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Protein

Neuronal pentraxin-2

Gene

Nptx2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner.

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi278Calcium 1By similarity1
Metal bindingi356Calcium 1By similarity1
Metal bindingi356Calcium 2By similarity1
Metal bindingi357Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi358Calcium 1By similarity1
Metal bindingi358Calcium 2By similarity1
Metal bindingi368Calcium 2By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Lectin, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal pentraxin-2
Short name:
NP2
Alternative name(s):
Neuronal activity-regulated pentraxin
Neuronal pentraxin II
Short name:
NP-II
Gene namesi
Name:Nptx2
Synonyms:Narp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1309447. Nptx2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 14Sequence analysisAdd BLAST14
ChainiPRO_000002355315 – 432Neuronal pentraxin-2Add BLAST418

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi149N-linked (GlcNAc...)Sequence analysis1
Glycosylationi190N-linked (GlcNAc...)Sequence analysis1
Glycosylationi394N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP97738.
PRIDEiP97738.

PTM databases

iPTMnetiP97738.
PhosphoSitePlusiP97738.

Expressioni

Inductioni

Rapidly induced in neurons of the hippocampus and cortex by physiological synaptic activity.

Interactioni

Subunit structurei

Homooligomer or heterooligomer (probably pentamer) with neuronal pentraxin receptor (NPTXR).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001331.

Structurei

3D structure databases

ProteinModelPortaliP97738.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini228 – 432PentaxinAdd BLAST205

Sequence similaritiesi

Contains 1 pentaxin domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFFF. Eukaryota.
ENOG410XR4W. LUCA.
HOGENOMiHOG000231267.
HOVERGENiHBG003608.
InParanoidiP97738.
PhylomeDBiP97738.

Family and domain databases

CDDicd00152. PTX. 1 hit.
Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001759. Pentaxin-related.
IPR030476. Pentaxin_CS.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00289. PENTAXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97738-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLALLTAGVA LAVAAGQAQD NPIPGSRFVC TALPPEAARA GCPLPAMPMQ
60 70 80 90 100
GGALSPEEEL RAAVLHWRET VVQQKETLGA QREAIRELTS KLARCEGLAG
110 120 130 140 150
GKARGTGATG KDTMGDLPRD PGHVVEQLSR SLQTLKDRLE SLELQLHTNA
160 170 180 190 200
SNAGLPSDFR EVLQRRLGEL ERQLLRKVAE LEDEKSLLHN ETSAHRQKTE
210 220 230 240 250
NTLNALLQRV TELERGNSAF KSPDAFKVSL PLRTNYLYGK IKKTLPELYA
260 270 280 290 300
FTICLWLRSS ASPGIGTPFS YAVPGQANEI VLIEWGNNPI ELLINDKVAQ
310 320 330 340 350
LPLFVSDGKW HHICITWTTR DGMWEAFQDG EKLGTGENLA PWHPIKPGGV
360 370 380 390 400
LILGQEQDTV GGRFDATQAF VGELSQFNIW DRVLRAQEII NIANCSTNMP
410 420 430
GNIIPWVDNN VDVFGGASKW PVETCEERLL DL
Length:432
Mass (Da):47,429
Last modified:May 1, 1997 - v1
Checksum:iDD642A6AA323D24A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82649 mRNA. Translation: AAB46783.1.
UniGeneiRn.162101.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82649 mRNA. Translation: AAB46783.1.
UniGeneiRn.162101.

3D structure databases

ProteinModelPortaliP97738.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001331.

PTM databases

iPTMnetiP97738.
PhosphoSitePlusiP97738.

Proteomic databases

PaxDbiP97738.
PRIDEiP97738.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi1309447. Nptx2.

Phylogenomic databases

eggNOGiENOG410IFFF. Eukaryota.
ENOG410XR4W. LUCA.
HOGENOMiHOG000231267.
HOVERGENiHBG003608.
InParanoidiP97738.
PhylomeDBiP97738.

Miscellaneous databases

PROiP97738.

Family and domain databases

CDDicd00152. PTX. 1 hit.
Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001759. Pentaxin-related.
IPR030476. Pentaxin_CS.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00289. PENTAXIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNPTX2_RAT
AccessioniPrimary (citable) accession number: P97738
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: May 1, 1997
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.