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P97720

- C11B1_MESAU

UniProt

P97720 - C11B1_MESAU

Protein

Cytochrome P450 11B1, mitochondrial

Gene

CYP11B1

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Forms corticosterone from 11-deoxycorticosterone. Possesses high and nearly equal 11-beta-hydroxylase and 19-hydroxylase activities and a lower 18-hydroxylase activity. Involved in the formation of the precursor of 19-nor-deoxycorticosterone, a very potent mineralocorticoid involved in the development of essential hypertension.

    Catalytic activityi

    A steroid + reduced adrenodoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenodoxin + H2O.

    Cofactori

    Heme group.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi446 – 4461Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. steroid 11-beta-monooxygenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glucocorticoid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Steroidogenesis

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00788.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 11B1, mitochondrial
    Alternative name(s):
    CYPXIB1
    Cytochrome P450C11
    Steroid 11-beta-hydroxylase (EC:1.14.15.4)
    Gene namesi
    Name:CYP11B1
    OrganismiMesocricetus auratus (Golden hamster)
    Taxonomic identifieri10036 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2424MitochondrionBy similarityAdd
    BLAST
    Chaini25 – 499475Cytochrome P450 11B1, mitochondrialPRO_0000003598Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4997037.

    Structurei

    3D structure databases

    ProteinModelPortaliP97720.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOVERGENiHBG051098.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002399. Cyt_P450_mitochondrial.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00408. MITP450.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P97720-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALRAKADVW LARPWQCLPR TRALGTTAAL APNTLRPFEA IPQYSRNRWL    50
    KMLQILREEG QEGLHLEMHE AFRELGPIFR YSMGRTQVVY VMLPEVAEKV 100
    FQADSTQPSR TLLEPWVAHR EHRGLSRGVF LLNGPEWRFN RLRINPHMLS 150
    PKAVQKFVPM VDMVARDFLE FLKKKVLANA HGSLSMNFYS SMFNYTIEAS 200
    HFVLFGERLG LLGDDLNSGS LKFVNALNSI MKTTPQLMLL PSGLTRWIST 250
    RVWKENFDSW DFVSEYVTKN VKNVYQEVQS GGPQSWSVIS QLVAEGALTM 300
    DAILANSLEL TAGSVDTTSV PLVMTLFELA RNPDVQQAVR QESLAAEASV 350
    AANPQRAMSD LPLLRAVLKE TLRLYPVAVF LERILSSDLV LQNYHVPAGT 400
    ILHMSLYSMG RNPAVFPRPE HYLPQRWLER NGSFQHLTFG FGVRQCLGKR 450
    LAQVEMLLLL HHVLKSFRVE TQEREDVRMV YRFVLAPSSS PLLTFRPVS 499
    Length:499
    Mass (Da):56,821
    Last modified:May 1, 1997 - v1
    Checksum:iC798467266D741BD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S82228 mRNA. Translation: AAB47144.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S82228 mRNA. Translation: AAB47144.1 .

    3D structure databases

    ProteinModelPortali P97720.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4997037.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG051098.

    Enzyme and pathway databases

    UniPathwayi UPA00788 .

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002399. Cyt_P450_mitochondrial.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00408. MITP450.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The hamster adrenal cytochrome P450C11 has equipotent 11beta-hydroxylase and 19-hydroxylase activities, but no aldosterone synthase activity."
      Veronneau S., Bernard H., Cloutier M., Courtemanche J., Ducharme L., Lefebvre A., Mason J.I., Lehoux J.-G.
      J. Steroid Biochem. Mol. Biol. 57:125-139(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Syrian.
      Tissue: Adrenal gland.

    Entry informationi

    Entry nameiC11B1_MESAU
    AccessioniPrimary (citable) accession number: P97720
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3