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P97762

- RP9_MOUSE

UniProt

P97762 - RP9_MOUSE

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Protein

Retinitis pigmentosa 9 protein homolog

Gene
rp9, Rp9h
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Is thought to be a target protein for the PIM1 kinase. May play some roles in B-cell proliferation in association with PIM1.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri96 – 11419CCHC-typeAdd
BLAST

GO - Molecular functioni

  1. nucleic acid binding Source: InterPro
  2. protein binding Source: UniProtKB
  3. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Retinitis pigmentosa 9 protein homolog
Alternative name(s):
Pim-1-associated protein
Short name:
PAP-1
Gene namesi
Name:rp9
Synonyms:Rp9h
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:2157166. Rp9.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213Retinitis pigmentosa 9 protein homologPRO_0000097429Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei204 – 2041Phosphoserine; by PIM1; in vitro Inferred
Modified residuei206 – 2061Phosphoserine; by PIM1; in vitro Inferred

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP97762.
PaxDbiP97762.
PRIDEiP97762.

PTM databases

PhosphoSiteiP97762.

Expressioni

Tissue specificityi

Highly expressed in the testis, moderately in the kidney, liver and spleen, and weakly in the skeletal muscle and heart.

Gene expression databases

ArrayExpressiP97762.
BgeeiP97762.
CleanExiMM_RP9.
GenevestigatoriP97762.

Interactioni

Subunit structurei

Binds to PIM1. Binds to ZNHIT4.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Cir1Q9DA196EBI-626715,EBI-309693

Protein-protein interaction databases

IntActiP97762. 3 interactions.
MINTiMINT-4132982.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 147147PIM1-bindingAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi166 – 1716Poly-Ser
Compositional biasi176 – 20530Lys-richAdd
BLAST

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri96 – 11419CCHC-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG283926.
HOGENOMiHOG000132948.
HOVERGENiHBG047374.
InParanoidiP97762.
OMAiRHERKRK.
OrthoDBiEOG72C52F.
PhylomeDBiP97762.
TreeFamiTF329160.

Family and domain databases

InterProiIPR001878. Znf_CCHC.
[Graphical view]
SMARTiSM00343. ZnF_C2HC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97762-1 [UniParc]FASTAAdd to Basket

« Hide

MSSGAGSRRP REPPEHELQR RREQKRRRHD AQQLQQLKHL ESFYEKPPPG    50
FIKEDETKPE DCIPDVPGNE HAREFLAHAP TKGLWMPLGR EVKVMQCWRC 100
KRYGHRTGDK ECPFFIKGNQ KLEQFRVAHE DPMYDIIREN KRHEKDVRIQ 150
QLKQLLEDST SDDDGSSSSS SGDREKRKKR KKKEKHKKRK KEKKKKKKRK 200
HKASKSSESS DSE 213
Length:213
Mass (Da):25,262
Last modified:May 1, 1997 - v1
Checksum:iEDFA8EEE2130E882
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D78255 mRNA. Translation: BAA11319.1.
CCDSiCCDS40564.1.
RefSeqiNP_061209.1. NM_018739.2.
UniGeneiMm.38235.

Genome annotation databases

EnsembliENSMUST00000034763; ENSMUSP00000034763; ENSMUSG00000032239.
GeneIDi55934.
KEGGimmu:55934.
UCSCiuc009ooq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D78255 mRNA. Translation: BAA11319.1 .
CCDSi CCDS40564.1.
RefSeqi NP_061209.1. NM_018739.2.
UniGenei Mm.38235.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P97762. 3 interactions.
MINTi MINT-4132982.

PTM databases

PhosphoSitei P97762.

Proteomic databases

MaxQBi P97762.
PaxDbi P97762.
PRIDEi P97762.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034763 ; ENSMUSP00000034763 ; ENSMUSG00000032239 .
GeneIDi 55934.
KEGGi mmu:55934.
UCSCi uc009ooq.2. mouse.

Organism-specific databases

CTDi 6100.
MGIi MGI:2157166. Rp9.

Phylogenomic databases

eggNOGi NOG283926.
HOGENOMi HOG000132948.
HOVERGENi HBG047374.
InParanoidi P97762.
OMAi RHERKRK.
OrthoDBi EOG72C52F.
PhylomeDBi P97762.
TreeFami TF329160.

Miscellaneous databases

NextBioi 311604.
PROi P97762.
SOURCEi Search...

Gene expression databases

ArrayExpressi P97762.
Bgeei P97762.
CleanExi MM_RP9.
Genevestigatori P97762.

Family and domain databases

InterProi IPR001878. Znf_CCHC.
[Graphical view ]
SMARTi SM00343. ZnF_C2HC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH PIM1, PHOSPHORYLATION AT SER-204 AND SER-206 BY PIM1.
    Tissue: T-cell lymphoma.
  2. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 1-8, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  3. "A novel nucleolar protein, PAPA-1, induces growth arrest as a result of cell cycle arrest at the G1 phase."
    Kuroda T.S., Maita H., Tabata T., Taira T., Kitaura H., Ariga H., Iguchi-Ariga S.M.M.
    Gene 340:83-98(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ZNHIT4.

Entry informationi

Entry nameiRP9_MOUSE
AccessioniPrimary (citable) accession number: P97762
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: May 1, 1997
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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