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P97718

- ADA1A_MOUSE

UniProt

P97718 - ADA1A_MOUSE

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Protein
Alpha-1A adrenergic receptor
Gene
Adra1a, Adra1c
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes By similarity.

GO - Molecular functioni

  1. alpha1-adrenergic receptor activity Source: MGI
  2. protein heterodimerization activity Source: UniProtKB

GO - Biological processi

  1. activation of phospholipase C activity Source: Ensembl
  2. adrenergic receptor signaling pathway Source: GOC
  3. adult heart development Source: MGI
  4. aging Source: Ensembl
  5. calcium ion transport into cytosol Source: Ensembl
  6. cell growth Source: MGI
  7. micturition Source: Ensembl
  8. negative regulation of Rho protein signal transduction Source: MGI
  9. negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure Source: MGI
  10. negative regulation of synaptic transmission, GABAergic Source: Ensembl
  11. norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure Source: MGI
  12. organ growth Source: MGI
  13. phospholipase C-activating G-protein coupled receptor signaling pathway Source: MGI
  14. pilomotor reflex Source: BHF-UCL
  15. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  16. positive regulation of MAPK cascade Source: MGI
  17. positive regulation of action potential Source: Ensembl
  18. positive regulation of cardiac muscle contraction Source: Ensembl
  19. positive regulation of heart rate by epinephrine-norepinephrine Source: MGI
  20. positive regulation of protein kinase C signaling Source: Ensembl
  21. positive regulation of smooth muscle contraction Source: BHF-UCL
  22. positive regulation of systemic arterial blood pressure Source: Ensembl
  23. positive regulation of the force of heart contraction by epinephrine-norepinephrine Source: MGI
  24. positive regulation of vasoconstriction Source: Ensembl
  25. response to drug Source: Ensembl
  26. response to hormone Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_204733. G alpha (12/13) signalling events.
REACT_207651. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1A adrenergic receptor
Alternative name(s):
Alpha-1A adrenoreceptor
Short name:
Alpha-1A adrenoceptor
Alpha-1C adrenergic receptor
Gene namesi
Name:Adra1a
Synonyms:Adra1c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:104773. Adra1a.

Subcellular locationi

Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein By similarity
Note: Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes By similarity.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727Extracellular By similarity
Add
BLAST
Transmembranei28 – 5124Helical; Name=1; By similarity
Add
BLAST
Topological domaini52 – 6413Cytoplasmic By similarity
Add
BLAST
Transmembranei65 – 8824Helical; Name=2; By similarity
Add
BLAST
Topological domaini89 – 9911Extracellular By similarity
Add
BLAST
Transmembranei100 – 12223Helical; Name=3; By similarity
Add
BLAST
Topological domaini123 – 14321Cytoplasmic By similarity
Add
BLAST
Transmembranei144 – 16724Helical; Name=4; By similarity
Add
BLAST
Topological domaini168 – 18114Extracellular By similarity
Add
BLAST
Transmembranei182 – 20524Helical; Name=5; By similarity
Add
BLAST
Topological domaini206 – 27368Cytoplasmic By similarity
Add
BLAST
Transmembranei274 – 29724Helical; Name=6; By similarity
Add
BLAST
Topological domaini298 – 3058Extracellular By similarity
Transmembranei306 – 32924Helical; Name=7; By similarity
Add
BLAST
Topological domaini330 – 466137Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. T-tubule Source: Ensembl
  2. Z disc Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. membrane Source: MGI
  5. nuclear membrane Source: UniProtKB
  6. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 466466Alpha-1A adrenergic receptor
PRO_0000069064Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...) Reviewed prediction
Glycosylationi13 – 131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi22 – 221N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi99 ↔ 176 By similarity
Modified residuei215 – 2151Phosphoserine; by PKA Reviewed prediction
Lipidationi345 – 3451S-palmitoyl cysteine Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PRIDEiP97718.

PTM databases

PhosphoSiteiP97718.

Expressioni

Gene expression databases

ArrayExpressiP97718.
BgeeiP97718.
CleanExiMM_ADRA1A.
GenevestigatoriP97718.

Interactioni

Subunit structurei

Homo- and heterooligomer By similarity. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes By similarity.

Structurei

3D structure databases

ProteinModelPortaliP97718.
SMRiP97718. Positions 29-341.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni334 – 34916Nuclear localization signal By similarity
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG253615.
GeneTreeiENSGT00750000117429.
HOGENOMiHOG000239244.
HOVERGENiHBG106962.
InParanoidiQ8BV77.
KOiK04135.
OMAiCTTARVR.
PhylomeDBiP97718.
TreeFamiTF331895.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR002233. ADR_fam.
IPR001004. ADRA1A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00557. ADRENRGCA1AR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97718-1 [UniParc]FASTAAdd to Basket

« Hide

MVLLSENASE GSNCTHPPAQ VNISKAILLG VILGGLIIFG VLGNILVILS    50
VACHRHLHSV THYYIVNLAV ADLLLTSTVL PFSAIFEILG YWAFGRVFCN 100
IWAAVDVLCC TASIMGLCII SIDRYIGVSY PLRYPTIVTQ RRGVRALLCV 150
WALSLVISIG PLFGWRQQAP EDETICQINE EPGYVLFSAL GSFYVPLTII 200
LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN VPAEGSGVSS 250
AKNKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGSFFPN 300
FKPPETVFKI VFWLGYLNSC INPIIYPCSS QEFKKAFQNV LRIQCLRRRQ 350
SSKHALGYTL HPPSQAVEGQ HRGMVRIPVG SGETFYKISK TDGVREWKFF 400
SSMPQGSARI TMPKDQSACT TARVRSKSFL QVCCCVGSST PRPEENHQVP 450
TIKIHTISLG ENGEEV 466
Length:466
Mass (Da):51,744
Last modified:July 27, 2011 - v3
Checksum:i8C5FE5C67E885795
GO

Sequence cautioni

The sequence AAB47044.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti369 – 3691G → E in AAC02658. 1 Publication
Sequence conflicti395 – 3951R → C in AAC02658. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF031431 mRNA. Translation: AAC02658.1.
AK079597 mRNA. Translation: BAC37694.1.
CH466535 Genomic DNA. Translation: EDL35992.1.
BC113139 mRNA. Translation: AAI13140.1.
S80220 mRNA. Translation: AAB47044.1. Different initiation.
CCDSiCCDS27223.1.
RefSeqiNP_001258689.1. NM_001271760.1.
NP_038489.2. NM_013461.4.
XP_006518507.1. XM_006518444.1.
XP_006518508.1. XM_006518445.1.
XP_006518509.1. XM_006518446.1.
XP_006518510.1. XM_006518447.1.
UniGeneiMm.57064.

Genome annotation databases

EnsembliENSMUST00000054661; ENSMUSP00000053703; ENSMUSG00000045875.
ENSMUST00000159068; ENSMUSP00000124570; ENSMUSG00000045875.
ENSMUST00000161339; ENSMUSP00000125354; ENSMUSG00000045875.
GeneIDi11549.
KEGGimmu:11549.
UCSCiuc007ukh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF031431 mRNA. Translation: AAC02658.1 .
AK079597 mRNA. Translation: BAC37694.1 .
CH466535 Genomic DNA. Translation: EDL35992.1 .
BC113139 mRNA. Translation: AAI13140.1 .
S80220 mRNA. Translation: AAB47044.1 . Different initiation.
CCDSi CCDS27223.1.
RefSeqi NP_001258689.1. NM_001271760.1.
NP_038489.2. NM_013461.4.
XP_006518507.1. XM_006518444.1.
XP_006518508.1. XM_006518445.1.
XP_006518509.1. XM_006518446.1.
XP_006518510.1. XM_006518447.1.
UniGenei Mm.57064.

3D structure databases

ProteinModelPortali P97718.
SMRi P97718. Positions 29-341.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi P97718.
ChEMBLi CHEMBL2111452.
GuidetoPHARMACOLOGYi 22.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P97718.

Proteomic databases

PRIDEi P97718.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000054661 ; ENSMUSP00000053703 ; ENSMUSG00000045875 .
ENSMUST00000159068 ; ENSMUSP00000124570 ; ENSMUSG00000045875 .
ENSMUST00000161339 ; ENSMUSP00000125354 ; ENSMUSG00000045875 .
GeneIDi 11549.
KEGGi mmu:11549.
UCSCi uc007ukh.1. mouse.

Organism-specific databases

CTDi 148.
MGIi MGI:104773. Adra1a.

Phylogenomic databases

eggNOGi NOG253615.
GeneTreei ENSGT00750000117429.
HOGENOMi HOG000239244.
HOVERGENi HBG106962.
InParanoidi Q8BV77.
KOi K04135.
OMAi CTTARVR.
PhylomeDBi P97718.
TreeFami TF331895.

Enzyme and pathway databases

Reactomei REACT_204733. G alpha (12/13) signalling events.
REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 279030.
PROi P97718.
SOURCEi Search...

Gene expression databases

ArrayExpressi P97718.
Bgeei P97718.
CleanExi MM_ADRA1A.
Genevestigatori P97718.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR002233. ADR_fam.
IPR001004. ADRA1A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01103. ADRENERGICR.
PR00557. ADRENRGCA1AR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, expression and characterization of cDNA encoding a mouse alpha1a-adrenoceptor."
    Xiao L., Scofield M.A., Jeffries W.B.
    Br. J. Pharmacol. 124:213-221(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    Strain: CD-1.
    Tissue: Brain and Kidney.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Spinal cord.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Molecular cloning of alpha 1d-adrenergic receptor and tissue distribution of three alpha 1-adrenergic receptor subtypes in mouse."
    Alonso-Llamazares A., Zamanillo D., Casanova E., Ovalle S., Calvo P., Chinchetru M.A.
    J. Neurochem. 65:2387-2392(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 197-280.
    Tissue: Brain.
  6. "Nuclear localization drives alpha1-adrenergic receptor oligomerization and signaling in cardiac myocytes."
    Wright C.D., Wu S.C., Dahl E.F., Sazama A.J., O'Connell T.D.
    Cell. Signal. 24:794-802(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiADA1A_MOUSE
AccessioniPrimary (citable) accession number: P97718
Secondary accession number(s): O54913, Q8BV77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi