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Protein

Retinitis pigmentosa 9 protein homolog

Gene

rp9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Is thought to be a target protein for the PIM1 kinase. May play some roles in B-cell proliferation in association with PIM1.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri96 – 114CCHC-typeAdd BLAST19

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Retinitis pigmentosa 9 protein homolog
Alternative name(s):
Pim-1-associated protein
Short name:
PAP-1
Gene namesi
Name:rp9
Synonyms:Rp9h
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2157166. Rp9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000974291 – 213Retinitis pigmentosa 9 protein homologAdd BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei204Phosphoserine; by PIM1; in vitro1 Publication1
Modified residuei206Phosphoserine; by PIM1; in vitro1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP97762.
PaxDbiP97762.
PeptideAtlasiP97762.
PRIDEiP97762.

PTM databases

iPTMnetiP97762.
PhosphoSitePlusiP97762.

Expressioni

Tissue specificityi

Highly expressed in the testis, moderately in the kidney, liver and spleen, and weakly in the skeletal muscle and heart.

Gene expression databases

BgeeiENSMUSG00000032239.
CleanExiMM_RP9.
ExpressionAtlasiP97762. baseline and differential.
GenevisibleiP97762. MM.

Interactioni

Subunit structurei

Binds to PIM1. Binds to ZNHIT4.

Binary interactionsi

WithEntry#Exp.IntActNotes
Cir1Q9DA196EBI-626715,EBI-309693

Protein-protein interaction databases

DIPiDIP-33838N.
IntActiP97762. 3 interactors.
MINTiMINT-4132982.
STRINGi10090.ENSMUSP00000034763.

Structurei

3D structure databases

ProteinModelPortaliP97762.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 147PIM1-bindingAdd BLAST147

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi166 – 171Poly-Ser6
Compositional biasi176 – 205Lys-richAdd BLAST30

Sequence similaritiesi

Contains 1 CCHC-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri96 – 114CCHC-typeAdd BLAST19

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3794. Eukaryota.
ENOG410ZVMR. LUCA.
GeneTreeiENSGT00510000047055.
HOGENOMiHOG000132948.
HOVERGENiHBG047374.
InParanoidiP97762.
KOiK19604.
OMAiNKRHEKE.
OrthoDBiEOG091G0X0Z.
PhylomeDBiP97762.
TreeFamiTF329160.

Sequencei

Sequence statusi: Complete.

P97762-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGAGSRRP REPPEHELQR RREQKRRRHD AQQLQQLKHL ESFYEKPPPG
60 70 80 90 100
FIKEDETKPE DCIPDVPGNE HAREFLAHAP TKGLWMPLGR EVKVMQCWRC
110 120 130 140 150
KRYGHRTGDK ECPFFIKGNQ KLEQFRVAHE DPMYDIIREN KRHEKDVRIQ
160 170 180 190 200
QLKQLLEDST SDDDGSSSSS SGDREKRKKR KKKEKHKKRK KEKKKKKKRK
210
HKASKSSESS DSE
Length:213
Mass (Da):25,262
Last modified:May 1, 1997 - v1
Checksum:iEDFA8EEE2130E882
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78255 mRNA. Translation: BAA11319.1.
CCDSiCCDS40564.1.
RefSeqiNP_061209.1. NM_018739.2.
UniGeneiMm.38235.

Genome annotation databases

EnsembliENSMUST00000034763; ENSMUSP00000034763; ENSMUSG00000032239.
GeneIDi55934.
KEGGimmu:55934.
UCSCiuc009ooq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78255 mRNA. Translation: BAA11319.1.
CCDSiCCDS40564.1.
RefSeqiNP_061209.1. NM_018739.2.
UniGeneiMm.38235.

3D structure databases

ProteinModelPortaliP97762.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-33838N.
IntActiP97762. 3 interactors.
MINTiMINT-4132982.
STRINGi10090.ENSMUSP00000034763.

PTM databases

iPTMnetiP97762.
PhosphoSitePlusiP97762.

Proteomic databases

EPDiP97762.
PaxDbiP97762.
PeptideAtlasiP97762.
PRIDEiP97762.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034763; ENSMUSP00000034763; ENSMUSG00000032239.
GeneIDi55934.
KEGGimmu:55934.
UCSCiuc009ooq.2. mouse.

Organism-specific databases

CTDi6100.
MGIiMGI:2157166. Rp9.

Phylogenomic databases

eggNOGiKOG3794. Eukaryota.
ENOG410ZVMR. LUCA.
GeneTreeiENSGT00510000047055.
HOGENOMiHOG000132948.
HOVERGENiHBG047374.
InParanoidiP97762.
KOiK19604.
OMAiNKRHEKE.
OrthoDBiEOG091G0X0Z.
PhylomeDBiP97762.
TreeFamiTF329160.

Miscellaneous databases

ChiTaRSiRp9. mouse.
PROiP97762.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032239.
CleanExiMM_RP9.
ExpressionAtlasiP97762. baseline and differential.
GenevisibleiP97762. MM.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiRP9_MOUSE
AccessioniPrimary (citable) accession number: P97762
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: May 1, 1997
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.