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P97769

- CITE1_MOUSE

UniProt

P97769 - CITE1_MOUSE

Protein

Cbp/p300-interacting transactivator 1

Gene

Cited1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Transcriptional coactivator of the p300/CBP-mediated trancription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner.3 Publications

    GO - Molecular functioni

    1. chromatin binding Source: UniProtKB
    2. protein binding Source: UniProtKB
    3. protein homodimerization activity Source: UniProtKB
    4. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    5. transcription coactivator activity Source: UniProtKB
    6. transcription regulatory region DNA binding Source: Ensembl

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. brain development Source: UniProtKB
    3. embryonic axis specification Source: Ensembl
    4. labyrinthine layer development Source: MGI
    5. melanin biosynthetic process Source: UniProtKB
    6. melanocyte differentiation Source: UniProtKB
    7. negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Source: Ensembl
    8. negative regulation of neuron apoptotic process Source: UniProtKB
    9. negative regulation of osteoblast differentiation Source: UniProtKB
    10. negative regulation of transcription, DNA-templated Source: UniProtKB
    11. nucleocytoplasmic transport Source: UniProtKB
    12. pigmentation Source: UniProtKB
    13. placenta development Source: UniProtKB
    14. positive regulation of gene expression Source: UniProtKB
    15. positive regulation of transcription, DNA-templated Source: UniProtKB
    16. response to cAMP Source: UniProtKB
    17. response to cytokine Source: UniProtKB
    18. response to estrogen Source: Ensembl
    19. response to insulin Source: UniProtKB
    20. response to interferon-gamma Source: UniProtKB
    21. response to interleukin-1 Source: UniProtKB
    22. response to interleukin-11 Source: UniProtKB
    23. response to interleukin-2 Source: UniProtKB
    24. response to interleukin-4 Source: UniProtKB
    25. response to interleukin-6 Source: UniProtKB
    26. response to interleukin-9 Source: UniProtKB
    27. response to lipopolysaccharide Source: UniProtKB
    28. response to parathyroid hormone Source: UniProtKB
    29. response to transforming growth factor beta Source: UniProtKB
    30. SMAD protein signal transduction Source: Ensembl
    31. spongiotrophoblast layer development Source: MGI
    32. transcription, DNA-templated Source: UniProtKB-KW
    33. transforming growth factor beta receptor signaling pathway Source: Ensembl
    34. vasculogenesis Source: MGI

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Apoptosis, Differentiation, Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cbp/p300-interacting transactivator 1
    Alternative name(s):
    Melanocyte-specific protein 1
    Gene namesi
    Name:Cited1
    Synonyms:Msg1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:108023. Cited1.

    Subcellular locationi

    Nucleus 3 Publications. Cytoplasm By similarity
    Note: Shuttles between the nucleus and the cytoplasm by a nuclear export signal (NES) and in a CRM1-dependent manner.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: UniProtKB
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Mice die shortly after birth. Mice show an abnormal placental development; the spongiotrophoblast layer is irregular in shape and enlarged while the labyrinthine layer is reduced in size, the blood spaces within the labyrinthine are disrupted. Produces more mineralized bone nodules and deposited twice as much calcium in the matrix.2 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 203203Cbp/p300-interacting transactivator 1PRO_0000144725Add
    BLAST

    Post-translational modificationi

    Phosphorylated. Phosphorylation changes in a cell cycle-dependent manner and reduces its transcriptional cofactor activity By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP97769.

    PTM databases

    PhosphoSiteiP97769.

    Expressioni

    Tissue specificityi

    Expressed in calvarial osteoblasts. Expressed in nulliparous mammary epithelial cells; absent in pregnant mice and in lacting mammary glands. Also expressed in mammary tumors (at protein level). Expressed only in melanocytes and testis. Expressed at high levels in the strongly pigmented melanoma cells but at low levels in the weakly pigmented cells.3 Publications

    Developmental stagei

    Expressed in trophectoderm-derived cells of the placenta.1 Publication

    Inductioni

    Up-regulated by parathyroid hormone, forskolin and phorbol ester in osteoblasts.1 Publication

    Gene expression databases

    BgeeiP97769.
    GenevestigatoriP97769.

    Interactioni

    Subunit structurei

    Homodimer. Binds to RBM14. Interacts (via N-terminus) with HSPA8; the interaction suppresses the association of CITED1 with p300/CBP and SMAD-mediated transcription transactivation. Interacts (via C-terminus) with TOX3 (via HGM box); the interaction increases estrogen-response element (ERE)-dependent transcription and protection against cell death. Interacts with ESR1; the interaction occurs in a estrogen-dependent manner By similarity. Interacts (unphosphorylated form preferentially and via C-terminus) with EP300. Interacts (via C-terminus) with CREBBP. Interacts with EGR2.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi198721. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP97769.
    SMRiP97769. Positions 160-199.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi168 – 17710Nuclear export signalBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi159 – 19840Asp/Glu-rich (acidic)Add
    BLAST

    Sequence similaritiesi

    Belongs to the CITED family.Curated

    Phylogenomic databases

    eggNOGiNOG41708.
    HOGENOMiHOG000072675.
    HOVERGENiHBG075182.
    InParanoidiP97769.
    OMAiQYHGMAA.
    OrthoDBiEOG7TJ3K5.
    PhylomeDBiP97769.
    TreeFamiTF331915.

