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P97769

- CITE1_MOUSE

UniProt

P97769 - CITE1_MOUSE

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Protein

Cbp/p300-interacting transactivator 1

Gene

Cited1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional coactivator of the p300/CBP-mediated trancription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner.3 Publications

GO - Molecular functioni

  1. chromatin binding Source: UniProtKB
  2. protein homodimerization activity Source: UniProtKB
  3. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  4. transcription coactivator activity Source: UniProtKB
  5. transcription regulatory region DNA binding Source: Ensembl

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. brain development Source: UniProtKB
  3. embryonic axis specification Source: Ensembl
  4. labyrinthine layer development Source: MGI
  5. melanin biosynthetic process Source: UniProtKB
  6. melanocyte differentiation Source: UniProtKB
  7. negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Source: Ensembl
  8. negative regulation of neuron apoptotic process Source: UniProtKB
  9. negative regulation of osteoblast differentiation Source: UniProtKB
  10. negative regulation of transcription, DNA-templated Source: UniProtKB
  11. nucleocytoplasmic transport Source: UniProtKB
  12. pigmentation Source: UniProtKB
  13. placenta development Source: UniProtKB
  14. positive regulation of gene expression Source: UniProtKB
  15. positive regulation of transcription, DNA-templated Source: UniProtKB
  16. response to cAMP Source: UniProtKB
  17. response to cytokine Source: UniProtKB
  18. response to estrogen Source: Ensembl
  19. response to insulin Source: UniProtKB
  20. response to interferon-gamma Source: UniProtKB
  21. response to interleukin-1 Source: UniProtKB
  22. response to interleukin-11 Source: UniProtKB
  23. response to interleukin-2 Source: UniProtKB
  24. response to interleukin-4 Source: UniProtKB
  25. response to interleukin-6 Source: UniProtKB
  26. response to interleukin-9 Source: UniProtKB
  27. response to lipopolysaccharide Source: UniProtKB
  28. response to parathyroid hormone Source: UniProtKB
  29. response to transforming growth factor beta Source: UniProtKB
  30. SMAD protein signal transduction Source: Ensembl
  31. spongiotrophoblast layer development Source: MGI
  32. transcription, DNA-templated Source: UniProtKB-KW
  33. transforming growth factor beta receptor signaling pathway Source: Ensembl
  34. vasculogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Apoptosis, Differentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cbp/p300-interacting transactivator 1
Alternative name(s):
Melanocyte-specific protein 1
Gene namesi
Name:Cited1
Synonyms:Msg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:108023. Cited1.

Subcellular locationi

Nucleus 3 Publications. Cytoplasm By similarity
Note: Shuttles between the nucleus and the cytoplasm by a nuclear export signal (NES) and in a CRM1-dependent manner.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytosol Source: UniProtKB
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice die shortly after birth. Mice show an abnormal placental development; the spongiotrophoblast layer is irregular in shape and enlarged while the labyrinthine layer is reduced in size, the blood spaces within the labyrinthine are disrupted. Produces more mineralized bone nodules and deposited twice as much calcium in the matrix.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 203203Cbp/p300-interacting transactivator 1PRO_0000144725Add
BLAST

Post-translational modificationi

Phosphorylated. Phosphorylation changes in a cell cycle-dependent manner and reduces its transcriptional cofactor activity (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP97769.

PTM databases

PhosphoSiteiP97769.

Expressioni

Tissue specificityi

Expressed in calvarial osteoblasts. Expressed in nulliparous mammary epithelial cells; absent in pregnant mice and in lacting mammary glands. Also expressed in mammary tumors (at protein level). Expressed only in melanocytes and testis. Expressed at high levels in the strongly pigmented melanoma cells but at low levels in the weakly pigmented cells.3 Publications

Developmental stagei

Expressed in trophectoderm-derived cells of the placenta.1 Publication

Inductioni

Up-regulated by parathyroid hormone, forskolin and phorbol ester in osteoblasts.1 Publication

Gene expression databases

BgeeiP97769.
ExpressionAtlasiP97769. baseline and differential.
GenevestigatoriP97769.

Interactioni

Subunit structurei

Homodimer. Binds to RBM14. Interacts (via N-terminus) with HSPA8; the interaction suppresses the association of CITED1 with p300/CBP and SMAD-mediated transcription transactivation. Interacts (via C-terminus) with TOX3 (via HGM box); the interaction increases estrogen-response element (ERE)-dependent transcription and protection against cell death. Interacts with ESR1; the interaction occurs in a estrogen-dependent manner (By similarity). Interacts (unphosphorylated form preferentially and via C-terminus) with EP300. Interacts (via C-terminus) with CREBBP. Interacts with EGR2.By similarity2 Publications

Protein-protein interaction databases

BioGridi198721. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP97769.
SMRiP97769. Positions 160-199.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi168 – 17710Nuclear export signalBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi159 – 19840Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the CITED family.Curated

Phylogenomic databases

eggNOGiNOG41708.
HOGENOMiHOG000072675.
HOVERGENiHBG075182.
InParanoidiP97769.
OMAiQYHGMAA.
OrthoDBiEOG7TJ3K5.
PhylomeDBiP97769.
TreeFamiTF331915.

