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P97794

- KCNJ8_MOUSE

UniProt

P97794 - KCNJ8_MOUSE

Protein

ATP-sensitive inward rectifier potassium channel 8

Gene

Kcnj8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei170 – 1701Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity

    GO - Molecular functioni

    1. ATP-activated inward rectifier potassium channel activity Source: Ensembl
    2. ATP binding Source: Ensembl

    GO - Biological processi

    1. defense response to virus Source: MGI
    2. heart development Source: MGI
    3. kidney development Source: Ensembl
    4. potassium ion import Source: Ensembl
    5. response to exogenous dsRNA Source: MGI
    6. response to lipopolysaccharide Source: MGI
    7. response to pH Source: Ensembl
    8. vasodilation Source: Ensembl

    Keywords - Molecular functioni

    Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_199102. ATP sensitive Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-sensitive inward rectifier potassium channel 8
    Alternative name(s):
    Inward rectifier K(+) channel Kir6.1
    Potassium channel, inwardly rectifying subfamily J member 8
    uKATP-1
    Gene namesi
    Name:Kcnj8
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1100508. Kcnj8.

    Subcellular locationi

    GO - Cellular componenti

    1. ATP-sensitive potassium channel complex Source: Ensembl
    2. mitochondrion Source: Ensembl
    3. myofibril Source: MGI
    4. sarcolemma Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 424424ATP-sensitive inward rectifier potassium channel 8PRO_0000154948Add
    BLAST

    Proteomic databases

    PRIDEiP97794.

    PTM databases

    PhosphoSiteiP97794.

    Expressioni

    Gene expression databases

    BgeeiP97794.
    GenevestigatoriP97794.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000032374.

    Structurei

    3D structure databases

    ProteinModelPortaliP97794.
    SMRiP97794. Positions 35-361.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6969CytoplasmicBy similarityAdd
    BLAST
    Topological domaini95 – 12632ExtracellularBy similarityAdd
    BLAST
    Topological domaini146 – 1549ExtracellularBy similarity
    Topological domaini177 – 424248CytoplasmicBy similarityAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei127 – 13812Helical; Pore-forming; Name=H5By similarityAdd
    BLAST
    Intramembranei139 – 1457Pore-formingBy similarity

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei70 – 9425Helical; Name=M1By similarityAdd
    BLAST
    Transmembranei155 – 17622Helical; Name=M2By similarityAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi140 – 1456Selectivity filterBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG72812.
    HOGENOMiHOG000237325.
    HOVERGENiHBG006178.
    InParanoidiP97794.
    KOiK05001.
    OMAiVIAVRNN.
    OrthoDBiEOG7XPZ5K.
    PhylomeDBiP97794.
    TreeFamiTF313676.

    Family and domain databases

    Gene3Di2.60.40.1400. 1 hit.
    InterProiIPR014756. Ig_E-set.
    IPR016449. K_chnl_inward-rec_Kir.
    IPR003278. K_chnl_inward-rec_Kir6.1.
    IPR013518. K_chnl_inward-rec_Kir_cyto.
    [Graphical view]
    PANTHERiPTHR11767. PTHR11767. 1 hit.
    PfamiPF01007. IRK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005465. GIRK_kir. 1 hit.
    PRINTSiPR01331. KIR61CHANNEL.
    PR01320. KIRCHANNEL.
    SUPFAMiSSF81296. SSF81296. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P97794-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLARKSIIPE EYVLARIAAE NLRKPRIRDR LPKARFIAKS GACNLAHKNI    50
    REQGRFLQDI FTTLVDLKWR HTLVIFTMSF LCSWLLFAIM WWLVAFAHGD 100
    IYAYMEKGTM EKSGLESAVC VTNVRSFTSA FLFSIEVQVT IGFGGRMMTE 150
    ECPLAITVLI LQNIVGLIIN AVMLGCIFMK TAQAHRRAET LIFSRHAVIA 200
    VRNGKLCFMF RVGDLRKSMI ISASVRIQVV KKTTTPEGEV VPIHQQDIPV 250
    DNPIESNNIF LVAPLIICHV IDKRSPLYDI SATDLANQDL EVIVILEGVV 300
    ETTGITTQAR TSYIAEEIQW GHRFVSIVTE EEGVYSVDYS KFGNTVRVAA 350
    PRCSARELDE KPSILIQTLQ KSELSHQNSL RKRNSMRRNN SMRRNNSIRR 400
    NNSSLMVPKV QFMTPEGNQC PSES 424
    Length:424
    Mass (Da):47,980
    Last modified:May 1, 1997 - v1
    Checksum:iBF02D1CC31970379
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D88159 mRNA. Translation: BAA13550.1.
    BC003756 mRNA. Translation: AAH03756.1.
    CCDSiCCDS20685.1.
    RefSeqiNP_032454.1. NM_008428.4.
    XP_006506978.1. XM_006506915.1.
    UniGeneiMm.1482.

    Genome annotation databases

    EnsembliENSMUST00000032374; ENSMUSP00000032374; ENSMUSG00000030247.
    GeneIDi16523.
    KEGGimmu:16523.
    UCSCiuc009epk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D88159 mRNA. Translation: BAA13550.1 .
    BC003756 mRNA. Translation: AAH03756.1 .
    CCDSi CCDS20685.1.
    RefSeqi NP_032454.1. NM_008428.4.
    XP_006506978.1. XM_006506915.1.
    UniGenei Mm.1482.

    3D structure databases

    ProteinModelPortali P97794.
    SMRi P97794. Positions 35-361.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000032374.

    Chemistry

    GuidetoPHARMACOLOGYi 441.

    PTM databases

    PhosphoSitei P97794.

    Proteomic databases

    PRIDEi P97794.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032374 ; ENSMUSP00000032374 ; ENSMUSG00000030247 .
    GeneIDi 16523.
    KEGGi mmu:16523.
    UCSCi uc009epk.1. mouse.

    Organism-specific databases

    CTDi 3764.
    MGIi MGI:1100508. Kcnj8.

    Phylogenomic databases

    eggNOGi NOG72812.
    HOGENOMi HOG000237325.
    HOVERGENi HBG006178.
    InParanoidi P97794.
    KOi K05001.
    OMAi VIAVRNN.
    OrthoDBi EOG7XPZ5K.
    PhylomeDBi P97794.
    TreeFami TF313676.

    Enzyme and pathway databases

    Reactomei REACT_199102. ATP sensitive Potassium channels.

    Miscellaneous databases

    ChiTaRSi KCNJ8. mouse.
    NextBioi 289911.
    PROi P97794.
    SOURCEi Search...

    Gene expression databases

    Bgeei P97794.
    Genevestigatori P97794.

    Family and domain databases

    Gene3Di 2.60.40.1400. 1 hit.
    InterProi IPR014756. Ig_E-set.
    IPR016449. K_chnl_inward-rec_Kir.
    IPR003278. K_chnl_inward-rec_Kir6.1.
    IPR013518. K_chnl_inward-rec_Kir_cyto.
    [Graphical view ]
    PANTHERi PTHR11767. PTHR11767. 1 hit.
    Pfami PF01007. IRK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005465. GIRK_kir. 1 hit.
    PRINTSi PR01331. KIR61CHANNEL.
    PR01320. KIRCHANNEL.
    SUPFAMi SSF81296. SSF81296. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel."
      Yamada M., Isomoto S., Matsumoto S., Kondo C., Shindo T., Horio Y., Kurachi Y.
      J. Physiol. (Lond.) 499:715-720(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiKCNJ8_MOUSE
    AccessioniPrimary (citable) accession number: P97794
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3