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Protein

Cryptic protein

Gene

Cfc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Nodal coreceptor involved in the correct establishment of the left-right axis. May play a role in mesoderm and/or neural patterning during gastrulation.2 Publications

GO - Molecular functioni

  • activin receptor binding Source: UniProtKB
  • nodal binding Source: MGI

GO - Biological processi

  • anatomical structure development Source: MGI
  • anterior/posterior pattern specification Source: MGI
  • atrial septum morphogenesis Source: MGI
  • BMP signaling pathway Source: MGI
  • canonical Wnt signaling pathway Source: MGI
  • determination of left/right symmetry Source: MGI
  • digestive tract morphogenesis Source: MGI
  • endoderm development Source: MGI
  • gastrulation Source: UniProtKB-KW
  • heart looping Source: MGI
  • heart morphogenesis Source: MGI
  • left lung morphogenesis Source: MGI
  • liver development Source: MGI
  • nodal signaling pathway Source: UniProtKB
  • post-embryonic development Source: MGI
  • respiratory system development Source: MGI
  • spleen development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Gastrulation

Enzyme and pathway databases

ReactomeiREACT_304594. Regulation of signaling by NODAL.
REACT_331083. Signaling by NODAL.

Names & Taxonomyi

Protein namesi
Recommended name:
Cryptic protein
Gene namesi
Name:Cfc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:109448. Cfc1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Disruption phenotypei

Positional defects in internal organs. The lung presents a right pulmonary isomerism. The stomach is located on either the left or the right and the spleen is small and has an abnormal shape. The apex of the heart pointed to the right or left. In addition malpositioning of heart outflow tracts is observed, the aorta is connected to the right ventricle and emerged from the heart in a ventral position and to the right of the pulmonary artery. This one is connected to either the left or the right ventricle.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535Sequence AnalysisAdd
BLAST
Chaini36 – 166131Cryptic proteinPRO_0000044631Add
BLAST
Propeptidei167 – 20236Removed in mature formBy similarityPRO_0000395409Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi98 ↔ 105PROSITE-ProRule annotation
Disulfide bondi99 ↔ 111PROSITE-ProRule annotation
Disulfide bondi113 ↔ 122PROSITE-ProRule annotation
Lipidationi166 – 1661GPI-anchor amidated aspartateBy similarity

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PRIDEiP97766.

Expressioni

Tissue specificityi

No expressed in adult tissues.1 Publication

Developmental stagei

Expressed during gastrulation (from 6.5 dpc to 11 dpc) in two spatial domains that correspond to the axial and lateral mesoderm. In the first domain expression is progressively localized to the anterior primitive streak, the head process, and the node and notochordal. In the second domain, expression is initially concentrated in the lateral region of the egg cylinder, and is later found circumferentially in the intermediate and lateral plate mesoderm. Furthermore, the expression can also be detected at the early head-fold stage in the midline neuroectoderm, and consequently is an early marker for the prospective floor plate of the neural tube. Expression ceases at the end of gastrulation, and has not been observed in later embryonic stages.1 Publication

Gene expression databases

BgeeiP97766.
CleanExiMM_CFC1.
GenevisibleiP97766. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027298.

Structurei

3D structure databases

ProteinModelPortaliP97766.
SMRiP97766. Positions 99-166.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini94 – 12330EGF-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 EGF-like domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

eggNOGiNOG311092.
GeneTreeiENSGT00530000063804.
HOGENOMiHOG000090236.
HOVERGENiHBG099834.
InParanoidiP97766.
OMAiCIFSALY.
OrthoDBiEOG7TJ3KK.
PhylomeDBiP97766.
TreeFamiTF333187.

Family and domain databases

InterProiIPR019011. Cryptic/Cripto_CFC-dom.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
[Graphical view]
PfamiPF09443. CFC. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97766-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRANSPTQGI SLKMHQARPL FLVTVALQLI GLGYSYQSEG DGAREVSNIL
60 70 80 90 100
SPVIPGTTLD RTLSNSSRKN DIPEGARLWD SLPDSSTLGE SAVPVSRCCH
110 120 130 140 150
NGGTCVLGSF CVCPAYFTGR YCEHDQRRRD CGALGHGAWT LHSCRLCRCI
160 170 180 190 200
FSALYCLPHQ TFSHCDLKSF LSSGARGSRE CSIPSLLLLV LCLLLQGVAG

KG
Length:202
Mass (Da):21,792
Last modified:May 1, 1997 - v1
Checksum:i57035AD339A16FD7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti83 – 831P → T in AAI00707 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57720 mRNA. Translation: AAC53042.1.
BC100705 mRNA. Translation: AAI00706.1.
BC100706 mRNA. Translation: AAI00707.1.
BC100708 mRNA. Translation: AAI00709.1.
BC100711 mRNA. Translation: AAI00712.1.
AF242430 Genomic DNA. Translation: AAF76323.1.
CCDSiCCDS14869.1.
RefSeqiNP_031711.1. NM_007685.2.
UniGeneiMm.2531.

Genome annotation databases

EnsembliENSMUST00000027298; ENSMUSP00000027298; ENSMUSG00000026124.
GeneIDi12627.
KEGGimmu:12627.
UCSCiuc007aow.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57720 mRNA. Translation: AAC53042.1.
BC100705 mRNA. Translation: AAI00706.1.
BC100706 mRNA. Translation: AAI00707.1.
BC100708 mRNA. Translation: AAI00709.1.
BC100711 mRNA. Translation: AAI00712.1.
AF242430 Genomic DNA. Translation: AAF76323.1.
CCDSiCCDS14869.1.
RefSeqiNP_031711.1. NM_007685.2.
UniGeneiMm.2531.

3D structure databases

ProteinModelPortaliP97766.
SMRiP97766. Positions 99-166.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027298.

Proteomic databases

PRIDEiP97766.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027298; ENSMUSP00000027298; ENSMUSG00000026124.
GeneIDi12627.
KEGGimmu:12627.
UCSCiuc007aow.1. mouse.

Organism-specific databases

CTDi55997.
MGIiMGI:109448. Cfc1.

Phylogenomic databases

eggNOGiNOG311092.
GeneTreeiENSGT00530000063804.
HOGENOMiHOG000090236.
HOVERGENiHBG099834.
InParanoidiP97766.
OMAiCIFSALY.
OrthoDBiEOG7TJ3KK.
PhylomeDBiP97766.
TreeFamiTF333187.

Enzyme and pathway databases

ReactomeiREACT_304594. Regulation of signaling by NODAL.
REACT_331083. Signaling by NODAL.

Miscellaneous databases

NextBioi281804.
PROiP97766.
SOURCEiSearch...

Gene expression databases

BgeeiP97766.
CleanExiMM_CFC1.
GenevisibleiP97766. MM.

Family and domain databases

InterProiIPR019011. Cryptic/Cripto_CFC-dom.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
[Graphical view]
PfamiPF09443. CFC. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A differential display strategy identifies Cryptic, a novel EGF-related gene expressed in the axial and lateral mesoderm during mouse gastrulation."
    Shen M.M., Wang H., Leder P.
    Development 124:429-442(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, GLYCOSYLATION.
    Strain: 129/Sv.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Subtractive hybridization identifies chick-cripto, a novel EGF-CFC ortholog expressed during gastrulation, neurulation and early cardiogenesis."
    Colas J.-F., Schoenwolf G.C.
    Gene 255:205-217(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-154.
  4. Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiCFC1_MOUSE
AccessioniPrimary (citable) accession number: P97766
Secondary accession number(s): Q496U5, Q9JIB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: May 1, 1997
Last modified: June 24, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.