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Protein

Endothelin-1

Gene

EDN1

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.

GO - Biological processi

Keywordsi

Molecular functionVasoactive, Vasoconstrictor

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-1
Short name:
ET-1
Alternative name(s):
Preproendothelin-1
Short name:
PPET1
Cleaved into the following chain:
Gene namesi
Name:EDN1
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_0000008052‹1 – 33By similarityAdd BLAST›33
PeptideiPRO_000043639536 – 74Big endothelin-1By similarityAdd BLAST39
PeptideiPRO_000000805336 – 56Endothelin-1Add BLAST21
PropeptideiPRO_000000805457 – ›149Add BLAST›93

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 50By similarity
Disulfide bondi38 ↔ 46By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei56 – 57Cleavage; by KELBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000008982.

Structurei

3D structure databases

SMRiP97740.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni93 – 107Endothelin-likeAdd BLAST15

Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Phylogenomic databases

eggNOGiENOG410IWVG. Eukaryota.
ENOG4111WED. LUCA.
HOGENOMiHOG000231110.
HOVERGENiHBG051441.
InParanoidiP97740.

Family and domain databases

InterProiView protein in InterPro
IPR020475. Endothelin.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
PfamiView protein in Pfam
PF00322. Endothelin. 1 hit.
PRINTSiPR00365. ENDOTHELIN.
SMARTiView protein in SMART
SM00272. END. 2 hits.
PROSITEiView protein in PROSITE
PS00270. ENDOTHELIN. 2 hits.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97740-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AAETVVSGAE LSLTANSGGE KTPPHAPGLL RRSKRCSCSS LMDKECVYFC
60 70 80 90 100
HLDIIWVNTP GHIAPYGLGG PFRSKRSLKE LFPTKATEHR NRCQCANQKD
110 120 130 140
KKCWNFCQAG KELSSQDTMQ KGWDNHKKGK DCSKLGKKCI SQQLGNGKK
Length:149
Mass (Da):16,455
Last modified:May 1, 1997 - v1
Checksum:iEC0EB64A18E7610E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei1491

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82654 mRNA. Translation: AAB46735.1.

Similar proteinsi

Entry informationi

Entry nameiEDN1_CAVPO
AccessioniPrimary (citable) accession number: P97740
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: December 20, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families