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Protein

GDNF family receptor alpha-1

Gene

Gfra1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity).By similarity

GO - Molecular functioni

  • receptor activity Source: MGI

GO - Biological processi

  • anatomical structure morphogenesis Source: MGI
  • nervous system development Source: MGI
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
GDNF family receptor alpha-1
Short name:
GDNF receptor alpha-1
Short name:
GDNFR-alpha-1
Short name:
GFR-alpha-1
Alternative name(s):
TGF-beta-related neurotrophic factor receptor 1
Gene namesi
Name:Gfra1
Synonyms:Gdnfra, Trnr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1100842. Gfra1.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • extracellular exosome Source: MGI
  • extrinsic component of membrane Source: MGI
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 430406GDNF family receptor alpha-1PRO_0000010779Add
BLAST
Propeptidei431 – 46838Removed in mature formSequence analysisPRO_0000010780Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 ↔ 87By similarity
Disulfide bondi36 ↔ 42By similarity
Disulfide bondi52 ↔ 72By similarity
Glycosylationi59 – 591N-linked (GlcNAc...)Sequence analysis
Disulfide bondi89 ↔ 99By similarity
Disulfide bondi154 ↔ 214By similarity
Disulfide bondi161 ↔ 167By similarity
Disulfide bondi178 ↔ 192By similarity
Disulfide bondi187 ↔ 233By similarity
Disulfide bondi216 ↔ 221By similarity
Disulfide bondi243 ↔ 313By similarity
Disulfide bondi250 ↔ 256By similarity
Disulfide bondi267 ↔ 285By similarity
Disulfide bondi277 ↔ 337By similarity
Disulfide bondi315 ↔ 325By similarity
Glycosylationi347 – 3471N-linked (GlcNAc...)Sequence analysis
Glycosylationi406 – 4061N-linked (GlcNAc...)Sequence analysis
Lipidationi430 – 4301GPI-anchor amidated serineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiP97785.
PaxDbiP97785.
PRIDEiP97785.

Expressioni

Tissue specificityi

Isoform 1 and isoform 2 are expressed in heart, brain, lung, liver, kidney and testis.1 Publication

Gene expression databases

BgeeiP97785.
ExpressionAtlasiP97785. baseline and differential.
GenevisibleiP97785. MM.

Interactioni

Subunit structurei

2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET.By similarity

Protein-protein interaction databases

IntActiP97785. 1 interaction.
STRINGi10090.ENSMUSP00000026076.

Structurei

3D structure databases

ProteinModelPortaliP97785.
SMRiP97785. Positions 25-349.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati25 – 113891Add
BLAST
Repeati150 – 238892Add
BLAST
Repeati239 – 3421043Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi362 – 3698Thr-rich

Sequence similaritiesi

Belongs to the GDNFR family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IU4F. Eukaryota.
ENOG410XPTA. LUCA.
GeneTreeiENSGT00550000074579.
HOGENOMiHOG000008695.
HOVERGENiHBG051725.
InParanoidiP97785.
KOiK19895.
OMAiNTHLCIS.
OrthoDBiEOG7FBRJ3.
PhylomeDBiP97785.
TreeFamiTF331647.

Family and domain databases

InterProiIPR016017. GDNF/GAS1.
IPR003438. GDNF_rcpt.
IPR003503. GDNF_rcpt_A1.
IPR017372. Glial_neurotroph_fac_rcpt_a1/2.
[Graphical view]
PfamiPF02351. GDNF. 3 hits.
[Graphical view]
PIRSFiPIRSF038071. GDNF_family_receptor_alpha. 1 hit.
PRINTSiPR01317. GDNFRALPHA1.
PR01316. GDNFRECEPTOR.
SMARTiSM00907. GDNF. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P97785-1) [UniParc]FASTAAdd to basket

Also known as: GDNFR-alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFLATLYFVL PLLDLLMSAE VSGGDRLDCV KASDQCLKEQ SCSTKYRTLR
60 70 80 90 100
QCVAGKETNF SLTSGLEAKD ECRSAMEALK QKSLYNCRCK RGMKKEKNCL
110 120 130 140 150
RIYWSMYQSL QGNDLLEDSP YEPVNSRLSD IFRAVPFISD VFQQVEHISK
160 170 180 190 200
GNNCLDAAKA CNLDDTCKKY RSAYITPCTT SMSNEVCNRR KCHKALRQFF
210 220 230 240 250
DKVPAKHSYG MLFCSCRDVA CTERRRQTIV PVCSYEERER PNCLNLQDSC
260 270 280 290 300
KTNYICRSRL ADFFTNCQPE SRSVSNCLKE NYADCLLAYS GLIGTVMTPN
310 320 330 340 350
YIDSSSLSVA PWCDCSNSGN DLEDCLKFLN FFKDNTCLKN AIQAFGNGSD
360 370 380 390 400
VTMWQPAPPV QTTTATTTTA FRIKNKPLGP AGSENEIPTH VLPPCANLQA
410 420 430 440 450
QKLKSNVSGS THLCLSDNDY GKDGLAGASS HITTKSMAAP PSCGLSSLPV
460
MVFTALAALL SVSLAETS
Length:468
Mass (Da):51,752
Last modified:July 27, 2011 - v2
Checksum:i997105C2A6DD6446
GO
Isoform 2 (identifier: P97785-2) [UniParc]FASTAAdd to basket

Also known as: GDNFR-beta

The sequence of this isoform differs from the canonical sequence as follows:
     140-144: Missing.

Show »
Length:463
Mass (Da):51,134
Checksum:iEAF2A1522622C037
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti366 – 3661T → M in BAA19185 (Ref. 2) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei140 – 1445Missing in isoform 2. 1 PublicationVSP_041630

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014117 mRNA. Translation: AAB86599.1.
AF015172 mRNA. Translation: AAB86600.1.
AB000800 mRNA. Translation: BAA19185.1.
CH466585 Genomic DNA. Translation: EDL01795.1.
CH466585 Genomic DNA. Translation: EDL01796.1.
BC054378 mRNA. Translation: AAH54378.1.
CCDSiCCDS38028.1. [P97785-1]
CCDS70967.1. [P97785-2]
RefSeqiNP_001272386.1. NM_001285457.1. [P97785-2]
NP_034409.1. NM_010279.3. [P97785-1]
XP_006526744.1. XM_006526681.1. [P97785-1]
XP_006526745.1. XM_006526682.1. [P97785-1]
XP_006526746.1. XM_006526683.2. [P97785-1]
XP_006526747.1. XM_006526684.1. [P97785-1]
XP_006526748.1. XM_006526685.2. [P97785-2]
UniGeneiMm.88367.

Genome annotation databases

EnsembliENSMUST00000026076; ENSMUSP00000026076; ENSMUSG00000025089. [P97785-1]
ENSMUST00000129100; ENSMUSP00000117196; ENSMUSG00000025089. [P97785-2]
ENSMUST00000152507; ENSMUSP00000120333; ENSMUSG00000025089. [P97785-1]
ENSMUST00000169850; ENSMUSP00000130128; ENSMUSG00000025089. [P97785-1]
GeneIDi14585.
KEGGimmu:14585.
UCSCiuc008ial.2. mouse. [P97785-2]
uc008ian.2. mouse. [P97785-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014117 mRNA. Translation: AAB86599.1.
AF015172 mRNA. Translation: AAB86600.1.
AB000800 mRNA. Translation: BAA19185.1.
CH466585 Genomic DNA. Translation: EDL01795.1.
CH466585 Genomic DNA. Translation: EDL01796.1.
BC054378 mRNA. Translation: AAH54378.1.
CCDSiCCDS38028.1. [P97785-1]
CCDS70967.1. [P97785-2]
RefSeqiNP_001272386.1. NM_001285457.1. [P97785-2]
NP_034409.1. NM_010279.3. [P97785-1]
XP_006526744.1. XM_006526681.1. [P97785-1]
XP_006526745.1. XM_006526682.1. [P97785-1]
XP_006526746.1. XM_006526683.2. [P97785-1]
XP_006526747.1. XM_006526684.1. [P97785-1]
XP_006526748.1. XM_006526685.2. [P97785-2]
UniGeneiMm.88367.

3D structure databases

ProteinModelPortaliP97785.
SMRiP97785. Positions 25-349.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP97785. 1 interaction.
STRINGi10090.ENSMUSP00000026076.

Proteomic databases

MaxQBiP97785.
PaxDbiP97785.
PRIDEiP97785.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026076; ENSMUSP00000026076; ENSMUSG00000025089. [P97785-1]
ENSMUST00000129100; ENSMUSP00000117196; ENSMUSG00000025089. [P97785-2]
ENSMUST00000152507; ENSMUSP00000120333; ENSMUSG00000025089. [P97785-1]
ENSMUST00000169850; ENSMUSP00000130128; ENSMUSG00000025089. [P97785-1]
GeneIDi14585.
KEGGimmu:14585.
UCSCiuc008ial.2. mouse. [P97785-2]
uc008ian.2. mouse. [P97785-1]

Organism-specific databases

CTDi2674.
MGIiMGI:1100842. Gfra1.

Phylogenomic databases

eggNOGiENOG410IU4F. Eukaryota.
ENOG410XPTA. LUCA.
GeneTreeiENSGT00550000074579.
HOGENOMiHOG000008695.
HOVERGENiHBG051725.
InParanoidiP97785.
KOiK19895.
OMAiNTHLCIS.
OrthoDBiEOG7FBRJ3.
PhylomeDBiP97785.
TreeFamiTF331647.

Miscellaneous databases

ChiTaRSiGfra1. mouse.
NextBioi286326.
PROiP97785.
SOURCEiSearch...

Gene expression databases

BgeeiP97785.
ExpressionAtlasiP97785. baseline and differential.
GenevisibleiP97785. MM.

Family and domain databases

InterProiIPR016017. GDNF/GAS1.
IPR003438. GDNF_rcpt.
IPR003503. GDNF_rcpt_A1.
IPR017372. Glial_neurotroph_fac_rcpt_a1/2.
[Graphical view]
PfamiPF02351. GDNF. 3 hits.
[Graphical view]
PIRSFiPIRSF038071. GDNF_family_receptor_alpha. 1 hit.
PRINTSiPR01317. GDNFRALPHA1.
PR01316. GDNFRECEPTOR.
SMARTiSM00907. GDNF. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a novel murine isoform of the glial cell line-derived neurotrophic factor receptor."
    Dey B.K., Wong Y.W., Too H.P.
    NeuroReport 9:37-42(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    Strain: C57BL/6J.
    Tissue: Liver.
  2. Watabe K.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Spinal ganglion.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiGFRA1_MOUSE
AccessioniPrimary (citable) accession number: P97785
Secondary accession number(s): O35246, O35252
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: May 11, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.