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P97821.
    Bgeei P97821.
    CleanExi MM_CTSC.
    Genevestigatori P97821.

    Family and domain databases

    Gene3Di 2.40.128.80. 1 hit.
    InterProi IPR014882. CathepsinC_exc.
    IPR025661. Pept_asp_AS.
    IPR000169. Pept_cys_AS.
    IPR025660. Pept_his_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    [Graphical view ]
    PANTHERi PTHR12411. PTHR12411. 1 hit.
    Pfami PF08773. CathepsinC_exc. 1 hit.
    PF00112. Peptidase_C1. 1 hit.
    [Graphical view ]
    PRINTSi PR00705. PAPAIN.
    SMARTi SM00645. Pept_C1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF75001. SSF75001. 1 hit.
    PROSITEi PS00640. THIOL_PROTEASE_ASN. 1 hit.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    PS00639. THIOL_PROTEASE_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, chromosomal localization, and expression of murine dipeptidyl peptidase I."
      Pham C.T.N., Armstrong R.J., Zimonjic D.B., Popescu N.C., Payan D.G., Ley T.J.
      J. Biol. Chem. 272:10695-10703(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129/SvJ.
    2. "Cloning and characterization of the cDNA encoding mouse dipeptidyl peptidase I (cathepsin C)."
      McGuire M.J., Lipsky P.E., Thiele D.L.
      Biochim. Biophys. Acta 1351:267-273(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    3. McGuire M.J., Lipsky P.E., Francisco N.M.C., Thiele D.L.
      Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Eye.

    Entry informationi

    Entry nameiCATC_MOUSE
    AccessioniPrimary (citable) accession number: P97821
    Secondary accession number(s): O08853
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3