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Protein

WW domain-binding protein 1

Gene

Wbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • WW domain binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
WW domain-binding protein 1
Short name:
WBP-1
Gene namesi
Name:Wbp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:104710. Wbp1.

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi162Y → A: Abolishes interaction with NEDD4. 1 Publication1
Mutagenesisi176Y → A: Abolishes interaction with NEDD4. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000659491 – 304WW domain-binding protein 1Add BLAST304

Proteomic databases

PaxDbiP97764.
PRIDEiP97764.

PTM databases

PhosphoSitePlusiP97764.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030035.
CleanExiMM_WBP1.
ExpressionAtlasiP97764. baseline and differential.
GenevisibleiP97764. MM.

Interactioni

Subunit structurei

Binds to the WW domain of YAP1, WWP1 and WWP2. Interacts with WWOX (By similarity). Interacts with NEDD4.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Nedd4P469353EBI-6304160,EBI-773516
YAP1P4693713EBI-6304160,EBI-1044059From a different organism.

GO - Molecular functioni

  • WW domain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi204545. 2 interactors.
IntActiP97764. 2 interactors.
MINTiMINT-147917.
STRINGi10090.ENSMUSP00000032111.

Structurei

3D structure databases

ProteinModelPortaliP97764.
SMRiP97764.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi159 – 162WW-binding 14
Motifi172 – 176WW-binding 25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi21 – 24Poly-Gln4
Compositional biasi120 – 125Poly-Gln6

Domaini

The WW-binding 2 motif mediates interaction with WWOX (By similarity). Both WW-binding motifs mediate interaction with NEDD4.By similarity1 Publication

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IWXA. Eukaryota.
ENOG41104IZ. LUCA.
GeneTreeiENSGT00530000063663.
HOGENOMiHOG000231948.
HOVERGENiHBG029355.
InParanoidiP97764.
OMAiPAHCEGT.
OrthoDBiEOG091G0ZU7.
PhylomeDBiP97764.
TreeFamiTF330726.

Family and domain databases

InterProiIPR021684. WBP1-like.
[Graphical view]
PfamiPF11669. WBP-1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P97764-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARASSRNSS EEAWGSLQAP QQQQSPAASS LEGAIWRRAG TQTRALDTIL
60 70 80 90 100
YHPQQSHLLR ELCPGVNTQP YLCETGHCCG ETGCCTYYYE LWWFWLLWTV
110 120 130 140 150
LILFSCCCAF RHRRAKLRLQ QQQRQREINL LAYHGACHGA GPVPTGSLLD
160 170 180 190 200
LRLLSAFKPP AYEDVVHHPG TPPPPYTVGP GYPWTTSSEC TRCSSESSCS
210 220 230 240 250
AHLEGTNVEG VSSQQSALPH QEGEPRAGLS PVHIPPSCRY RRLTGDSGIE
260 270 280 290 300
LCPCPDSSEG EPLKEARASA SQPDLEDHSP CALPPDSVSQ VPPMGLASSC

GDIP
Length:304
Mass (Da):33,165
Last modified:November 15, 2002 - v2
Checksum:i2A5C95D34D9D7520
GO
Isoform 2 (identifier: P97764-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-58: Missing.

Show »
Length:269
Mass (Da):29,322
Checksum:iF6F962CB80D499A7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti302 – 304DIP → TSHK in AAB40892 (PubMed:7644498).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00402224 – 58Missing in isoform 2. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40825 mRNA. Translation: AAB40892.1.
BC005666 mRNA. Translation: AAH05666.1.
BC019889 mRNA. Translation: AAH19889.1.
CCDSiCCDS39528.1. [P97764-2]
CCDS39529.1. [P97764-1]
RefSeqiNP_001077392.1. NM_001083923.1. [P97764-2]
NP_058037.2. NM_016757.2. [P97764-1]
UniGeneiMm.1109.

Genome annotation databases

EnsembliENSMUST00000032111; ENSMUSP00000032111; ENSMUSG00000030035. [P97764-1]
ENSMUST00000113936; ENSMUSP00000109569; ENSMUSG00000030035. [P97764-2]
GeneIDi22377.
KEGGimmu:22377.
UCSCiuc009cmo.1. mouse. [P97764-1]
uc009cmq.1. mouse. [P97764-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40825 mRNA. Translation: AAB40892.1.
BC005666 mRNA. Translation: AAH05666.1.
BC019889 mRNA. Translation: AAH19889.1.
CCDSiCCDS39528.1. [P97764-2]
CCDS39529.1. [P97764-1]
RefSeqiNP_001077392.1. NM_001083923.1. [P97764-2]
NP_058037.2. NM_016757.2. [P97764-1]
UniGeneiMm.1109.

3D structure databases

ProteinModelPortaliP97764.
SMRiP97764.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204545. 2 interactors.
IntActiP97764. 2 interactors.
MINTiMINT-147917.
STRINGi10090.ENSMUSP00000032111.

PTM databases

PhosphoSitePlusiP97764.

Proteomic databases

PaxDbiP97764.
PRIDEiP97764.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032111; ENSMUSP00000032111; ENSMUSG00000030035. [P97764-1]
ENSMUST00000113936; ENSMUSP00000109569; ENSMUSG00000030035. [P97764-2]
GeneIDi22377.
KEGGimmu:22377.
UCSCiuc009cmo.1. mouse. [P97764-1]
uc009cmq.1. mouse. [P97764-2]

Organism-specific databases

CTDi23559.
MGIiMGI:104710. Wbp1.

Phylogenomic databases

eggNOGiENOG410IWXA. Eukaryota.
ENOG41104IZ. LUCA.
GeneTreeiENSGT00530000063663.
HOGENOMiHOG000231948.
HOVERGENiHBG029355.
InParanoidiP97764.
OMAiPAHCEGT.
OrthoDBiEOG091G0ZU7.
PhylomeDBiP97764.
TreeFamiTF330726.

Miscellaneous databases

PROiP97764.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030035.
CleanExiMM_WBP1.
ExpressionAtlasiP97764. baseline and differential.
GenevisibleiP97764. MM.

Family and domain databases

InterProiIPR021684. WBP1-like.
[Graphical view]
PfamiPF11669. WBP-1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWBP1_MOUSE
AccessioniPrimary (citable) accession number: P97764
Secondary accession number(s): Q8WUP5, Q99J20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 15, 2002
Last modified: November 2, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.