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Protein

Alpha-1B adrenergic receptor

Gene

Adra1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_Central
  • adult heart development Source: MGI
  • behavioral response to cocaine Source: MGI
  • blood vessel remodeling Source: MGI
  • cell-cell signaling Source: GO_Central
  • cell growth Source: MGI
  • glucose homeostasis Source: MGI
  • locomotory behavior Source: MGI
  • negative regulation of glycogen catabolic process Source: MGI
  • negative regulation of Rho protein signal transduction Source: MGI
  • norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure Source: GO_Central
  • organ growth Source: MGI
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: GO_Central
  • positive regulation of cytosolic calcium ion concentration Source: GO_Central
  • positive regulation of glycogen catabolic process Source: MGI
  • positive regulation of heart rate by epinephrine-norepinephrine Source: MGI
  • positive regulation of MAPK cascade Source: UniProtKB
  • positive regulation of smooth muscle contraction Source: GO_Central
  • positive regulation of the force of heart contraction by epinephrine-norepinephrine Source: MGI
  • positive regulation of vasoconstriction Source: GO_Central
  • regulation of cardiac muscle contraction Source: InterPro
  • response to amphetamine Source: MGI
  • response to morphine Source: MGI
  • vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure Source: MGI
  • visual learning Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1B adrenergic receptor
Alternative name(s):
Alpha-1B adrenoreceptor
Short name:
Alpha-1B adrenoceptor
Gene namesi
Name:Adra1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:104774. Adra1b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4545ExtracellularBy similarityAdd
BLAST
Transmembranei46 – 6924Helical; Name=1By similarityAdd
BLAST
Topological domaini70 – 8213CytoplasmicBy similarityAdd
BLAST
Transmembranei83 – 10422Helical; Name=2By similarityAdd
BLAST
Topological domaini105 – 11410ExtracellularBy similarity
Transmembranei115 – 14026Helical; Name=3By similarityAdd
BLAST
Topological domaini141 – 16020CytoplasmicBy similarityAdd
BLAST
Transmembranei161 – 18323Helical; Name=4By similarityAdd
BLAST
Topological domaini184 – 20017ExtracellularBy similarityAdd
BLAST
Transmembranei201 – 22323Helical; Name=5By similarityAdd
BLAST
Topological domaini224 – 29471CytoplasmicBy similarityAdd
BLAST
Transmembranei295 – 31824Helical; Name=6By similarityAdd
BLAST
Topological domaini319 – 3257ExtracellularBy similarity
Transmembranei326 – 35025Helical; Name=7By similarityAdd
BLAST
Topological domaini351 – 514164CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Alpha-1B adrenergic receptorPRO_0000069071Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi34 – 341N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi117 ↔ 194PROSITE-ProRule annotation
Lipidationi364 – 3641S-palmitoyl cysteineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP97717.
PRIDEiP97717.

PTM databases

PhosphoSiteiP97717.

Expressioni

Gene expression databases

CleanExiMM_ADRA1B.
GenevestigatoriP97717.

Interactioni

Subunit structurei

Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes.By similarity

Structurei

3D structure databases

ProteinModelPortaliP97717.
SMRiP97717. Positions 15-363.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi367 – 37711Nuclear localization signalBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi370 – 3778Poly-Arg

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1B sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG253615.
HOVERGENiHBG106962.
InParanoidiP97717.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR001115. ADRA1B_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF17. PTHR24248:SF17. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00556. ADRENRGCA1BR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97717-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPDLDTGHN TSAPAHWGEL KDANFTGPNQ TSSNSTLPQL DVTRAISVGC
60 70 80 90 100
LGAFILFAIV GNILVILSVA CNRHLRTPTN YFIVNLAIAD LLLSFTDLPF
110 120 130 140 150
SATLEVLGYW VLGRIFCDIW AAVDVLCCTA SILSLCAISI DRYIGVRYSL
160 170 180 190 200
QYPTLVTRRK AILALLSVWV LSTVISIGPL LGWKEPAPND DKECGVTEEP
210 220 230 240 250
FYALFSSLGS FYIPLAVILV MYCRVYIVAK RTTKNLEAGV MKEMSNSKEL
260 270 280 290 300
TLRIHSKNFH EDTLSSTKAK GHNPRSSIAV KLFKFSREKK AAKTLGIVVG
310 320 330 340 350
MFILCWLPFF IALPLGSLFS TLKPPDAVFK VVFWLGYFNS CLNPIIYPCS
360 370 380 390 400
SKEFKRAFMR ILGCQCRGGR RRRRRRRLGA CAYTYRPWTR GGSLERSQSR
410 420 430 440 450
KDSLDDSGSC MSGSQRTLPS ASPSPGYLGR GTQPPVELCA FPEWKPGALL
460 470 480 490 500
SLPEPPGRRG RLDSGPLFTF KLLGEPESPG TEGDASNGGC DTTTDLANGQ
510
PGFKSNMPLA PGHF
Length:514
Mass (Da):56,418
Last modified:January 1, 1998 - v2
Checksum:i17CFD10123DC2B29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12738 mRNA. Translation: CAA73272.1.
S80219 mRNA. Translation: AAB47043.1.
UniGeneiMm.39086.
Mm.487939.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12738 mRNA. Translation: CAA73272.1.
S80219 mRNA. Translation: AAB47043.1.
UniGeneiMm.39086.
Mm.487939.

3D structure databases

ProteinModelPortaliP97717.
SMRiP97717. Positions 15-363.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

ChEMBLiCHEMBL2486.
GuidetoPHARMACOLOGYi23.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP97717.

Proteomic databases

PaxDbiP97717.
PRIDEiP97717.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:104774. Adra1b.

Phylogenomic databases

eggNOGiNOG253615.
HOVERGENiHBG106962.
InParanoidiP97717.

Miscellaneous databases

PROiP97717.
SOURCEiSearch...

Gene expression databases

CleanExiMM_ADRA1B.
GenevestigatoriP97717.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR001115. ADRA1B_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF17. PTHR24248:SF17. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00556. ADRENRGCA1BR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cotecchia S., Lattion-Zellweger A.
    Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  2. "Molecular cloning of alpha 1d-adrenergic receptor and tissue distribution of three alpha 1-adrenergic receptor subtypes in mouse."
    Alonso-Llamazares A., Zamanillo D., Casanova E., Ovalle S., Calvo P., Chinchetru M.A.
    J. Neurochem. 65:2387-2392(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 238-276.
  3. "Nuclear localization drives alpha1-adrenergic receptor oligomerization and signaling in cardiac myocytes."
    Wright C.D., Wu S.C., Dahl E.F., Sazama A.J., O'Connell T.D.
    Cell. Signal. 24:794-802(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiADA1B_MOUSE
AccessioniPrimary (citable) accession number: P97717
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: May 27, 2015
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.