Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neurensin-1

Gene

Nrsn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play an important role in neural organelle transport, and in transduction of nerve signals or in nerve growth (PubMed:12445626, PubMed:16527258, PubMed:16696124, PubMed:9191101). May play a role in neurite extension (PubMed:26430118).5 Publications

GO - Biological processi

  • nervous system development Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Neurensin-1
Alternative name(s):
Neuro-p24
Vesicular membrane protein of 24 kDa
Short name:
Vesicular membrane protein p24
Gene namesi
Name:Nrsn1Imported
Synonyms:VmpImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:894662. Nrsn1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei67 – 8721HelicalSequence analysisAdd
BLAST
Transmembranei121 – 14121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasmic, membrane-bounded vesicle Source: MGI
  • growth cone Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • neuronal cell body Source: MGI
  • neuron projection Source: UniProtKB
  • transport vesicle Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 196196Neurensin-1PRO_0000270584Add
BLAST

Proteomic databases

PaxDbiP97799.
PRIDEiP97799.

PTM databases

iPTMnetiP97799.
PhosphoSiteiP97799.

Expressioni

Tissue specificityi

Expressed predominantly in brain. Also weakly expressed in lung and spleen. In brain, expressed strongly in nerve fibers of the cerebral cortex, anterior cerebral nuclei, hypothalamus, amygdaloid complex, brain stem of the metaencephalon and medulla oblongata, and moderately expressed in soma of neurons of the dentate gyrus of the hippocampus and Purkinje cells of the cerebellum.1 Publication

Developmental stagei

Expression is developmentally regulated as axonal fibers innervate, extend collateral fibers and finally attain a stable state. First detected at postnatal day 6 in cell bodies and apical dendrites of pyramidal neurons in the developing cerebral cortex, with expression gradually increasing during postnatal development. In P1 retina, strongly expressed in the optic nerve fiber layer, and weakly expressed in ganglion cells, presumptive amacrine and horizontal cells. At P10, also strongly expressed in other parts of the retina such as the ganglion cells, inner plexiform layer and horizontal cells. Expression decreases as the retina develops further to maturity.2 Publications

Inductioni

By retinoic acid in neuroblastoma Neuro2a cells. Down-regulated following fear conditioning (at protein level) (PubMed:26430118).3 Publications

Gene expression databases

BgeeiENSMUSG00000048978.
CleanExiMM_NRSN1.
GenevisibleiP97799. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055048.

Family & Domainsi

Sequence similaritiesi

Belongs to the VMP family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJHW. Eukaryota.
ENOG4111HTK. LUCA.
GeneTreeiENSGT00530000063877.
HOGENOMiHOG000231873.
HOVERGENiHBG053471.
InParanoidiP97799.
OMAiTSIWEYE.
OrthoDBiEOG091G0K9J.
PhylomeDBiP97799.
TreeFamiTF332090.

Family and domain databases

InterProiIPR024883. Neurensin.
IPR029698. Nrsn1.
[Graphical view]
PANTHERiPTHR14796. PTHR14796. 1 hit.
PTHR14796:SF6. PTHR14796:SF6. 1 hit.

Sequencei

Sequence statusi: Complete.

P97799-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSCSNTCGS RRAQADTEGG YQQRYGVRSY LHQFYEDCTA SIWEYEDDFQ
60 70 80 90 100
IQRSPNRWSS VFWKVGLISG TVFVILGLTV LAVGFLVPPK IEAFGEADFM
110 120 130 140 150
VVDTHAVKYN GALDTCKLAG AVLFCIGGTS MAGCLLMSVF AKSYSKEEKF
160 170 180 190
LQQKFKERIA DIKAHTQPIT KAPGPGDTKI PVTLSRVQNV QPLSAT
Length:196
Mass (Da):21,595
Last modified:May 1, 1997 - v1
Checksum:iF866AB20ADB934BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83206 mRNA. Translation: BAA18947.1.
AK138191 mRNA. Translation: BAE23574.1.
AK153741 mRNA. Translation: BAE32162.1.
AL589766 Genomic DNA. Translation: CAI24436.1.
BC052019 mRNA. Translation: AAH52019.1.
CCDSiCCDS26387.1.
RefSeqiNP_033539.1. NM_009513.2.
XP_006516721.1. XM_006516658.2.
XP_011242608.1. XM_011244306.1.
UniGeneiMm.4766.

Genome annotation databases

EnsembliENSMUST00000057866; ENSMUSP00000055048; ENSMUSG00000048978.
ENSMUST00000167305; ENSMUSP00000128979; ENSMUSG00000048978.
GeneIDi22360.
KEGGimmu:22360.
UCSCiuc007pwx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83206 mRNA. Translation: BAA18947.1.
AK138191 mRNA. Translation: BAE23574.1.
AK153741 mRNA. Translation: BAE32162.1.
AL589766 Genomic DNA. Translation: CAI24436.1.
BC052019 mRNA. Translation: AAH52019.1.
CCDSiCCDS26387.1.
RefSeqiNP_033539.1. NM_009513.2.
XP_006516721.1. XM_006516658.2.
XP_011242608.1. XM_011244306.1.
UniGeneiMm.4766.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055048.

PTM databases

iPTMnetiP97799.
PhosphoSiteiP97799.

Proteomic databases

PaxDbiP97799.
PRIDEiP97799.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057866; ENSMUSP00000055048; ENSMUSG00000048978.
ENSMUST00000167305; ENSMUSP00000128979; ENSMUSG00000048978.
GeneIDi22360.
KEGGimmu:22360.
UCSCiuc007pwx.2. mouse.

Organism-specific databases

CTDi140767.
MGIiMGI:894662. Nrsn1.

Phylogenomic databases

eggNOGiENOG410IJHW. Eukaryota.
ENOG4111HTK. LUCA.
GeneTreeiENSGT00530000063877.
HOGENOMiHOG000231873.
HOVERGENiHBG053471.
InParanoidiP97799.
OMAiTSIWEYE.
OrthoDBiEOG091G0K9J.
PhylomeDBiP97799.
TreeFamiTF332090.

Miscellaneous databases

PROiP97799.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048978.
CleanExiMM_NRSN1.
GenevisibleiP97799. MM.

Family and domain databases

InterProiIPR024883. Neurensin.
IPR029698. Nrsn1.
[Graphical view]
PANTHERiPTHR14796. PTHR14796. 1 hit.
PTHR14796:SF6. PTHR14796:SF6. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNRSN1_MOUSE
AccessioniPrimary (citable) accession number: P97799
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: May 1, 1997
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.