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Protein

Vasoactive intestinal polypeptide receptor 1

Gene

Vipr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Vasoactive intestinal polypeptide receptor 1
Short name:
VIP-R-1
Alternative name(s):
Pituitary adenylate cyclase-activating polypeptide type II receptor
Short name:
PACAP type II receptor
Short name:
PACAP-R-2
Short name:
PACAP-R2
VPAC1
Gene namesi
Name:Vipr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:109272. Vipr1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 143ExtracellularSequence analysisAdd BLAST113
Transmembranei144 – 168Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini169 – 175CytoplasmicSequence analysis7
Transmembranei176 – 195Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini196 – 217ExtracellularSequence analysisAdd BLAST22
Transmembranei218 – 241Helical; Name=3Sequence analysisAdd BLAST24
Topological domaini242 – 255CytoplasmicSequence analysisAdd BLAST14
Transmembranei256 – 277Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini278 – 294ExtracellularSequence analysisAdd BLAST17
Transmembranei295 – 318Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini319 – 343CytoplasmicSequence analysisAdd BLAST25
Transmembranei344 – 363Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini364 – 375ExtracellularSequence analysisAdd BLAST12
Transmembranei376 – 395Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini396 – 459CytoplasmicSequence analysisAdd BLAST64

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000001285631 – 459Vasoactive intestinal polypeptide receptor 1Add BLAST429

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 72By similarity
Glycosylationi58N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi63 ↔ 105By similarity
Glycosylationi69N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi86 ↔ 122By similarity
Glycosylationi100N-linked (GlcNAc...)Sequence analysis1
Glycosylationi104N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi216 ↔ 286By similarity
Glycosylationi292N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP97751.
PRIDEiP97751.

PTM databases

iPTMnetiP97751.
PhosphoSitePlusiP97751.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032528.
CleanExiMM_VIPR1.
GenevisibleiP97751. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035115.

Structurei

3D structure databases

ProteinModelPortaliP97751.
SMRiP97751.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008249.
HOVERGENiHBG008318.
InParanoidiP97751.
KOiK04589.
OMAiVWTIIRI.
OrthoDBiEOG091G0NF8.
PhylomeDBiP97751.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR001571. GPCR_2_VIP_rcpt.
IPR001771. GPCR_2_VIP_rcpt_1.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00491. VASOACTVEIPR.
PR01154. VIP1RECEPTOR.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97751-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPPSLPPAR WLCVLAGALA CALGPAGSRA ASPHQECEYL QMIEKQRQQC
60 70 80 90 100
LEEAQLENET TGCSKMWDNL TCWPTTPWGQ VVVLDCPLIF QLFSPIHGYN
110 120 130 140 150
ISRNCTEEGW SQLEPGPYHI ACGLNDRASS MDEQQQTEFY DAVKTGYTIG
160 170 180 190 200
YSLSLASLLV AMAILSLFRK LHCTRNYIHM HLFMSFILRA TAVFIKDMAL
210 220 230 240 250
FNNGETDHCS EASVSCKAAV VFFQYCVMAN FFWLLVEGLY LHTLLAVSFF
260 270 280 290 300
SERKYFWGYI LIGWGVPSVF IMIWTIVRIH FEDFGCWDTI INSSLWWIIK
310 320 330 340 350
GPILISILVN FILFICIIRI LVQKLRPPDI GKNDSSPYSR LAKSTLLLIP
360 370 380 390 400
LFGVHYVMFA FFPDNFKAQV KMVFELVVGS FQGFVVAILY CFLNGEVQAE
410 420 430 440 450
LRRKWRRWHL QGVLGWSSKS QHPWGGSNGV SCSTQVSMLT RVSPSARRSS

SFQAEVSLV
Length:459
Mass (Da):52,096
Last modified:June 20, 2003 - v3
Checksum:i9D1ADFB8567D4D7F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59E → K in BAA81896 (PubMed:10331949).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022860 Genomic DNA. Translation: BAA81896.1.
AF266282 mRNA. Translation: AAF77053.1.
AK052465 mRNA. Translation: BAC35004.1.
S82970 Genomic DNA. Translation: AAN86759.1.
CCDSiCCDS23633.1.
RefSeqiNP_035833.2. NM_011703.4.
UniGeneiMm.282007.

Genome annotation databases

EnsembliENSMUST00000035115; ENSMUSP00000035115; ENSMUSG00000032528.
GeneIDi22354.
KEGGimmu:22354.
UCSCiuc009sdl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022860 Genomic DNA. Translation: BAA81896.1.
AF266282 mRNA. Translation: AAF77053.1.
AK052465 mRNA. Translation: BAC35004.1.
S82970 Genomic DNA. Translation: AAN86759.1.
CCDSiCCDS23633.1.
RefSeqiNP_035833.2. NM_011703.4.
UniGeneiMm.282007.

3D structure databases

ProteinModelPortaliP97751.
SMRiP97751.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035115.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP97751.
PhosphoSitePlusiP97751.

Proteomic databases

PaxDbiP97751.
PRIDEiP97751.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035115; ENSMUSP00000035115; ENSMUSG00000032528.
GeneIDi22354.
KEGGimmu:22354.
UCSCiuc009sdl.2. mouse.

Organism-specific databases

CTDi7433.
MGIiMGI:109272. Vipr1.

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008249.
HOVERGENiHBG008318.
InParanoidiP97751.
KOiK04589.
OMAiVWTIIRI.
OrthoDBiEOG091G0NF8.
PhylomeDBiP97751.
TreeFamiTF315710.

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiP97751.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032528.
CleanExiMM_VIPR1.
GenevisibleiP97751. MM.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR001571. GPCR_2_VIP_rcpt.
IPR001771. GPCR_2_VIP_rcpt_1.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00491. VASOACTVEIPR.
PR01154. VIP1RECEPTOR.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVIPR1_MOUSE
AccessioniPrimary (citable) accession number: P97751
Secondary accession number(s): Q9JI40, Q9R1T8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 20, 2003
Last modified: November 2, 2016
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.