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Protein

Alpha-1A adrenergic receptor

Gene

Adra1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).By similarity

GO - Molecular functioni

  • alpha1-adrenergic receptor activity Source: MGI
  • protein heterodimerization activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-390696 Adrenoceptors
R-MMU-416476 G alpha (q) signalling events
R-MMU-416482 G alpha (12/13) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1A adrenergic receptor
Alternative name(s):
Alpha-1A adrenoreceptor
Short name:
Alpha-1A adrenoceptor
Alpha-1C adrenergic receptor
Gene namesi
Name:Adra1a
Synonyms:Adra1c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:104773 Adra1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularBy similarityAdd BLAST27
Transmembranei28 – 51Helical; Name=1By similarityAdd BLAST24
Topological domaini52 – 64CytoplasmicBy similarityAdd BLAST13
Transmembranei65 – 88Helical; Name=2By similarityAdd BLAST24
Topological domaini89 – 99ExtracellularBy similarityAdd BLAST11
Transmembranei100 – 122Helical; Name=3By similarityAdd BLAST23
Topological domaini123 – 143CytoplasmicBy similarityAdd BLAST21
Transmembranei144 – 167Helical; Name=4By similarityAdd BLAST24
Topological domaini168 – 181ExtracellularBy similarityAdd BLAST14
Transmembranei182 – 205Helical; Name=5By similarityAdd BLAST24
Topological domaini206 – 273CytoplasmicBy similarityAdd BLAST68
Transmembranei274 – 297Helical; Name=6By similarityAdd BLAST24
Topological domaini298 – 305ExtracellularBy similarity8
Transmembranei306 – 329Helical; Name=7By similarityAdd BLAST24
Topological domaini330 – 466CytoplasmicBy similarityAdd BLAST137

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2111452

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690641 – 466Alpha-1A adrenergic receptorAdd BLAST466

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi13N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi22N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi99 ↔ 176PROSITE-ProRule annotation
Modified residuei215Phosphoserine; by PKASequence analysis1
Lipidationi345S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP97718
PRIDEiP97718

PTM databases

iPTMnetiP97718
PhosphoSitePlusiP97718

Expressioni

Gene expression databases

BgeeiENSMUSG00000045875
CleanExiMM_ADRA1A
ExpressionAtlasiP97718 baseline and differential
GenevisibleiP97718 MM

Interactioni

Subunit structurei

Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes. Interacts with CAVIN4.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053703

Chemistry databases

BindingDBiP97718

Structurei

3D structure databases

ProteinModelPortaliP97718
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi334 – 349Nuclear localization signalBy similarityAdd BLAST16

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118795
HOGENOMiHOG000239244
HOVERGENiHBG106962
InParanoidiP97718
KOiK04135
OMAiEILGYWA
OrthoDBiEOG091G06VI
PhylomeDBiP97718
TreeFamiTF331895

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR001004 ADRA1A_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00557 ADRENRGCA1AR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P97718-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLLSENASE GSNCTHPPAQ VNISKAILLG VILGGLIIFG VLGNILVILS
60 70 80 90 100
VACHRHLHSV THYYIVNLAV ADLLLTSTVL PFSAIFEILG YWAFGRVFCN
110 120 130 140 150
IWAAVDVLCC TASIMGLCII SIDRYIGVSY PLRYPTIVTQ RRGVRALLCV
160 170 180 190 200
WALSLVISIG PLFGWRQQAP EDETICQINE EPGYVLFSAL GSFYVPLTII
210 220 230 240 250
LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN VPAEGSGVSS
260 270 280 290 300
AKNKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGSFFPN
310 320 330 340 350
FKPPETVFKI VFWLGYLNSC INPIIYPCSS QEFKKAFQNV LRIQCLRRRQ
360 370 380 390 400
SSKHALGYTL HPPSQAVEGQ HRGMVRIPVG SGETFYKISK TDGVREWKFF
410 420 430 440 450
SSMPQGSARI TMPKDQSACT TARVRSKSFL QVCCCVGSST PRPEENHQVP
460
TIKIHTISLG ENGEEV
Length:466
Mass (Da):51,744
Last modified:July 27, 2011 - v3
Checksum:i8C5FE5C67E885795
GO

Sequence cautioni

The sequence AAB47044 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti369G → E in AAC02658 (PubMed:9630362).Curated1
Sequence conflicti395R → C in AAC02658 (PubMed:9630362).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031431 mRNA Translation: AAC02658.1
AK079597 mRNA Translation: BAC37694.1
CH466535 Genomic DNA Translation: EDL35992.1
BC113139 mRNA Translation: AAI13140.1
S80220 mRNA Translation: AAB47044.1 Different initiation.
CCDSiCCDS27223.1
RefSeqiNP_001258689.1, NM_001271760.1
NP_038489.2, NM_013461.4
XP_006518507.1, XM_006518444.3
XP_011243225.1, XM_011244923.2
XP_011243226.1, XM_011244924.2
XP_011243227.1, XM_011244925.2
XP_017171289.1, XM_017315800.1
XP_017171290.1, XM_017315801.1
UniGeneiMm.57064

Genome annotation databases

EnsembliENSMUST00000054661; ENSMUSP00000053703; ENSMUSG00000045875
ENSMUST00000159068; ENSMUSP00000124570; ENSMUSG00000045875
ENSMUST00000161339; ENSMUSP00000125354; ENSMUSG00000045875
GeneIDi11549
KEGGimmu:11549
UCSCiuc007ukh.2 mouse

Similar proteinsi

Entry informationi

Entry nameiADA1A_MOUSE
AccessioniPrimary (citable) accession number: P97718
Secondary accession number(s): O54913, Q8BV77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 151 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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