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P97762

- RP9_MOUSE

UniProt

P97762 - RP9_MOUSE

Protein

Retinitis pigmentosa 9 protein homolog

Gene

rp9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Is thought to be a target protein for the PIM1 kinase. May play some roles in B-cell proliferation in association with PIM1.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri96 – 11419CCHC-typeAdd
    BLAST

    GO - Molecular functioni

    1. nucleic acid binding Source: InterPro
    2. protein binding Source: UniProtKB
    3. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Retinitis pigmentosa 9 protein homolog
    Alternative name(s):
    Pim-1-associated protein
    Short name:
    PAP-1
    Gene namesi
    Name:rp9
    Synonyms:Rp9h
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:2157166. Rp9.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 213213Retinitis pigmentosa 9 protein homologPRO_0000097429Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei204 – 2041Phosphoserine; by PIM1; in vitro1 Publication
    Modified residuei206 – 2061Phosphoserine; by PIM1; in vitro1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP97762.
    PaxDbiP97762.
    PRIDEiP97762.

    PTM databases

    PhosphoSiteiP97762.

    Expressioni

    Tissue specificityi

    Highly expressed in the testis, moderately in the kidney, liver and spleen, and weakly in the skeletal muscle and heart.

    Gene expression databases

    ArrayExpressiP97762.
    BgeeiP97762.
    CleanExiMM_RP9.
    GenevestigatoriP97762.

    Interactioni

    Subunit structurei

    Binds to PIM1. Binds to ZNHIT4.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Cir1Q9DA196EBI-626715,EBI-309693

    Protein-protein interaction databases

    IntActiP97762. 3 interactions.
    MINTiMINT-4132982.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 147147PIM1-bindingAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi166 – 1716Poly-Ser
    Compositional biasi176 – 20530Lys-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CCHC-type zinc finger.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri96 – 11419CCHC-typeAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG283926.
    HOGENOMiHOG000132948.
    HOVERGENiHBG047374.
    InParanoidiP97762.
    OMAiRHERKRK.
    OrthoDBiEOG72C52F.
    PhylomeDBiP97762.
    TreeFamiTF329160.

    Family and domain databases

    InterProiIPR001878. Znf_CCHC.
    [Graphical view]
    SMARTiSM00343. ZnF_C2HC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P97762-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSGAGSRRP REPPEHELQR RREQKRRRHD AQQLQQLKHL ESFYEKPPPG    50
    FIKEDETKPE DCIPDVPGNE HAREFLAHAP TKGLWMPLGR EVKVMQCWRC 100
    KRYGHRTGDK ECPFFIKGNQ KLEQFRVAHE DPMYDIIREN KRHEKDVRIQ 150
    QLKQLLEDST SDDDGSSSSS SGDREKRKKR KKKEKHKKRK KEKKKKKKRK 200
    HKASKSSESS DSE 213
    Length:213
    Mass (Da):25,262
    Last modified:May 1, 1997 - v1
    Checksum:iEDFA8EEE2130E882
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D78255 mRNA. Translation: BAA11319.1.
    CCDSiCCDS40564.1.
    RefSeqiNP_061209.1. NM_018739.2.
    UniGeneiMm.38235.

    Genome annotation databases

    EnsembliENSMUST00000034763; ENSMUSP00000034763; ENSMUSG00000032239.
    GeneIDi55934.
    KEGGimmu:55934.
    UCSCiuc009ooq.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D78255 mRNA. Translation: BAA11319.1 .
    CCDSi CCDS40564.1.
    RefSeqi NP_061209.1. NM_018739.2.
    UniGenei Mm.38235.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P97762. 3 interactions.
    MINTi MINT-4132982.

    PTM databases

    PhosphoSitei P97762.

    Proteomic databases

    MaxQBi P97762.
    PaxDbi P97762.
    PRIDEi P97762.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034763 ; ENSMUSP00000034763 ; ENSMUSG00000032239 .
    GeneIDi 55934.
    KEGGi mmu:55934.
    UCSCi uc009ooq.2. mouse.

    Organism-specific databases

    CTDi 6100.
    MGIi MGI:2157166. Rp9.

    Phylogenomic databases

    eggNOGi NOG283926.
    HOGENOMi HOG000132948.
    HOVERGENi HBG047374.
    InParanoidi P97762.
    OMAi RHERKRK.
    OrthoDBi EOG72C52F.
    PhylomeDBi P97762.
    TreeFami TF329160.

    Miscellaneous databases

    NextBioi 311604.
    PROi P97762.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P97762.
    Bgeei P97762.
    CleanExi MM_RP9.
    Genevestigatori P97762.

    Family and domain databases

    InterProi IPR001878. Znf_CCHC.
    [Graphical view ]
    SMARTi SM00343. ZnF_C2HC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH PIM1, PHOSPHORYLATION AT SER-204 AND SER-206 BY PIM1.
      Tissue: T-cell lymphoma.
    2. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 1-8, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.
    3. "A novel nucleolar protein, PAPA-1, induces growth arrest as a result of cell cycle arrest at the G1 phase."
      Kuroda T.S., Maita H., Tabata T., Taira T., Kitaura H., Ariga H., Iguchi-Ariga S.M.M.
      Gene 340:83-98(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ZNHIT4.

    Entry informationi

    Entry nameiRP9_MOUSE
    AccessioniPrimary (citable) accession number: P97762
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 14, 2003
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3