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Protein

Retinitis pigmentosa 9 protein homolog

Gene

rp9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Is thought to be a target protein for the PIM1 kinase. May play some roles in B-cell proliferation in association with PIM1.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri96 – 114CCHC-typeAdd BLAST19

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Retinitis pigmentosa 9 protein homolog
Alternative name(s):
Pim-1-associated protein
Short name:
PAP-1
Gene namesi
Name:rp9
Synonyms:Rp9h
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2157166. Rp9.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000974291 – 213Retinitis pigmentosa 9 protein homologAdd BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki121Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei204Phosphoserine; by PIM1; in vitro1 Publication1
Modified residuei206Phosphoserine; by PIM1; in vitro1 Publication1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP97762.
PaxDbiP97762.
PeptideAtlasiP97762.
PRIDEiP97762.

PTM databases

iPTMnetiP97762.
PhosphoSitePlusiP97762.

Expressioni

Tissue specificityi

Highly expressed in the testis, moderately in the kidney, liver and spleen, and weakly in the skeletal muscle and heart.

Gene expression databases

BgeeiENSMUSG00000032239.
CleanExiMM_RP9.
ExpressionAtlasiP97762. baseline and differential.
GenevisibleiP97762. MM.

Interactioni

Subunit structurei

Binds to PIM1. Binds to ZNHIT4.

Binary interactionsi

WithEntry#Exp.IntActNotes
Cir1Q9DA196EBI-626715,EBI-309693

Protein-protein interaction databases

DIPiDIP-33838N.
IntActiP97762. 3 interactors.
MINTiMINT-4132982.
STRINGi10090.ENSMUSP00000034763.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 147PIM1-bindingAdd BLAST147

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi166 – 171Poly-Ser6
Compositional biasi176 – 205Lys-richAdd BLAST30

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri96 – 114CCHC-typeAdd BLAST19

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3794. Eukaryota.
ENOG410ZVMR. LUCA.
GeneTreeiENSGT00510000047055.
HOGENOMiHOG000132948.
HOVERGENiHBG047374.
InParanoidiP97762.
KOiK19604.
OMAiNKRHEKE.
OrthoDBiEOG091G0X0Z.
PhylomeDBiP97762.
TreeFamiTF329160.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiView protein in InterPro
IPR032675. L_dom-like.
IPR034585. PAP-1.
PANTHERiPTHR35252. PTHR35252. 1 hit.

Sequencei

Sequence statusi: Complete.

P97762-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGAGSRRP REPPEHELQR RREQKRRRHD AQQLQQLKHL ESFYEKPPPG
60 70 80 90 100
FIKEDETKPE DCIPDVPGNE HAREFLAHAP TKGLWMPLGR EVKVMQCWRC
110 120 130 140 150
KRYGHRTGDK ECPFFIKGNQ KLEQFRVAHE DPMYDIIREN KRHEKDVRIQ
160 170 180 190 200
QLKQLLEDST SDDDGSSSSS SGDREKRKKR KKKEKHKKRK KEKKKKKKRK
210
HKASKSSESS DSE
Length:213
Mass (Da):25,262
Last modified:May 1, 1997 - v1
Checksum:iEDFA8EEE2130E882
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78255 mRNA. Translation: BAA11319.1.
CCDSiCCDS40564.1.
RefSeqiNP_061209.1. NM_018739.2.
UniGeneiMm.38235.

Genome annotation databases

EnsembliENSMUST00000034763; ENSMUSP00000034763; ENSMUSG00000032239.
GeneIDi55934.
KEGGimmu:55934.
UCSCiuc009ooq.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiRP9_MOUSE
AccessioniPrimary (citable) accession number: P97762
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: May 1, 1997
Last modified: August 30, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot