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P97772

- GRM1_MOUSE

UniProt

P97772 - GRM1_MOUSE

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Protein

Metabotropic glutamate receptor 1

Gene
Grm1, Gprc1a, Mglur1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (By. similarity).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei74 – 741Glutamate By similarity
Binding sitei165 – 1651Glutamate By similarity
Binding sitei236 – 2361Glutamate By similarity
Binding sitei318 – 3181Glutamate By similarity
Binding sitei409 – 4091Glutamate By similarity

GO - Molecular functioni

  1. glutamate receptor activity Source: RefGenome
  2. G-protein coupled receptor activity Source: UniProtKB-KW
  3. PLC activating G-protein coupled glutamate receptor activity Source: MGI
  4. protein binding Source: MGI

GO - Biological processi

  1. activation of MAPK activity Source: UniProtKB
  2. activation of MAPKK activity Source: UniProtKB
  3. cellular response to electrical stimulus Source: MGI
  4. G-protein coupled glutamate receptor signaling pathway Source: RefGenome
  5. locomotory behavior Source: UniProtKB
  6. phospholipase C-activating G-protein coupled glutamate receptor signaling pathway Source: GOC
  7. protein kinase C-activating G-protein coupled receptor signaling pathway Source: RefGenome
  8. regulation of MAPK cascade Source: UniProtKB
  9. regulation of sensory perception of pain Source: UniProtKB
  10. regulation of synaptic transmission, glutamatergic Source: RefGenome
  11. sensory perception of pain Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Metabotropic glutamate receptor 1
Short name:
mGluR1
Gene namesi
Name:Grm1
Synonyms:Gprc1a, Mglur1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1351338. Grm1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 593573Extracellular Reviewed predictionAdd
BLAST
Transmembranei594 – 61421Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini615 – 62915Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei630 – 65021Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini651 – 66010Extracellular Reviewed prediction
Transmembranei661 – 68121Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini682 – 70625Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei707 – 72721Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini728 – 75124Extracellular Reviewed predictionAdd
BLAST
Transmembranei752 – 77221Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini773 – 78614Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei787 – 80721Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini808 – 8114Extracellular Reviewed prediction
Transmembranei812 – 83221Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini833 – 1199367Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. dendrite Source: UniProtKB
  2. G-protein coupled receptor homodimeric complex Source: Ensembl
  3. integral component of plasma membrane Source: RefGenome
  4. neuronal cell body Source: UniProtKB
  5. neuron projection Source: BHF-UCL
  6. nucleus Source: MGI
  7. postsynaptic density Source: MGI
  8. postsynaptic membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Chaini21 – 11991179Metabotropic glutamate receptor 1PRO_0000012923Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi67 ↔ 109 By similarity
Glycosylationi98 – 981N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi140 – 140Interchain By similarity
Glycosylationi223 – 2231N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi289 ↔ 291 By similarity
Disulfide bondi378 ↔ 394 By similarity
Glycosylationi397 – 3971N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi432 ↔ 439 By similarity
Glycosylationi515 – 5151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi747 – 7471N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP97772.
PRIDEiP97772.

PTM databases

PhosphoSiteiP97772.

Expressioni

Gene expression databases

BgeeiP97772.
CleanExiMM_GRM1.
GenevestigatoriP97772.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP By similarity.

Protein-protein interaction databases

BioGridi200073. 9 interactions.
IntActiP97772. 4 interactions.
MINTiMINT-4595385.

Structurei

3D structure databases

ProteinModelPortaliP97772.
SMRiP97772. Positions 35-578, 581-846.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni186 – 1883Glutamate binding By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1014 – 104128Gln/Pro-richAdd
BLAST
Compositional biasi1073 – 108715Gln/Pro-richAdd
BLAST
Compositional biasi1101 – 113535Asp/Glu-rich (acidic)Add
BLAST
Compositional biasi1147 – 119953Ser-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG295200.
GeneTreeiENSGT00750000117484.
HOGENOMiHOG000218636.
HOVERGENiHBG107965.
InParanoidiP97772.
KOiK04603.
OMAiKTNETAC.
OrthoDBiEOG7Z0JXG.
PhylomeDBiP97772.
TreeFamiTF313240.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001256. GPCR_3_mtglu_rcpt_1.
IPR019588. Metabotropic_Glu_rcpt_Homer-bd.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF10606. GluR_Homer-bdg. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PR01051. MTABOTROPC1R.
PR00593. MTABOTROPICR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P97772-1) [UniParc]FASTAAdd to Basket

Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVRLLLIFFP MIFLEMSILP RMPDRKVLLA GASSQRSVAR MDGDVIIGAL     50
FSVHHQPPAE KVPERKCGEI REQYGIQRVE AMFHTLDKIN ADPVLLPNIT 100
LGSEIRDSCW HSSVALEQSI EFIRDSLISI RDEKDGLNRC LPDGQTLPPG 150
RTKKPIAGVI GPGSSSVAIQ VQNLLQLFDI PQIAYSATSI DLSDKTLYKY 200
FLRVVPSDTL QARAMLDIVK RYNWTYVSAV HTEGNYGESG MDAFKELAAQ 250
EGLCIAHSDK IYSNAGEKSF DRLLRKLRER LPKARVVVCF CEGMTVRGLL 300
SAMRRLGVVG EFSLIGSDGW ADRDEVIEGY EVEANGGITI KLQSPEVRSF 350
DDYFLKLRLD TNTRNPWFPE FWQHRFQCRL PGHLLENPNF KKVCTGNESL 400
EENYVQDSKM GFVINAIYAM AHGLQNMHHA LCPGYVGLCD AMKPIDGRKL 450
LDFLIKSSFV GVSGEEVWFD EKGDAPGRYD IMNLQYTEAN RYDYVHVGTW 500
HEGVLNIDDY KIQMNKSGMV RSVCSEPCLK GQIKVIRKGE VSCCWICTAC 550
KENEFVQDEF TCRACDLGWW PNAELTGCEP ITIRYLEWSD IESIIAIAFS 600
CLGILVTLFV TLIFVLYRDT PVVKSSSREL CYIILAGIFL GYVCPFTLIA 650
KPTTTSCYLQ RLLVGLSSAM CYSALVTKTN RIARILAGSK KKICTRKPRF 700
MSAWAQVIIA SILISVQLTL VVTLIIMEPP MPILSYPSIK EVYLICNTSN 750
LGVVAPVGYN GLLIMSCTYY AFKTRNVPAN FNEAKYIAFT MYTTCIIWLA 800
FVPIYFGSNY KIITTCFAVS LSVTVALGCM FTPKMYIIIA KPERNVRSAF 850
TTSDVVRMHV GDGKLPCRSN TFLNIFRRKK PGAGNANSNG KSVSWSEPGG 900
RQAPKGQHVW QRLSVHVKTN ETACNQTAVI KPLTKSYQGS GKSLTFSDAS 950
TKTLYNVEEE DNTPSTHFSP PSSPSMVVHR RGPPVATTPP LPPHLSAEET 1000
PLFLADSVIP KGLPPPLPQQ QQQPPPQPPP QQPKSLMDQL QGVVTNFGSG 1050
IPDFHAVLAG PGTPGNGLRS LYPPPPPPQH LQMLPLQLST FREEPISPPG 1100
EDDDDDSSER FKLLQEFVYE REGNTEEDDL EEEEDLPAAS KLTPEDSPAL 1150
TPPSPFRDSV ASGSSVPSSP VSESVLCTPP NVTYASVILR DYKQSSSTL 1199
Length:1,199
Mass (Da):133,212
Last modified:April 11, 2003 - v2
Checksum:iFE5370AF160CC16E
GO
Isoform 2 (identifier: P97772-2) [UniParc]FASTAAdd to Basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     887-906: NSNGKSVSWSEPGGRQAPKG → KKRQPEFSPSSQCPSAHVQL
     907-1199: Missing.

Show »
Length:906
Mass (Da):101,710
Checksum:iB9223F00A9C6851C
GO
Isoform 3 (identifier: P97772-3) [UniParc]FASTAAdd to Basket

Also known as: E55

The sequence of this isoform differs from the canonical sequence as follows:
     317-321: SDGWA → RDSRN
     322-1199: Missing.

Show »
Length:321
Mass (Da):35,852
Checksum:i9DC2B123A5211A2C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei317 – 3215SDGWA → RDSRN in isoform 3. VSP_007184
Alternative sequencei322 – 1199878Missing in isoform 3. VSP_007185Add
BLAST
Alternative sequencei887 – 90620NSNGK…QAPKG → KKRQPEFSPSSQCPSAHVQL in isoform 2. VSP_007186Add
BLAST
Alternative sequencei907 – 1199293Missing in isoform 2. VSP_007187Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF320126 mRNA. Translation: AAG41991.2.
BC067057 mRNA. Translation: AAH67057.1.
BC079566 mRNA. Translation: AAH79566.1.
U89891 mRNA. Translation: AAB48099.1.
CCDSiCCDS23696.1. [P97772-1]
CCDS48499.1. [P97772-2]
RefSeqiNP_001107805.1. NM_001114333.2. [P97772-2]
NP_058672.1. NM_016976.3. [P97772-1]
XP_006512611.1. XM_006512548.1. [P97772-1]
XP_006512612.1. XM_006512549.1. [P97772-1]
XP_006512615.1. XM_006512552.1. [P97772-2]
UniGeneiMm.391904.
Mm.482986.

