P97714 (ADA1D_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 94.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Alpha-1D adrenergic receptor Alternative name(s): Alpha-1A adrenergic receptor Alpha-1D adrenoreceptor Short name=Alpha-1D adrenoceptor | ||||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus |
Protein attributes
| Sequence length | 562 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. |
| Subcellular location | |
| Sequence similarities | Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane |
| Domain | Transmembrane Transmembrane helix |
| Molecular function | G-protein coupled receptor Receptor Transducer |
| PTM | Glycoprotein Lipoprotein Palmitate Phosphoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | alpha1-adrenergic receptor activity Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 562 | 562 | Alpha-1D adrenergic receptor | PRO_0000069074 | |||||
Regions | |||||||||
| Topological domain | 1 – 90 | 90 | Extracellular By similarity | ||||||
| Transmembrane | 91 – 115 | 25 | Helical; Name=1; By similarity | ||||||
| Topological domain | 116 – 127 | 12 | Cytoplasmic By similarity | ||||||
| Transmembrane | 128 – 153 | 26 | Helical; Name=2; By similarity | ||||||
| Topological domain | 154 – 163 | 10 | Extracellular By similarity | ||||||
| Transmembrane | 164 – 186 | 23 | Helical; Name=3; By similarity | ||||||
| Topological domain | 187 – 207 | 21 | Cytoplasmic By similarity | ||||||
| Transmembrane | 208 – 232 | 25 | Helical; Name=4; By similarity | ||||||
| Topological domain | 233 – 245 | 13 | Extracellular By similarity | ||||||
| Transmembrane | 246 – 269 | 24 | Helical; Name=5; By similarity | ||||||
| Topological domain | 270 – 342 | 73 | Cytoplasmic By similarity | ||||||
| Transmembrane | 343 – 367 | 25 | Helical; Name=6; By similarity | ||||||
| Topological domain | 368 – 374 | 7 | Extracellular By similarity | ||||||
| Transmembrane | 375 – 399 | 25 | Helical; Name=7; By similarity | ||||||
| Topological domain | 400 – 562 | 163 | Cytoplasmic By similarity | ||||||
| Compositional bias | 21 – 57 | 37 | Gly-rich | ||||||
| Compositional bias | 416 – 421 | 6 | Poly-Arg | ||||||
Amino acid modifications | |||||||||
| Lipidation | 413 | 1 | S-palmitoyl cysteine Potential | ||||||
| Glycosylation | 60 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 76 | 1 | N-linked (GlcNAc...) Potential | ||||||
Experimental info | |||||||||
| Sequence conflict | 330 | 1 | R → G in AAA16854. Ref.3 | ||||||
Sequences
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References
| [1] | "Molecular cloning of alpha 1d-adrenergic receptor and tissue distribution of three alpha 1-adrenergic receptor subtypes in mouse." Alonso-Llamazares A., Zamanillo D., Casanova E., Ovalle S., Calvo P., Chinchetru M.A. J. Neurochem. 65:2387-2392(1995) [PubMed: 7595531] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. |
| [2] | "Characterization of the mouse alpha1D-adrenergic receptor gene." Arai K., Tanoue A., Goda N., Takeda M., Takahashi K., Tsujimoto G. Jpn. J. Pharmacol. 81:271-278(1999) [PubMed: 10622215] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors." Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I., Copeland N.G., Jenkins N.A. Genomics 18:175-184(1993) [PubMed: 8288218] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 190-350. Tissue: Testis. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | S80044 mRNA. Translation: AAB47042.1. AB030642 Genomic DNA. Translation: BAA90312.1. L20333 mRNA. Translation: AAA16854.1. |
| IPI | IPI00128833. |
| PIR | D48909. |
| UniGene | Mm.389380. |
3D structure databases | |
| ProteinModelPortal | P97714. |
| SMR | P97714. Positions 87-413. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P97714. |
Protein family/group databases | |
| GPCRDB | Search... |
Proteomic databases | |
| PRIDE | P97714. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Organism-specific databases | |
| MGI | MGI:106673. Adra1d. |
Phylogenomic databases | |
| GeneTree | ENSGT00600000084087. |
| HOVERGEN | HBG106962. |
Gene expression databases | |
| ArrayExpress | P97714. |
| Bgee | P97714. |
| CleanEx | MM_ADRA1A. MM_ADRA1D. |
| Genevestigator | P97714. |
Family and domain databases | |
| InterPro | IPR000276. 7TM_GPCR_Rhodpsn. IPR000363. Adren_rcpt_A1A. IPR002233. Adrnrgc_rcpt. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view] |
| Pfam | PF00001. 7tm_1. 1 hit. [Graphical view] |
| PRINTS | PR01103. ADRENERGICR. PR00240. ADRENRGCA1DR. PR00237. GPCRRHODOPSN. |
| PROSITE | PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| SOURCE | Search... |
Entry information
| Entry name | ADA1D_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P97714 Secondary accession number(s): Q61619 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| 7-transmembrane G-linked receptors List of 7-transmembrane G-linked receptor entries |
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with