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P97766

- CFC1_MOUSE

UniProt

P97766 - CFC1_MOUSE

Protein

Cryptic protein

Gene

Cfc1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Nodal coreceptor involved in the correct establishment of the left-right axis. May play a role in mesoderm and/or neural patterning during gastrulation.2 Publications

    GO - Molecular functioni

    1. activin receptor binding Source: UniProtKB

    GO - Biological processi

    1. anatomical structure development Source: MGI
    2. anterior/posterior pattern specification Source: MGI
    3. atrial septum morphogenesis Source: MGI
    4. BMP signaling pathway Source: MGI
    5. canonical Wnt signaling pathway Source: MGI
    6. determination of left/right symmetry Source: MGI
    7. digestive tract morphogenesis Source: MGI
    8. endoderm development Source: MGI
    9. gastrulation Source: UniProtKB-KW
    10. heart looping Source: MGI
    11. heart morphogenesis Source: MGI
    12. left lung morphogenesis Source: MGI
    13. liver development Source: MGI
    14. nodal signaling pathway Source: UniProtKB
    15. post-embryonic development Source: MGI
    16. respiratory system development Source: MGI
    17. spleen development Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Gastrulation

    Enzyme and pathway databases

    ReactomeiREACT_199125. Regulation of signaling by NODAL.
    REACT_220645. Signaling by NODAL.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cryptic protein
    Gene namesi
    Name:Cfc1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:109448. Cfc1.

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity. Secreted By similarity

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. extracellular region Source: UniProtKB-SubCell
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Disruption phenotypei

    Positional defects in internal organs. The lung presents a right pulmonary isomerism. The stomach is located on either the left or the right and the spleen is small and has an abnormal shape. The apex of the heart pointed to the right or left. In addition malpositioning of heart outflow tracts is observed, the aorta is connected to the right ventricle and emerged from the heart in a ventral position and to the right of the pulmonary artery. This one is connected to either the left or the right ventricle.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3535Sequence AnalysisAdd
    BLAST
    Chaini36 – 166131Cryptic proteinPRO_0000044631Add
    BLAST
    Propeptidei167 – 20236Removed in mature formBy similarityPRO_0000395409Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi98 ↔ 105PROSITE-ProRule annotation
    Disulfide bondi99 ↔ 111PROSITE-ProRule annotation
    Disulfide bondi113 ↔ 122PROSITE-ProRule annotation
    Lipidationi166 – 1661GPI-anchor amidated aspartateBy similarity

    Post-translational modificationi

    N-glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PRIDEiP97766.

    Expressioni

    Tissue specificityi

    No expressed in adult tissues.1 Publication

    Developmental stagei

    Expressed during gastrulation (from 6.5 dpc to 11 dpc) in two spatial domains that correspond to the axial and lateral mesoderm. In the first domain expression is progressively localized to the anterior primitive streak, the head process, and the node and notochordal. In the second domain, expression is initially concentrated in the lateral region of the egg cylinder, and is later found circumferentially in the intermediate and lateral plate mesoderm. Furthermore, the expression can also be detected at the early head-fold stage in the midline neuroectoderm, and consequently is an early marker for the prospective floor plate of the neural tube. Expression ceases at the end of gastrulation, and has not been observed in later embryonic stages.1 Publication

    Gene expression databases

    BgeeiP97766.
    CleanExiMM_CFC1.
    GenevestigatoriP97766.

    Structurei

    3D structure databases

    ProteinModelPortaliP97766.
    SMRiP97766. Positions 99-166.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini94 – 12330EGF-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 EGF-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Signal

    Phylogenomic databases

    eggNOGiNOG311092.
    GeneTreeiENSGT00530000063804.
    HOGENOMiHOG000090236.
    HOVERGENiHBG099834.
    InParanoidiP97766.
    OMAiRGIASND.
    OrthoDBiEOG7TJ3KK.
    PhylomeDBiP97766.
    TreeFamiTF333187.

    Family and domain databases

    InterProiIPR019011. Cryptic/Cripto_CFC-dom.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    [Graphical view]
    PfamiPF09443. CFC. 1 hit.
    [Graphical view]
    PROSITEiPS00022. EGF_1. 1 hit.
    PS50026. EGF_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P97766-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRANSPTQGI SLKMHQARPL FLVTVALQLI GLGYSYQSEG DGAREVSNIL    50
    SPVIPGTTLD RTLSNSSRKN DIPEGARLWD SLPDSSTLGE SAVPVSRCCH 100
    NGGTCVLGSF CVCPAYFTGR YCEHDQRRRD CGALGHGAWT LHSCRLCRCI 150
    FSALYCLPHQ TFSHCDLKSF LSSGARGSRE CSIPSLLLLV LCLLLQGVAG 200
    KG 202
    Length:202
    Mass (Da):21,792
    Last modified:May 1, 1997 - v1
    Checksum:i57035AD339A16FD7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti83 – 831P → T in AAI00707. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U57720 mRNA. Translation: AAC53042.1.
    BC100705 mRNA. Translation: AAI00706.1.
    BC100706 mRNA. Translation: AAI00707.1.
    BC100708 mRNA. Translation: AAI00709.1.
    BC100711 mRNA. Translation: AAI00712.1.
    AF242430 Genomic DNA. Translation: AAF76323.1.
    CCDSiCCDS14869.1.
    RefSeqiNP_031711.1. NM_007685.2.
    UniGeneiMm.2531.

    Genome annotation databases

    EnsembliENSMUST00000027298; ENSMUSP00000027298; ENSMUSG00000026124.
    GeneIDi12627.
    KEGGimmu:12627.
    UCSCiuc007aow.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U57720 mRNA. Translation: AAC53042.1 .
    BC100705 mRNA. Translation: AAI00706.1 .
    BC100706 mRNA. Translation: AAI00707.1 .
    BC100708 mRNA. Translation: AAI00709.1 .
    BC100711 mRNA. Translation: AAI00712.1 .
    AF242430 Genomic DNA. Translation: AAF76323.1 .
    CCDSi CCDS14869.1.
    RefSeqi NP_031711.1. NM_007685.2.
    UniGenei Mm.2531.

    3D structure databases

    ProteinModelPortali P97766.
    SMRi P97766. Positions 99-166.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P97766.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027298 ; ENSMUSP00000027298 ; ENSMUSG00000026124 .
    GeneIDi 12627.
    KEGGi mmu:12627.
    UCSCi uc007aow.1. mouse.

    Organism-specific databases

    CTDi 55997.
    MGIi MGI:109448. Cfc1.

    Phylogenomic databases

    eggNOGi NOG311092.
    GeneTreei ENSGT00530000063804.
    HOGENOMi HOG000090236.
    HOVERGENi HBG099834.
    InParanoidi P97766.
    OMAi RGIASND.
    OrthoDBi EOG7TJ3KK.
    PhylomeDBi P97766.
    TreeFami TF333187.

    Enzyme and pathway databases

    Reactomei REACT_199125. Regulation of signaling by NODAL.
    REACT_220645. Signaling by NODAL.

    Miscellaneous databases

    NextBioi 281804.
    PROi P97766.
    SOURCEi Search...

    Gene expression databases

    Bgeei P97766.
    CleanExi MM_CFC1.
    Genevestigatori P97766.

    Family and domain databases

    InterProi IPR019011. Cryptic/Cripto_CFC-dom.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    [Graphical view ]
    Pfami PF09443. CFC. 1 hit.
    [Graphical view ]
    PROSITEi PS00022. EGF_1. 1 hit.
    PS50026. EGF_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A differential display strategy identifies Cryptic, a novel EGF-related gene expressed in the axial and lateral mesoderm during mouse gastrulation."
      Shen M.M., Wang H., Leder P.
      Development 124:429-442(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, GLYCOSYLATION.
      Strain: 129/Sv.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Subtractive hybridization identifies chick-cripto, a novel EGF-CFC ortholog expressed during gastrulation, neurulation and early cardiogenesis."
      Colas J.-F., Schoenwolf G.C.
      Gene 255:205-217(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-154.
    4. Cited for: FUNCTION, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiCFC1_MOUSE
    AccessioniPrimary (citable) accession number: P97766
    Secondary accession number(s): Q496U5, Q9JIB7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3