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Reviewed, UniProtKB/Swiss-Prot P97793 (ALK_MOUSE)

Last modified June 16, 2009. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    ALK tyrosine kinase receptor
    EC=2.7.10.1
Alternative name(s):
    Anaplastic lymphoma kinase
    CD_antigen=CD246
Gene names
Name: Alk
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length1621 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Orphan receptor with a tyrosine-protein kinase activity. Appears to play an important role in the normal development and function of the nervous system. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif By similarity.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subunit structure

Homodimer. When bound to ligand By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein Probable.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

Contains 1 LDL-receptor class A domain.

Contains 2 MAM domains.

Contains 1 protein kinase domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 16211603ALK tyrosine kinase receptor
PRO_0000016741

Regions

Topological domain19 – 10421024Extracellular Potential
Transmembrane1043 – 106321 Potential
Topological domain1064 – 1621558Cytoplasmic Potential
Domain268 – 431164MAM 1
Domain441 – 47737LDL-receptor class A
Domain482 – 640159MAM 2
Domain1120 – 1396277Protein kinase
Nucleotide binding1126 – 11349ATP By similarity
Compositional bias820 – 944125Gly-rich

Sites

Active site12531Proton acceptor By similarity
Binding site11541ATP By similarity

Amino acid modifications

Modified residue2161Phosphoserine By similarity
Modified residue10821Phosphotyrosine By similarity
Modified residue10961Phosphotyrosine By similarity
Modified residue11001Phosphotyrosine By similarity
Modified residue11351Phosphotyrosine By similarity
Modified residue12821Phosphotyrosine By similarity
Modified residue12861Phosphotyrosine; by autocatalysis By similarity
Modified residue12871Phosphotyrosine By similarity
Modified residue13631Phosphotyrosine By similarity
Modified residue15161Phosphotyrosine By similarity
Modified residue15901Phosphotyrosine By similarity
Glycosylation1741N-linked (GlcNAc...) Potential
Glycosylation2481N-linked (GlcNAc...) Potential
Glycosylation2891N-linked (GlcNAc...) Potential
Glycosylation3281N-linked (GlcNAc...) Potential
Glycosylation4151N-linked (GlcNAc...) Potential
Glycosylation4281N-linked (GlcNAc...) Potential
Glycosylation4491N-linked (GlcNAc...) Potential
Glycosylation5671N-linked (GlcNAc...) Potential
Glycosylation5751N-linked (GlcNAc...) Potential
Glycosylation6311N-linked (GlcNAc...) Potential
Glycosylation6731N-linked (GlcNAc...) Potential
Glycosylation7131N-linked (GlcNAc...) Potential
Glycosylation8121N-linked (GlcNAc...) Potential
Glycosylation8681N-linked (GlcNAc...) Potential
Glycosylation8901N-linked (GlcNAc...) Potential
Glycosylation9901N-linked (GlcNAc...) Potential

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Sequences

Sequence LengthMass (Da)Tools
P97793-1 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 16E252BF21AADE22

FASTA1,621174,920
        10         20         30         40         50         60 
MGAAGFLWLL PPLLLAAASY SGAATDQRAG SPASGPPLQP REPLSYSRLQ RKSLAVDFVV 

        70         80         90        100        110        120 
PSLFRVYARD LLLPQPRSPS EPEAGGLEAR GSLALDCEPL LRLLGPLPGI SWADGASSPS 

       130        140        150        160        170        180 
PEAGPTLSRV LKGGSVRNVR RAKQLVLELG EETILEGCIG PPEEVAAVGI LQFNLSELFS 

       190        200        210        220        230        240 
WWILHGEGRL RIRLMPEKKA SEVGREGRLS SAIRASQPRL LFQIFGTGHS SLESPSETPS 

       250        260        270        280        290        300 
PPGTFMWNLT WTMKDSFPFL SHRSRYGLEC SFDFPCELEY SPPLHNHGNQ SWSWRHVPSE 

       310        320        330        340        350        360 
EASRMNLLDG PEAEHSQEMP RGSFLLLNTS ADSKHTILSP WMRSSSDHCT LAVSVHRHLQ 

       370        380        390        400        410        420 
PSGRYVAQLL PHNEAGREIL LVPTPGKHGW TVLQGRVGRP ANPFRVALEY ISSGNRSLSA 

       430        440        450        460        470        480 
VDFFALKNCS EGTSPGSKMA LQSSFTCWNG TVLQLGQACD FHQDCAQGED EGQLCSKLPA 

       490        500        510        520        530        540 
GFYCNFENGF CGWTQSPLSP HMPRWQVRTL RDAHSQGHQG RALLLSTTDI LASEGATVTS 

       550        560        570        580        590        600 
ATFPAPMKNS PCELRMSWLI RGVLRGNVSL VLVENKTGKE QSRTVWHVAT DEGLSLWQHT 

       610        620        630        640        650        660 
VLSLLDVTDR FWLQIVTWWG PGSRATVGFD NISISLDCYL TISGEEKMSL NSVPKSRNLF 

       670        680        690        700        710        720 
EKNPNKESKS WANISGPTPI FDPTVHWLFT TCGASGPHGP TQAQCNNAYQ NSNLSVVVGS 

       730        740        750        760        770        780 
EGPLKGVQIW KVPATDTYSI SGYGAAGGKG GKNTMMRSHG VSVLGIFNLE KGDTLYILVG 

       790        800        810        820        830        840 
QQGEDACPRA NQLIQKVCVG ENNVIEEEIR VNRSVHEWAG GGGGGGGATY VFKMKDGVPV 

       850        860        870        880        890        900 
PLIIAAGGGG RAYGAKRETF HPERLESNSS VLGLNGNSGA AGGGGGWNDN TSLLWAGKSL 

       910        920        930        940        950        960 
LEGAAGGHSC PQAMKKWGWE TRGGFGGGGG GCSSGGGGGG YIGGNAASNN DPEMDGEDGV 

       970        980        990       1000       1010       1020 
SFISPLGILY TPALKVMEGH GEVNIKHYLN CSHCEVDECH MDPESHKVIC FCDHGTVLAD 

      1030       1040       1050       1060       1070       1080 
DGVSCIVSPT PEPHLPLSLI LSVVTSALVA ALVLAFSGIM IVYRRKHQEL QAMQIQLQSP 

      1090       1100       1110       1120       1130       1140 
EYKLSKLRTS TIMTDYNPNY CFAGKTSSIS DLKEVPRKNI TLIRGLGHGA FGEVYEGQVS 

      1150       1160       1170       1180       1190       1200 
GMPNDPSPLQ VAVKTLPEVC SEQDELDFLM EALIISKFNH QNIVRCIGVS LQALPRFILL 

      1210       1220       1230       1240       1250       1260 
ELMAGGDLKS FLRETRPRPN QPTSLAMLDL LHVARDIACG CQYLEENHFI HRDIAARNCL 

      1270       1280       1290       1300       1310       1320 
LTCPGAGRIA KIGDFGMARD IYRASYYRKG GCAMLPVKWM PPEAFMEGIF TSKTDTWSFG 

      1330       1340       1350       1360       1370       1380 
VLLWEIFSLG YMPYPSKSNQ EVLEFVTSGG RMDPPKNCPG PVYRIMTQCW QHQPEDRPNF 

      1390       1400       1410       1420       1430       1440 
AIILERIEYC TQDPDVINTA LPIEYGPVVE EEEKVPMRPK DPEGMPPLLV SPQPAKHEEA 

      1450       1460       1470       1480       1490       1500 
SAAPQPAALT APGPSVKKPP GAGAGAGAGA GAGPVPRGAA DRGHVNMAFS QPNPPPELHK 

      1510       1520       1530       1540       1550       1560 
GPGSRNKPTS LWNPTYGSWF TAKPAKKTHP PPGAEPQARA GAAEGGWTGP GAGPRRAEAA 

      1570       1580       1590       1600       1610       1620 
LLLEPSALSA TMKEVPLFRL RHFPCPNVNY GYQQQGLPLE ATAAPGDTML KSKNKVTQPG 


P

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References

[1]"Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system."
Iwahara T., Fujimoto J., Wen D., Cupples R., Bucay N., Arakawa T., Mori S., Ratzkin B., Yamamoto T.
Oncogene 14:439-449(1997) [PubMed: 9053841] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain and Testis.
+Additional computationally mapped references.

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Cross-references

Sequence databases

D83002 mRNA. Translation: BAA11673.1.
IPIIPI00620900.
PIRT30200.
RefSeqNP_031465.2.
UniGeneMm.311854

3D structure databases

HSSPHSSP built from PDB template 1JQH based on UniProtKB P08069.
ModBaseSearch...

PTM databases

PhosphoSiteP97793.

Proteomic databases

PRIDEP97793.

Genome annotation databases

EnsemblENSMUSG00000055471. Mus musculus. [Contig view]
GeneID11682.
KEGGmmu:11682.

Organism-specific databases

MGIMGI:103305. Alk.

Phylogenomic databases

HOGENOMP97793.
HOVERGENP97793.

Enzyme and pathway databases

BRENDA2.7.10.1. 244.

Gene expression databases

ArrayExpressP97793.
BgeeP97793.
CleanExMM_ALK.
GermOnlineENSMUSG00000055471. Mus musculus.

Family and domain databases

InterProIPR002172. LDL_rcpt_classA_cys-rich.
IPR000998. MAM.
IPR000719. Prot_kinase_core.
IPR017441. Protein_kinase_ATP_BS.
IPR002011. Recept_tyr_kinase-II_CS.
IPR001245. Tyr_pkinase.
IPR008266. Tyr_pkinase_AS.
[Graphical view]
PfamPF00629. MAM. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSPR00109. TYRKINASE.
ProDomPD000001. Prot_kinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00192. LDLa. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
PROSITEPS01209. LDLRA_1. False negative.
PS50068. LDLRA_2. False negative.
PS00740. MAM_1. False negative.
PS50060. MAM_2. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio279315.
SOURCESearch...

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Entry information

Entry nameALK_MOUSE
AccessionPrimary (citable) accession number: P97793
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: May 1, 1997
Last modified: June 16, 2009
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents