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P97766

- CFC1_MOUSE

UniProt

P97766 - CFC1_MOUSE

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Protein
Cryptic protein
Gene
Cfc1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Nodal coreceptor involved in the correct establishment of the left-right axis. May play a role in mesoderm and/or neural patterning during gastrulation.2 Publications

GO - Molecular functioni

  1. activin receptor binding Source: UniProtKB

GO - Biological processi

  1. BMP signaling pathway Source: MGI
  2. anatomical structure development Source: MGI
  3. anterior/posterior pattern specification Source: MGI
  4. atrial septum morphogenesis Source: MGI
  5. canonical Wnt signaling pathway Source: MGI
  6. determination of left/right symmetry Source: MGI
  7. digestive tract morphogenesis Source: MGI
  8. endoderm development Source: MGI
  9. gastrulation Source: UniProtKB-KW
  10. heart looping Source: MGI
  11. heart morphogenesis Source: MGI
  12. left lung morphogenesis Source: MGI
  13. liver development Source: MGI
  14. nodal signaling pathway Source: UniProtKB
  15. post-embryonic development Source: MGI
  16. respiratory system development Source: MGI
  17. spleen development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Gastrulation

Enzyme and pathway databases

ReactomeiREACT_199125. Regulation of signaling by NODAL.
REACT_220645. Signaling by NODAL.

Names & Taxonomyi

Protein namesi
Recommended name:
Cryptic protein
Gene namesi
Name:Cfc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:109448. Cfc1.

Subcellular locationi

Cell membrane; Lipid-anchorGPI-anchor By similarity. Secreted By similarity

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. extracellular region Source: UniProtKB-SubCell
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Disruption phenotypei

Positional defects in internal organs. The lung presents a right pulmonary isomerism. The stomach is located on either the left or the right and the spleen is small and has an abnormal shape. The apex of the heart pointed to the right or left. In addition malpositioning of heart outflow tracts is observed, the aorta is connected to the right ventricle and emerged from the heart in a ventral position and to the right of the pulmonary artery. This one is connected to either the left or the right ventricle.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535 Reviewed prediction
Add
BLAST
Chaini36 – 166131Cryptic protein
PRO_0000044631Add
BLAST
Propeptidei167 – 20236Removed in mature form By similarity
PRO_0000395409Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi65 – 651N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi98 ↔ 105 By similarity
Disulfide bondi99 ↔ 111 By similarity
Disulfide bondi113 ↔ 122 By similarity
Lipidationi166 – 1661GPI-anchor amidated aspartate By similarity

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PRIDEiP97766.

Expressioni

Tissue specificityi

No expressed in adult tissues.1 Publication

Developmental stagei

Expressed during gastrulation (from 6.5 dpc to 11 dpc) in two spatial domains that correspond to the axial and lateral mesoderm. In the first domain expression is progressively localized to the anterior primitive streak, the head process, and the node and notochordal. In the second domain, expression is initially concentrated in the lateral region of the egg cylinder, and is later found circumferentially in the intermediate and lateral plate mesoderm. Furthermore, the expression can also be detected at the early head-fold stage in the midline neuroectoderm, and consequently is an early marker for the prospective floor plate of the neural tube. Expression ceases at the end of gastrulation, and has not been observed in later embryonic stages.1 Publication

Gene expression databases

BgeeiP97766.
CleanExiMM_CFC1.
GenevestigatoriP97766.

Structurei

3D structure databases

ProteinModelPortaliP97766.
SMRiP97766. Positions 99-166.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini94 – 12330EGF-like
Add
BLAST

Sequence similaritiesi

Contains 1 EGF-like domain.

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

eggNOGiNOG311092.
GeneTreeiENSGT00530000063804.
HOGENOMiHOG000090236.
HOVERGENiHBG099834.
InParanoidiP97766.
OMAiRGIASND.
OrthoDBiEOG7TJ3KK.
PhylomeDBiP97766.
TreeFamiTF333187.

Family and domain databases

InterProiIPR019011. Cryptic/Cripto_CFC-dom.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
[Graphical view]
PfamiPF09443. CFC. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97766-1 [UniParc]FASTAAdd to Basket

« Hide

MRANSPTQGI SLKMHQARPL FLVTVALQLI GLGYSYQSEG DGAREVSNIL    50
SPVIPGTTLD RTLSNSSRKN DIPEGARLWD SLPDSSTLGE SAVPVSRCCH 100
NGGTCVLGSF CVCPAYFTGR YCEHDQRRRD CGALGHGAWT LHSCRLCRCI 150
FSALYCLPHQ TFSHCDLKSF LSSGARGSRE CSIPSLLLLV LCLLLQGVAG 200
KG 202
Length:202
Mass (Da):21,792
Last modified:May 1, 1997 - v1
Checksum:i57035AD339A16FD7
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti83 – 831P → T in AAI00707. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U57720 mRNA. Translation: AAC53042.1.
BC100705 mRNA. Translation: AAI00706.1.
BC100706 mRNA. Translation: AAI00707.1.
BC100708 mRNA. Translation: AAI00709.1.
BC100711 mRNA. Translation: AAI00712.1.
AF242430 Genomic DNA. Translation: AAF76323.1.
CCDSiCCDS14869.1.
RefSeqiNP_031711.1. NM_007685.2.
UniGeneiMm.2531.

Genome annotation databases

EnsembliENSMUST00000027298; ENSMUSP00000027298; ENSMUSG00000026124.
GeneIDi12627.
KEGGimmu:12627.
UCSCiuc007aow.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U57720 mRNA. Translation: AAC53042.1 .
BC100705 mRNA. Translation: AAI00706.1 .
BC100706 mRNA. Translation: AAI00707.1 .
BC100708 mRNA. Translation: AAI00709.1 .
BC100711 mRNA. Translation: AAI00712.1 .
AF242430 Genomic DNA. Translation: AAF76323.1 .
CCDSi CCDS14869.1.
RefSeqi NP_031711.1. NM_007685.2.
UniGenei Mm.2531.

3D structure databases

ProteinModelPortali P97766.
SMRi P97766. Positions 99-166.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P97766.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027298 ; ENSMUSP00000027298 ; ENSMUSG00000026124 .
GeneIDi 12627.
KEGGi mmu:12627.
UCSCi uc007aow.1. mouse.

Organism-specific databases

CTDi 55997.
MGIi MGI:109448. Cfc1.

Phylogenomic databases

eggNOGi NOG311092.
GeneTreei ENSGT00530000063804.
HOGENOMi HOG000090236.
HOVERGENi HBG099834.
InParanoidi P97766.
OMAi RGIASND.
OrthoDBi EOG7TJ3KK.
PhylomeDBi P97766.
TreeFami TF333187.

Enzyme and pathway databases

Reactomei REACT_199125. Regulation of signaling by NODAL.
REACT_220645. Signaling by NODAL.

Miscellaneous databases

NextBioi 281804.
PROi P97766.
SOURCEi Search...

Gene expression databases

Bgeei P97766.
CleanExi MM_CFC1.
Genevestigatori P97766.

Family and domain databases

InterProi IPR019011. Cryptic/Cripto_CFC-dom.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
[Graphical view ]
Pfami PF09443. CFC. 1 hit.
[Graphical view ]
PROSITEi PS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A differential display strategy identifies Cryptic, a novel EGF-related gene expressed in the axial and lateral mesoderm during mouse gastrulation."
    Shen M.M., Wang H., Leder P.
    Development 124:429-442(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, GLYCOSYLATION.
    Strain: 129/Sv.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Subtractive hybridization identifies chick-cripto, a novel EGF-CFC ortholog expressed during gastrulation, neurulation and early cardiogenesis."
    Colas J.-F., Schoenwolf G.C.
    Gene 255:205-217(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-154.
  4. Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiCFC1_MOUSE
AccessioniPrimary (citable) accession number: P97766
Secondary accession number(s): Q496U5, Q9JIB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: May 1, 1997
Last modified: September 3, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi