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P97821

- CATC_MOUSE

UniProt

P97821 - CATC_MOUSE

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Protein

Dipeptidyl peptidase 1

Gene

Ctsc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro.

Cofactori

chlorideBy similarityNote: Binds 1 Cl(-) ion per heavy chain.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei257 – 2571By similarity
Binding sitei301 – 3011ChlorideBy similarity
Binding sitei303 – 3031Chloride; via amide nitrogenBy similarity
Binding sitei346 – 3461ChlorideBy similarity
Active sitei404 – 4041By similarity
Active sitei426 – 4261By similarity

GO - Molecular functioni

  1. chloride ion binding Source: Ensembl
  2. cysteine-type peptidase activity Source: UniProtKB-KW
  3. peptidase activator activity involved in apoptotic process Source: MGI
  4. serine-type endopeptidase activity Source: UniProtKB

GO - Biological processi

  1. aging Source: Ensembl
  2. apoptotic process Source: GOC
  3. positive regulation of apoptotic signaling pathway Source: MGI
  4. proteolysis Source: UniProtKB
  5. response to organic substance Source: Ensembl
  6. T cell mediated cytotoxicity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Ligandi

Chloride

Protein family/group databases

MEROPSiC01.070.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidyl peptidase 1 (EC:3.4.14.1)
Alternative name(s):
Cathepsin C
Cathepsin J
Dipeptidyl peptidase I
Short name:
DPP-I
Short name:
DPPI
Dipeptidyl transferase
Cleaved into the following 3 chains:
Alternative name(s):
Dipeptidyl peptidase I exclusion domain chain
Alternative name(s):
Dipeptidyl peptidase I heavy chain
Alternative name(s):
Dipeptidyl peptidase I light chain
Gene namesi
Name:Ctsc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:109553. Ctsc.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: Ensembl
  2. extracellular space Source: Ensembl
  3. extracellular vesicular exosome Source: Ensembl
  4. Golgi apparatus Source: Ensembl
  5. lysosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 134110Dipeptidyl peptidase 1 exclusion domain chainBy similarityPRO_0000026346Add
BLAST
Propeptidei135 – 23096By similarityPRO_0000026347Add
BLAST
Chaini231 – 393163Dipeptidyl peptidase 1 heavy chainPRO_0000026348Add
BLAST
Chaini394 – 46269Dipeptidyl peptidase 1 light chainPRO_0000026349Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi30 ↔ 118By similarity
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi54 ↔ 136By similarity
Disulfide bondi254 ↔ 297By similarity
Glycosylationi275 – 2751N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi290 ↔ 330By similarity
Disulfide bondi320 ↔ 336By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiP97821.
PaxDbiP97821.
PRIDEiP97821.

PTM databases

PhosphoSiteiP97821.

Expressioni

Tissue specificityi

Broadly distributed, but higher levels found in lung, liver, kidney and spleen. Lower levels found in testis and brain.

Gene expression databases

BgeeiP97821.
CleanExiMM_CTSC.
ExpressionAtlasiP97821. baseline and differential.
GenevestigatoriP97821.

Interactioni

Subunit structurei

Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.By similarity

Protein-protein interaction databases

IntActiP97821. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP97821.
SMRiP97821. Positions 25-144, 174-462.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4870.
HOGENOMiHOG000068022.
HOVERGENiHBG005248.
InParanoidiP97821.
KOiK01275.
OMAiYDDFLHY.
OrthoDBiEOG74R1QK.
PhylomeDBiP97821.
TreeFamiTF313225.

