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P97718

- ADA1A_MOUSE

UniProt

P97718 - ADA1A_MOUSE

Protein

Alpha-1A adrenergic receptor

Gene

Adra1a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes By similarity.By similarity

    GO - Molecular functioni

    1. alpha1-adrenergic receptor activity Source: MGI
    2. protein heterodimerization activity Source: UniProtKB

    GO - Biological processi

    1. activation of phospholipase C activity Source: Ensembl
    2. adrenergic receptor signaling pathway Source: GOC
    3. adult heart development Source: MGI
    4. aging Source: Ensembl
    5. calcium ion transport into cytosol Source: Ensembl
    6. cell growth Source: MGI
    7. micturition Source: Ensembl
    8. negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure Source: MGI
    9. negative regulation of Rho protein signal transduction Source: MGI
    10. negative regulation of synaptic transmission, GABAergic Source: Ensembl
    11. norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure Source: MGI
    12. organ growth Source: MGI
    13. phospholipase C-activating G-protein coupled receptor signaling pathway Source: MGI
    14. pilomotor reflex Source: BHF-UCL
    15. positive regulation of action potential Source: Ensembl
    16. positive regulation of cardiac muscle contraction Source: Ensembl
    17. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    18. positive regulation of heart rate by epinephrine-norepinephrine Source: MGI
    19. positive regulation of MAPK cascade Source: MGI
    20. positive regulation of protein kinase C signaling Source: Ensembl
    21. positive regulation of smooth muscle contraction Source: BHF-UCL
    22. positive regulation of systemic arterial blood pressure Source: Ensembl
    23. positive regulation of the force of heart contraction by epinephrine-norepinephrine Source: MGI
    24. positive regulation of vasoconstriction Source: Ensembl
    25. response to drug Source: Ensembl
    26. response to hormone Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_204733. G alpha (12/13) signalling events.
    REACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-1A adrenergic receptor
    Alternative name(s):
    Alpha-1A adrenoreceptor
    Short name:
    Alpha-1A adrenoceptor
    Alpha-1C adrenergic receptor
    Gene namesi
    Name:Adra1a
    Synonyms:Adra1c
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:104773. Adra1a.

    Subcellular locationi

    Nucleus membrane 1 Publication; Multi-pass membrane protein 1 Publication. Cell membrane By similarity; Multi-pass membrane protein By similarity
    Note: Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes By similarity.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: MGI
    3. nuclear membrane Source: UniProtKB
    4. nucleus Source: UniProtKB
    5. T-tubule Source: Ensembl
    6. Z disc Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 466466Alpha-1A adrenergic receptorPRO_0000069064Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi13 – 131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi22 – 221N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi99 ↔ 176PROSITE-ProRule annotation
    Modified residuei215 – 2151Phosphoserine; by PKASequence Analysis
    Lipidationi345 – 3451S-palmitoyl cysteineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    PRIDEiP97718.

    PTM databases

    PhosphoSiteiP97718.

    Expressioni

    Gene expression databases

    ArrayExpressiP97718.
    BgeeiP97718.
    CleanExiMM_ADRA1A.
    GenevestigatoriP97718.

    Interactioni

    Subunit structurei

    Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP97718.
    SMRiP97718. Positions 29-341.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2727ExtracellularBy similarityAdd
    BLAST
    Topological domaini52 – 6413CytoplasmicBy similarityAdd
    BLAST
    Topological domaini89 – 9911ExtracellularBy similarityAdd
    BLAST
    Topological domaini123 – 14321CytoplasmicBy similarityAdd
    BLAST
    Topological domaini168 – 18114ExtracellularBy similarityAdd
    BLAST
    Topological domaini206 – 27368CytoplasmicBy similarityAdd
    BLAST
    Topological domaini298 – 3058ExtracellularBy similarity
    Topological domaini330 – 466137CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 5124Helical; Name=1By similarityAdd
    BLAST
    Transmembranei65 – 8824Helical; Name=2By similarityAdd
    BLAST
    Transmembranei100 – 12223Helical; Name=3By similarityAdd
    BLAST
    Transmembranei144 – 16724Helical; Name=4By similarityAdd
    BLAST
    Transmembranei182 – 20524Helical; Name=5By similarityAdd
    BLAST
    Transmembranei274 – 29724Helical; Name=6By similarityAdd
    BLAST
    Transmembranei306 – 32924Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni334 – 34916Nuclear localization signalBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG253615.
    GeneTreeiENSGT00750000117429.
    HOGENOMiHOG000239244.
    HOVERGENiHBG106962.
    InParanoidiQ8BV77.
    KOiK04135.
    OMAiCTTARVR.
    PhylomeDBiP97718.
    TreeFamiTF331895.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR002233. ADR_fam.
    IPR001004. ADRA1A_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01103. ADRENERGICR.
    PR00557. ADRENRGCA1AR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P97718-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVLLSENASE GSNCTHPPAQ VNISKAILLG VILGGLIIFG VLGNILVILS    50
    VACHRHLHSV THYYIVNLAV ADLLLTSTVL PFSAIFEILG YWAFGRVFCN 100
    IWAAVDVLCC TASIMGLCII SIDRYIGVSY PLRYPTIVTQ RRGVRALLCV 150
    WALSLVISIG PLFGWRQQAP EDETICQINE EPGYVLFSAL GSFYVPLTII 200
    LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN VPAEGSGVSS 250
    AKNKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGSFFPN 300
    FKPPETVFKI VFWLGYLNSC INPIIYPCSS QEFKKAFQNV LRIQCLRRRQ 350
    SSKHALGYTL HPPSQAVEGQ HRGMVRIPVG SGETFYKISK TDGVREWKFF 400
    SSMPQGSARI TMPKDQSACT TARVRSKSFL QVCCCVGSST PRPEENHQVP 450
    TIKIHTISLG ENGEEV 466
    Length:466
    Mass (Da):51,744
    Last modified:July 27, 2011 - v3
    Checksum:i8C5FE5C67E885795
    GO

    Sequence cautioni

    The sequence AAB47044.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti369 – 3691G → E in AAC02658. (PubMed:9630362)Curated
    Sequence conflicti395 – 3951R → C in AAC02658. (PubMed:9630362)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF031431 mRNA. Translation: AAC02658.1.
    AK079597 mRNA. Translation: BAC37694.1.
    CH466535 Genomic DNA. Translation: EDL35992.1.
    BC113139 mRNA. Translation: AAI13140.1.
    S80220 mRNA. Translation: AAB47044.1. Different initiation.
    CCDSiCCDS27223.1.
    RefSeqiNP_001258689.1. NM_001271760.1.
    NP_038489.2. NM_013461.4.
    XP_006518507.1. XM_006518444.1.
    XP_006518508.1. XM_006518445.1.
    XP_006518509.1. XM_006518446.1.
    XP_006518510.1. XM_006518447.1.
    UniGeneiMm.57064.

    Genome annotation databases

    EnsembliENSMUST00000054661; ENSMUSP00000053703; ENSMUSG00000045875.
    ENSMUST00000159068; ENSMUSP00000124570; ENSMUSG00000045875.
    ENSMUST00000161339; ENSMUSP00000125354; ENSMUSG00000045875.
    GeneIDi11549.
    KEGGimmu:11549.
    UCSCiuc007ukh.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF031431 mRNA. Translation: AAC02658.1 .
    AK079597 mRNA. Translation: BAC37694.1 .
    CH466535 Genomic DNA. Translation: EDL35992.1 .
    BC113139 mRNA. Translation: AAI13140.1 .
    S80220 mRNA. Translation: AAB47044.1 . Different initiation.
    CCDSi CCDS27223.1.
    RefSeqi NP_001258689.1. NM_001271760.1.
    NP_038489.2. NM_013461.4.
    XP_006518507.1. XM_006518444.1.
    XP_006518508.1. XM_006518445.1.
    XP_006518509.1. XM_006518446.1.
    XP_006518510.1. XM_006518447.1.
    UniGenei Mm.57064.

    3D structure databases

    ProteinModelPortali P97718.
    SMRi P97718. Positions 29-341.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P97718.
    ChEMBLi CHEMBL2111452.
    GuidetoPHARMACOLOGYi 22.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P97718.

    Proteomic databases

    PRIDEi P97718.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000054661 ; ENSMUSP00000053703 ; ENSMUSG00000045875 .
    ENSMUST00000159068 ; ENSMUSP00000124570 ; ENSMUSG00000045875 .
    ENSMUST00000161339 ; ENSMUSP00000125354 ; ENSMUSG00000045875 .
    GeneIDi 11549.
    KEGGi mmu:11549.
    UCSCi uc007ukh.1. mouse.

    Organism-specific databases

    CTDi 148.
    MGIi MGI:104773. Adra1a.

    Phylogenomic databases

    eggNOGi NOG253615.
    GeneTreei ENSGT00750000117429.
    HOGENOMi HOG000239244.
    HOVERGENi HBG106962.
    InParanoidi Q8BV77.
    KOi K04135.
    OMAi CTTARVR.
    PhylomeDBi P97718.
    TreeFami TF331895.

    Enzyme and pathway databases

    Reactomei REACT_204733. G alpha (12/13) signalling events.
    REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 279030.
    PROi P97718.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P97718.
    Bgeei P97718.
    CleanExi MM_ADRA1A.
    Genevestigatori P97718.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR002233. ADR_fam.
    IPR001004. ADRA1A_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01103. ADRENERGICR.
    PR00557. ADRENRGCA1AR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, expression and characterization of cDNA encoding a mouse alpha1a-adrenoceptor."
      Xiao L., Scofield M.A., Jeffries W.B.
      Br. J. Pharmacol. 124:213-221(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
      Strain: CD-1.
      Tissue: Brain and Kidney.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Spinal cord.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Molecular cloning of alpha 1d-adrenergic receptor and tissue distribution of three alpha 1-adrenergic receptor subtypes in mouse."
      Alonso-Llamazares A., Zamanillo D., Casanova E., Ovalle S., Calvo P., Chinchetru M.A.
      J. Neurochem. 65:2387-2392(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 197-280.
      Tissue: Brain.
    6. "Nuclear localization drives alpha1-adrenergic receptor oligomerization and signaling in cardiac myocytes."
      Wright C.D., Wu S.C., Dahl E.F., Sazama A.J., O'Connell T.D.
      Cell. Signal. 24:794-802(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiADA1A_MOUSE
    AccessioniPrimary (citable) accession number: P97718
    Secondary accession number(s): O54913, Q8BV77
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 124 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3