Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P97793

- ALK_MOUSE

UniProt

P97793 - ALK_MOUSE

Protein

ALK tyrosine kinase receptor

Gene

Alk

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Neuronal orphan receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK.4 Publications

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Enzyme regulationi

    Activated by ligand-binding and subsequent phosphorylation By similarity. Inactivated through dephosphorylation by receptor protein tyrosine phosphatase beta and zeta complex (PTPRB/PTPRZ1), when there is no stimulation by a ligand. Staurosporine, crizotinib and CH5424802 act as inhibitors of ALK kinase activity By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei1128 – 11281ATP; via carbonyl oxygenPROSITE-ProRule annotation
    Binding sitei1154 – 11541ATPPROSITE-ProRule annotation
    Binding sitei1154 – 11541InhibitorBy similarity
    Binding sitei1203 – 12031Inhibitor; via amide nitrogenBy similarity
    Binding sitei1207 – 12071InhibitorBy similarity
    Binding sitei1214 – 12141InhibitorBy similarity
    Active sitei1253 – 12531Proton acceptorPROSITE-ProRule annotation
    Binding sitei1274 – 12741ATPPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi1126 – 11349ATPPROSITE-ProRule annotation
    Nucleotide bindingi1201 – 12033ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. transmembrane receptor protein tyrosine kinase activity Source: MGI

    GO - Biological processi

    1. activation of MAPK activity Source: InterPro
    2. neuron development Source: InterPro
    3. transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Kinase, Receptor, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.1. 3474.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ALK tyrosine kinase receptor (EC:2.7.10.1)
    Alternative name(s):
    Anaplastic lymphoma kinase
    CD_antigen: CD246
    Gene namesi
    Name:Alk
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:103305. Alk.

    Subcellular locationi

    Cell membrane By similarity; Single-pass type I membrane protein By similarity
    Note: Membrane attachment was crucial for promotion of neuron-like differentiation and cell proliferation arrest through specific activation of the MAP kinase pathway.By similarity

    GO - Cellular componenti

    1. integral component of plasma membrane Source: MGI
    2. protein complex Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 16211603ALK tyrosine kinase receptorPRO_0000016741Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence Analysis
    Modified residuei216 – 2161PhosphoserineBy similarity
    Glycosylationi248 – 2481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi289 – 2891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi328 – 3281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi415 – 4151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi428 – 4281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi449 – 4491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi567 – 5671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi575 – 5751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi631 – 6311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi673 – 6731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi713 – 7131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi812 – 8121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi868 – 8681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi890 – 8901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi990 – 9901N-linked (GlcNAc...)Sequence Analysis
    Modified residuei1082 – 10821PhosphotyrosineBy similarity
    Modified residuei1096 – 10961PhosphotyrosineBy similarity
    Modified residuei1100 – 11001PhosphotyrosineBy similarity
    Modified residuei1135 – 11351PhosphotyrosineBy similarity
    Modified residuei1282 – 12821PhosphotyrosineBy similarity
    Modified residuei1286 – 12861Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei1287 – 12871PhosphotyrosineBy similarity
    Modified residuei1363 – 13631PhosphotyrosineBy similarity
    Modified residuei1516 – 15161PhosphotyrosineBy similarity
    Modified residuei1590 – 15901PhosphotyrosineBy similarity

    Post-translational modificationi

    Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity. In cells not stimulated by a ligand, receptor protein tyrosine phosphatase beta and zeta complex (PTPRB/PTPRZ1) dephosphorylates ALK at the sites in ALK that are undergoing autophosphorylation through autoactivation.By similarity
    N-glycosylated.By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP97793.
    PRIDEiP97793.

    PTM databases

    PhosphoSiteiP97793.

    Expressioni

    Tissue specificityi

    Mainly expressed in central nervous system (CNS) and other parts of the brain. Expression is also found in peripheral nervous systems, eye, nasal epithelium, olfactory nerve, tongue, skin, tissue surrounding the esophagus, stomach, midgut, as well as testis and ovary.1 Publication

    Gene expression databases

    BgeeiP97793.
    CleanExiMM_ALK.
    GenevestigatoriP97793.

    Interactioni

    Subunit structurei

    Homodimer. Homodimerizes when bound to ligand By similarity. Interacts with CBL, IRS1, PIK3R1, PLCG1 and SHC1. Interacts with FRS2, PTN and MDK.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi198070. 1 interaction.
    STRINGi10090.ENSMUSP00000083840.

    Structurei

    3D structure databases

    ProteinModelPortaliP97793.
    SMRiP97793. Positions 1100-1403.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 10421024ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1064 – 1621558CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1043 – 106321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini268 – 431164MAM 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini441 – 47737LDL-receptor class AAdd
    BLAST
    Domaini482 – 640159MAM 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1120 – 1396277Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1201 – 12033Inhibitor bindingBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi820 – 944125Gly-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.PROSITE-ProRule annotation
    Contains 1 LDL-receptor class A domain.Curated
    Contains 2 MAM domains.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00750000117362.
    HOGENOMiHOG000231766.
    HOVERGENiHBG018726.
    InParanoidiP97793.
    KOiK05119.
    OMAiLIQKVCI.
    OrthoDBiEOG7GN2KT.
    TreeFamiTF351636.

    Family and domain databases

    Gene3Di4.10.400.10. 1 hit.
    InterProiIPR026830. ALK.
    IPR008985. ConA-like_lec_gl_sf.
    IPR011009. Kinase-like_dom.
    IPR002172. LDrepeatLR_classA_rpt.
    IPR000998. MAM_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR002011. Tyr_kinase_rcpt_2_CS.
    [Graphical view]
    PANTHERiPTHR24416:SF276. PTHR24416:SF276. 1 hit.
    PfamiPF00629. MAM. 2 hits.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00192. LDLa. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 2 hits.
    SSF56112. SSF56112. 1 hit.
    SSF57424. SSF57424. 1 hit.
    PROSITEiPS50060. MAM_2. 2 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P97793-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGAAGFLWLL PPLLLAAASY SGAATDQRAG SPASGPPLQP REPLSYSRLQ     50
    RKSLAVDFVV PSLFRVYARD LLLPQPRSPS EPEAGGLEAR GSLALDCEPL 100
    LRLLGPLPGI SWADGASSPS PEAGPTLSRV LKGGSVRKLR RAKQLVLELG 150
    EETILEGCIG PPEEVAAVGI LQFNLSELFS WWILHGEGRL RIRLMPEKKA 200
    SEVGREGRLS SAIRASQPRL LFQIFGTGHS SMESPSETPS PPGTFMWNLT 250
    WTMKDSFPFL SHRSRYGLEC SFDFPCELEY SPPLHNHGNQ SWSWRHVPSE 300
    EASRMNLLDG PEAEHSQEMP RGSFLLLNTS ADSKHTILSP WMRSSSDHCT 350
    LAVSVHRHLQ PSGRYVAQLL PHNEAGREIL LVPTPGKHGW TVLQGRVGRP 400
    ANPFRVALEY ISSGNRSLSA VDFFALKNCS EGTSPGSKMA LQSSFTCWNG 450
    TVLQLGQACD FHQDCAQGED EGQLCSKLPA GFYCNFENGF CGWTQSPLSP 500
    HMPRWQVRTL RDAHSQGHQG RALLLSTTDI LASEGATVTS ATFPAPMKNS 550
    PCELRMSWLI RGVLRGNVSL VLVENKTGKE QSRTVWHVAT DEGLSLWQHT 600
    VLSLLDVTDR FWLQIVTWWG PGSRATVGFD NISISLDCYL TISGEEKMSL 650
    NSVPKSRNLF EKNPNKESKS WANISGPTPI FDPTVHWLFT TCGASGPHGP 700
    TQAQCNNAYQ NSNLSVVVGS EGPLKGVQIW KVPATDTYSI SGYGAAGGKG 750
    GKNTMMRSHG VSVLGIFNLE KGDTLYILVG QQGEDACPRA NQLIQKVCVG 800
    ENNVIEEEIR VNRSVHEWAG GGGGGGGATY VFKMKDGVPV PLIIAAGGGG 850
    RAYGAKTETF HPERLESNSS VLGLNGNSGA AGGGGGWNDN TSLLWAGKSL 900
    LEGAAGGHSC PQAMKKWGWE TRGGFGGGGG GCSSGGGGGG YIGGNAASNN 950
    DPEMDGEDGV SFISPLGILY TPALKVMEGH GEVNIKHYLN CSHCEVDECH 1000
    MDPESHKVIC FCDHGTVLAD DGVSCIVSPT PEPHLPLSLI LSVVTSALVA 1050
    ALVLAFSGIM IVYRRKHQEL QAMQMELQSP EYKLSKLRTS TIMTDYNPNY 1100
    CFAGKTSSIS DLKEVPRKNI TLIRGLGHGA FGEVYEGQVS GMPNDPSPLQ 1150
    VAVKTLPEVC SEQDELDFLM EALIISKFNH QNIVRCIGVS LQALPRFILL 1200
    ELMAGGDLKS FLRETRPRPN QPTSLAMLDL LHVARDIACG CQYLEENHFI 1250
    HRDIAARNCL LTCPGAGRIA KIGDFGMARD IYRASYYRKG GCAMLPVKWM 1300
    PPEAFMEGIF TSKTDTWSFG VLLWEIFSLG YMPYPSKSNQ EVLEFVTSGG 1350
    RMDPPKNCPG PVYRIMTQCW QHQPEDRPNF AIILERIEYC TQDPDVINTA 1400
    LPIEYGPVVE EEEKVPMRPK DPEGMPPLLV SPQPAKHEEA SAAPQPAALT 1450
    APGPSVKKPP GAGAGAGAGA GAGPVPRGAA DRGHVNMAFS QPNPPPELHK 1500
    GPGSRNKPTS LWNPTYGSWF TEKPAKKTHP PPGAEPQARA GAAEGGWTGP 1550
    GAGPRRAEAA LLLEPSALSA TMKEVPLFRL RHFPCGNVNY GYQQQGLPLE 1600
    ATAAPGDTML KSKNKVTQPG P 1621
    Length:1,621
    Mass (Da):174,948
    Last modified:July 27, 2011 - v2
    Checksum:i72D1022E117F303E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti138 – 1392KL → NV in BAA11673. (PubMed:9053841)Curated
    Sequence conflicti232 – 2321M → L in BAA11673. (PubMed:9053841)Curated
    Sequence conflicti857 – 8571T → R in BAA11673. (PubMed:9053841)Curated
    Sequence conflicti1075 – 10762ME → IQ in BAA11673. (PubMed:9053841)Curated
    Sequence conflicti1522 – 15221E → A in BAA11673. (PubMed:9053841)Curated
    Sequence conflicti1586 – 15861G → P in BAA11673. (PubMed:9053841)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D83002 mRNA. Translation: BAA11673.1.
    AC122746 Genomic DNA. No translation available.
    AC151265 Genomic DNA. No translation available.
    AC154458 Genomic DNA. No translation available.
    AC154602 Genomic DNA. No translation available.
    AC154659 Genomic DNA. No translation available.
    AC155242 Genomic DNA. No translation available.
    CCDSiCCDS37688.1.
    PIRiT30200.
    RefSeqiNP_031465.2. NM_007439.2.
    UniGeneiMm.311854.

    Genome annotation databases

    EnsembliENSMUST00000086639; ENSMUSP00000083840; ENSMUSG00000055471.
    GeneIDi11682.
    KEGGimmu:11682.
    UCSCiuc008dnb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D83002 mRNA. Translation: BAA11673.1 .
    AC122746 Genomic DNA. No translation available.
    AC151265 Genomic DNA. No translation available.
    AC154458 Genomic DNA. No translation available.
    AC154602 Genomic DNA. No translation available.
    AC154659 Genomic DNA. No translation available.
    AC155242 Genomic DNA. No translation available.
    CCDSi CCDS37688.1.
    PIRi T30200.
    RefSeqi NP_031465.2. NM_007439.2.
    UniGenei Mm.311854.

    3D structure databases

    ProteinModelPortali P97793.
    SMRi P97793. Positions 1100-1403.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198070. 1 interaction.
    STRINGi 10090.ENSMUSP00000083840.

    Chemistry

    BindingDBi P97793.
    ChEMBLi CHEMBL5771.

    PTM databases

    PhosphoSitei P97793.

    Proteomic databases

    PaxDbi P97793.
    PRIDEi P97793.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000086639 ; ENSMUSP00000083840 ; ENSMUSG00000055471 .
    GeneIDi 11682.
    KEGGi mmu:11682.
    UCSCi uc008dnb.1. mouse.

    Organism-specific databases

    CTDi 238.
    MGIi MGI:103305. Alk.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00750000117362.
    HOGENOMi HOG000231766.
    HOVERGENi HBG018726.
    InParanoidi P97793.
    KOi K05119.
    OMAi LIQKVCI.
    OrthoDBi EOG7GN2KT.
    TreeFami TF351636.

    Enzyme and pathway databases

    BRENDAi 2.7.10.1. 3474.

    Miscellaneous databases

    NextBioi 279315.
    PROi P97793.
    SOURCEi Search...

    Gene expression databases

    Bgeei P97793.
    CleanExi MM_ALK.
    Genevestigatori P97793.

    Family and domain databases

    Gene3Di 4.10.400.10. 1 hit.
    InterProi IPR026830. ALK.
    IPR008985. ConA-like_lec_gl_sf.
    IPR011009. Kinase-like_dom.
    IPR002172. LDrepeatLR_classA_rpt.
    IPR000998. MAM_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR002011. Tyr_kinase_rcpt_2_CS.
    [Graphical view ]
    PANTHERi PTHR24416:SF276. PTHR24416:SF276. 1 hit.
    Pfami PF00629. MAM. 2 hits.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00192. LDLa. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 2 hits.
    SSF56112. SSF56112. 1 hit.
    SSF57424. SSF57424. 1 hit.
    PROSITEi PS50060. MAM_2. 2 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system."
      Iwahara T., Fujimoto J., Wen D., Cupples R., Bucay N., Arakawa T., Mori S., Ratzkin B., Yamamoto T.
      Oncogene 14:439-449(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain and Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth."
      Motegi A., Fujimoto J., Kotani M., Sakuraba H., Yamamoto T.
      J. Cell Sci. 117:3319-3329(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION, INTERACTION WITH CBL; IRS1; PIK3R1; PLCG1 AND SHC1, FUNCTION IN PHOSPHORYLATION OF CBL; IRS1 AND SHC1.
    4. "Characterization of the expression of the ALK receptor tyrosine kinase in mice."
      Vernersson E., Khoo N.K., Henriksson M.L., Roos G., Palmer R.H., Hallberg B.
      Gene Expr. Patterns 6:448-461(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, FUNCTION.
    5. "Recruitment of insulin receptor substrate-1 and activation of NF-kappaB essential for midkine growth signaling through anaplastic lymphoma kinase."
      Kuo A.H., Stoica G.E., Riegel A.T., Wellstein A.
      Oncogene 26:859-869(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH IRS1 AND SHC, PHOSPHORYLATION AT TYR-1096, FUNCTION.
    6. "ALK (Anaplastic Lymphoma Kinase) expression in DRG neurons and its involvement in neuron-Schwann cells interaction."
      Degoutin J., Brunet-de Carvalho N., Cifuentes-Diaz C., Vigny M.
      Eur. J. Neurosci. 29:275-286(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Anaplastic lymphoma kinase: signalling in development and disease."
      Palmer R.H., Vernersson E., Grabbe C., Hallberg B.
      Biochem. J. 420:345-361(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON FUNCTION.

    Entry informationi

    Entry nameiALK_MOUSE
    AccessioniPrimary (citable) accession number: P97793
    Secondary accession number(s): E9QKV3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 133 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3