Genome annotation databases

EnsembliENSMUST00000044306; ENSMUSP00000037255; ENSMUSG00000019828. [P97772-1]
ENSMUST00000105560; ENSMUSP00000101189; ENSMUSG00000019828. [P97772-2]
ENSMUST00000105561; ENSMUSP00000101190; ENSMUSG00000019828. [P97772-2]
GeneIDi14816.
KEGGimmu:14816.
UCSCiuc007ejh.2. mouse. [P97772-2]
uc007eji.2. mouse. [P97772-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF320126 mRNA. Translation: AAG41991.2 .
BC067057 mRNA. Translation: AAH67057.1 .
BC079566 mRNA. Translation: AAH79566.1 .
U89891 mRNA. Translation: AAB48099.1 .
CCDSi CCDS23696.1. [P97772-1 ]
CCDS48499.1. [P97772-2 ]
RefSeqi NP_001107805.1. NM_001114333.2. [P97772-2 ]
NP_058672.1. NM_016976.3. [P97772-1 ]
XP_006512611.1. XM_006512548.1. [P97772-1 ]
XP_006512612.1. XM_006512549.1. [P97772-1 ]
XP_006512615.1. XM_006512552.1. [P97772-2 ]
UniGenei Mm.391904.
Mm.482986.

3D structure databases

ProteinModelPortali P97772.
SMRi P97772. Positions 35-578, 581-846.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200073. 9 interactions.
IntActi P97772. 4 interactions.
MINTi MINT-4595385.

Chemistry

BindingDBi P97772.
ChEMBLi CHEMBL2892.
GuidetoPHARMACOLOGYi 289.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P97772.

Proteomic databases

PaxDbi P97772.
PRIDEi P97772.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000044306 ; ENSMUSP00000037255 ; ENSMUSG00000019828 . [P97772-1 ]
ENSMUST00000105560 ; ENSMUSP00000101189 ; ENSMUSG00000019828 . [P97772-2 ]
ENSMUST00000105561 ; ENSMUSP00000101190 ; ENSMUSG00000019828 . [P97772-2 ]
GeneIDi 14816.
KEGGi mmu:14816.
UCSCi uc007ejh.2. mouse. [P97772-2 ]
uc007eji.2. mouse. [P97772-1 ]

Organism-specific databases

CTDi 2911.
MGIi MGI:1351338. Grm1.

Phylogenomic databases

eggNOGi NOG295200.
GeneTreei ENSGT00750000117484.
HOGENOMi HOG000218636.
HOVERGENi HBG107965.
InParanoidi P97772.
KOi K04603.
OMAi KTNETAC.
OrthoDBi EOG7Z0JXG.
PhylomeDBi P97772.
TreeFami TF313240.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 287019.
PROi P97772.
SOURCEi Search...

Gene expression databases

Bgeei P97772.
CleanExi MM_GRM1.
Genevestigatori P97772.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001256. GPCR_3_mtglu_rcpt_1.
IPR019588. Metabotropic_Glu_rcpt_Homer-bd.
IPR028082. Peripla_BP_I.
[Graphical view ]
Pfami PF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF10606. GluR_Homer-bdg. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view ]
PRINTSi PR00248. GPCRMGR.
PR01051. MTABOTROPC1R.
PR00593. MTABOTROPICR.
SUPFAMi SSF53822. SSF53822. 1 hit.
PROSITEi PS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of novel splice variants of mouse mGluR1."
    Zhu H., Ryan K., Chen S.
    Brain Res. Mol. Brain Res. 73:93-103(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
    Strain: ICR.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6.
    Tissue: Brain.
  3. Watanabe M.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 945-1127 (ISOFORM 1).
    Strain: C57BL/6J.
  4. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiGRM1_MOUSE
AccessioniPrimary (citable) accession number: P97772
Secondary accession number(s): Q6AXG4, Q9EPV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: April 11, 2003
Last modified: September 3, 2014
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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