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Protein

Growth/differentiation factor 10

Gene

Gdf10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway (PubMed:22155034). Plays an inhibitory role in the process of adipogenesis (PubMed:21712809).2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Keywords - Biological processi

Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Growth/differentiation factor 10
Short name:
GDF-10
Alternative name(s):
Bone morphogenetic protein 3B
Short name:
BMP-3B
Gene namesi
Name:Gdf10Imported
Synonyms:Bmp3b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:95684. Gdf10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
PropeptideiPRO_000003384630 – 366Sequence analysisAdd BLAST337
ChainiPRO_0000033847367 – 476Growth/differentiation factor 10Add BLAST110

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi114N-linked (GlcNAc...)Sequence analysis1
Glycosylationi152N-linked (GlcNAc...)Sequence analysis1
Glycosylationi277N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi374 ↔ 441By similarity
Disulfide bondi403 ↔ 473By similarity
Disulfide bondi407 ↔ 475By similarity
Disulfide bondi440InterchainBy similarity
Glycosylationi467N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP97737.
PaxDbiP97737.
PRIDEiP97737.

PTM databases

PhosphoSitePlusiP97737.

Expressioni

Tissue specificityi

Highly expressed in epididymal adipose tissue, brain, bone and aorta and to a lesser extent in liver and spleen. Expressed at higher levels in preadipocytes than in mature adipocytes (PubMed:21712809). Strongly expressed in glial cells of the cerebellum (PubMed:24963847).4 Publications

Developmental stagei

During embryogenes is expressed most prominently in developing skeletal structures both in the craniofacial region and in the vertebral column.1 Publication

Gene expression databases

BgeeiENSMUSG00000021943.
CleanExiMM_GDF10.
GenevisibleiP97737. MM.

Interactioni

Subunit structurei

Homodimer or heterodimer. Can form a non-covalent complex of the mature region and the pro-region (PubMed:21712809).Curated1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128621.

Structurei

3D structure databases

ProteinModelPortaliP97737.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00740000114888.
HOVERGENiHBG004857.
InParanoidiP97737.
KOiK05496.
OMAiTSMQDSE.
OrthoDBiEOG091G0WGP.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR017197. BMP3/BMP3B.
IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 2 hits.
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF037403. BMP3/GDF10. 1 hit.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97737-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPGPARISL GSQLLPMVPL LLLLRGAGCG HRGPSWSSLP SAAAGLQGDR
60 70 80 90 100
DSQQSPGDAA AALGPGAQDM VAIHMLRLYE KYNRRGAPPG GGNTVRSFRA
110 120 130 140 150
RLEMIDQKPV YFFNLTSMQD SEMILTAAFH FYSEPPRWPR AREVFCKPRA
160 170 180 190 200
KNASCRLLTP GLPARLHLIF RSLSQNTATQ GLLRGAMALT PPPRGLWQAK
210 220 230 240 250
DISSIIKAAR RDGELLLSAQ LDTGEKDPGV PRPSSHMPYI LVYANDLAIS
260 270 280 290 300
EPNSVAVSLQ RYDPFPAGDF EPGAAPNSSA DPRVRRAAQV SKPLQDNELP
310 320 330 340 350
GLDERPAPAL HAQNFHKHEF WSSPFRALKP RTGRKDRKKK DQDTFTAASS
360 370 380 390 400
QVLDFDEKTM QKARRRQWDE PRVCSRRYLK VDFADIGWNE WIISPKSFDA
410 420 430 440 450
YYCAGACEFP MPKIVRPSNH ATIQSIVRAV GIVPGIPEPC CVPDKMNSLG
460 470
VLFLDENRNA VLKVYPNMSV ETCACR
Length:476
Mass (Da):52,575
Last modified:July 27, 2011 - v2
Checksum:iFCFBD71BDBCE7E50
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti142R → G in AAB46753 (PubMed:8679252).Curated1
Sequence conflicti333G → A in AAB46753 (PubMed:8679252).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82648 mRNA. Translation: AAB46753.1.
BC058358 mRNA. Translation: AAH58358.1.
CCDSiCCDS26927.1.
RefSeqiNP_665684.2. NM_145741.3.
UniGeneiMm.432071.

Genome annotation databases

EnsembliENSMUST00000168727; ENSMUSP00000128621; ENSMUSG00000021943.
GeneIDi14560.
KEGGimmu:14560.
UCSCiuc007tab.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82648 mRNA. Translation: AAB46753.1.
BC058358 mRNA. Translation: AAH58358.1.
CCDSiCCDS26927.1.
RefSeqiNP_665684.2. NM_145741.3.
UniGeneiMm.432071.

3D structure databases

ProteinModelPortaliP97737.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128621.

PTM databases

PhosphoSitePlusiP97737.

Proteomic databases

MaxQBiP97737.
PaxDbiP97737.
PRIDEiP97737.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000168727; ENSMUSP00000128621; ENSMUSG00000021943.
GeneIDi14560.
KEGGimmu:14560.
UCSCiuc007tab.1. mouse.

Organism-specific databases

CTDi2662.
MGIiMGI:95684. Gdf10.

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00740000114888.
HOVERGENiHBG004857.
InParanoidiP97737.
KOiK05496.
OMAiTSMQDSE.
OrthoDBiEOG091G0WGP.
TreeFamiTF316134.

Miscellaneous databases

PROiP97737.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021943.
CleanExiMM_GDF10.
GenevisibleiP97737. MM.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR017197. BMP3/BMP3B.
IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 2 hits.
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF037403. BMP3/GDF10. 1 hit.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGDF10_MOUSE
AccessioniPrimary (citable) accession number: P97737
Secondary accession number(s): Q6PE07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

3T3-L1 cells endogenously secrete biologically active Gdf10 as a unique complex that contains both the pro-region and the mature region.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.