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P97772

- GRM1_MOUSE

UniProt

P97772 - GRM1_MOUSE

Protein

Metabotropic glutamate receptor 1

Gene

Grm1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 2 (11 Apr 2003)
      Previous versions | rss
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    Functioni

    G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (By. similarity).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei74 – 741GlutamateBy similarity
    Binding sitei165 – 1651GlutamateBy similarity
    Binding sitei236 – 2361GlutamateBy similarity
    Binding sitei318 – 3181GlutamateBy similarity
    Binding sitei409 – 4091GlutamateBy similarity

    GO - Molecular functioni

    1. glutamate receptor activity Source: UniProtKB
    2. G-protein coupled receptor activity Source: UniProtKB-KW
    3. PLC activating G-protein coupled glutamate receptor activity Source: MGI
    4. protein binding Source: MGI

    GO - Biological processi

    1. activation of MAPK activity Source: UniProtKB
    2. activation of MAPKK activity Source: UniProtKB
    3. cellular response to electrical stimulus Source: MGI
    4. dimeric G-protein coupled receptor signaling pathway Source: UniProtKB
    5. G-protein coupled glutamate receptor signaling pathway Source: UniProtKB
    6. G-protein coupled receptor signaling pathway Source: UniProtKB
    7. locomotory behavior Source: UniProtKB
    8. phospholipase C-activating G-protein coupled glutamate receptor signaling pathway Source: GOC
    9. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: UniProtKB
    10. protein kinase C-activating G-protein coupled receptor signaling pathway Source: RefGenome
    11. regulation of MAPK cascade Source: UniProtKB
    12. regulation of sensory perception of pain Source: UniProtKB
    13. regulation of synaptic transmission, glutamatergic Source: RefGenome
    14. sensory perception of pain Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metabotropic glutamate receptor 1
    Short name:
    mGluR1
    Gene namesi
    Name:Grm1
    Synonyms:Gprc1a, Mglur1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1351338. Grm1.

    Subcellular locationi

    GO - Cellular componenti

    1. dendrite Source: UniProtKB
    2. G-protein coupled receptor homodimeric complex Source: Ensembl
    3. integral component of plasma membrane Source: UniProtKB
    4. neuronal cell body Source: UniProtKB
    5. neuron projection Source: BHF-UCL
    6. nucleus Source: MGI
    7. postsynaptic density Source: MGI
    8. postsynaptic membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 11991179Metabotropic glutamate receptor 1PRO_0000012923Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi67 ↔ 109By similarity
    Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi140 – 140InterchainBy similarity
    Glycosylationi223 – 2231N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi289 ↔ 291By similarity
    Disulfide bondi378 ↔ 394By similarity
    Glycosylationi397 – 3971N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi432 ↔ 439By similarity
    Glycosylationi515 – 5151N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi657 ↔ 746By similarity
    Glycosylationi747 – 7471N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP97772.
    PRIDEiP97772.

    PTM databases

    PhosphoSiteiP97772.

    Expressioni

    Gene expression databases

    BgeeiP97772.
    CleanExiMM_GRM1.
    GenevestigatoriP97772.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked. The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP By similarity.By similarity

    Protein-protein interaction databases

    BioGridi200073. 9 interactions.
    IntActiP97772. 4 interactions.
    MINTiMINT-4595385.

    Structurei

    3D structure databases

    ProteinModelPortaliP97772.
    SMRiP97772. Positions 35-578, 581-846.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 592572ExtracellularBy similarityAdd
    BLAST
    Topological domaini616 – 62914CytoplasmicBy similarityAdd
    BLAST
    Topological domaini651 – 6588ExtracellularBy similarity
    Topological domaini681 – 70323CytoplasmicBy similarityAdd
    BLAST
    Topological domaini728 – 75023ExtracellularBy similarityAdd
    BLAST
    Topological domaini773 – 78513CytoplasmicBy similarityAdd
    BLAST
    Topological domaini808 – 8158ExtracellularBy similarity
    Topological domaini841 – 1199359CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei593 – 61523Helical; Name=1By similarityAdd
    BLAST
    Transmembranei630 – 65021Helical; Name=2By similarityAdd
    BLAST
    Transmembranei659 – 68022Helical; Name=3By similarityAdd
    BLAST
    Transmembranei704 – 72724Helical; Name=4By similarityAdd
    BLAST
    Transmembranei751 – 77222Helical; Name=5By similarityAdd
    BLAST
    Transmembranei786 – 80722Helical; Name=6By similarityAdd
    BLAST
    Transmembranei816 – 84025Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni186 – 1883Glutamate bindingBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1014 – 104128Gln/Pro-richAdd
    BLAST
    Compositional biasi1073 – 108715Gln/Pro-richAdd
    BLAST
    Compositional biasi1101 – 113535Asp/Glu-rich (acidic)Add
    BLAST
    Compositional biasi1147 – 119953Ser-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG295200.
    GeneTreeiENSGT00750000117484.
    HOGENOMiHOG000218636.
    HOVERGENiHBG107965.
    InParanoidiP97772.
    KOiK04603.
    OMAiKTNETAC.
    OrthoDBiEOG7Z0JXG.
    PhylomeDBiP97772.
    TreeFamiTF313240.

    Family and domain databases

    InterProiIPR001828. ANF_lig-bd_rcpt.
    IPR000337. GPCR_3.
    IPR011500. GPCR_3_9-Cys_dom.
    IPR017978. GPCR_3_C.
    IPR017979. GPCR_3_CS.
    IPR000162. GPCR_3_mtglu_rcpt.
    IPR001256. GPCR_3_mtglu_rcpt_1.
    IPR019588. Metabotropic_Glu_rcpt_Homer-bd.
    IPR028082. Peripla_BP_I.
    [Graphical view]
    PfamiPF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF10606. GluR_Homer-bdg. 1 hit.
    PF07562. NCD3G. 1 hit.
    [Graphical view]
    PRINTSiPR00248. GPCRMGR.
    PR01051. MTABOTROPC1R.
    PR00593. MTABOTROPICR.
    SUPFAMiSSF53822. SSF53822. 1 hit.
    PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
    PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
    PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
    PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P97772-1) [UniParc]FASTAAdd to Basket

    Also known as: A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVRLLLIFFP MIFLEMSILP RMPDRKVLLA GASSQRSVAR MDGDVIIGAL     50
    FSVHHQPPAE KVPERKCGEI REQYGIQRVE AMFHTLDKIN ADPVLLPNIT 100
    LGSEIRDSCW HSSVALEQSI EFIRDSLISI RDEKDGLNRC LPDGQTLPPG 150
    RTKKPIAGVI GPGSSSVAIQ VQNLLQLFDI PQIAYSATSI DLSDKTLYKY 200
    FLRVVPSDTL QARAMLDIVK RYNWTYVSAV HTEGNYGESG MDAFKELAAQ 250
    EGLCIAHSDK IYSNAGEKSF DRLLRKLRER LPKARVVVCF CEGMTVRGLL 300
    SAMRRLGVVG EFSLIGSDGW ADRDEVIEGY EVEANGGITI KLQSPEVRSF 350
    DDYFLKLRLD TNTRNPWFPE FWQHRFQCRL PGHLLENPNF KKVCTGNESL 400
    EENYVQDSKM GFVINAIYAM AHGLQNMHHA LCPGYVGLCD AMKPIDGRKL 450
    LDFLIKSSFV GVSGEEVWFD EKGDAPGRYD IMNLQYTEAN RYDYVHVGTW 500
    HEGVLNIDDY KIQMNKSGMV RSVCSEPCLK GQIKVIRKGE VSCCWICTAC 550
    KENEFVQDEF TCRACDLGWW PNAELTGCEP ITIRYLEWSD IESIIAIAFS 600
    CLGILVTLFV TLIFVLYRDT PVVKSSSREL CYIILAGIFL GYVCPFTLIA 650
    KPTTTSCYLQ RLLVGLSSAM CYSALVTKTN RIARILAGSK KKICTRKPRF 700
    MSAWAQVIIA SILISVQLTL VVTLIIMEPP MPILSYPSIK EVYLICNTSN 750
    LGVVAPVGYN GLLIMSCTYY AFKTRNVPAN FNEAKYIAFT MYTTCIIWLA 800
    FVPIYFGSNY KIITTCFAVS LSVTVALGCM FTPKMYIIIA KPERNVRSAF 850
    TTSDVVRMHV GDGKLPCRSN TFLNIFRRKK PGAGNANSNG KSVSWSEPGG 900
    RQAPKGQHVW QRLSVHVKTN ETACNQTAVI KPLTKSYQGS GKSLTFSDAS 950
    TKTLYNVEEE DNTPSTHFSP PSSPSMVVHR RGPPVATTPP LPPHLSAEET 1000
    PLFLADSVIP KGLPPPLPQQ QQQPPPQPPP QQPKSLMDQL QGVVTNFGSG 1050
    IPDFHAVLAG PGTPGNGLRS LYPPPPPPQH LQMLPLQLST FREEPISPPG 1100
    EDDDDDSSER FKLLQEFVYE REGNTEEDDL EEEEDLPAAS KLTPEDSPAL 1150
    TPPSPFRDSV ASGSSVPSSP VSESVLCTPP NVTYASVILR DYKQSSSTL 1199
    Length:1,199
    Mass (Da):133,212
    Last modified:April 11, 2003 - v2
    Checksum:iFE5370AF160CC16E
    GO
    Isoform 2 (identifier: P97772-2) [UniParc]FASTAAdd to Basket