Family and domain databases

InterProiIPR007576. CITED.
[Graphical view]
PANTHERiPTHR17045. PTHR17045. 1 hit.
PfamiPF04487. CITED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97769-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPTMSRPALD VKGGTTSGKE DANQEMNSLA YSNLGVKDRK AVTVLHYPGV
60 70 80 90 100
TANGAKANGV PTSSSGSTSP IGSPTATPSS KPPSFNLHPT PHLMASMQLQ
110 120 130 140 150
KLNSQYQGAA ATAAAALTGA GLPGEEEPMQ NWVTAPLVVG GSPGSVSPPA
160 170 180 190 200
GAQSPALIDS DPVDEEVLMS LVVELGLDRA NELPELWLGQ NEFDFTADFP

SGC
Length:203
Mass (Da):20,800
Last modified:May 1, 1997 - v1
Checksum:iBE968A5182873003
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65091 mRNA. Translation: AAC53048.1.
BC052030 mRNA. Translation: AAH52030.1.
CCDSiCCDS30322.1.
PIRiJC6113.
RefSeqiNP_001263395.1. NM_001276466.1.
NP_001263402.1. NM_001276473.1.
NP_001263403.1. NM_001276474.1.
NP_031735.1. NM_007709.4.
UniGeneiMm.2390.

Genome annotation databases

EnsembliENSMUST00000050551; ENSMUSP00000051789; ENSMUSG00000051159.
ENSMUST00000101336; ENSMUSP00000098890; ENSMUSG00000051159.
GeneIDi12705.
KEGGimmu:12705.
UCSCiuc009tyn.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65091 mRNA. Translation: AAC53048.1 .
BC052030 mRNA. Translation: AAH52030.1 .
CCDSi CCDS30322.1.
PIRi JC6113.
RefSeqi NP_001263395.1. NM_001276466.1.
NP_001263402.1. NM_001276473.1.
NP_001263403.1. NM_001276474.1.
NP_031735.1. NM_007709.4.
UniGenei Mm.2390.

3D structure databases

ProteinModelPortali P97769.
SMRi P97769. Positions 160-199.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198721. 1 interaction.

PTM databases

PhosphoSitei P97769.

Proteomic databases

PRIDEi P97769.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000050551 ; ENSMUSP00000051789 ; ENSMUSG00000051159 .
ENSMUST00000101336 ; ENSMUSP00000098890 ; ENSMUSG00000051159 .
GeneIDi 12705.
KEGGi mmu:12705.
UCSCi uc009tyn.2. mouse.

Organism-specific databases

CTDi 4435.
MGIi MGI:108023. Cited1.

Phylogenomic databases

eggNOGi NOG41708.
HOGENOMi HOG000072675.
HOVERGENi HBG075182.
InParanoidi P97769.
OMAi QYHGMAA.
OrthoDBi EOG7TJ3K5.
PhylomeDBi P97769.
TreeFami TF331915.

Miscellaneous databases

ChiTaRSi Cited1. mouse.
NextBioi 281970.
PROi P97769.
SOURCEi Search...

Gene expression databases

Bgeei P97769.
ExpressionAtlasi P97769. baseline and differential.
Genevestigatori P97769.

Family and domain databases

InterProi IPR007576. CITED.
[Graphical view ]
PANTHERi PTHR17045. PTHR17045. 1 hit.
Pfami PF04487. CITED. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation."
    Shioda T., Fenner M.H., Isselbacher K.J.
    Proc. Natl. Acad. Sci. U.S.A. 93:12298-12303(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. "The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors."
    Yahata T., de Caestecker M.P., Lechleider R.J., Andriole S., Roberts A.B., Isselbacher K.J., Shioda T.
    J. Biol. Chem. 275:8825-8834(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CREBBP AND EP300.
  4. "Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein."
    Yahata T., Shao W., Endoh H., Hur J., Coser K.R., Sun H., Ueda Y., Kato S., Isselbacher K.J., Brown M., Shioda T.
    Genes Dev. 15:2598-2612(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  5. "Cited1 is required in trophoblasts for placental development and for embryo growth and survival."
    Rodriguez T.A., Sparrow D.B., Scott A.N., Withington S.L., Preis J.I., Michalicek J., Clements M., Tsang T.E., Shioda T., Beddington R.S., Dunwoodie S.L.
    Mol. Cell. Biol. 24:228-244(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
  6. "An EGR2/CITED1 transcription factor complex and the 14-3-3sigma tumor suppressor are involved in regulating ErbB2 expression in a transgenic-mouse model of human breast cancer."
    Dillon R.L., Brown S.T., Ling C., Shioda T., Muller W.J.
    Mol. Cell. Biol. 27:8648-8657(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH EGR2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  7. "CBP/p300-interacting protein CITED1 modulates parathyroid hormone regulation of osteoblastic differentiation."
    Yang D., Guo J., Divieti P., Shioda T., Bringhurst F.R.
    Endocrinology 149:1728-1735(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, INDUCTION.

Entry informationi

Entry nameiCITE1_MOUSE
AccessioniPrimary (citable) accession number: P97769
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: November 26, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3