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Protein

Protein AF1q

Gene

Mllt11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cofactor for the transcription factor TCF7. Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T-cell fate.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein AF1q
Gene namesi
Name:Mllt11
Synonyms:Af1q
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1929671. Mllt11.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity
  • Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity

  • Note: Continuous nuclear export is followed by degradation.By similarity

GO - Cellular componenti

  • cytoplasm Source: MGI
  • intracellular Source: UniProtKB
  • microtubule organizing center Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9090Protein AF1qPRO_0000064472Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei84 – 841PhosphoserineCombined sources

Post-translational modificationi

Ubiquitinated, leading to degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP97783.
PeptideAtlasiP97783.
PRIDEiP97783.

PTM databases

iPTMnetiP97783.
PhosphoSiteiP97783.

Expressioni

Tissue specificityi

Detected in embryonic brain cortex.1 Publication

Inductioni

Up-regulated during neuronal differentiation (in vitro).1 Publication

Gene expression databases

BgeeiP97783.
ExpressionAtlasiP97783. baseline and differential.
GenevisibleiP97783. MM.

Interactioni

Subunit structurei

Interacts with HSPA8 and LAMP2 isoform A; the interaction may target MLLT11 for degradation via chaperone-mediated autophagy. Interacts with TCF7.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066448.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi24 – 329Nuclear export signalBy similarity

Sequence similaritiesi

Belongs to the MLLT11 family.Curated

Phylogenomic databases

eggNOGiENOG410IZF7. Eukaryota.
ENOG4112CHF. LUCA.
HOGENOMiHOG000033833.
HOVERGENiHBG003435.
InParanoidiP97783.
OMAiKMTGQAT.
OrthoDBiEOG7TBC4V.
PhylomeDBiP97783.
TreeFamiTF336906.

Family and domain databases

InterProiIPR026778. MLLT11_fam.
IPR033461. WRNPLPNID.
[Graphical view]
PANTHERiPTHR15404. PTHR15404. 1 hit.
PfamiPF15017. WRNPLPNID. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97783-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDPVSSQYS SFLFWRMPIP ELDLSELEGL GLSDTPTYES KDSSSVGKMN
60 70 80 90
GQASGTEQKN PEGDPLLEYS TFNFWRAPIA SIHSVDLDLL
Length:90
Mass (Da):10,029
Last modified:May 1, 1997 - v1
Checksum:i5A8BCE378D1922F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000733 mRNA. Translation: BAA19173.1.
U95498 mRNA. Translation: AAD00803.1.
BC022963 mRNA. Translation: AAH22963.1.
CCDSiCCDS38544.1.
RefSeqiNP_064298.1. NM_019914.4.
XP_006501863.1. XM_006501800.2.
UniGeneiMm.331208.

Genome annotation databases

EnsembliENSMUST00000065482; ENSMUSP00000066448; ENSMUSG00000053192.
ENSMUST00000196025; ENSMUSP00000143755; ENSMUSG00000053192.
ENSMUST00000198948; ENSMUSP00000142604; ENSMUSG00000053192.
GeneIDi56772.
KEGGimmu:56772.
UCSCiuc008qit.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000733 mRNA. Translation: BAA19173.1.
U95498 mRNA. Translation: AAD00803.1.
BC022963 mRNA. Translation: AAH22963.1.
CCDSiCCDS38544.1.
RefSeqiNP_064298.1. NM_019914.4.
XP_006501863.1. XM_006501800.2.
UniGeneiMm.331208.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066448.

PTM databases

iPTMnetiP97783.
PhosphoSiteiP97783.

Proteomic databases

PaxDbiP97783.
PeptideAtlasiP97783.
PRIDEiP97783.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065482; ENSMUSP00000066448; ENSMUSG00000053192.
ENSMUST00000196025; ENSMUSP00000143755; ENSMUSG00000053192.
ENSMUST00000198948; ENSMUSP00000142604; ENSMUSG00000053192.
GeneIDi56772.
KEGGimmu:56772.
UCSCiuc008qit.2. mouse.

Organism-specific databases

CTDi10962.
MGIiMGI:1929671. Mllt11.

Phylogenomic databases

eggNOGiENOG410IZF7. Eukaryota.
ENOG4112CHF. LUCA.
HOGENOMiHOG000033833.
HOVERGENiHBG003435.
InParanoidiP97783.
OMAiKMTGQAT.
OrthoDBiEOG7TBC4V.
PhylomeDBiP97783.
TreeFamiTF336906.

Miscellaneous databases

PROiP97783.
SOURCEiSearch...

Gene expression databases

BgeeiP97783.
ExpressionAtlasiP97783. baseline and differential.
GenevisibleiP97783. MM.

Family and domain databases

InterProiIPR026778. MLLT11_fam.
IPR033461. WRNPLPNID.
[Graphical view]
PANTHERiPTHR15404. PTHR15404. 1 hit.
PfamiPF15017. WRNPLPNID. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of mouse AF1q homologue."
    Matsuo N., Kawamoto S., Okubo K., Matsubara K.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Hippocampus.
  2. "AF1q in fetal mouse brain."
    Koduru P.K., Tse W., Liu J., Broome J.D.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Retina.
  4. "AF1q, a differentially expressed gene during neuronal differentiation, transforms HEK cells into neuron-like cells."
    Lin H.J., Shaffer K.M., Sun Z., Jay G., He W.-W., Ma W.
    Brain Res. Mol. Brain Res. 131:126-130(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-84, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain and Testis.

Entry informationi

Entry nameiAF1Q_MOUSE
AccessioniPrimary (citable) accession number: P97783
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1997
Last modified: July 6, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.