    Also known as: B

    The sequence of this isoform differs from the canonical sequence as follows:
         887-906: NSNGKSVSWSEPGGRQAPKG → KKRQPEFSPSSQCPSAHVQL
         907-1199: Missing.

    Show »
    Length:906
    Mass (Da):101,710
    Checksum:iB9223F00A9C6851C
    GO
    Isoform 3 (identifier: P97772-3) [UniParc]FASTAAdd to Basket

    Also known as: E55

    The sequence of this isoform differs from the canonical sequence as follows:
         317-321: SDGWA → RDSRN
         322-1199: Missing.

    Show »
    Length:321
    Mass (Da):35,852
    Checksum:i9DC2B123A5211A2C
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei317 – 3215SDGWA → RDSRN in isoform 3. 1 PublicationVSP_007184
    Alternative sequencei322 – 1199878Missing in isoform 3. 1 PublicationVSP_007185Add
    BLAST
    Alternative sequencei887 – 90620NSNGK…QAPKG → KKRQPEFSPSSQCPSAHVQL in isoform 2. 2 PublicationsVSP_007186Add
    BLAST
    Alternative sequencei907 – 1199293Missing in isoform 2. 2 PublicationsVSP_007187Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF320126 mRNA. Translation: AAG41991.2.
    BC067057 mRNA. Translation: AAH67057.1.
    BC079566 mRNA. Translation: AAH79566.1.
    U89891 mRNA. Translation: AAB48099.1.
    CCDSiCCDS23696.1. [P97772-1]
    CCDS48499.1. [P97772-2]
    RefSeqiNP_001107805.1. NM_001114333.2. [P97772-2]
    NP_058672.1. NM_016976.3. [P97772-1]
    XP_006512611.1. XM_006512548.1. [P97772-1]
    XP_006512612.1. XM_006512549.1. [P97772-1]
    XP_006512615.1. XM_006512552.1. [P97772-2]
    UniGeneiMm.391904.
    Mm.482986.

