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P97794

- KCNJ8_MOUSE

UniProt

P97794 - KCNJ8_MOUSE

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Protein
ATP-sensitive inward rectifier potassium channel 8
Gene
Kcnj8
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei170 – 1701Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium By similarity

GO - Molecular functioni

  1. ATP binding Source: Ensembl
  2. ATP-activated inward rectifier potassium channel activity Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. defense response to virus Source: MGI
  2. heart development Source: MGI
  3. kidney development Source: Ensembl
  4. potassium ion import Source: Ensembl
  5. response to exogenous dsRNA Source: MGI
  6. response to lipopolysaccharide Source: MGI
  7. response to pH Source: Ensembl
  8. vasodilation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_199102. ATP sensitive Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-sensitive inward rectifier potassium channel 8
Alternative name(s):
Inward rectifier K(+) channel Kir6.1
Potassium channel, inwardly rectifying subfamily J member 8
uKATP-1
Gene namesi
Name:Kcnj8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1100508. Kcnj8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6969Cytoplasmic By similarity
Add
BLAST
Transmembranei70 – 9425Helical; Name=M1; By similarity
Add
BLAST
Topological domaini95 – 12632Extracellular By similarity
Add
BLAST
Intramembranei127 – 13812Helical; Pore-forming; Name=H5; By similarity
Add
BLAST
Intramembranei139 – 1457Pore-forming; By similarity
Topological domaini146 – 1549Extracellular By similarity
Transmembranei155 – 17622Helical; Name=M2; By similarity
Add
BLAST
Topological domaini177 – 424248Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. ATP-sensitive potassium channel complex Source: Ensembl
  2. mitochondrion Source: Ensembl
  3. myofibril Source: MGI
  4. sarcolemma Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 424424ATP-sensitive inward rectifier potassium channel 8
PRO_0000154948Add
BLAST

Proteomic databases

PRIDEiP97794.

PTM databases

PhosphoSiteiP97794.

Expressioni

Gene expression databases

BgeeiP97794.
GenevestigatoriP97794.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032374.

Structurei

3D structure databases

ProteinModelPortaliP97794.
SMRiP97794. Positions 35-361.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi140 – 1456Selectivity filter By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG72812.
HOGENOMiHOG000237325.
HOVERGENiHBG006178.
InParanoidiP97794.
KOiK05001.
OMAiVIAVRNN.
OrthoDBiEOG7XPZ5K.
PhylomeDBiP97794.
TreeFamiTF313676.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003278. K_chnl_inward-rec_Kir6.1.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01331. KIR61CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

P97794-1 [UniParc]FASTAAdd to Basket

« Hide

MLARKSIIPE EYVLARIAAE NLRKPRIRDR LPKARFIAKS GACNLAHKNI    50
REQGRFLQDI FTTLVDLKWR HTLVIFTMSF LCSWLLFAIM WWLVAFAHGD 100
IYAYMEKGTM EKSGLESAVC VTNVRSFTSA FLFSIEVQVT IGFGGRMMTE 150
ECPLAITVLI LQNIVGLIIN AVMLGCIFMK TAQAHRRAET LIFSRHAVIA 200
VRNGKLCFMF RVGDLRKSMI ISASVRIQVV KKTTTPEGEV VPIHQQDIPV 250
DNPIESNNIF LVAPLIICHV IDKRSPLYDI SATDLANQDL EVIVILEGVV 300
ETTGITTQAR TSYIAEEIQW GHRFVSIVTE EEGVYSVDYS KFGNTVRVAA 350
PRCSARELDE KPSILIQTLQ KSELSHQNSL RKRNSMRRNN SMRRNNSIRR 400
NNSSLMVPKV QFMTPEGNQC PSES 424
Length:424
Mass (Da):47,980
Last modified:May 1, 1997 - v1
Checksum:iBF02D1CC31970379
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D88159 mRNA. Translation: BAA13550.1.
BC003756 mRNA. Translation: AAH03756.1.
CCDSiCCDS20685.1.
RefSeqiNP_032454.1. NM_008428.4.
XP_006506978.1. XM_006506915.1.
UniGeneiMm.1482.

Genome annotation databases

EnsembliENSMUST00000032374; ENSMUSP00000032374; ENSMUSG00000030247.
GeneIDi16523.
KEGGimmu:16523.
UCSCiuc009epk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D88159 mRNA. Translation: BAA13550.1 .
BC003756 mRNA. Translation: AAH03756.1 .
CCDSi CCDS20685.1.
RefSeqi NP_032454.1. NM_008428.4.
XP_006506978.1. XM_006506915.1.
UniGenei Mm.1482.

3D structure databases

ProteinModelPortali P97794.
SMRi P97794. Positions 35-361.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000032374.

Chemistry

GuidetoPHARMACOLOGYi 441.

PTM databases

PhosphoSitei P97794.

Proteomic databases

PRIDEi P97794.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032374 ; ENSMUSP00000032374 ; ENSMUSG00000030247 .
GeneIDi 16523.
KEGGi mmu:16523.
UCSCi uc009epk.1. mouse.

Organism-specific databases

CTDi 3764.
MGIi MGI:1100508. Kcnj8.

Phylogenomic databases

eggNOGi NOG72812.
HOGENOMi HOG000237325.
HOVERGENi HBG006178.
InParanoidi P97794.
KOi K05001.
OMAi VIAVRNN.
OrthoDBi EOG7XPZ5K.
PhylomeDBi P97794.
TreeFami TF313676.

Enzyme and pathway databases

Reactomei REACT_199102. ATP sensitive Potassium channels.

Miscellaneous databases

ChiTaRSi KCNJ8. mouse.
NextBioi 289911.
PROi P97794.
SOURCEi Search...

Gene expression databases

Bgeei P97794.
Genevestigatori P97794.

Family and domain databases

Gene3Di 2.60.40.1400. 1 hit.
InterProi IPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003278. K_chnl_inward-rec_Kir6.1.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view ]
PANTHERi PTHR11767. PTHR11767. 1 hit.
Pfami PF01007. IRK. 1 hit.
[Graphical view ]
PIRSFi PIRSF005465. GIRK_kir. 1 hit.
PRINTSi PR01331. KIR61CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMi SSF81296. SSF81296. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel."
    Yamada M., Isomoto S., Matsumoto S., Kondo C., Shindo T., Horio Y., Kurachi Y.
    J. Physiol. (Lond.) 499:715-720(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.

Entry informationi

Entry nameiKCNJ8_MOUSE
AccessioniPrimary (citable) accession number: P97794
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: September 3, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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