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Protein

Cytochrome P450 11B1, mitochondrial

Gene

CYP11B1

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Forms corticosterone from 11-deoxycorticosterone. Possesses high and nearly equal 11-beta-hydroxylase and 19-hydroxylase activities and a lower 18-hydroxylase activity. Involved in the formation of the precursor of 19-nor-deoxycorticosterone, a very potent mineralocorticoid involved in the development of essential hypertension.

Catalytic activityi

A steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11-beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O.

Cofactori

hemeBy similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi446 – 4461Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. steroid 11-beta-monooxygenase activity Source: UniProtKB-EC

GO - Biological processi

  1. glucocorticoid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Steroidogenesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00788.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 11B1, mitochondrial
Alternative name(s):
CYPXIB1
Cytochrome P450C11
Steroid 11-beta-hydroxylase (EC:1.14.15.4)
Gene namesi
Name:CYP11B1
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2424MitochondrionBy similarityAdd
BLAST
Chaini25 – 499475Cytochrome P450 11B1, mitochondrialPRO_0000003598Add
BLAST

Interactioni

Protein-protein interaction databases

MINTiMINT-4997037.

Structurei

3D structure databases

ProteinModelPortaliP97720.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG051098.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002399. Cyt_P450_mitochondrial.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00408. MITP450.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97720-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRAKADVW LARPWQCLPR TRALGTTAAL APNTLRPFEA IPQYSRNRWL
60 70 80 90 100
KMLQILREEG QEGLHLEMHE AFRELGPIFR YSMGRTQVVY VMLPEVAEKV
110 120 130 140 150
FQADSTQPSR TLLEPWVAHR EHRGLSRGVF LLNGPEWRFN RLRINPHMLS
160 170 180 190 200
PKAVQKFVPM VDMVARDFLE FLKKKVLANA HGSLSMNFYS SMFNYTIEAS
210 220 230 240 250
HFVLFGERLG LLGDDLNSGS LKFVNALNSI MKTTPQLMLL PSGLTRWIST
260 270 280 290 300
RVWKENFDSW DFVSEYVTKN VKNVYQEVQS GGPQSWSVIS QLVAEGALTM
310 320 330 340 350
DAILANSLEL TAGSVDTTSV PLVMTLFELA RNPDVQQAVR QESLAAEASV
360 370 380 390 400
AANPQRAMSD LPLLRAVLKE TLRLYPVAVF LERILSSDLV LQNYHVPAGT
410 420 430 440 450
ILHMSLYSMG RNPAVFPRPE HYLPQRWLER NGSFQHLTFG FGVRQCLGKR
460 470 480 490
LAQVEMLLLL HHVLKSFRVE TQEREDVRMV YRFVLAPSSS PLLTFRPVS
Length:499
Mass (Da):56,821
Last modified:May 1, 1997 - v1
Checksum:iC798467266D741BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82228 mRNA. Translation: AAB47144.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82228 mRNA. Translation: AAB47144.1.

3D structure databases

ProteinModelPortaliP97720.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4997037.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG051098.

Enzyme and pathway databases

UniPathwayiUPA00788.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002399. Cyt_P450_mitochondrial.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00408. MITP450.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The hamster adrenal cytochrome P450C11 has equipotent 11beta-hydroxylase and 19-hydroxylase activities, but no aldosterone synthase activity."
    Veronneau S., Bernard H., Cloutier M., Courtemanche J., Ducharme L., Lefebvre A., Mason J.I., Lehoux J.-G.
    J. Steroid Biochem. Mol. Biol. 57:125-139(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Syrian.
    Tissue: Adrenal gland.

Entry informationi

Entry nameiC11B1_MESAU
AccessioniPrimary (citable) accession number: P97720
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: January 7, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.