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P97720 (C11B1_MESAU) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 11B1, mitochondrial
Alternative name(s):
CYPXIB1
Cytochrome P450C11
Steroid 11-beta-hydroxylase
EC=1.14.15.4
Gene names
Name:CYP11B1
OrganismMesocricetus auratus (Golden hamster)
Taxonomic identifier10036 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Protein attributes

Sequence length499 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Forms corticosterone from 11-deoxycorticosterone. Possesses high and nearly equal 11-beta-hydroxylase and 19-hydroxylase activities and a lower 18-hydroxylase activity. Involved in the formation of the precursor of 19-nor-deoxycorticosterone, a very potent mineralocorticoid involved in the development of essential hypertension.

Catalytic activity

A steroid + reduced adrenodoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenodoxin + H2O.

Cofactor

Heme group By similarity.

Pathway

Steroid biosynthesis; glucocorticoid biosynthesis.

Subcellular location

Mitochondrion membrane.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Keywords
   Biological processSteroidogenesis
   Cellular componentMembrane
Mitochondrion
   DomainTransit peptide
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
Gene Ontology (GO)
   Biological_processglucocorticoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentmitochondrial membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionheme binding

Inferred from electronic annotation. Source: InterPro

iron ion binding

Inferred from electronic annotation. Source: InterPro

steroid 11-beta-monooxygenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2424Mitochondrion By similarity
Chain25 – 499475Cytochrome P450 11B1, mitochondrial
PRO_0000003598

Sites

Metal binding4461Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
P97720 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: C798467266D741BD

FASTA49956,821
        10         20         30         40         50         60 
MALRAKADVW LARPWQCLPR TRALGTTAAL APNTLRPFEA IPQYSRNRWL KMLQILREEG 

        70         80         90        100        110        120 
QEGLHLEMHE AFRELGPIFR YSMGRTQVVY VMLPEVAEKV FQADSTQPSR TLLEPWVAHR 

       130        140        150        160        170        180 
EHRGLSRGVF LLNGPEWRFN RLRINPHMLS PKAVQKFVPM VDMVARDFLE FLKKKVLANA 

       190        200        210        220        230        240 
HGSLSMNFYS SMFNYTIEAS HFVLFGERLG LLGDDLNSGS LKFVNALNSI MKTTPQLMLL 

       250        260        270        280        290        300 
PSGLTRWIST RVWKENFDSW DFVSEYVTKN VKNVYQEVQS GGPQSWSVIS QLVAEGALTM 

       310        320        330        340        350        360 
DAILANSLEL TAGSVDTTSV PLVMTLFELA RNPDVQQAVR QESLAAEASV AANPQRAMSD 

       370        380        390        400        410        420 
LPLLRAVLKE TLRLYPVAVF LERILSSDLV LQNYHVPAGT ILHMSLYSMG RNPAVFPRPE 

       430        440        450        460        470        480 
HYLPQRWLER NGSFQHLTFG FGVRQCLGKR LAQVEMLLLL HHVLKSFRVE TQEREDVRMV 

       490 
YRFVLAPSSS PLLTFRPVS 

« Hide

References

[1]"The hamster adrenal cytochrome P450C11 has equipotent 11beta-hydroxylase and 19-hydroxylase activities, but no aldosterone synthase activity."
Veronneau S., Bernard H., Cloutier M., Courtemanche J., Ducharme L., Lefebvre A., Mason J.I., Lehoux J.-G.
J. Steroid Biochem. Mol. Biol. 57:125-139(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Syrian.
Tissue: Adrenal gland.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S82228 mRNA. Translation: AAB47144.1.

3D structure databases

ProteinModelPortalP97720.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4997037.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG051098.

Enzyme and pathway databases

UniPathwayUPA00788.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002399. Cyt_P450_mitochondrial.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00408. MITP450.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC11B1_MESAU
AccessionPrimary (citable) accession number: P97720
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: December 11, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways