Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

WW domain-binding protein 2

Gene

Wbp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
WW domain-binding protein 2
Short name:
WBP-2
Gene namesi
Name:Wbp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:104709. Wbp2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi170 – 1701Y → A: No effect on interaction with NEDD4. 1 Publication
Mutagenesisi200 – 2001Y → A: Abolishes interaction with NEDD4. 1 Publication
Mutagenesisi252 – 2521Y → A: No effect on interaction with NEDD4. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261WW domain-binding protein 2PRO_0000065951Add
BLAST

Proteomic databases

EPDiP97765.
PaxDbiP97765.
PRIDEiP97765.

PTM databases

iPTMnetiP97765.
PhosphoSiteiP97765.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiP97765.
CleanExiMM_WBP2.
ExpressionAtlasiP97765. baseline and differential.
GenevisibleiP97765. MM.

Interactioni

Subunit structurei

Binds to the WW domain of YAP1, WWP1 and WWP2 (By similarity). Interacts with NEDD4.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Nedd4P469355EBI-6304181,EBI-773516

Protein-protein interaction databases

BioGridi204546. 2 interactions.
IntActiP97765. 3 interactions.
MINTiMINT-147897.
STRINGi10090.ENSMUSP00000074204.

Structurei

3D structure databases

ProteinModelPortaliP97765.
SMRiP97765. Positions 13-81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8484GRAMAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi196 – 2005WW-binding 1
Motifi248 – 2525WW-binding 2

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi146 – 255110Pro-richAdd
BLAST

Domaini

The WW-binding 1 motif mediates interaction with NEDD4.1 Publication

Sequence similaritiesi

Contains 1 GRAM domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3294. Eukaryota.
ENOG4111FQW. LUCA.
HOGENOMiHOG000231103.
HOVERGENiHBG027489.
InParanoidiP97765.
OMAiYLMKGCE.
OrthoDBiEOG73805Q.
PhylomeDBiP97765.
TreeFamiTF314141.

Family and domain databases

InterProiIPR004182. GRAM.
IPR011993. PH_dom-like.
IPR018826. WW-domain-binding.
[Graphical view]
PfamiPF02893. GRAM. 1 hit.
PF10349. WWbp. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.

Sequencei

Sequence statusi: Complete.

P97765-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALNKNHSEG GGVIVNNTES ILMSYDHVEL TFNDMKNVPE AFKGTKKGTV
60 70 80 90 100
YLTPYRVIFL SKGKDAMQSF MMPFYLMKDC EIKQPVFGAN FIKGIVKAEA
110 120 130 140 150
GGGWEGSASY KLTFTAGGAI EFGQRMLQVA SQASRGEVPN GAYGYPYMPS
160 170 180 190 200
GAYVFPPPVA NGMYPCPPGY PYPPPPPEFY PGPPMMDGAM GYVQPPPPPY
210 220 230 240 250
PGPMEPPVSG PSAPATPAAE AKAAEAAASA YYNPGNPHNV YMPTSQPPPP
260
PYYPPEDKKT Q
Length:261
Mass (Da):28,032
Last modified:May 1, 1997 - v1
Checksum:iDA475B184F284380
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40826 mRNA. Translation: AAB40893.1.
BC055058 mRNA. Translation: AAH55058.1.
CCDSiCCDS25657.1.
RefSeqiNP_058548.1. NM_016852.2.
UniGeneiMm.284792.

Genome annotation databases

EnsembliENSMUST00000074628; ENSMUSP00000074204; ENSMUSG00000034341.
GeneIDi22378.
KEGGimmu:22378.
UCSCiuc007mjv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40826 mRNA. Translation: AAB40893.1.
BC055058 mRNA. Translation: AAH55058.1.
CCDSiCCDS25657.1.
RefSeqiNP_058548.1. NM_016852.2.
UniGeneiMm.284792.

3D structure databases

ProteinModelPortaliP97765.
SMRiP97765. Positions 13-81.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204546. 2 interactions.
IntActiP97765. 3 interactions.
MINTiMINT-147897.
STRINGi10090.ENSMUSP00000074204.

PTM databases

iPTMnetiP97765.
PhosphoSiteiP97765.

Proteomic databases

EPDiP97765.
PaxDbiP97765.
PRIDEiP97765.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000074628; ENSMUSP00000074204; ENSMUSG00000034341.
GeneIDi22378.
KEGGimmu:22378.
UCSCiuc007mjv.1. mouse.

Organism-specific databases

CTDi23558.
MGIiMGI:104709. Wbp2.

Phylogenomic databases

eggNOGiKOG3294. Eukaryota.
ENOG4111FQW. LUCA.
HOGENOMiHOG000231103.
HOVERGENiHBG027489.
InParanoidiP97765.
OMAiYLMKGCE.
OrthoDBiEOG73805Q.
PhylomeDBiP97765.
TreeFamiTF314141.

Miscellaneous databases

ChiTaRSiWbp2. mouse.
NextBioi302733.
PROiP97765.
SOURCEiSearch...

Gene expression databases

BgeeiP97765.
CleanExiMM_WBP2.
ExpressionAtlasiP97765. baseline and differential.
GenevisibleiP97765. MM.

Family and domain databases

InterProiIPR004182. GRAM.
IPR011993. PH_dom-like.
IPR018826. WW-domain-binding.
[Graphical view]
PfamiPF02893. GRAM. 1 hit.
PF10349. WWbp. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules."
    Chen H.I., Sudol M.
    Proc. Natl. Acad. Sci. U.S.A. 92:7819-7823(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH YAP1.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  3. "Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4."
    Jolliffe C.N., Harvey K.F., Haines B.P., Parasivam G., Kumar S.
    Biochem. J. 351:557-565(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NEDD4, DOMAINS, MUTAGENESIS OF TYR-170; TYR-200 AND TYR-252.
    Tissue: Embryo.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiWBP2_MOUSE
AccessioniPrimary (citable) accession number: P97765
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: May 1, 1997
Last modified: March 16, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.