Reviewed,
UniProtKB/Swiss-Prot P97714 (ADA1D_MOUSE)
Last modified
July 7, 2009.
Version 72.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Alpha-1D adrenergic receptor Alternative name(s): Alpha 1D-adrenoreceptor Alpha 1D-adrenoceptor Alpha-1A adrenergic receptor | ||||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 562 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. |
| Subcellular location | |
| Sequence similarities | Belongs to the G-protein coupled receptor 1 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane |
| Domain | Transmembrane |
| Molecular function | G-protein coupled receptor Receptor Transducer |
| PTM | Glycoprotein Lipoprotein Palmitate Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of the force of heart contraction during baroreceptor response to increased systemic arterial blood pressureInferred from mutant phenotype. Source: MGI norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressureInferred from mutant phenotype. Source: MGI |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | alpha1-adrenergic receptor activity Inferred from direct assay. Source: MGI |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 562 | 562 | Alpha-1D adrenergic receptor | PRO_0000069074 | |||||
Regions | |||||||||
| Topological domain | 1 – 90 | 90 | Extracellular By similarity | ||||||
| Transmembrane | 91 – 115 | 25 | 1 By similarity | ||||||
| Topological domain | 116 – 127 | 12 | Cytoplasmic By similarity | ||||||
| Transmembrane | 128 – 153 | 26 | 2 By similarity | ||||||
| Topological domain | 154 – 163 | 10 | Extracellular By similarity | ||||||
| Transmembrane | 164 – 186 | 23 | 3 By similarity | ||||||
| Topological domain | 187 – 207 | 21 | Cytoplasmic By similarity | ||||||
| Transmembrane | 208 – 232 | 25 | 4 By similarity | ||||||
| Topological domain | 233 – 245 | 13 | Extracellular By similarity | ||||||
| Transmembrane | 246 – 269 | 24 | 5 By similarity | ||||||
| Topological domain | 270 – 342 | 73 | Cytoplasmic By similarity | ||||||
| Transmembrane | 343 – 367 | 25 | 6 By similarity | ||||||
| Topological domain | 368 – 374 | 7 | Extracellular By similarity | ||||||
| Transmembrane | 375 – 399 | 25 | 7 By similarity | ||||||
| Topological domain | 400 – 562 | 163 | Cytoplasmic By similarity | ||||||
| Compositional bias | 21 – 57 | 37 | Gly-rich | ||||||
| Compositional bias | 416 – 421 | 6 | Poly-Arg | ||||||
Amino acid modifications | |||||||||
| Lipidation | 413 | 1 | S-palmitoyl cysteine Potential | ||||||
| Glycosylation | 60 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 76 | 1 | N-linked (GlcNAc...) Potential | ||||||
Experimental info | |||||||||
| Sequence conflict | 330 | 1 | R → G in AAA16854. Ref.3 | ||||||
Sequences
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References
| [1] | "Molecular cloning of alpha 1d-adrenergic receptor and tissue distribution of three alpha 1-adrenergic receptor subtypes in mouse." Alonso-Llamazares A., Zamanillo D., Casanova E., Ovalle S., Calvo P., Chinchetru M.A. J. Neurochem. 65:2387-2392(1995) [PubMed: 7595531] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. |
| [2] | "Characterization of the mouse alpha1D-adrenergic receptor gene." Arai K., Tanoue A., Goda N., Takeda M., Takahashi K., Tsujimoto G. Jpn. J. Pharmacol. 81:271-278(1999) [PubMed: 10622215] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors." Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I., Copeland N.G., Jenkins N.A. Genomics 18:175-184(1993) [PubMed: 8288218] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 190-350. Tissue: Testis. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| S80044 mRNA. Translation: AAB47042.1. AB030642 Genomic DNA. Translation: BAA90312.1. L20333 mRNA. Translation: AAA16854.1. | |
| IPI | IPI00128833. |
| PIR | D48909. |
| UniGene | Mm.389380 |
3D structure databases | |
| ModBase | Search... |
Protein family/group databases | |
| GPCRDB | Search... |
Proteomic databases | |
| PRIDE | P97714. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000027335. Mus musculus. [Contig view] |
Organism-specific databases | |
| MGI | MGI:106673. Adra1d. |
Phylogenomic databases | |
| HOGENOM | P97714. |
| HOVERGEN | P97714. |
Gene expression databases | |
| ArrayExpress | P97714. |
| CleanEx | MM_ADRA1A. MM_ADRA1D. |
Family and domain databases | |
| InterPro | IPR000276. 7TM_GPCR_Rhodpsn. IPR000363. Adren_rcpt_A1A. IPR002233. Adrnrgc_rcpt. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view] |
| Pfam | PF00001. 7tm_1. 1 hit. [Graphical view] |
| PRINTS | PR01103. ADRENERGICR. PR00240. ADRENRGCA1DR. PR00237. GPCRRHODOPSN. |
| PROSITE | PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | ADA1D_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P97714 Secondary accession number(s): Q61619 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| 7-transmembrane G-linked receptors List of 7-transmembrane G-linked receptor entries |
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


