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Protein

Metabotropic glutamate receptor 1

Gene

Grm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (By. similarity).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei74GlutamateBy similarity1
Binding sitei165GlutamateBy similarity1
Binding sitei236GlutamateBy similarity1
Binding sitei318GlutamateBy similarity1
Binding sitei409GlutamateBy similarity1

GO - Molecular functioni

  • glutamate receptor activity Source: UniProtKB
  • PLC activating G-protein coupled glutamate receptor activity Source: MGI

GO - Biological processi

  • activation of MAPK activity Source: UniProtKB
  • activation of MAPKK activity Source: UniProtKB
  • cellular response to electrical stimulus Source: MGI
  • dimeric G-protein coupled receptor signaling pathway Source: UniProtKB
  • G-protein coupled glutamate receptor signaling pathway Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: UniProtKB
  • locomotory behavior Source: UniProtKB
  • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: UniProtKB
  • protein kinase C-activating G-protein coupled receptor signaling pathway Source: GO_Central
  • regulation of MAPK cascade Source: UniProtKB
  • regulation of sensory perception of pain Source: UniProtKB
  • regulation of synaptic transmission, glutamatergic Source: GO_Central
  • sensory perception of pain Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-416476. G alpha (q) signalling events.
R-MMU-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).
R-MMU-6794361. Interactions of neurexins and neuroligins at synapses.

Names & Taxonomyi

Protein namesi
Recommended name:
Metabotropic glutamate receptor 1
Short name:
mGluR1
Gene namesi
Name:Grm1
Synonyms:Gprc1a, Mglur1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1351338. Grm1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 592ExtracellularBy similarityAdd BLAST572
Transmembranei593 – 615Helical; Name=1By similarityAdd BLAST23
Topological domaini616 – 629CytoplasmicBy similarityAdd BLAST14
Transmembranei630 – 650Helical; Name=2By similarityAdd BLAST21
Topological domaini651 – 658ExtracellularBy similarity8
Transmembranei659 – 680Helical; Name=3By similarityAdd BLAST22
Topological domaini681 – 703CytoplasmicBy similarityAdd BLAST23
Transmembranei704 – 727Helical; Name=4By similarityAdd BLAST24
Topological domaini728 – 750ExtracellularBy similarityAdd BLAST23
Transmembranei751 – 772Helical; Name=5By similarityAdd BLAST22
Topological domaini773 – 785CytoplasmicBy similarityAdd BLAST13
Transmembranei786 – 807Helical; Name=6By similarityAdd BLAST22
Topological domaini808 – 815ExtracellularBy similarity8
Transmembranei816 – 840Helical; Name=7By similarityAdd BLAST25
Topological domaini841 – 1199CytoplasmicBy similarityAdd BLAST359

GO - Cellular componenti

  • dendrite Source: UniProtKB
  • G-protein coupled receptor dimeric complex Source: MGI
  • G-protein coupled receptor homodimeric complex Source: MGI
  • integral component of plasma membrane Source: UniProtKB
  • neuronal cell body Source: UniProtKB
  • neuron projection Source: BHF-UCL
  • nucleus Source: MGI
  • postsynaptic density Source: MGI
  • postsynaptic membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2892.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001292321 – 1199Metabotropic glutamate receptor 1Add BLAST1179

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi67 ↔ 109By similarity
Glycosylationi98N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi140InterchainBy similarity
Glycosylationi223N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi289 ↔ 291By similarity
Disulfide bondi378 ↔ 394By similarity
Glycosylationi397N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi432 ↔ 439By similarity
Glycosylationi515N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi657 ↔ 746By similarity
Glycosylationi747N-linked (GlcNAc...)Sequence analysis1
Modified residuei853PhosphoserineCombined sources1
Modified residuei871PhosphothreonineCombined sources1
Modified residuei894PhosphoserineBy similarity1
Modified residuei969PhosphoserineCombined sources1
Modified residuei1097PhosphoserineCombined sources1
Modified residuei1147PhosphoserineCombined sources1
Modified residuei1151PhosphothreonineBy similarity1
Modified residuei1154PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP97772.
PaxDbiP97772.
PeptideAtlasiP97772.
PRIDEiP97772.

PTM databases

iPTMnetiP97772.
PhosphoSitePlusiP97772.

Expressioni

Gene expression databases

BgeeiENSMUSG00000019828.
CleanExiMM_GRM1.
GenevisibleiP97772. MM.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP (By similarity).By similarity

Protein-protein interaction databases

BioGridi200073. 8 interactors.
IntActiP97772. 4 interactors.
MINTiMINT-4595385.
STRINGi10090.ENSMUSP00000037255.

Chemistry databases

BindingDBiP97772.

Structurei

3D structure databases

ProteinModelPortaliP97772.
SMRiP97772.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni186 – 188Glutamate bindingBy similarity3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1014 – 1041Gln/Pro-richAdd BLAST28
Compositional biasi1073 – 1087Gln/Pro-richAdd BLAST15
Compositional biasi1101 – 1135Asp/Glu-rich (acidic)Add BLAST35
Compositional biasi1147 – 1199Ser-richAdd BLAST53

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
GeneTreeiENSGT00760000118884.
HOGENOMiHOG000218636.
HOVERGENiHBG107965.
InParanoidiP97772.
KOiK04603.
OMAiKTNETAC.
OrthoDBiEOG091G177R.
PhylomeDBiP97772.
TreeFamiTF313240.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001256. GPCR_3_mtglu_rcpt_1.
IPR019588. Metabotropic_Glu_rcpt_Homer-bd.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF10606. GluR_Homer-bdg. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PR01051. MTABOTROPC1R.
PR00593. MTABOTROPICR.
SMARTiSM01229. GluR_Homer-bdg. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P97772-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVRLLLIFFP MIFLEMSILP RMPDRKVLLA GASSQRSVAR MDGDVIIGAL
60 70 80 90 100
FSVHHQPPAE KVPERKCGEI REQYGIQRVE AMFHTLDKIN ADPVLLPNIT
110 120 130 140 150
LGSEIRDSCW HSSVALEQSI EFIRDSLISI RDEKDGLNRC LPDGQTLPPG
160 170 180 190 200
RTKKPIAGVI GPGSSSVAIQ VQNLLQLFDI PQIAYSATSI DLSDKTLYKY
210 220 230 240 250
FLRVVPSDTL QARAMLDIVK RYNWTYVSAV HTEGNYGESG MDAFKELAAQ
260 270 280 290 300
EGLCIAHSDK IYSNAGEKSF DRLLRKLRER LPKARVVVCF CEGMTVRGLL
310 320 330 340 350
SAMRRLGVVG EFSLIGSDGW ADRDEVIEGY EVEANGGITI KLQSPEVRSF
360 370 380 390 400
DDYFLKLRLD TNTRNPWFPE FWQHRFQCRL PGHLLENPNF KKVCTGNESL
410 420 430 440 450
EENYVQDSKM GFVINAIYAM AHGLQNMHHA LCPGYVGLCD AMKPIDGRKL
460 470 480 490 500
LDFLIKSSFV GVSGEEVWFD EKGDAPGRYD IMNLQYTEAN RYDYVHVGTW
510 520 530 540 550
HEGVLNIDDY KIQMNKSGMV RSVCSEPCLK GQIKVIRKGE VSCCWICTAC
560 570 580 590 600
KENEFVQDEF TCRACDLGWW PNAELTGCEP ITIRYLEWSD IESIIAIAFS
610 620 630 640 650
CLGILVTLFV TLIFVLYRDT PVVKSSSREL CYIILAGIFL GYVCPFTLIA
660 670 680 690 700
KPTTTSCYLQ RLLVGLSSAM CYSALVTKTN RIARILAGSK KKICTRKPRF
710 720 730 740 750
MSAWAQVIIA SILISVQLTL VVTLIIMEPP MPILSYPSIK EVYLICNTSN
760 770 780 790 800
LGVVAPVGYN GLLIMSCTYY AFKTRNVPAN FNEAKYIAFT MYTTCIIWLA
810 820 830 840 850
FVPIYFGSNY KIITTCFAVS LSVTVALGCM FTPKMYIIIA KPERNVRSAF
860 870 880 890 900
TTSDVVRMHV GDGKLPCRSN TFLNIFRRKK PGAGNANSNG KSVSWSEPGG
910 920 930 940 950
RQAPKGQHVW QRLSVHVKTN ETACNQTAVI KPLTKSYQGS GKSLTFSDAS
960 970 980 990 1000
TKTLYNVEEE DNTPSTHFSP PSSPSMVVHR RGPPVATTPP LPPHLSAEET
1010 1020 1030 1040 1050
PLFLADSVIP KGLPPPLPQQ QQQPPPQPPP QQPKSLMDQL QGVVTNFGSG
1060 1070 1080 1090 1100
IPDFHAVLAG PGTPGNGLRS LYPPPPPPQH LQMLPLQLST FREEPISPPG
1110 1120 1130 1140 1150
EDDDDDSSER FKLLQEFVYE REGNTEEDDL EEEEDLPAAS KLTPEDSPAL
1160 1170 1180 1190
TPPSPFRDSV ASGSSVPSSP VSESVLCTPP NVTYASVILR DYKQSSSTL
Length:1,199
Mass (Da):133,212
Last modified:April 11, 2003 - v2
Checksum:iFE5370AF160CC16E
GO
Isoform 2 (identifier: P97772-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     887-906: NSNGKSVSWSEPGGRQAPKG → KKRQPEFSPSSQCPSAHVQL
     907-1199: Missing.