    Family and domain databases

    InterProiIPR007576. CITED.
    [Graphical view]
    PANTHERiPTHR17045. PTHR17045. 1 hit.
    PfamiPF04487. CITED. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P97769-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPTMSRPALD VKGGTTSGKE DANQEMNSLA YSNLGVKDRK AVTVLHYPGV    50
    TANGAKANGV PTSSSGSTSP IGSPTATPSS KPPSFNLHPT PHLMASMQLQ 100
    KLNSQYQGAA ATAAAALTGA GLPGEEEPMQ NWVTAPLVVG GSPGSVSPPA 150
    GAQSPALIDS DPVDEEVLMS LVVELGLDRA NELPELWLGQ NEFDFTADFP 200
    SGC 203
    Length:203
    Mass (Da):20,800
    Last modified:May 1, 1997 - v1
    Checksum:iBE968A5182873003
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U65091 mRNA. Translation: AAC53048.1.
    BC052030 mRNA. Translation: AAH52030.1.
    CCDSiCCDS30322.1.
    PIRiJC6113.
    RefSeqiNP_001263395.1. NM_001276466.1.
    NP_001263402.1. NM_001276473.1.
    NP_001263403.1. NM_001276474.1.
    NP_031735.1. NM_007709.4.
    UniGeneiMm.2390.

    Genome annotation databases

    EnsembliENSMUST00000050551; ENSMUSP00000051789; ENSMUSG00000051159.
    ENSMUST00000101336; ENSMUSP00000098890; ENSMUSG00000051159.
    GeneIDi12705.
    KEGGimmu:12705.
    UCSCiuc009tyn.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U65091 mRNA. Translation: AAC53048.1 .
    BC052030 mRNA. Translation: AAH52030.1 .
    CCDSi CCDS30322.1.
    PIRi JC6113.
    RefSeqi NP_001263395.1. NM_001276466.1.
    NP_001263402.1. NM_001276473.1.
    NP_001263403.1. NM_001276474.1.
    NP_031735.1. NM_007709.4.
    UniGenei Mm.2390.

    3D structure databases

    ProteinModelPortali P97769.
    SMRi P97769. Positions 160-199.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198721. 1 interaction.

    PTM databases

    PhosphoSitei P97769.

    Proteomic databases

    PRIDEi P97769.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000050551 ; ENSMUSP00000051789 ; ENSMUSG00000051159 .
    ENSMUST00000101336 ; ENSMUSP00000098890 ; ENSMUSG00000051159 .
    GeneIDi 12705.
    KEGGi mmu:12705.
    UCSCi uc009tyn.2. mouse.

    Organism-specific databases

    CTDi 4435.
    MGIi MGI:108023. Cited1.

    Phylogenomic databases

    eggNOGi NOG41708.
    HOGENOMi HOG000072675.
    HOVERGENi HBG075182.
    InParanoidi P97769.
    OMAi QYHGMAA.
    OrthoDBi EOG7TJ3K5.
    PhylomeDBi P97769.
    TreeFami TF331915.

    Miscellaneous databases

    ChiTaRSi CITED1. mouse.
    NextBioi 281970.
    PROi P97769.
    SOURCEi Search...

    Gene expression databases

    Bgeei P97769.
    Genevestigatori P97769.

    Family and domain databases

    InterProi IPR007576. CITED.
    [Graphical view ]
    PANTHERi PTHR17045. PTHR17045. 1 hit.
    Pfami PF04487. CITED. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation."
      Shioda T., Fenner M.H., Isselbacher K.J.
      Proc. Natl. Acad. Sci. U.S.A. 93:12298-12303(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    3. "The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors."
      Yahata T., de Caestecker M.P., Lechleider R.J., Andriole S., Roberts A.B., Isselbacher K.J., Shioda T.
      J. Biol. Chem. 275:8825-8834(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CREBBP AND EP300.
    4. "Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein."
      Yahata T., Shao W., Endoh H., Hur J., Coser K.R., Sun H., Ueda Y., Kato S., Isselbacher K.J., Brown M., Shioda T.
      Genes Dev. 15:2598-2612(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    5. "Cited1 is required in trophoblasts for placental development and for embryo growth and survival."
      Rodriguez T.A., Sparrow D.B., Scott A.N., Withington S.L., Preis J.I., Michalicek J., Clements M., Tsang T.E., Shioda T., Beddington R.S., Dunwoodie S.L.
      Mol. Cell. Biol. 24:228-244(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
    6. "An EGR2/CITED1 transcription factor complex and the 14-3-3sigma tumor suppressor are involved in regulating ErbB2 expression in a transgenic-mouse model of human breast cancer."
      Dillon R.L., Brown S.T., Ling C., Shioda T., Muller W.J.
      Mol. Cell. Biol. 27:8648-8657(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH EGR2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    7. "CBP/p300-interacting protein CITED1 modulates parathyroid hormone regulation of osteoblastic differentiation."
      Yang D., Guo J., Divieti P., Shioda T., Bringhurst F.R.
      Endocrinology 149:1728-1735(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, INDUCTION.

    Entry informationi

    Entry nameiCITE1_MOUSE
    AccessioniPrimary (citable) accession number: P97769
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3