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Protein

Neuronal pentraxin-2

Gene

Nptx2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner.

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi278Calcium 1By similarity1
Metal bindingi356Calcium 1By similarity1
Metal bindingi356Calcium 2PROSITE-ProRule annotation1
Metal bindingi357Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi358Calcium 1By similarity1
Metal bindingi358Calcium 2PROSITE-ProRule annotation1
Metal bindingi368Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

LigandCalcium, Lectin, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal pentraxin-2
Short name:
NP2
Alternative name(s):
Neuronal activity-regulated pentraxin
Neuronal pentraxin II
Short name:
NP-II
Gene namesi
Name:Nptx2
Synonyms:Narp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1309447 Nptx2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 14Sequence analysisAdd BLAST14
ChainiPRO_000002355315 – 432Neuronal pentraxin-2Add BLAST418

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi149N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi254 ↔ 314PROSITE-ProRule annotation
Glycosylationi394N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP97738
PRIDEiP97738

PTM databases

iPTMnetiP97738
PhosphoSitePlusiP97738

Expressioni

Inductioni

Rapidly induced in neurons of the hippocampus and cortex by physiological synaptic activity.

Interactioni

Subunit structurei

Homooligomer or heterooligomer (probably pentamer) with neuronal pentraxin receptor (NPTXR).By similarity

Protein-protein interaction databases

CORUMiP97738
STRINGi10116.ENSRNOP00000001331

Structurei

3D structure databases

ProteinModelPortaliP97738
SMRiP97738
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini224 – 425Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST202

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFFF Eukaryota
ENOG410XR4W LUCA
HOGENOMiHOG000231267
HOVERGENiHBG003608
InParanoidiP97738
PhylomeDBiP97738

Family and domain databases

CDDicd00152 PTX, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR030476 Pentaxin_CS
IPR001759 Pentraxin-related
PfamiView protein in Pfam
PF00354 Pentaxin, 1 hit
PRINTSiPR00895 PENTAXIN
SMARTiView protein in SMART
SM00159 PTX, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00289 PTX_1, 1 hit
PS51828 PTX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97738-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLALLTAGVA LAVAAGQAQD NPIPGSRFVC TALPPEAARA GCPLPAMPMQ
60 70 80 90 100
GGALSPEEEL RAAVLHWRET VVQQKETLGA QREAIRELTS KLARCEGLAG
110 120 130 140 150
GKARGTGATG KDTMGDLPRD PGHVVEQLSR SLQTLKDRLE SLELQLHTNA
160 170 180 190 200
SNAGLPSDFR EVLQRRLGEL ERQLLRKVAE LEDEKSLLHN ETSAHRQKTE
210 220 230 240 250
NTLNALLQRV TELERGNSAF KSPDAFKVSL PLRTNYLYGK IKKTLPELYA
260 270 280 290 300
FTICLWLRSS ASPGIGTPFS YAVPGQANEI VLIEWGNNPI ELLINDKVAQ
310 320 330 340 350
LPLFVSDGKW HHICITWTTR DGMWEAFQDG EKLGTGENLA PWHPIKPGGV
360 370 380 390 400
LILGQEQDTV GGRFDATQAF VGELSQFNIW DRVLRAQEII NIANCSTNMP
410 420 430
GNIIPWVDNN VDVFGGASKW PVETCEERLL DL
Length:432
Mass (Da):47,429
Last modified:May 1, 1997 - v1
Checksum:iDD642A6AA323D24A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82649 mRNA Translation: AAB46783.1
UniGeneiRn.162101

Similar proteinsi

Entry informationi

Entry nameiNPTX2_RAT
AccessioniPrimary (citable) accession number: P97738
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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