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Protein

Retinitis pigmentosa 9 protein homolog

Gene

rp9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Is thought to be a target protein for the PIM1 kinase. May play some roles in B-cell proliferation in association with PIM1.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri96 – 11419CCHC-typeAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Retinitis pigmentosa 9 protein homolog
Alternative name(s):
Pim-1-associated protein
Short name:
PAP-1
Gene namesi
Name:rp9
Synonyms:Rp9h
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2157166. Rp9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213Retinitis pigmentosa 9 protein homologPRO_0000097429Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei204 – 2041Phosphoserine; by PIM1; in vitro1 Publication
Modified residuei206 – 2061Phosphoserine; by PIM1; in vitro1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP97762.
PaxDbiP97762.
PRIDEiP97762.

PTM databases

PhosphoSiteiP97762.

Expressioni

Tissue specificityi

Highly expressed in the testis, moderately in the kidney, liver and spleen, and weakly in the skeletal muscle and heart.

Gene expression databases

BgeeiP97762.
CleanExiMM_RP9.
ExpressionAtlasiP97762. baseline and differential.
GenevisibleiP97762. MM.

Interactioni

Subunit structurei

Binds to PIM1. Binds to ZNHIT4.

Binary interactionsi

WithEntry#Exp.IntActNotes
Cir1Q9DA196EBI-626715,EBI-309693

Protein-protein interaction databases

IntActiP97762. 3 interactions.
MINTiMINT-4132982.
STRINGi10090.ENSMUSP00000034763.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 147147PIM1-bindingAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi166 – 1716Poly-Ser
Compositional biasi176 – 20530Lys-richAdd
BLAST

Sequence similaritiesi

Contains 1 CCHC-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri96 – 11419CCHC-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG283926.
GeneTreeiENSGT00510000047055.
HOGENOMiHOG000132948.
HOVERGENiHBG047374.
InParanoidiP97762.
OMAiNKRHEKE.
OrthoDBiEOG72C52F.
PhylomeDBiP97762.
TreeFamiTF329160.

Family and domain databases

InterProiIPR001878. Znf_CCHC.
[Graphical view]
SMARTiSM00343. ZnF_C2HC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97762-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGAGSRRP REPPEHELQR RREQKRRRHD AQQLQQLKHL ESFYEKPPPG
60 70 80 90 100
FIKEDETKPE DCIPDVPGNE HAREFLAHAP TKGLWMPLGR EVKVMQCWRC
110 120 130 140 150
KRYGHRTGDK ECPFFIKGNQ KLEQFRVAHE DPMYDIIREN KRHEKDVRIQ
160 170 180 190 200
QLKQLLEDST SDDDGSSSSS SGDREKRKKR KKKEKHKKRK KEKKKKKKRK
210
HKASKSSESS DSE
Length:213
Mass (Da):25,262
Last modified:May 1, 1997 - v1
Checksum:iEDFA8EEE2130E882
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78255 mRNA. Translation: BAA11319.1.
CCDSiCCDS40564.1.
RefSeqiNP_061209.1. NM_018739.2.
UniGeneiMm.38235.

Genome annotation databases

EnsembliENSMUST00000034763; ENSMUSP00000034763; ENSMUSG00000032239.
GeneIDi55934.
KEGGimmu:55934.
UCSCiuc009ooq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78255 mRNA. Translation: BAA11319.1.
CCDSiCCDS40564.1.
RefSeqiNP_061209.1. NM_018739.2.
UniGeneiMm.38235.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP97762. 3 interactions.
MINTiMINT-4132982.
STRINGi10090.ENSMUSP00000034763.

PTM databases

PhosphoSiteiP97762.

Proteomic databases

MaxQBiP97762.
PaxDbiP97762.
PRIDEiP97762.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034763; ENSMUSP00000034763; ENSMUSG00000032239.
GeneIDi55934.
KEGGimmu:55934.
UCSCiuc009ooq.2. mouse.

Organism-specific databases

CTDi6100.
MGIiMGI:2157166. Rp9.

Phylogenomic databases

eggNOGiNOG283926.
GeneTreeiENSGT00510000047055.
HOGENOMiHOG000132948.
HOVERGENiHBG047374.
InParanoidiP97762.
OMAiNKRHEKE.
OrthoDBiEOG72C52F.
PhylomeDBiP97762.
TreeFamiTF329160.

Miscellaneous databases

ChiTaRSiRp9. mouse.
NextBioi311604.
PROiP97762.
SOURCEiSearch...

Gene expression databases

BgeeiP97762.
CleanExiMM_RP9.
ExpressionAtlasiP97762. baseline and differential.
GenevisibleiP97762. MM.

Family and domain databases

InterProiIPR001878. Znf_CCHC.
[Graphical view]
SMARTiSM00343. ZnF_C2HC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH PIM1, PHOSPHORYLATION AT SER-204 AND SER-206 BY PIM1.
    Tissue: T-cell lymphoma.
  2. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 1-8, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  3. "A novel nucleolar protein, PAPA-1, induces growth arrest as a result of cell cycle arrest at the G1 phase."
    Kuroda T.S., Maita H., Tabata T., Taira T., Kitaura H., Ariga H., Iguchi-Ariga S.M.M.
    Gene 340:83-98(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ZNHIT4.

Entry informationi

Entry nameiRP9_MOUSE
AccessioniPrimary (citable) accession number: P97762
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: May 1, 1997
Last modified: July 22, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.