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Reviewed, UniProtKB/Swiss-Prot P97717 (ADA1B_MOUSE)

Last modified June 16, 2009. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Alpha-1B adrenergic receptor
Alternative name(s):
    Alpha 1B-adrenoreceptor
    Alpha 1B-adrenoceptor
Gene names
Name: Adra1b
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length514 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Lipoprotein
Palmitate
Phosphoprotein
Gene Ontology (GO)
   Biological processG-protein coupled receptor protein signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

adult heart development

Inferred from genetic interaction. Source: MGI

behavioral response to cocaine

Inferred from mutant phenotype. Source: MGI

blood vessel remodeling

Inferred from mutant phenotype. Source: MGI

cell growth

Inferred from genetic interaction. Source: MGI

glucose homeostasis

Inferred from mutant phenotype. Source: MGI

locomotory behavior

Inferred from mutant phenotype. Source: MGI

negative regulation of glycogen catabolic process

Inferred from mutant phenotype. Source: MGI

organ growth

Inferred from genetic interaction. Source: MGI

positive regulation of glycogen catabolic process

Inferred from mutant phenotype. Source: MGI

positive regulation of heart rate by epinephrine-norepinephrine

Inferred from genetic interaction. Source: MGI

positive regulation of the force of heart contraction by epinephrine-norepinephrine

Inferred from genetic interaction. Source: MGI

response to amphetamine

Inferred from mutant phenotype. Source: MGI

response to morphine

Inferred from mutant phenotype. Source: MGI

vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure

Inferred from mutant phenotype. Source: MGI

visual learning

Inferred from mutant phenotype. Source: MGI

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

integral to membrane of membrane fraction

Inferred from direct assay. Source: MGI

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionalpha1-adrenergic receptor activity

Inferred from direct assay. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 514514Alpha-1B adrenergic receptor
PRO_0000069071

Regions

Topological domain1 – 4545Extracellular By similarity
Transmembrane46 – 69241 By similarity
Topological domain70 – 8213Cytoplasmic By similarity
Transmembrane83 – 104222 By similarity
Topological domain105 – 11410Extracellular By similarity
Transmembrane115 – 140263 By similarity
Topological domain141 – 16020Cytoplasmic By similarity
Transmembrane161 – 183234 By similarity
Topological domain184 – 20017Extracellular By similarity
Transmembrane201 – 223235 By similarity
Topological domain224 – 29471Cytoplasmic By similarity
Transmembrane295 – 318246 By similarity
Topological domain319 – 3257Extracellular By similarity
Transmembrane326 – 350257 By similarity
Topological domain351 – 514164Cytoplasmic By similarity
Compositional bias370 – 3778Poly-Arg

Amino acid modifications

Modified residue2631Phosphothreonine Ref.3
Modified residue2661Phosphoserine Ref.3
Lipidation3641S-palmitoyl cysteine Potential
Glycosylation101N-linked (GlcNAc...) Potential
Glycosylation241N-linked (GlcNAc...) Potential
Glycosylation291N-linked (GlcNAc...) Potential
Glycosylation341N-linked (GlcNAc...) Potential
Disulfide bond117 ↔ 194 By similarity

Sequences

Sequence LengthMass (Da)Tools
P97717-1 [UniParc].

Last modified January 1, 1998. Version 2.
Checksum: 17CFD10123DC2B29

FASTA51456,418
        10         20         30         40         50         60 
MNPDLDTGHN TSAPAHWGEL KDANFTGPNQ TSSNSTLPQL DVTRAISVGC LGAFILFAIV 

        70         80         90        100        110        120 
GNILVILSVA CNRHLRTPTN YFIVNLAIAD LLLSFTDLPF SATLEVLGYW VLGRIFCDIW 

       130        140        150        160        170        180 
AAVDVLCCTA SILSLCAISI DRYIGVRYSL QYPTLVTRRK AILALLSVWV LSTVISIGPL 

       190        200        210        220        230        240 
LGWKEPAPND DKECGVTEEP FYALFSSLGS FYIPLAVILV MYCRVYIVAK RTTKNLEAGV 

       250        260        270        280        290        300 
MKEMSNSKEL TLRIHSKNFH EDTLSSTKAK GHNPRSSIAV KLFKFSREKK AAKTLGIVVG 

       310        320        330        340        350        360 
MFILCWLPFF IALPLGSLFS TLKPPDAVFK VVFWLGYFNS CLNPIIYPCS SKEFKRAFMR 

       370        380        390        400        410        420 
ILGCQCRGGR RRRRRRRLGA CAYTYRPWTR GGSLERSQSR KDSLDDSGSC MSGSQRTLPS 

       430        440        450        460        470        480 
ASPSPGYLGR GTQPPVELCA FPEWKPGALL SLPEPPGRRG RLDSGPLFTF KLLGEPESPG 

       490        500        510 
TEGDASNGGC DTTTDLANGQ PGFKSNMPLA PGHF 

« Hide

References

« Hide 'large scale' references
[1]Cotecchia S., Lattion-Zellweger A.
Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Brain.
[2]"Molecular cloning of alpha 1d-adrenergic receptor and tissue distribution of three alpha 1-adrenergic receptor subtypes in mouse."
Alonso-Llamazares A., Zamanillo D., Casanova E., Ovalle S., Calvo P., Chinchetru M.A.
J. Neurochem. 65:2387-2392(1995) [PubMed: 7595531] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 238-276.
[3]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed: 17242355] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-263 AND SER-266, MASS SPECTROMETRY.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

Y12738 mRNA. Translation: CAA73272.1.
S80219 mRNA. Translation: AAB47043.1.
IPIIPI00314429.
UniGeneMm.39086

3D structure databases

HSSPHSSP built from PDB template 1MMH based on UniProtKB P29274.
ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP97717.

Genome annotation databases

EnsemblENSMUSG00000050541. Mus musculus. [Contig view]

Organism-specific databases

MGIMGI:104774. Adra1b.

Phylogenomic databases

HOVERGENP97717.

Gene expression databases

ArrayExpressP97717.
BgeeP97717.
CleanExMM_ADRA1B.
GermOnlineENSMUSG00000050541. Mus musculus.

Family and domain databases

InterProIPR000276. 7TM_GPCR_Rhodpsn.
IPR001115. Adrene_rcpt_A1B.
IPR002233. Adrnrgc_rcpt.
IPR017452. GPCR_Rhodpsn_supfam.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01103. ADRENERGICR.
PR00556. ADRENRGCA1BR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

Entry information

Entry nameADA1B_MOUSE
AccessionPrimary (citable) accession number: P97717
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: June 16, 2009
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents