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P97718

- ADA1A_MOUSE

UniProt

P97718 - ADA1A_MOUSE

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Protein

Alpha-1A adrenergic receptor

Gene

Adra1a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).By similarity

GO - Molecular functioni

  1. alpha1-adrenergic receptor activity Source: MGI
  2. protein heterodimerization activity Source: UniProtKB

GO - Biological processi

  1. activation of phospholipase C activity Source: Ensembl
  2. adrenergic receptor signaling pathway Source: GOC
  3. adult heart development Source: MGI
  4. aging Source: Ensembl
  5. calcium ion transport into cytosol Source: Ensembl
  6. cell growth Source: MGI
  7. micturition Source: Ensembl
  8. negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure Source: MGI
  9. negative regulation of Rho protein signal transduction Source: MGI
  10. negative regulation of synaptic transmission, GABAergic Source: Ensembl
  11. norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure Source: MGI
  12. organ growth Source: MGI
  13. phospholipase C-activating G-protein coupled receptor signaling pathway Source: MGI
  14. pilomotor reflex Source: BHF-UCL
  15. positive regulation of action potential Source: Ensembl
  16. positive regulation of cardiac muscle contraction Source: Ensembl
  17. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  18. positive regulation of heart rate by epinephrine-norepinephrine Source: MGI
  19. positive regulation of MAPK cascade Source: MGI
  20. positive regulation of protein kinase C signaling Source: Ensembl
  21. positive regulation of smooth muscle contraction Source: BHF-UCL
  22. positive regulation of systemic arterial blood pressure Source: Ensembl
  23. positive regulation of the force of heart contraction by epinephrine-norepinephrine Source: MGI
  24. positive regulation of vasoconstriction Source: Ensembl
  25. response to drug Source: Ensembl
  26. response to hormone Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_204733. G alpha (12/13) signalling events.
REACT_207651. G alpha (q) signalling events.
REACT_255413. Adrenoceptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1A adrenergic receptor
Alternative name(s):
Alpha-1A adrenoreceptor
Short name:
Alpha-1A adrenoceptor
Alpha-1C adrenergic receptor
Gene namesi
Name:Adra1a
Synonyms:Adra1c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:104773. Adra1a.

Subcellular locationi

Nucleus membrane 1 Publication; Multi-pass membrane protein 1 Publication. Cell membrane By similarity; Multi-pass membrane protein By similarity
Note: Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes (By similarity).By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularBy similarityAdd
BLAST
Transmembranei28 – 5124Helical; Name=1By similarityAdd
BLAST
Topological domaini52 – 6413CytoplasmicBy similarityAdd
BLAST
Transmembranei65 – 8824Helical; Name=2By similarityAdd
BLAST
Topological domaini89 – 9911ExtracellularBy similarityAdd
BLAST
Transmembranei100 – 12223Helical; Name=3By similarityAdd
BLAST
Topological domaini123 – 14321CytoplasmicBy similarityAdd
BLAST
Transmembranei144 – 16724Helical; Name=4By similarityAdd
BLAST
Topological domaini168 – 18114ExtracellularBy similarityAdd
BLAST
Transmembranei182 – 20524Helical; Name=5By similarityAdd
BLAST
Topological domaini206 – 27368CytoplasmicBy similarityAdd
BLAST
Transmembranei274 – 29724Helical; Name=6By similarityAdd
BLAST
Topological domaini298 – 3058ExtracellularBy similarity
Transmembranei306 – 32924Helical; Name=7By similarityAdd
BLAST
Topological domaini330 – 466137CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: MGI
  3. nuclear membrane Source: UniProtKB
  4. nucleus Source: UniProtKB
  5. T-tubule Source: Ensembl
  6. Z disc Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 466466Alpha-1A adrenergic receptorPRO_0000069064Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
Glycosylationi13 – 131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi22 – 221N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi99 ↔ 176PROSITE-ProRule annotation
Modified residuei215 – 2151Phosphoserine; by PKASequence Analysis
Lipidationi345 – 3451S-palmitoyl cysteineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PRIDEiP97718.

PTM databases

PhosphoSiteiP97718.

Expressioni

Gene expression databases

BgeeiP97718.
CleanExiMM_ADRA1A.
ExpressionAtlasiP97718. baseline and differential.
GenevestigatoriP97718.

Interactioni

Subunit structurei

Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes.By similarity

Structurei

3D structure databases

ProteinModelPortaliP97718.
SMRiP97718. Positions 29-361.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni334 – 34916Nuclear localization signalBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG253615.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239244.
HOVERGENiHBG106962.
InParanoidiP97718.
KOiK04135.
OMAiCTTARVR.
PhylomeDBiP97718.
TreeFamiTF331895.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR002233. ADR_fam.
IPR001004. ADRA1A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00557. ADRENRGCA1AR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97718-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLLSENASE GSNCTHPPAQ VNISKAILLG VILGGLIIFG VLGNILVILS
60 70 80 90 100
VACHRHLHSV THYYIVNLAV ADLLLTSTVL PFSAIFEILG YWAFGRVFCN
110 120 130 140 150
IWAAVDVLCC TASIMGLCII SIDRYIGVSY PLRYPTIVTQ RRGVRALLCV
160 170 180 190 200
WALSLVISIG PLFGWRQQAP EDETICQINE EPGYVLFSAL GSFYVPLTII
210 220 230 240 250
LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN VPAEGSGVSS
260 270 280 290 300
AKNKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGSFFPN
310 320 330 340 350
FKPPETVFKI VFWLGYLNSC INPIIYPCSS QEFKKAFQNV LRIQCLRRRQ
360 370 380 390 400
SSKHALGYTL HPPSQAVEGQ HRGMVRIPVG SGETFYKISK TDGVREWKFF
410 420 430 440 450
SSMPQGSARI TMPKDQSACT TARVRSKSFL QVCCCVGSST PRPEENHQVP
460
TIKIHTISLG ENGEEV
Length:466
Mass (Da):51,744
Last modified:July 27, 2011 - v3
Checksum:i8C5FE5C67E885795
GO

Sequence cautioni

The sequence AAB47044.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti369 – 3691G → E in AAC02658. (PubMed:9630362)Curated
Sequence conflicti395 – 3951R → C in AAC02658. (PubMed:9630362)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031431 mRNA. Translation: AAC02658.1.
AK079597 mRNA. Translation: BAC37694.1.
CH466535 Genomic DNA. Translation: EDL35992.1.
BC113139 mRNA. Translation: AAI13140.1.
S80220 mRNA. Translation: AAB47044.1. Different initiation.
CCDSiCCDS27223.1.
RefSeqiNP_001258689.1. NM_001271760.1.
NP_038489.2. NM_013461.4.
XP_006518507.1. XM_006518444.1.
XP_006518508.1. XM_006518445.1.
XP_006518509.1. XM_006518446.1.
XP_006518510.1. XM_006518447.1.
UniGeneiMm.57064.

Genome annotation databases

EnsembliENSMUST00000054661; ENSMUSP00000053703; ENSMUSG00000045875.
ENSMUST00000159068; ENSMUSP00000124570; ENSMUSG00000045875.
ENSMUST00000161339; ENSMUSP00000125354; ENSMUSG00000045875.
GeneIDi11549.
KEGGimmu:11549.
UCSCiuc007ukh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031431 mRNA. Translation: AAC02658.1 .
AK079597 mRNA. Translation: BAC37694.1 .
CH466535 Genomic DNA. Translation: EDL35992.1 .
BC113139 mRNA. Translation: AAI13140.1 .
S80220 mRNA. Translation: AAB47044.1 . Different initiation.
CCDSi CCDS27223.1.
RefSeqi NP_001258689.1. NM_001271760.1.
NP_038489.2. NM_013461.4.
XP_006518507.1. XM_006518444.1.
XP_006518508.1. XM_006518445.1.
XP_006518509.1. XM_006518446.1.
XP_006518510.1. XM_006518447.1.
UniGenei Mm.57064.

3D structure databases

ProteinModelPortali P97718.
SMRi P97718. Positions 29-361.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL2111452.
GuidetoPHARMACOLOGYi 22.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P97718.

Proteomic databases

PRIDEi P97718.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000054661 ; ENSMUSP00000053703 ; ENSMUSG00000045875 .
ENSMUST00000159068 ; ENSMUSP00000124570 ; ENSMUSG00000045875 .
ENSMUST00000161339 ; ENSMUSP00000125354 ; ENSMUSG00000045875 .
GeneIDi 11549.
KEGGi mmu:11549.
UCSCi uc007ukh.1. mouse.

Organism-specific databases

CTDi 148.
MGIi MGI:104773. Adra1a.

Phylogenomic databases

eggNOGi NOG253615.
GeneTreei ENSGT00760000118795.
HOGENOMi HOG000239244.
HOVERGENi HBG106962.
InParanoidi P97718.
KOi K04135.
OMAi CTTARVR.
PhylomeDBi P97718.
TreeFami TF331895.

Enzyme and pathway databases

Reactomei REACT_204733. G alpha (12/13) signalling events.
REACT_207651. G alpha (q) signalling events.
REACT_255413. Adrenoceptors.

Miscellaneous databases

NextBioi 279030.
PROi P97718.
SOURCEi Search...

Gene expression databases

Bgeei P97718.
CleanExi MM_ADRA1A.
ExpressionAtlasi P97718. baseline and differential.
Genevestigatori P97718.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR002233. ADR_fam.
IPR001004. ADRA1A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01103. ADRENERGICR.
PR00557. ADRENRGCA1AR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, expression and characterization of cDNA encoding a mouse alpha1a-adrenoceptor."
    Xiao L., Scofield M.A., Jeffries W.B.
    Br. J. Pharmacol. 124:213-221(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    Strain: CD-1.
    Tissue: Brain and Kidney.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Spinal cord.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Molecular cloning of alpha 1d-adrenergic receptor and tissue distribution of three alpha 1-adrenergic receptor subtypes in mouse."
    Alonso-Llamazares A., Zamanillo D., Casanova E., Ovalle S., Calvo P., Chinchetru M.A.
    J. Neurochem. 65:2387-2392(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 197-280.
    Tissue: Brain.
  6. "Nuclear localization drives alpha1-adrenergic receptor oligomerization and signaling in cardiac myocytes."
    Wright C.D., Wu S.C., Dahl E.F., Sazama A.J., O'Connell T.D.
    Cell. Signal. 24:794-802(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiADA1A_MOUSE
AccessioniPrimary (citable) accession number: P97718
Secondary accession number(s): O54913, Q8BV77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3