ATP-sensitive inward rectifier potassium channel 8

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P97794 (IRK8_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 105. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
ATP-sensitive inward rectifier potassium channel 8

Alternative name(s):
Inward rectifier K(+) channel Kir6.1
Potassium channel, inwardly rectifying subfamily J member 8
uKATP-1

Gene names

Name:

Kcnj8

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	424 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ8 subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ion channel Voltage-gated channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	defense response to virus Inferred from mutant phenotype PubMed 18026101. Source: MGI heart development Inferred from mutant phenotype PubMed 18026101. Source: MGI kidney development Inferred from electronic annotation. Source: Compara potassium ion import Inferred from electronic annotation. Source: Compara response to exogenous dsRNA Inferred from mutant phenotype PubMed 18026101. Source: MGI response to lipopolysaccharide Inferred from mutant phenotype PubMed 18026101. Source: MGI response to pH Inferred from electronic annotation. Source: Compara vasodilation Inferred from electronic annotation. Source: Compara
Cellular_component	ATP-sensitive potassium channel complex Inferred from electronic annotation. Source: Compara mitochondrion Inferred from electronic annotation. Source: Compara myofibril Inferred from direct assay PubMed 16085792. Source: MGI sarcolemma Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: Compara ATP-activated inward rectifier potassium channel activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 424

424

ATP-sensitive inward rectifier potassium channel 8

PRO_0000154948

Regions

Topological domain

1 – 69

Cytoplasmic By similarity

Transmembrane

70 – 94

Helical; Name=M1; By similarity

Topological domain

95 – 126

Extracellular By similarity

Intramembrane

127 – 138

Helical; Pore-forming; Name=H5; By similarity

Intramembrane

139 – 145

Pore-forming; By similarity

Topological domain

146 – 154

Extracellular By similarity

Transmembrane

155 – 176

Helical; Name=M2; By similarity

Topological domain

177 – 424

248

Cytoplasmic By similarity

Motif

140 – 145

Selectivity filter By similarity

Sites

Site

170

Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P97794 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: BF02D1CC31970379
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FASTA

424

47,980

        10         20         30         40         50         60 
MLARKSIIPE EYVLARIAAE NLRKPRIRDR LPKARFIAKS GACNLAHKNI REQGRFLQDI 

        70         80         90        100        110        120 
FTTLVDLKWR HTLVIFTMSF LCSWLLFAIM WWLVAFAHGD IYAYMEKGTM EKSGLESAVC 

       130        140        150        160        170        180 
VTNVRSFTSA FLFSIEVQVT IGFGGRMMTE ECPLAITVLI LQNIVGLIIN AVMLGCIFMK 

       190        200        210        220        230        240 
TAQAHRRAET LIFSRHAVIA VRNGKLCFMF RVGDLRKSMI ISASVRIQVV KKTTTPEGEV 

       250        260        270        280        290        300 
VPIHQQDIPV DNPIESNNIF LVAPLIICHV IDKRSPLYDI SATDLANQDL EVIVILEGVV 

       310        320        330        340        350        360 
ETTGITTQAR TSYIAEEIQW GHRFVSIVTE EEGVYSVDYS KFGNTVRVAA PRCSARELDE 

       370        380        390        400        410        420 
KPSILIQTLQ KSELSHQNSL RKRNSMRRNN SMRRNNSIRR NNSSLMVPKV QFMTPEGNQC 


PSES

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel." Yamada M., Isomoto S., Matsumoto S., Kondo C., Shindo T., Horio Y., Kurachi Y. J. Physiol. (Lond.) 499:715-720(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Mammary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D88159 mRNA. Translation: BAA13550.1. BC003756 mRNA. Translation: AAH03756.1.
IPI	IPI00129154.
RefSeq	NP_032454.1. NM_008428.4.
UniGene	Mm.1482.
3D structure databases
ProteinModelPortal	P97794.
SMR	P97794. Positions 35-361.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000032374.
PTM databases
PhosphoSite	P97794.
Proteomic databases
PRIDE	P97794.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000032374; ENSMUSP00000032374; ENSMUSG00000030247.
GeneID	16523.
KEGG	mmu:16523.
Organism-specific databases
CTD	3764.
MGI	MGI:1100508. Kcnj8.
Phylogenomic databases
eggNOG	NOG72812.
HOGENOM	HOG000237325.
HOVERGEN	HBG006178.
InParanoid	P97794.
KO	K05001.
OMA	VIAVRNN.
OrthoDB	EOG4DFPNM.
Gene expression databases
ArrayExpress	P97794.
Bgee	P97794.
Genevestigator	P97794.
GermOnline	ENSMUSG00000030247. Mus musculus.
Family and domain databases
Gene3D	2.60.40.1400. 1 hit.
InterPro	IPR014756. Ig_E-set. IPR016449. K_chnl_inward-rec_Kir. IPR003278. K_chnl_inward-rec_Kir6.1. IPR013518. K_chnl_inward-rec_Kir_cyto. [Graphical view]
PANTHER	PTHR11767. PTHR11767. 1 hit.
Pfam	PF01007. IRK. 1 hit. [Graphical view]
PIRSF	PIRSF005465. GIRK_kir. 1 hit.
PRINTS	PR01331. KIR61CHANNEL. PR01320. KIRCHANNEL.
SUPFAM	SSF81296. Ig_E-set. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	KCNJ8. mouse.
NextBio	289911.
SOURCE	Search...

Entry information

Entry name

IRK8_MOUSE

Accession

Primary (citable) accession number: P97794

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 1, 1997
Last modified:	May 1, 2013
This is version 105 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents