Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P97793

- ALK_MOUSE

UniProt

P97793 - ALK_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

ALK tyrosine kinase receptor

Gene

Alk

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Neuronal orphan receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK.4 Publications

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Enzyme regulationi

Activated by ligand-binding and subsequent phosphorylation (By similarity). Inactivated through dephosphorylation by receptor protein tyrosine phosphatase beta and zeta complex (PTPRB/PTPRZ1), when there is no stimulation by a ligand. Staurosporine, crizotinib and CH5424802 act as inhibitors of ALK kinase activity (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1128 – 11281ATP; via carbonyl oxygenPROSITE-ProRule annotation
Binding sitei1154 – 11541ATPPROSITE-ProRule annotation
Binding sitei1154 – 11541InhibitorBy similarity
Binding sitei1203 – 12031Inhibitor; via amide nitrogenBy similarity
Binding sitei1207 – 12071InhibitorBy similarity
Binding sitei1214 – 12141InhibitorBy similarity
Active sitei1253 – 12531Proton acceptorPROSITE-ProRule annotation
Binding sitei1274 – 12741ATPPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1126 – 11349ATPPROSITE-ProRule annotation
Nucleotide bindingi1201 – 12033ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. transmembrane receptor protein tyrosine kinase activity Source: MGI

GO - Biological processi

  1. activation of MAPK activity Source: InterPro
  2. neuron development Source: InterPro
  3. peptidyl-tyrosine phosphorylation Source: GOC
  4. transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
ALK tyrosine kinase receptor (EC:2.7.10.1)
Alternative name(s):
Anaplastic lymphoma kinase
CD_antigen: CD246
Gene namesi
Name:Alk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:103305. Alk.

Subcellular locationi

Cell membrane By similarity; Single-pass type I membrane protein By similarity
Note: Membrane attachment was crucial for promotion of neuron-like differentiation and cell proliferation arrest through specific activation of the MAP kinase pathway.By similarity

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. integral component of plasma membrane Source: MGI
  3. protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 16211603ALK tyrosine kinase receptorPRO_0000016741Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence Analysis
Modified residuei216 – 2161PhosphoserineBy similarity
Glycosylationi248 – 2481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi289 – 2891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi328 – 3281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi415 – 4151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi428 – 4281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi449 – 4491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi567 – 5671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi575 – 5751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi631 – 6311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi673 – 6731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi713 – 7131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi812 – 8121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi868 – 8681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi890 – 8901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi990 – 9901N-linked (GlcNAc...)Sequence Analysis
Modified residuei1082 – 10821PhosphotyrosineBy similarity
Modified residuei1096 – 10961PhosphotyrosineBy similarity
Modified residuei1100 – 11001PhosphotyrosineBy similarity
Modified residuei1135 – 11351PhosphotyrosineBy similarity
Modified residuei1282 – 12821PhosphotyrosineBy similarity
Modified residuei1286 – 12861Phosphotyrosine; by autocatalysisBy similarity
Modified residuei1287 – 12871PhosphotyrosineBy similarity
Modified residuei1363 – 13631PhosphotyrosineBy similarity
Modified residuei1516 – 15161PhosphotyrosineBy similarity
Modified residuei1590 – 15901PhosphotyrosineBy similarity

Post-translational modificationi

Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity. In cells not stimulated by a ligand, receptor protein tyrosine phosphatase beta and zeta complex (PTPRB/PTPRZ1) dephosphorylates ALK at the sites in ALK that are undergoing autophosphorylation through autoactivation.By similarity
N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP97793.
PaxDbiP97793.
PRIDEiP97793.

PTM databases

PhosphoSiteiP97793.

Expressioni

Tissue specificityi

Mainly expressed in central nervous system (CNS) and other parts of the brain. Expression is also found in peripheral nervous systems, eye, nasal epithelium, olfactory nerve, tongue, skin, tissue surrounding the esophagus, stomach, midgut, as well as testis and ovary.1 Publication

Gene expression databases

BgeeiP97793.
CleanExiMM_ALK.
GenevestigatoriP97793.

Interactioni

Subunit structurei

Homodimer. Homodimerizes when bound to ligand (By similarity). Interacts with CBL, IRS1, PIK3R1, PLCG1 and SHC1. Interacts with FRS2, PTN and MDK.By similarity2 Publications

Protein-protein interaction databases

BioGridi198070. 1 interaction.
STRINGi10090.ENSMUSP00000083840.

Structurei

3D structure databases

ProteinModelPortaliP97793.
SMRiP97793. Positions 1100-1403.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 10421024ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1064 – 1621558CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1043 – 106321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini268 – 431164MAM 1PROSITE-ProRule annotationAdd
BLAST
Domaini441 – 47737LDL-receptor class AAdd
BLAST
Domaini482 – 640159MAM 2PROSITE-ProRule annotationAdd
BLAST
Domaini1120 – 1396277Protein kinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1201 – 12033Inhibitor bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi820 – 944125Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.PROSITE-ProRule annotation
Contains 1 LDL-receptor class A domain.Curated
Contains 2 MAM domains.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118818.
HOGENOMiHOG000231766.
HOVERGENiHBG018726.
InParanoidiP97793.
KOiK05119.
OMAiLIQKVCI.
OrthoDBiEOG7GN2KT.
TreeFamiTF351636.

Family and domain databases

Gene3Di4.10.400.10. 1 hit.
InterProiIPR026830. ALK.
IPR013320. ConA-like_dom.
IPR011009. Kinase-like_dom.
IPR002172. LDrepeatLR_classA_rpt.
IPR000998. MAM_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
PANTHERiPTHR24416:SF276. PTHR24416:SF276. 1 hit.
PfamiPF00629. MAM. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00192. LDLa. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
SSF56112. SSF56112. 1 hit.
SSF57424. SSF57424. 1 hit.
PROSITEiPS50060. MAM_2. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97793-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGAAGFLWLL PPLLLAAASY SGAATDQRAG SPASGPPLQP REPLSYSRLQ
60 70 80 90 100
RKSLAVDFVV PSLFRVYARD LLLPQPRSPS EPEAGGLEAR GSLALDCEPL
110 120 130 140 150
LRLLGPLPGI SWADGASSPS PEAGPTLSRV LKGGSVRKLR RAKQLVLELG
160 170 180 190 200
EETILEGCIG PPEEVAAVGI LQFNLSELFS WWILHGEGRL RIRLMPEKKA
210 220 230 240 250
SEVGREGRLS SAIRASQPRL LFQIFGTGHS SMESPSETPS PPGTFMWNLT
260 270 280 290 300
WTMKDSFPFL SHRSRYGLEC SFDFPCELEY SPPLHNHGNQ SWSWRHVPSE
310 320 330 340 350
EASRMNLLDG PEAEHSQEMP RGSFLLLNTS ADSKHTILSP WMRSSSDHCT
360 370 380 390 400
LAVSVHRHLQ PSGRYVAQLL PHNEAGREIL LVPTPGKHGW TVLQGRVGRP
410 420 430 440 450
ANPFRVALEY ISSGNRSLSA VDFFALKNCS EGTSPGSKMA LQSSFTCWNG
460 470 480 490 500
TVLQLGQACD FHQDCAQGED EGQLCSKLPA GFYCNFENGF CGWTQSPLSP
510 520 530 540 550
HMPRWQVRTL RDAHSQGHQG RALLLSTTDI LASEGATVTS ATFPAPMKNS
560 570 580 590 600
PCELRMSWLI RGVLRGNVSL VLVENKTGKE QSRTVWHVAT DEGLSLWQHT
610 620 630 640 650
VLSLLDVTDR FWLQIVTWWG PGSRATVGFD NISISLDCYL TISGEEKMSL
660 670 680 690 700
NSVPKSRNLF EKNPNKESKS WANISGPTPI FDPTVHWLFT TCGASGPHGP
710 720 730 740 750
TQAQCNNAYQ NSNLSVVVGS EGPLKGVQIW KVPATDTYSI SGYGAAGGKG
760 770 780 790 800
GKNTMMRSHG VSVLGIFNLE KGDTLYILVG QQGEDACPRA NQLIQKVCVG
810 820 830 840 850
ENNVIEEEIR VNRSVHEWAG GGGGGGGATY VFKMKDGVPV PLIIAAGGGG
860 870 880 890 900
RAYGAKTETF HPERLESNSS VLGLNGNSGA AGGGGGWNDN TSLLWAGKSL
910 920 930 940 950
LEGAAGGHSC PQAMKKWGWE TRGGFGGGGG GCSSGGGGGG YIGGNAASNN
960 970 980 990 1000
DPEMDGEDGV SFISPLGILY TPALKVMEGH GEVNIKHYLN CSHCEVDECH
1010 1020 1030 1040 1050
MDPESHKVIC FCDHGTVLAD DGVSCIVSPT PEPHLPLSLI LSVVTSALVA
1060 1070 1080 1090 1100
ALVLAFSGIM IVYRRKHQEL QAMQMELQSP EYKLSKLRTS TIMTDYNPNY
1110 1120 1130 1140 1150
CFAGKTSSIS DLKEVPRKNI TLIRGLGHGA FGEVYEGQVS GMPNDPSPLQ
1160 1170 1180 1190 1200
VAVKTLPEVC SEQDELDFLM EALIISKFNH QNIVRCIGVS LQALPRFILL
1210 1220 1230 1240 1250
ELMAGGDLKS FLRETRPRPN QPTSLAMLDL LHVARDIACG CQYLEENHFI
1260 1270 1280 1290 1300
HRDIAARNCL LTCPGAGRIA KIGDFGMARD IYRASYYRKG GCAMLPVKWM
1310 1320 1330 1340 1350
PPEAFMEGIF TSKTDTWSFG VLLWEIFSLG YMPYPSKSNQ EVLEFVTSGG
1360 1370 1380 1390 1400
RMDPPKNCPG PVYRIMTQCW QHQPEDRPNF AIILERIEYC TQDPDVINTA
1410 1420 1430 1440 1450
LPIEYGPVVE EEEKVPMRPK DPEGMPPLLV SPQPAKHEEA SAAPQPAALT
1460 1470 1480 1490 1500
APGPSVKKPP GAGAGAGAGA GAGPVPRGAA DRGHVNMAFS QPNPPPELHK
1510 1520 1530 1540 1550
GPGSRNKPTS LWNPTYGSWF TEKPAKKTHP PPGAEPQARA GAAEGGWTGP
1560 1570 1580 1590 1600
GAGPRRAEAA LLLEPSALSA TMKEVPLFRL RHFPCGNVNY GYQQQGLPLE
1610 1620
ATAAPGDTML KSKNKVTQPG P
Length:1,621
Mass (Da):174,948
Last modified:July 27, 2011 - v2
Checksum:i72D1022E117F303E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti138 – 1392KL → NV in BAA11673. (PubMed:9053841)Curated
Sequence conflicti232 – 2321M → L in BAA11673. (PubMed:9053841)Curated
Sequence conflicti857 – 8571T → R in BAA11673. (PubMed:9053841)Curated
Sequence conflicti1075 – 10762ME → IQ in BAA11673. (PubMed:9053841)Curated
Sequence conflicti1522 – 15221E → A in BAA11673. (PubMed:9053841)Curated
Sequence conflicti1586 – 15861G → P in BAA11673. (PubMed:9053841)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D83002 mRNA. Translation: BAA11673.1.
AC122746 Genomic DNA. No translation available.
AC151265 Genomic DNA. No translation available.
AC154458 Genomic DNA. No translation available.
AC154602 Genomic DNA. No translation available.
AC154659 Genomic DNA. No translation available.
AC155242 Genomic DNA. No translation available.
CCDSiCCDS37688.1.
PIRiT30200.
RefSeqiNP_031465.2. NM_007439.2.
UniGeneiMm.311854.

Genome annotation databases

EnsembliENSMUST00000086639; ENSMUSP00000083840; ENSMUSG00000055471.
GeneIDi11682.
KEGGimmu:11682.
UCSCiuc008dnb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D83002 mRNA. Translation: BAA11673.1 .
AC122746 Genomic DNA. No translation available.
AC151265 Genomic DNA. No translation available.
AC154458 Genomic DNA. No translation available.
AC154602 Genomic DNA. No translation available.
AC154659 Genomic DNA. No translation available.
AC155242 Genomic DNA. No translation available.
CCDSi CCDS37688.1.
PIRi T30200.
RefSeqi NP_031465.2. NM_007439.2.
UniGenei Mm.311854.

3D structure databases

ProteinModelPortali P97793.
SMRi P97793. Positions 1100-1403.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198070. 1 interaction.
STRINGi 10090.ENSMUSP00000083840.

Chemistry

BindingDBi P97793.
ChEMBLi CHEMBL5771.

PTM databases

PhosphoSitei P97793.

Proteomic databases

MaxQBi P97793.
PaxDbi P97793.
PRIDEi P97793.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000086639 ; ENSMUSP00000083840 ; ENSMUSG00000055471 .
GeneIDi 11682.
KEGGi mmu:11682.
UCSCi uc008dnb.1. mouse.

Organism-specific databases

CTDi 238.
MGIi MGI:103305. Alk.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118818.
HOGENOMi HOG000231766.
HOVERGENi HBG018726.
InParanoidi P97793.
KOi K05119.
OMAi LIQKVCI.
OrthoDBi EOG7GN2KT.
TreeFami TF351636.

Enzyme and pathway databases

BRENDAi 2.7.10.1. 3474.

Miscellaneous databases

NextBioi 279315.
PROi P97793.
SOURCEi Search...

Gene expression databases

Bgeei P97793.
CleanExi MM_ALK.
Genevestigatori P97793.

Family and domain databases

Gene3Di 4.10.400.10. 1 hit.
InterProi IPR026830. ALK.
IPR013320. ConA-like_dom.
IPR011009. Kinase-like_dom.
IPR002172. LDrepeatLR_classA_rpt.
IPR000998. MAM_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view ]
PANTHERi PTHR24416:SF276. PTHR24416:SF276. 1 hit.
Pfami PF00629. MAM. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
PRINTSi PR00109. TYRKINASE.
SMARTi SM00192. LDLa. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 2 hits.
SSF56112. SSF56112. 1 hit.
SSF57424. SSF57424. 1 hit.
PROSITEi PS50060. MAM_2. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system."
    Iwahara T., Fujimoto J., Wen D., Cupples R., Bucay N., Arakawa T., Mori S., Ratzkin B., Yamamoto T.
    Oncogene 14:439-449(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain and Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth."
    Motegi A., Fujimoto J., Kotani M., Sakuraba H., Yamamoto T.
    J. Cell Sci. 117:3319-3329(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION, INTERACTION WITH CBL; IRS1; PIK3R1; PLCG1 AND SHC1, FUNCTION IN PHOSPHORYLATION OF CBL; IRS1 AND SHC1.
  4. "Characterization of the expression of the ALK receptor tyrosine kinase in mice."
    Vernersson E., Khoo N.K., Henriksson M.L., Roos G., Palmer R.H., Hallberg B.
    Gene Expr. Patterns 6:448-461(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, FUNCTION.
  5. "Recruitment of insulin receptor substrate-1 and activation of NF-kappaB essential for midkine growth signaling through anaplastic lymphoma kinase."
    Kuo A.H., Stoica G.E., Riegel A.T., Wellstein A.
    Oncogene 26:859-869(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IRS1 AND SHC, PHOSPHORYLATION AT TYR-1096, FUNCTION.
  6. "ALK (Anaplastic Lymphoma Kinase) expression in DRG neurons and its involvement in neuron-Schwann cells interaction."
    Degoutin J., Brunet-de Carvalho N., Cifuentes-Diaz C., Vigny M.
    Eur. J. Neurosci. 29:275-286(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Anaplastic lymphoma kinase: signalling in development and disease."
    Palmer R.H., Vernersson E., Grabbe C., Hallberg B.
    Biochem. J. 420:345-361(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON FUNCTION.

Entry informationi

Entry nameiALK_MOUSE
AccessioniPrimary (citable) accession number: P97793
Secondary accession number(s): E9QKV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3