Show »
Length:906
Mass (Da):101,710
Checksum:iB9223F00A9C6851C
GO
Isoform 3 (identifier: P97772-3) [UniParc]FASTAAdd to basket
Also known as: E55

The sequence of this isoform differs from the canonical sequence as follows:
     317-321: SDGWA → RDSRN
     322-1199: Missing.

Show »
Length:321
Mass (Da):35,852
Checksum:i9DC2B123A5211A2C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007184317 – 321SDGWA → RDSRN in isoform 3. 1 Publication5
Alternative sequenceiVSP_007185322 – 1199Missing in isoform 3. 1 PublicationAdd BLAST878
Alternative sequenceiVSP_007186887 – 906NSNGK…QAPKG → KKRQPEFSPSSQCPSAHVQL in isoform 2. 2 PublicationsAdd BLAST20
Alternative sequenceiVSP_007187907 – 1199Missing in isoform 2. 2 PublicationsAdd BLAST293

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF320126 mRNA. Translation: AAG41991.2.
BC067057 mRNA. Translation: AAH67057.1.
BC079566 mRNA. Translation: AAH79566.1.
U89891 mRNA. Translation: AAB48099.1.
CCDSiCCDS23696.1. [P97772-1]
CCDS48499.1. [P97772-2]
RefSeqiNP_001107805.1. NM_001114333.2. [P97772-2]
NP_058672.1. NM_016976.3. [P97772-1]
XP_006512612.1. XM_006512549.3. [P97772-1]
UniGeneiMm.391904.
Mm.482986.

Genome annotation databases

EnsembliENSMUST00000044306; ENSMUSP00000037255; ENSMUSG00000019828. [P97772-1]
ENSMUST00000105560; ENSMUSP00000101189; ENSMUSG00000019828. [P97772-2]
ENSMUST00000105561; ENSMUSP00000101190; ENSMUSG00000019828. [P97772-2]
GeneIDi14816.
KEGGimmu:14816.
UCSCiuc007ejh.2. mouse. [P97772-2]
uc007eji.2. mouse. [P97772-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF320126 mRNA. Translation: AAG41991.2.
BC067057 mRNA. Translation: AAH67057.1.
BC079566 mRNA. Translation: AAH79566.1.
U89891 mRNA. Translation: AAB48099.1.
CCDSiCCDS23696.1. [P97772-1]
CCDS48499.1. [P97772-2]
RefSeqiNP_001107805.1. NM_001114333.2. [P97772-2]
NP_058672.1. NM_016976.3. [P97772-1]
XP_006512612.1. XM_006512549.3. [P97772-1]
UniGeneiMm.391904.
Mm.482986.

3D structure databases

ProteinModelPortaliP97772.
SMRiP97772.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200073. 8 interactors.
IntActiP97772. 4 interactors.
MINTiMINT-4595385.
STRINGi10090.ENSMUSP00000037255.

Chemistry databases

BindingDBiP97772.
ChEMBLiCHEMBL2892.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP97772.
PhosphoSitePlusiP97772.

Proteomic databases

MaxQBiP97772.
PaxDbiP97772.
PeptideAtlasiP97772.
PRIDEiP97772.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044306; ENSMUSP00000037255; ENSMUSG00000019828. [P97772-1]
ENSMUST00000105560; ENSMUSP00000101189; ENSMUSG00000019828. [P97772-2]
ENSMUST00000105561; ENSMUSP00000101190; ENSMUSG00000019828. [P97772-2]
GeneIDi14816.
KEGGimmu:14816.
UCSCiuc007ejh.2. mouse. [P97772-2]
uc007eji.2. mouse. [P97772-1]

Organism-specific databases

CTDi2911.
MGIiMGI:1351338. Grm1.

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
GeneTreeiENSGT00760000118884.
HOGENOMiHOG000218636.
HOVERGENiHBG107965.
InParanoidiP97772.
KOiK04603.
OMAiKTNETAC.
OrthoDBiEOG091G177R.
PhylomeDBiP97772.
TreeFamiTF313240.

Enzyme and pathway databases

ReactomeiR-MMU-416476. G alpha (q) signalling events.
R-MMU-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).
R-MMU-6794361. Interactions of neurexins and neuroligins at synapses.

Miscellaneous databases

PROiP97772.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019828.
CleanExiMM_GRM1.
GenevisibleiP97772. MM.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001256. GPCR_3_mtglu_rcpt_1.
IPR019588. Metabotropic_Glu_rcpt_Homer-bd.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF10606. GluR_Homer-bdg. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PR01051. MTABOTROPC1R.
PR00593. MTABOTROPICR.
SMARTiSM01229. GluR_Homer-bdg. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGRM1_MOUSE
AccessioniPrimary (citable) accession number: P97772
Secondary accession number(s): Q6AXG4, Q9EPV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: April 11, 2003
Last modified: November 2, 2016
This is version 160 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.