    Genome annotation databases

    EnsembliENSMUST00000044306; ENSMUSP00000037255; ENSMUSG00000019828. [P97772-1]
    ENSMUST00000105560; ENSMUSP00000101189; ENSMUSG00000019828. [P97772-2]
    ENSMUST00000105561; ENSMUSP00000101190; ENSMUSG00000019828. [P97772-2]
    GeneIDi14816.
    KEGGimmu:14816.
    UCSCiuc007ejh.2. mouse. [P97772-2]
    uc007eji.2. mouse. [P97772-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF320126 mRNA. Translation: AAG41991.2 .
    BC067057 mRNA. Translation: AAH67057.1 .
    BC079566 mRNA. Translation: AAH79566.1 .
    U89891 mRNA. Translation: AAB48099.1 .
    CCDSi CCDS23696.1. [P97772-1 ]
    CCDS48499.1. [P97772-2 ]
    RefSeqi NP_001107805.1. NM_001114333.2. [P97772-2 ]
    NP_058672.1. NM_016976.3. [P97772-1 ]
    XP_006512611.1. XM_006512548.1. [P97772-1 ]
    XP_006512612.1. XM_006512549.1. [P97772-1 ]
    XP_006512615.1. XM_006512552.1. [P97772-2 ]
    UniGenei Mm.391904.
    Mm.482986.

    3D structure databases

    ProteinModelPortali P97772.
    SMRi P97772. Positions 35-578, 581-846.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200073. 9 interactions.
    IntActi P97772. 4 interactions.
    MINTi MINT-4595385.

    Chemistry

    BindingDBi P97772.
    ChEMBLi CHEMBL2892.
    GuidetoPHARMACOLOGYi 289.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P97772.

    Proteomic databases

    PaxDbi P97772.
    PRIDEi P97772.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000044306 ; ENSMUSP00000037255 ; ENSMUSG00000019828 . [P97772-1 ]
    ENSMUST00000105560 ; ENSMUSP00000101189 ; ENSMUSG00000019828 . [P97772-2 ]
    ENSMUST00000105561 ; ENSMUSP00000101190 ; ENSMUSG00000019828 . [P97772-2 ]
    GeneIDi 14816.
    KEGGi mmu:14816.
    UCSCi uc007ejh.2. mouse. [P97772-2 ]
    uc007eji.2. mouse. [P97772-1 ]

    Organism-specific databases

    CTDi 2911.
    MGIi MGI:1351338. Grm1.

    Phylogenomic databases

    eggNOGi NOG295200.
    GeneTreei ENSGT00750000117484.
    HOGENOMi HOG000218636.
    HOVERGENi HBG107965.
    InParanoidi P97772.
    KOi K04603.
    OMAi KTNETAC.
    OrthoDBi EOG7Z0JXG.
    PhylomeDBi P97772.
    TreeFami TF313240.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 287019.
    PROi P97772.
    SOURCEi Search...

    Gene expression databases

    Bgeei P97772.
    CleanExi MM_GRM1.
    Genevestigatori P97772.

    Family and domain databases

    InterProi IPR001828. ANF_lig-bd_rcpt.
    IPR000337. GPCR_3.
    IPR011500. GPCR_3_9-Cys_dom.
    IPR017978. GPCR_3_C.
    IPR017979. GPCR_3_CS.
    IPR000162. GPCR_3_mtglu_rcpt.
    IPR001256. GPCR_3_mtglu_rcpt_1.
    IPR019588. Metabotropic_Glu_rcpt_Homer-bd.
    IPR028082. Peripla_BP_I.
    [Graphical view ]
    Pfami PF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF10606. GluR_Homer-bdg. 1 hit.
    PF07562. NCD3G. 1 hit.
    [Graphical view ]
    PRINTSi PR00248. GPCRMGR.
    PR01051. MTABOTROPC1R.
    PR00593. MTABOTROPICR.
    SUPFAMi SSF53822. SSF53822. 1 hit.
    PROSITEi PS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
    PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
    PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
    PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of novel splice variants of mouse mGluR1."
      Zhu H., Ryan K., Chen S.
      Brain Res. Mol. Brain Res. 73:93-103(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
      Strain: ICR.
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6.
      Tissue: Brain.
    3. Watanabe M.
      Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 945-1127 (ISOFORM 1).
      Strain: C57BL/6J.
    4. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.

    Entry informationi

    Entry nameiGRM1_MOUSE
    AccessioniPrimary (citable) accession number: P97772
    Secondary accession number(s): Q6AXG4, Q9EPV6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: April 11, 2003
    Last modified: October 1, 2014
    This is version 141 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3