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Protein

Cbp/p300-interacting transactivator 1

Gene

Cited1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner.3 Publications

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • brain development Source: UniProtKB
  • embryonic axis specification Source: Ensembl
  • labyrinthine layer development Source: MGI
  • melanin biosynthetic process Source: UniProtKB
  • melanocyte differentiation Source: UniProtKB
  • negative regulation of neuron apoptotic process Source: UniProtKB
  • negative regulation of osteoblast differentiation Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • nucleocytoplasmic transport Source: UniProtKB
  • pigmentation Source: UniProtKB
  • placenta development Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • regulation of transcription from RNA polymerase II promoter Source: GO_Central
  • response to cAMP Source: UniProtKB
  • response to cytokine Source: UniProtKB
  • response to estrogen Source: MGI
  • response to insulin Source: UniProtKB
  • response to interferon-gamma Source: UniProtKB
  • response to interleukin-1 Source: UniProtKB
  • response to interleukin-11 Source: UniProtKB
  • response to interleukin-2 Source: UniProtKB
  • response to interleukin-4 Source: UniProtKB
  • response to interleukin-6 Source: UniProtKB
  • response to interleukin-9 Source: UniProtKB
  • response to lipopolysaccharide Source: UniProtKB
  • response to parathyroid hormone Source: UniProtKB
  • response to transforming growth factor beta Source: UniProtKB
  • SMAD protein signal transduction Source: MGI
  • spongiotrophoblast layer development Source: MGI
  • transforming growth factor beta receptor signaling pathway Source: MGI
  • vasculogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Apoptosis, Differentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cbp/p300-interacting transactivator 1
Alternative name(s):
Melanocyte-specific protein 1
Gene namesi
Name:Cited1
Synonyms:Msg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:108023. Cited1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice die shortly after birth. Mice show an abnormal placental development; the spongiotrophoblast layer is irregular in shape and enlarged while the labyrinthine layer is reduced in size, the blood spaces within the labyrinthine are disrupted. Produces more mineralized bone nodules and deposited twice as much calcium in the matrix.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447251 – 203Cbp/p300-interacting transactivator 1Add BLAST203

Post-translational modificationi

Phosphorylated. Phosphorylation changes in a cell cycle-dependent manner and reduces its transcriptional cofactor activity (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP97769.
PRIDEiP97769.

PTM databases

iPTMnetiP97769.
PhosphoSitePlusiP97769.

Expressioni

Tissue specificityi

Expressed in calvarial osteoblasts. Expressed in nulliparous mammary epithelial cells; absent in pregnant mice and in lacting mammary glands. Also expressed in mammary tumors (at protein level). Expressed only in melanocytes and testis. Expressed at high levels in the strongly pigmented melanoma cells but at low levels in the weakly pigmented cells.3 Publications

Developmental stagei

Expressed in trophectoderm-derived cells of the placenta.1 Publication

Inductioni

Up-regulated by parathyroid hormone, forskolin and phorbol ester in osteoblasts.1 Publication

Gene expression databases

BgeeiENSMUSG00000051159.
ExpressionAtlasiP97769. baseline and differential.
GenevisibleiP97769. MM.

Interactioni

Subunit structurei

Homodimer. Binds to RBM14. Interacts (via N-terminus) with HSPA8; the interaction suppresses the association of CITED1 with p300/CBP and SMAD-mediated transcription transactivation. Interacts (via C-terminus) with TOX3 (via HGM box); the interaction increases estrogen-response element (ERE)-dependent transcription and protection against cell death. Interacts with ESR1; the interaction occurs in a estrogen-dependent manner (By similarity). Interacts (unphosphorylated form preferentially and via C-terminus) with EP300. Interacts (via C-terminus) with CREBBP. Interacts with EGR2.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198721. 1 interactor.
STRINGi10090.ENSMUSP00000051789.

