Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

FXYD domain-containing ion transport regulator 5

Gene

Fxyd5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
FXYD domain-containing ion transport regulator 5
Alternative name(s):
EF-8
Ion channel homolog RIC
Oncoprotein-induced protein 2
Gene namesi
Name:Fxyd5
Synonyms:Oit2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1201785. Fxyd5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 145ExtracellularSequence analysisAdd BLAST124
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Topological domaini167 – 178CytoplasmicSequence analysisAdd BLAST12

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000038899622 – 178FXYD domain-containing ion transport regulator 5Add BLAST157

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP97808.
PaxDbiP97808.
PeptideAtlasiP97808.
PRIDEiP97808.

PTM databases

iPTMnetiP97808.
PhosphoSitePlusiP97808.
SwissPalmiP97808.

Expressioni

Tissue specificityi

Spleen, lung, skeletal muscle, and testis.

Developmental stagei

Exhibits biphasic expression during development.

Gene expression databases

BgeeiENSMUSG00000009687.
CleanExiMM_FXYD5.
ExpressionAtlasiP97808. baseline and differential.
GenevisibleiP97808. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124203.

Structurei

3D structure databases

ProteinModelPortaliP97808.
SMRiP97808.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi88 – 134Pro-richAdd BLAST47

Sequence similaritiesi

Belongs to the FXYD family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JCU8. Eukaryota.
ENOG4111E7R. LUCA.
GeneTreeiENSGT00410000026316.
HOGENOMiHOG000112679.
HOVERGENiHBG051678.
InParanoidiP97808.
KOiK13362.
PhylomeDBiP97808.
TreeFamiTF338182.

Family and domain databases

InterProiIPR000272. Ion-transport_regulator_FXYD.
[Graphical view]
PfamiPF02038. ATP1G1_PLM_MAT8. 1 hit.
[Graphical view]
ProDomiPD005989. PD005989. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01310. FXYD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97808-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSSRLCLL TIVALILPSR GQTPKKPTSI FTADQTSATT RDNVPDPDQT
60 70 80 90 100
SPGVQTTPLI WTREEATGSQ TAAQTETQQL TKMATSNPVS DPGPHTSSKK
110 120 130 140 150
GTPAVSRIEP LSPSKNFMPP SYIEHPLDSN ENNPFYYDDT TLRKRGLLVA
160 170
AVLFITGIII LTSGKCRQLS QFCLNRHR
Length:178
Mass (Da):19,454
Last modified:November 24, 2009 - v3
Checksum:i466FBF1E05D861C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72680 mRNA. Translation: AAB51040.1.
AK003068 mRNA. Translation: BAB22545.1.
CCDSiCCDS21121.1.
RefSeqiNP_001104543.1. NM_001111073.2.
NP_001274142.1. NM_001287213.1.
NP_032787.1. NM_008761.4.
UniGeneiMm.1870.

Genome annotation databases

EnsembliENSMUST00000159924; ENSMUSP00000124219; ENSMUSG00000009687.
ENSMUST00000161684; ENSMUSP00000125285; ENSMUSG00000009687.
ENSMUST00000161805; ENSMUSP00000125398; ENSMUSG00000009687.
ENSMUST00000162087; ENSMUSP00000125065; ENSMUSG00000009687.
ENSMUST00000162116; ENSMUSP00000124203; ENSMUSG00000009687.
GeneIDi18301.
KEGGimmu:18301.
UCSCiuc009ghp.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72680 mRNA. Translation: AAB51040.1.
AK003068 mRNA. Translation: BAB22545.1.
CCDSiCCDS21121.1.
RefSeqiNP_001104543.1. NM_001111073.2.
NP_001274142.1. NM_001287213.1.
NP_032787.1. NM_008761.4.
UniGeneiMm.1870.

3D structure databases

ProteinModelPortaliP97808.
SMRiP97808.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124203.

PTM databases

iPTMnetiP97808.
PhosphoSitePlusiP97808.
SwissPalmiP97808.

Proteomic databases

EPDiP97808.
PaxDbiP97808.
PeptideAtlasiP97808.
PRIDEiP97808.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000159924; ENSMUSP00000124219; ENSMUSG00000009687.
ENSMUST00000161684; ENSMUSP00000125285; ENSMUSG00000009687.
ENSMUST00000161805; ENSMUSP00000125398; ENSMUSG00000009687.
ENSMUST00000162087; ENSMUSP00000125065; ENSMUSG00000009687.
ENSMUST00000162116; ENSMUSP00000124203; ENSMUSG00000009687.
GeneIDi18301.
KEGGimmu:18301.
UCSCiuc009ghp.3. mouse.

Organism-specific databases

CTDi53827.
MGIiMGI:1201785. Fxyd5.

Phylogenomic databases

eggNOGiENOG410JCU8. Eukaryota.
ENOG4111E7R. LUCA.
GeneTreeiENSGT00410000026316.
HOGENOMiHOG000112679.
HOVERGENiHBG051678.
InParanoidiP97808.
KOiK13362.
PhylomeDBiP97808.
TreeFamiTF338182.

Miscellaneous databases

ChiTaRSiFxyd5. mouse.
PROiP97808.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000009687.
CleanExiMM_FXYD5.
ExpressionAtlasiP97808. baseline and differential.
GenevisibleiP97808. MM.

Family and domain databases

InterProiIPR000272. Ion-transport_regulator_FXYD.
[Graphical view]
PfamiPF02038. ATP1G1_PLM_MAT8. 1 hit.
[Graphical view]
ProDomiPD005989. PD005989. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01310. FXYD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFXYD5_MOUSE
AccessioniPrimary (citable) accession number: P97808
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 24, 2009
Last modified: November 2, 2016
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.