P97808 (FXYD5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
FXYD domain-containing ion transport regulator 5

Alternative name(s):
EF-8
Ion channel homolog RIC
Oncoprotein-induced protein 2

Gene names

Name:	Fxyd5
Synonyms:	Oit2

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	178 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Tissue specificity	Spleen, lung, skeletal muscle, and testis.
Developmental stage	Exhibits biphasic expression during development.
Post-translational modification	Glycosylated By similarity.
Sequence similarities	Belongs to the FXYD family.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Ionic channel
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ion channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 178	157	FXYD domain-containing ion transport regulator 5		PRO_0000388996
Regions
	Topological domain	22 – 145	124	Extracellular Potential
	Transmembrane	146 – 166	21	Helical; Potential
	Topological domain	167 – 178	12	Cytoplasmic Potential
	Compositional bias	88 – 134	47	Pro-rich
Amino acid modifications
	Modified residue	112	1	Phosphoserine Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P97808 [UniParc]. Last modified November 24, 2009. Version 3. Checksum: 466FBF1E05D861C5	FASTA	178	19,454
	10 20 30 40 50 60 MSLSSRLCLL TIVALILPSR GQTPKKPTSI FTADQTSATT RDNVPDPDQT SPGVQTTPLI 70 80 90 100 110 120 WTREEATGSQ TAAQTETQQL TKMATSNPVS DPGPHTSSKK GTPAVSRIEP LSPSKNFMPP 130 140 150 160 170 SYIEHPLDSN ENNPFYYDDT TLRKRGLLVA AVLFITGIII LTSGKCRQLS QFCLNRHR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts." Fu X., Kamps M.P. Mol. Cell. Biol. 17:1503-1512(1997) [PubMed: 9032278] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Spleen.
[3]	"The phagosomal proteome in interferon-gamma-activated macrophages." Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P. Immunity 30:143-154(2009) [PubMed: 19144319] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-112, MASS SPECTROMETRY. Tissue: Macrophage.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U72680 mRNA. Translation: AAB51040.1. AK003068 mRNA. Translation: BAB22545.1.
IPI	IPI00129933.
RefSeq	NP_001104543.1. NM_001111073.1. NP_032787.1. NM_008761.3.
UniGene	Mm.1870.
3D structure databases
ProteinModelPortal	P97808.
SMR	P97808. Positions 133-163.
ModBase	Search...
Protein-protein interaction databases
STRING	P97808.
Proteomic databases
PRIDE	P97808.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000159924; ENSMUSP00000124219; ENSMUSG00000009687. ENSMUST00000161684; ENSMUSP00000125285; ENSMUSG00000009687. ENSMUST00000161805; ENSMUSP00000125398; ENSMUSG00000009687. ENSMUST00000162087; ENSMUSP00000125065; ENSMUSG00000009687. ENSMUST00000162116; ENSMUSP00000124203; ENSMUSG00000009687.
GeneID	18301.
KEGG	mmu:18301.
Organism-specific databases
CTD	53827.
MGI	MGI:1201785. Fxyd5.
Phylogenomic databases
eggNOG	roNOG17831.
GeneTree	ENSGT00410000026316.
HOGENOM	HBG283367.
HOVERGEN	HBG051678.
InParanoid	P97808.
OMA	TIPTEPA.
OrthoDB	EOG4VDQ18.
Gene expression databases
ArrayExpress	P97808.
Bgee	P97808.
CleanEx	MM_FXYD5.
Genevestigator	P97808.
GermOnline	ENSMUSG00000009687. Mus musculus.
Family and domain databases
InterPro	IPR000272. Ion-transport_regulator_FXYD. [Graphical view]
KO	K13362.
Pfam	PF02038. ATP1G1_PLM_MAT8. 1 hit. [Graphical view]
ProDom	PD005989. PD005989. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS01310. FXYD. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	293758.
SOURCE	Search...

Entry information

Entry name

FXYD5_MOUSE

Accession

Primary (citable) accession number: P97808

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 24, 2009
Last modified:	December 14, 2011
This is version 93 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program