Structurei

3D structure databases

ProteinModelPortaliP97769.
SMRiP97769.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi168 – 177Nuclear export signalBy similarity10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi159 – 198Asp/Glu-rich (acidic)Add BLAST40

Sequence similaritiesi

Belongs to the CITED family.Curated

Phylogenomic databases

eggNOGiENOG410J22W. Eukaryota.
ENOG4111X66. LUCA.
GeneTreeiENSGT00530000063624.
HOGENOMiHOG000072675.
HOVERGENiHBG075182.
InParanoidiP97769.
OMAiQYHGMAA.
OrthoDBiEOG091G0IQ0.
PhylomeDBiP97769.
TreeFamiTF331915.

Family and domain databases

InterProiIPR007576. CITED.
[Graphical view]
PANTHERiPTHR17045. PTHR17045. 1 hit.
PfamiPF04487. CITED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97769-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTMSRPALD VKGGTTSGKE DANQEMNSLA YSNLGVKDRK AVTVLHYPGV
60 70 80 90 100
TANGAKANGV PTSSSGSTSP IGSPTATPSS KPPSFNLHPT PHLMASMQLQ
110 120 130 140 150
KLNSQYQGAA ATAAAALTGA GLPGEEEPMQ NWVTAPLVVG GSPGSVSPPA
160 170 180 190 200
GAQSPALIDS DPVDEEVLMS LVVELGLDRA NELPELWLGQ NEFDFTADFP

SGC
Length:203
Mass (Da):20,800
Last modified:May 1, 1997 - v1
Checksum:iBE968A5182873003
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65091 mRNA. Translation: AAC53048.1.
BC052030 mRNA. Translation: AAH52030.1.
CCDSiCCDS30322.1.
PIRiJC6113.
RefSeqiNP_001263395.1. NM_001276466.1.
NP_001263402.1. NM_001276473.1.
NP_001263403.1. NM_001276474.1.
NP_031735.1. NM_007709.4.
UniGeneiMm.2390.

Genome annotation databases

EnsembliENSMUST00000050551; ENSMUSP00000051789; ENSMUSG00000051159.
ENSMUST00000101336; ENSMUSP00000098890; ENSMUSG00000051159.
GeneIDi12705.
KEGGimmu:12705.
UCSCiuc009tyn.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65091 mRNA. Translation: AAC53048.1.
BC052030 mRNA. Translation: AAH52030.1.
CCDSiCCDS30322.1.
PIRiJC6113.
RefSeqiNP_001263395.1. NM_001276466.1.
NP_001263402.1. NM_001276473.1.
NP_001263403.1. NM_001276474.1.
NP_031735.1. NM_007709.4.
UniGeneiMm.2390.

3D structure databases

ProteinModelPortaliP97769.
SMRiP97769.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198721. 1 interactor.
STRINGi10090.ENSMUSP00000051789.

PTM databases

iPTMnetiP97769.
PhosphoSitePlusiP97769.

Proteomic databases

PaxDbiP97769.
PRIDEiP97769.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050551; ENSMUSP00000051789; ENSMUSG00000051159.
ENSMUST00000101336; ENSMUSP00000098890; ENSMUSG00000051159.
GeneIDi12705.
KEGGimmu:12705.
UCSCiuc009tyn.3. mouse.

Organism-specific databases

CTDi4435.
MGIiMGI:108023. Cited1.

Phylogenomic databases

eggNOGiENOG410J22W. Eukaryota.
ENOG4111X66. LUCA.
GeneTreeiENSGT00530000063624.
HOGENOMiHOG000072675.
HOVERGENiHBG075182.
InParanoidiP97769.
OMAiQYHGMAA.
OrthoDBiEOG091G0IQ0.
PhylomeDBiP97769.
TreeFamiTF331915.

Miscellaneous databases

ChiTaRSiCited1. mouse.
PROiP97769.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051159.
ExpressionAtlasiP97769. baseline and differential.
GenevisibleiP97769. MM.

Family and domain databases

InterProiIPR007576. CITED.
[Graphical view]
PANTHERiPTHR17045. PTHR17045. 1 hit.
PfamiPF04487. CITED. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCITE1_MOUSE
AccessioniPrimary (citable) accession number: P97769
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.