Family and domain databases

Gene3Di2.40.128.80. 1 hit.
InterProiIPR014882. CathepsinC_exc.
IPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08773. CathepsinC_exc. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
SUPFAMiSSF75001. SSF75001. 1 hit.
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97821-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGPWTHSLRA VLLLVLLGVC TVRSDTPANC TYPDLLGTWV FQVGPRSSRS
60 70 80 90 100
DINCSVMEAT EEKVVVHLKK LDTAYDELGN SGHFTLIYNQ GFEIVLNDYK
110 120 130 140 150
WFAFFKYEVR GHTAISYCHE TMTGWVHDVL GRNWACFVGK KVESHIEKVN
160 170 180 190 200
MNAAHLGGLQ ERYSERLYTH NHNFVKAINT VQKSWTATAY KEYEKMSLRD
210 220 230 240 250
LIRRSGHSQR IPRPKPAPMT DEIQQQILNL PESWDWRNVQ GVNYVSPVRN
260 270 280 290 300
QESCGSCYSF ASMGMLEARI RILTNNSQTP ILSPQEVVSC SPYAQGCDGG
310 320 330 340 350
FPYLIAGKYA QDFGVVEESC FPYTAKDSPC KPRENCLRYY SSDYYYVGGF
360 370 380 390 400
YGGCNEALMK LELVKHGPMA VAFEVHDDFL HYHSGIYHHT GLSDPFNPFE
410 420 430 440 450
LTNHAVLLVG YGRDPVTGIE YWIIKNSWGS NWGESGYFRI RRGTDECAIE
460
SIAVAAIPIP KL
Length:462
Mass (Da):52,376
Last modified:May 1, 1997 - v1
Checksum:i56574B38D7DF4710
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89269 mRNA. Translation: AAB49457.1.
U74683 mRNA. Translation: AAB58400.3.
BC067063 mRNA. Translation: AAH67063.1.
CCDSiCCDS21438.1.
RefSeqiNP_034112.3. NM_009982.4.
UniGeneiMm.322945.

Genome annotation databases

EnsembliENSMUST00000032779; ENSMUSP00000032779; ENSMUSG00000030560.
GeneIDi13032.
KEGGimmu:13032.
UCSCiuc009ifu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89269 mRNA. Translation: AAB49457.1 .
U74683 mRNA. Translation: AAB58400.3 .
BC067063 mRNA. Translation: AAH67063.1 .
CCDSi CCDS21438.1.
RefSeqi NP_034112.3. NM_009982.4.
UniGenei Mm.322945.

3D structure databases

ProteinModelPortali P97821.
SMRi P97821. Positions 25-144, 174-462.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P97821. 1 interaction.

Chemistry

BindingDBi P97821.
ChEMBLi CHEMBL3454.

Protein family/group databases

MEROPSi C01.070.

PTM databases

PhosphoSitei P97821.

Proteomic databases

MaxQBi P97821.
PaxDbi P97821.
PRIDEi P97821.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032779 ; ENSMUSP00000032779 ; ENSMUSG00000030560 .
GeneIDi 13032.
KEGGi mmu:13032.
UCSCi uc009ifu.2. mouse.

Organism-specific databases

CTDi 1075.
MGIi MGI:109553. Ctsc.

Phylogenomic databases

eggNOGi COG4870.
HOGENOMi HOG000068022.
HOVERGENi HBG005248.
InParanoidi P97821.
KOi K01275.
OMAi YDDFLHY.
OrthoDBi EOG74R1QK.
PhylomeDBi P97821.
TreeFami TF313225.

Miscellaneous databases

ChiTaRSi Ctsc. mouse.
NextBioi 282904.
PROi P97821.
SOURCEi Search...

Gene expression databases

Bgeei P97821.
CleanExi MM_CTSC.
ExpressionAtlasi P97821. baseline and differential.
Genevestigatori P97821.

Family and domain databases

Gene3Di 2.40.128.80. 1 hit.
InterProi IPR014882. CathepsinC_exc.
IPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view ]
PANTHERi PTHR12411. PTHR12411. 1 hit.
Pfami PF08773. CathepsinC_exc. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view ]
PRINTSi PR00705. PAPAIN.
SMARTi SM00645. Pept_C1. 1 hit.
[Graphical view ]
SUPFAMi SSF75001. SSF75001. 1 hit.
PROSITEi PS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, chromosomal localization, and expression of murine dipeptidyl peptidase I."
    Pham C.T.N., Armstrong R.J., Zimonjic D.B., Popescu N.C., Payan D.G., Ley T.J.
    J. Biol. Chem. 272:10695-10703(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/SvJ.
  2. "Cloning and characterization of the cDNA encoding mouse dipeptidyl peptidase I (cathepsin C)."
    McGuire M.J., Lipsky P.E., Thiele D.L.
    Biochim. Biophys. Acta 1351:267-273(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  3. McGuire M.J., Lipsky P.E., Francisco N.M.C., Thiele D.L.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Eye.

Entry informationi

Entry nameiCATC_MOUSE
AccessioniPrimary (citable) accession number: P97821
Secondary accession number(s): O08853
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: November 26, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3