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P97717

- ADA1B_MOUSE

UniProt

P97717 - ADA1B_MOUSE

Protein

Alpha-1B adrenergic receptor

Gene

Adra1b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes By similarity.By similarity

    GO - Molecular functioni

    1. alpha1-adrenergic receptor activity Source: MGI
    2. protein heterodimerization activity Source: UniProtKB

    GO - Biological processi

    1. adrenergic receptor signaling pathway Source: GOC
    2. adult heart development Source: MGI
    3. behavioral response to cocaine Source: MGI
    4. blood vessel remodeling Source: MGI
    5. cell growth Source: MGI
    6. glucose homeostasis Source: MGI
    7. locomotory behavior Source: MGI
    8. negative regulation of glycogen catabolic process Source: MGI
    9. negative regulation of Rho protein signal transduction Source: MGI
    10. organ growth Source: MGI
    11. positive regulation of glycogen catabolic process Source: MGI
    12. positive regulation of heart rate by epinephrine-norepinephrine Source: MGI
    13. positive regulation of MAPK cascade Source: UniProtKB
    14. positive regulation of the force of heart contraction by epinephrine-norepinephrine Source: MGI
    15. regulation of cardiac muscle contraction Source: InterPro
    16. regulation of vasoconstriction Source: InterPro
    17. response to amphetamine Source: MGI
    18. response to morphine Source: MGI
    19. vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure Source: MGI
    20. visual learning Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-1B adrenergic receptor
    Alternative name(s):
    Alpha-1B adrenoreceptor
    Short name:
    Alpha-1B adrenoceptor
    Gene namesi
    Name:Adra1b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:104774. Adra1b.

    Subcellular locationi

    Nucleus membrane 1 Publication; Multi-pass membrane protein 1 Publication. Cell membrane By similarity; Multi-pass membrane protein By similarity
    Note: Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes By similarity.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: MGI
    2. nuclear membrane Source: UniProtKB
    3. nucleus Source: UniProtKB
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 514514Alpha-1B adrenergic receptorPRO_0000069071Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi34 – 341N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi117 ↔ 194PROSITE-ProRule annotation
    Lipidationi364 – 3641S-palmitoyl cysteineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP97717.
    PRIDEiP97717.

    PTM databases

    PhosphoSiteiP97717.

    Expressioni

    Gene expression databases

    CleanExiMM_ADRA1B.
    GenevestigatoriP97717.

    Interactioni

    Subunit structurei

    Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP97717.
    SMRiP97717. Positions 53-363.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4545ExtracellularBy similarityAdd
    BLAST
    Topological domaini70 – 8213CytoplasmicBy similarityAdd
    BLAST
    Topological domaini105 – 11410ExtracellularBy similarity
    Topological domaini141 – 16020CytoplasmicBy similarityAdd
    BLAST
    Topological domaini184 – 20017ExtracellularBy similarityAdd
    BLAST
    Topological domaini224 – 29471CytoplasmicBy similarityAdd
    BLAST
    Topological domaini319 – 3257ExtracellularBy similarity
    Topological domaini351 – 514164CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei46 – 6924Helical; Name=1By similarityAdd
    BLAST
    Transmembranei83 – 10422Helical; Name=2By similarityAdd
    BLAST
    Transmembranei115 – 14026Helical; Name=3By similarityAdd
    BLAST
    Transmembranei161 – 18323Helical; Name=4By similarityAdd
    BLAST
    Transmembranei201 – 22323Helical; Name=5By similarityAdd
    BLAST
    Transmembranei295 – 31824Helical; Name=6By similarityAdd
    BLAST
    Transmembranei326 – 35025Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni367 – 37711Nuclear localization signalBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi370 – 3778Poly-Arg

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1B sub-subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG253615.
    HOVERGENiHBG106962.
    InParanoidiP97717.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR002233. ADR_fam.
    IPR001115. ADRA1B_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24248:SF17. PTHR24248:SF17. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01103. ADRENERGICR.
    PR00556. ADRENRGCA1BR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P97717-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNPDLDTGHN TSAPAHWGEL KDANFTGPNQ TSSNSTLPQL DVTRAISVGC    50
    LGAFILFAIV GNILVILSVA CNRHLRTPTN YFIVNLAIAD LLLSFTDLPF 100
    SATLEVLGYW VLGRIFCDIW AAVDVLCCTA SILSLCAISI DRYIGVRYSL 150
    QYPTLVTRRK AILALLSVWV LSTVISIGPL LGWKEPAPND DKECGVTEEP 200
    FYALFSSLGS FYIPLAVILV MYCRVYIVAK RTTKNLEAGV MKEMSNSKEL 250
    TLRIHSKNFH EDTLSSTKAK GHNPRSSIAV KLFKFSREKK AAKTLGIVVG 300
    MFILCWLPFF IALPLGSLFS TLKPPDAVFK VVFWLGYFNS CLNPIIYPCS 350
    SKEFKRAFMR ILGCQCRGGR RRRRRRRLGA CAYTYRPWTR GGSLERSQSR 400
    KDSLDDSGSC MSGSQRTLPS ASPSPGYLGR GTQPPVELCA FPEWKPGALL 450
    SLPEPPGRRG RLDSGPLFTF KLLGEPESPG TEGDASNGGC DTTTDLANGQ 500
    PGFKSNMPLA PGHF 514
    Length:514
    Mass (Da):56,418
    Last modified:January 1, 1998 - v2
    Checksum:i17CFD10123DC2B29
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y12738 mRNA. Translation: CAA73272.1.
    S80219 mRNA. Translation: AAB47043.1.
    UniGeneiMm.39086.
    Mm.487939.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y12738 mRNA. Translation: CAA73272.1 .
    S80219 mRNA. Translation: AAB47043.1 .
    UniGenei Mm.39086.
    Mm.487939.

    3D structure databases

    ProteinModelPortali P97717.
    SMRi P97717. Positions 53-363.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P97717.
    ChEMBLi CHEMBL2111452.
    GuidetoPHARMACOLOGYi 23.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P97717.

    Proteomic databases

    PaxDbi P97717.
    PRIDEi P97717.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:104774. Adra1b.

    Phylogenomic databases

    eggNOGi NOG253615.
    HOVERGENi HBG106962.
    InParanoidi P97717.

    Miscellaneous databases

    PROi P97717.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_ADRA1B.
    Genevestigatori P97717.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR002233. ADR_fam.
    IPR001115. ADRA1B_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24248:SF17. PTHR24248:SF17. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01103. ADRENERGICR.
    PR00556. ADRENRGCA1BR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cotecchia S., Lattion-Zellweger A.
      Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Brain.
    2. "Molecular cloning of alpha 1d-adrenergic receptor and tissue distribution of three alpha 1-adrenergic receptor subtypes in mouse."
      Alonso-Llamazares A., Zamanillo D., Casanova E., Ovalle S., Calvo P., Chinchetru M.A.
      J. Neurochem. 65:2387-2392(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 238-276.
    3. "Nuclear localization drives alpha1-adrenergic receptor oligomerization and signaling in cardiac myocytes."
      Wright C.D., Wu S.C., Dahl E.F., Sazama A.J., O'Connell T.D.
      Cell. Signal. 24:794-802(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiADA1B_MOUSE
    AccessioniPrimary (citable) accession number: P97717
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3