P97769CITE1_MOUSECbp/p300-interacting transactivator 1Melanocyte-specific protein 1Cited1Msg1Mus musculusMouseEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMusmsg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation.NUCLEOTIDE SEQUENCE [MRNA]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors.FUNCTIONINTERACTION WITH CREBBP AND EP300Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein.SUBCELLULAR LOCATIONTISSUE SPECIFICITYCited1 is required in trophoblasts for placental development and for embryo growth and survival.FUNCTIONDISRUPTION PHENOTYPESUBCELLULAR LOCATIONDEVELOPMENTAL STAGEAn EGR2/CITED1 transcription factor complex and the 14-3-3sigma tumor suppressor are involved in regulating ErbB2 expression in a transgenic-mouse model of human breast cancer.INTERACTION WITH EGR2SUBCELLULAR LOCATIONTISSUE SPECIFICITYCBP/p300-interacting protein CITED1 modulates parathyroid hormone regulation of osteoblastic differentiation.FUNCTIONDISRUPTION PHENOTYPETISSUE SPECIFICITYINDUCTIONTranscriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner.Homodimer. Binds to RBM14. Interacts (via N-terminus) with HSPA8; the interaction suppresses the association of CITED1 with p300/CBP and SMAD-mediated transcription transactivation. Interacts (via C-terminus) with TOX3 (via HGM box); the interaction increases estrogen-response element (ERE)-dependent transcription and protection against cell death. Interacts with ESR1; the interaction occurs in a estrogen-dependent manner (By similarity). Interacts (unphosphorylated form preferentially and via C-terminus) with EP300. Interacts (via C-terminus) with CREBBP. Interacts with EGR2.NucleusCytoplasmShuttles between the nucleus and the cytoplasm by a nuclear export signal (NES) and in a CRM1-dependent manner.Expressed in calvarial osteoblasts. Expressed in nulliparous mammary epithelial cells; absent in pregnant mice and in lacting mammary glands. Also expressed in mammary tumors (at protein level). Expressed only in melanocytes and testis. Expressed at high levels in the strongly pigmented melanoma cells but at low levels in the weakly pigmented cells.Expressed in trophectoderm-derived cells of the placenta.Up-regulated by parathyroid hormone, forskolin and phorbol ester in osteoblasts.Phosphorylated. Phosphorylation changes in a cell cycle-dependent manner and reduces its transcriptional cofactor activity (By similarity).Mice die shortly after birth. Mice show an abnormal placental development; the spongiotrophoblast layer is irregular in shape and enlarged while the labyrinthine layer is reduced in size, the blood spaces within the labyrinthine are disrupted. Produces more mineralized bone nodules and deposited twice as much calcium in the matrix.Belongs to the CITED family.ActivatorApoptosisCytoplasmDevelopmental proteinDifferentiationNucleusPhosphoproteinReference proteomeTranscriptionTranscription regulationMPTMSRPALDVKGGTTSGKEDANQEMNSLAYSNLGVKDRKAVTVLHYPGVTANGAKANGVPTSSSGSTSPIGSPTATPSSKPPSFNLHPTPHLMASMQLQKLNSQYQGAAATAAAALTGAGLPGEEEPMQNWVTAPLVVGGSPGSVSPPAGAQSPALIDSDPVDEEVLMSLVVELGLDRANELPELWLGQNEFDFTADFPSGC
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