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Protein

Alpha-1D adrenergic receptor

Gene

Adra1d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

GO - Molecular functioni

  • alpha1-adrenergic receptor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1D adrenergic receptor
Alternative name(s):
Alpha-1A adrenergic receptor
Alpha-1D adrenoreceptor
Short name:
Alpha-1D adrenoceptor
Gene namesi
Name:Adra1d
Synonyms:Adra1a, Gpcr8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:106673 Adra1d

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 90ExtracellularBy similarityAdd BLAST90
Transmembranei91 – 115Helical; Name=1By similarityAdd BLAST25
Topological domaini116 – 127CytoplasmicBy similarityAdd BLAST12
Transmembranei128 – 153Helical; Name=2By similarityAdd BLAST26
Topological domaini154 – 163ExtracellularBy similarity10
Transmembranei164 – 186Helical; Name=3By similarityAdd BLAST23
Topological domaini187 – 207CytoplasmicBy similarityAdd BLAST21
Transmembranei208 – 232Helical; Name=4By similarityAdd BLAST25
Topological domaini233 – 245ExtracellularBy similarityAdd BLAST13
Transmembranei246 – 269Helical; Name=5By similarityAdd BLAST24
Topological domaini270 – 342CytoplasmicBy similarityAdd BLAST73
Transmembranei343 – 367Helical; Name=6By similarityAdd BLAST25
Topological domaini368 – 374ExtracellularBy similarity7
Transmembranei375 – 399Helical; Name=7By similarityAdd BLAST25
Topological domaini400 – 562CytoplasmicBy similarityAdd BLAST163

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2111452

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690741 – 562Alpha-1D adrenergic receptorAdd BLAST562

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi76N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi413S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiP97714

PTM databases

PhosphoSitePlusiP97714

Expressioni

Gene expression databases

CleanExiMM_ADRA1A
MM_ADRA1D

Interactioni

Subunit structurei

Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.By similarity

Chemistry databases

BindingDBiP97714

Structurei

3D structure databases

ProteinModelPortaliP97714
SMRiP97714
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi21 – 57Gly-richAdd BLAST37
Compositional biasi416 – 421Poly-Arg6

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000239244
HOVERGENiHBG106962
InParanoidiP97714

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR000363 ADRA1D_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24248:SF14 PTHR24248:SF14, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00240 ADRENRGCA1DR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P97714-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFRDILSVT FEGPRASSST GGSGAGGGAG TVGPEGPAVG GVPGATGGSA
60 70 80 90 100
VVGTGSGEDN QSSTAEAGAA ASGEVNGSAA VGGLVVSAQG VGVGVFLAAF
110 120 130 140 150
ILTAVAGNLL VILSVACNRH LQTVTNYFIV NLAVADLLLS AAVLPFSATM
160 170 180 190 200
EVLGFWPFGR TFCDVWAAVD VLCCTASILS LCTISVDRYV GVRHSLKYPA
210 220 230 240 250
IMTERKAAAI LALLWAVALV VSVGPLLGWK EPVPPDERFC GITEEVGYAI
260 270 280 290 300
FSSVCSFYLP MAVIVVMYCR VYVVARSTTR SLEAGIKREP GKASEVVLRI
310 320 330 340 350
HCRGAATSAK GNPGTQSSKG HTLRSSLSVR LLKFSREKKA AKTLAIVVGV
360 370 380 390 400
FVLCWFPFFF VLPLGSLFPQ LKPSEGVFKV IFWLGYFNSC VNPLIYPCSS
410 420 430 440 450
REFKRAFLRL LRCQCRRRRR RLWPSLRPPL ASLDRRPALR LCPQPAHRTP
460 470 480 490 500
RGSPSPHCTP RPGLRRHAGG AGFGLRPSKA SLRLREWRLL GPLQRPTTQL
510 520 530 540 550
RAKVSSLSHK FRSGGARRAE TACALRSEVE AVSLNVPQDG AEAVICQAYE
560
PGDLSNLRET DI
Length:562
Mass (Da):59,858
Last modified:May 1, 1997 - v1
Checksum:i6CF15515B5F7FA47
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti330R → G in AAA16854 (PubMed:8288218).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S80044 mRNA Translation: AAB47042.1
AB030642 Genomic DNA Translation: BAA90312.1
L20333 mRNA Translation: AAA16854.1
PIRiD48909
UniGeneiMm.389380

Entry informationi

Entry nameiADA1D_MOUSE
AccessioniPrimary (citable) accession number: P97714
Secondary accession number(s): Q61619
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: April 25, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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