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P97762 (RP9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Retinitis pigmentosa 9 protein homolog
Alternative name(s):
Pim-1-associated protein
Short name=PAP-1
Gene names
Name:rp9
Synonyms:Rp9h
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length213 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Is thought to be a target protein for the PIM1 kinase. May play some roles in B-cell proliferation in association with PIM1.

Subunit structure

Binds to PIM1. Binds to ZNHIT4. Ref.1 Ref.3

Subcellular location

Nucleus Probable.

Tissue specificity

Highly expressed in the testis, moderately in the kidney, liver and spleen, and weakly in the skeletal muscle and heart.

Sequence similarities

Contains 1 CCHC-type zinc finger.

Ontologies

Keywords
   Cellular componentNucleus
   DomainZinc-finger
   LigandMetal-binding
Zinc
   PTMPhosphoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionnucleic acid binding

Inferred from electronic annotation. Source: InterPro

protein binding

Inferred from physical interaction PubMed 15652350. Source: UniProtKB

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Cir1Q9DA196EBI-626715,EBI-309693

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 213213Retinitis pigmentosa 9 protein homolog
PRO_0000097429

Regions

Zinc finger96 – 11419CCHC-type
Region1 – 147147PIM1-binding
Compositional bias166 – 1716Poly-Ser
Compositional bias176 – 20530Lys-rich

Amino acid modifications

Modified residue2041Phosphoserine; by PIM1; in vitro Probable
Modified residue2061Phosphoserine; by PIM1; in vitro Probable

Sequences

Sequence LengthMass (Da)Tools
P97762 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: EDFA8EEE2130E882

FASTA21325,262
        10         20         30         40         50         60 
MSSGAGSRRP REPPEHELQR RREQKRRRHD AQQLQQLKHL ESFYEKPPPG FIKEDETKPE 

        70         80         90        100        110        120 
DCIPDVPGNE HAREFLAHAP TKGLWMPLGR EVKVMQCWRC KRYGHRTGDK ECPFFIKGNQ 

       130        140        150        160        170        180 
KLEQFRVAHE DPMYDIIREN KRHEKDVRIQ QLKQLLEDST SDDDGSSSSS SGDREKRKKR 

       190        200        210 
KKKEKHKKRK KEKKKKKKRK HKASKSSESS DSE 

« Hide

References

[1]"PAP-1, a novel target protein of phosphorylation by Pim-1 kinase."
Maita H., Harada Y., Nagakubo D., Kitaura H., Ikeda M., Tamai K., Takahashi K., Ariga H., Iguchi-Ariga S.M.M.
Eur. J. Biochem. 267:5168-5178(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH PIM1, PHOSPHORYLATION AT SER-204 AND SER-206 BY PIM1.
Tissue: T-cell lymphoma.
[2]Lubec G., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 1-8, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: OF1.
Tissue: Hippocampus.
[3]"A novel nucleolar protein, PAPA-1, induces growth arrest as a result of cell cycle arrest at the G1 phase."
Kuroda T.S., Maita H., Tabata T., Taira T., Kitaura H., Ariga H., Iguchi-Ariga S.M.M.
Gene 340:83-98(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ZNHIT4.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D78255 mRNA. Translation: BAA11319.1.
CCDSCCDS40564.1.
RefSeqNP_061209.1. NM_018739.2.
UniGeneMm.38235.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP97762. 3 interactions.
MINTMINT-4132982.

PTM databases

PhosphoSiteP97762.

Proteomic databases

MaxQBP97762.
PaxDbP97762.
PRIDEP97762.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000034763; ENSMUSP00000034763; ENSMUSG00000032239.
GeneID55934.
KEGGmmu:55934.
UCSCuc009ooq.2. mouse.

Organism-specific databases

CTD6100.
MGIMGI:2157166. Rp9.

Phylogenomic databases

eggNOGNOG283926.
HOGENOMHOG000132948.
HOVERGENHBG047374.
InParanoidP97762.
OMARHERKRK.
OrthoDBEOG72C52F.
PhylomeDBP97762.
TreeFamTF329160.

Gene expression databases

ArrayExpressP97762.
BgeeP97762.
CleanExMM_RP9.
GenevestigatorP97762.

Family and domain databases

InterProIPR001878. Znf_CCHC.
[Graphical view]
SMARTSM00343. ZnF_C2HC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio311604.
PROP97762.
SOURCESearch...

Entry information

Entry nameRP9_MOUSE
AccessionPrimary (citable) accession number: P97762
Entry history
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: May 1, 1997
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot