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Protein

Alpha-1A adrenergic receptor

Gene

Adra1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).By similarity

GO - Molecular functioni

  • alpha1-adrenergic receptor activity Source: MGI
  • protein heterodimerization activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-390696. Adrenoceptors.
R-MMU-416476. G alpha (q) signalling events.
R-MMU-416482. G alpha (12/13) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1A adrenergic receptor
Alternative name(s):
Alpha-1A adrenoreceptor
Short name:
Alpha-1A adrenoceptor
Alpha-1C adrenergic receptor
Gene namesi
Name:Adra1a
Synonyms:Adra1c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:104773. Adra1a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularBy similarityAdd BLAST27
Transmembranei28 – 51Helical; Name=1By similarityAdd BLAST24
Topological domaini52 – 64CytoplasmicBy similarityAdd BLAST13
Transmembranei65 – 88Helical; Name=2By similarityAdd BLAST24
Topological domaini89 – 99ExtracellularBy similarityAdd BLAST11
Transmembranei100 – 122Helical; Name=3By similarityAdd BLAST23
Topological domaini123 – 143CytoplasmicBy similarityAdd BLAST21
Transmembranei144 – 167Helical; Name=4By similarityAdd BLAST24
Topological domaini168 – 181ExtracellularBy similarityAdd BLAST14
Transmembranei182 – 205Helical; Name=5By similarityAdd BLAST24
Topological domaini206 – 273CytoplasmicBy similarityAdd BLAST68
Transmembranei274 – 297Helical; Name=6By similarityAdd BLAST24
Topological domaini298 – 305ExtracellularBy similarity8
Transmembranei306 – 329Helical; Name=7By similarityAdd BLAST24
Topological domaini330 – 466CytoplasmicBy similarityAdd BLAST137

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • membrane Source: MGI
  • nuclear membrane Source: UniProtKB
  • nucleus Source: UniProtKB
  • T-tubule Source: Ensembl
  • Z disc Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2111452.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690641 – 466Alpha-1A adrenergic receptorAdd BLAST466

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...)Sequence analysis1
Glycosylationi13N-linked (GlcNAc...)Sequence analysis1
Glycosylationi22N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi99 ↔ 176PROSITE-ProRule annotation
Modified residuei215Phosphoserine; by PKASequence analysis1
Lipidationi345S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP97718.
PRIDEiP97718.

PTM databases

iPTMnetiP97718.
PhosphoSitePlusiP97718.

Expressioni

Gene expression databases

BgeeiENSMUSG00000045875.
CleanExiMM_ADRA1A.
ExpressionAtlasiP97718. baseline and differential.
GenevisibleiP97718. MM.

Interactioni

Subunit structurei

Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053703.

Structurei

3D structure databases

ProteinModelPortaliP97718.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi334 – 349Nuclear localization signalBy similarityAdd BLAST16

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239244.
HOVERGENiHBG106962.
InParanoidiP97718.
KOiK04135.
OMAiETFYRIS.
OrthoDBiEOG091G06VI.
PhylomeDBiP97718.
TreeFamiTF331895.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR001004. ADRA1A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00557. ADRENRGCA1AR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97718-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLLSENASE GSNCTHPPAQ VNISKAILLG VILGGLIIFG VLGNILVILS
60 70 80 90 100
VACHRHLHSV THYYIVNLAV ADLLLTSTVL PFSAIFEILG YWAFGRVFCN
110 120 130 140 150
IWAAVDVLCC TASIMGLCII SIDRYIGVSY PLRYPTIVTQ RRGVRALLCV
160 170 180 190 200
WALSLVISIG PLFGWRQQAP EDETICQINE EPGYVLFSAL GSFYVPLTII
210 220 230 240 250
LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN VPAEGSGVSS
260 270 280 290 300
AKNKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGSFFPN
310 320 330 340 350
FKPPETVFKI VFWLGYLNSC INPIIYPCSS QEFKKAFQNV LRIQCLRRRQ
360 370 380 390 400
SSKHALGYTL HPPSQAVEGQ HRGMVRIPVG SGETFYKISK TDGVREWKFF
410 420 430 440 450
SSMPQGSARI TMPKDQSACT TARVRSKSFL QVCCCVGSST PRPEENHQVP
460
TIKIHTISLG ENGEEV
Length:466
Mass (Da):51,744
Last modified:July 27, 2011 - v3
Checksum:i8C5FE5C67E885795
GO

Sequence cautioni

The sequence AAB47044 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti369G → E in AAC02658 (PubMed:9630362).Curated1
Sequence conflicti395R → C in AAC02658 (PubMed:9630362).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031431 mRNA. Translation: AAC02658.1.
AK079597 mRNA. Translation: BAC37694.1.
CH466535 Genomic DNA. Translation: EDL35992.1.
BC113139 mRNA. Translation: AAI13140.1.
S80220 mRNA. Translation: AAB47044.1. Different initiation.
CCDSiCCDS27223.1.
RefSeqiNP_001258689.1. NM_001271760.1.
NP_038489.2. NM_013461.4.
XP_006518507.1. XM_006518444.3.
XP_011243225.1. XM_011244923.2.
XP_011243226.1. XM_011244924.2.
XP_011243227.1. XM_011244925.2.
XP_017171289.1. XM_017315800.1.
XP_017171290.1. XM_017315801.1.
UniGeneiMm.57064.

Genome annotation databases

EnsembliENSMUST00000054661; ENSMUSP00000053703; ENSMUSG00000045875.
ENSMUST00000159068; ENSMUSP00000124570; ENSMUSG00000045875.
ENSMUST00000161339; ENSMUSP00000125354; ENSMUSG00000045875.
GeneIDi11549.
KEGGimmu:11549.
UCSCiuc007ukh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031431 mRNA. Translation: AAC02658.1.
AK079597 mRNA. Translation: BAC37694.1.
CH466535 Genomic DNA. Translation: EDL35992.1.
BC113139 mRNA. Translation: AAI13140.1.
S80220 mRNA. Translation: AAB47044.1. Different initiation.
CCDSiCCDS27223.1.
RefSeqiNP_001258689.1. NM_001271760.1.
NP_038489.2. NM_013461.4.
XP_006518507.1. XM_006518444.3.
XP_011243225.1. XM_011244923.2.
XP_011243226.1. XM_011244924.2.
XP_011243227.1. XM_011244925.2.
XP_017171289.1. XM_017315800.1.
XP_017171290.1. XM_017315801.1.
UniGeneiMm.57064.

3D structure databases

ProteinModelPortaliP97718.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053703.

Chemistry databases

ChEMBLiCHEMBL2111452.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP97718.
PhosphoSitePlusiP97718.

Proteomic databases

PaxDbiP97718.
PRIDEiP97718.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054661; ENSMUSP00000053703; ENSMUSG00000045875.
ENSMUST00000159068; ENSMUSP00000124570; ENSMUSG00000045875.
ENSMUST00000161339; ENSMUSP00000125354; ENSMUSG00000045875.
GeneIDi11549.
KEGGimmu:11549.
UCSCiuc007ukh.2. mouse.

Organism-specific databases

CTDi148.
MGIiMGI:104773. Adra1a.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239244.
HOVERGENiHBG106962.
InParanoidiP97718.
KOiK04135.
OMAiETFYRIS.
OrthoDBiEOG091G06VI.
PhylomeDBiP97718.
TreeFamiTF331895.

Enzyme and pathway databases

ReactomeiR-MMU-390696. Adrenoceptors.
R-MMU-416476. G alpha (q) signalling events.
R-MMU-416482. G alpha (12/13) signalling events.

Miscellaneous databases

PROiP97718.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045875.
CleanExiMM_ADRA1A.
ExpressionAtlasiP97718. baseline and differential.
GenevisibleiP97718. MM.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR001004. ADRA1A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00557. ADRENRGCA1AR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADA1A_MOUSE
AccessioniPrimary (citable) accession number: P97718
Secondary accession number(s): O54913, Q8BV77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.