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P97714 (ADA1D_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-1D adrenergic receptor
Alternative name(s):
Alpha-1A adrenergic receptor
Alpha-1D adrenoreceptor
Short name=Alpha-1D adrenoceptor
Gene names
Name:Adra1d
Synonyms:Adra1a, Gpcr8
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length562 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 562562Alpha-1D adrenergic receptor
PRO_0000069074

Regions

Topological domain1 – 9090Extracellular By similarity
Transmembrane91 – 11525Helical; Name=1; By similarity
Topological domain116 – 12712Cytoplasmic By similarity
Transmembrane128 – 15326Helical; Name=2; By similarity
Topological domain154 – 16310Extracellular By similarity
Transmembrane164 – 18623Helical; Name=3; By similarity
Topological domain187 – 20721Cytoplasmic By similarity
Transmembrane208 – 23225Helical; Name=4; By similarity
Topological domain233 – 24513Extracellular By similarity
Transmembrane246 – 26924Helical; Name=5; By similarity
Topological domain270 – 34273Cytoplasmic By similarity
Transmembrane343 – 36725Helical; Name=6; By similarity
Topological domain368 – 3747Extracellular By similarity
Transmembrane375 – 39925Helical; Name=7; By similarity
Topological domain400 – 562163Cytoplasmic By similarity
Compositional bias21 – 5737Gly-rich
Compositional bias416 – 4216Poly-Arg

Amino acid modifications

Lipidation4131S-palmitoyl cysteine Potential
Glycosylation601N-linked (GlcNAc...) Potential
Glycosylation761N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict3301R → G in AAA16854. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P97714 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 6CF15515B5F7FA47

FASTA56259,858
        10         20         30         40         50         60 
MTFRDILSVT FEGPRASSST GGSGAGGGAG TVGPEGPAVG GVPGATGGSA VVGTGSGEDN 

        70         80         90        100        110        120 
QSSTAEAGAA ASGEVNGSAA VGGLVVSAQG VGVGVFLAAF ILTAVAGNLL VILSVACNRH 

       130        140        150        160        170        180 
LQTVTNYFIV NLAVADLLLS AAVLPFSATM EVLGFWPFGR TFCDVWAAVD VLCCTASILS 

       190        200        210        220        230        240 
LCTISVDRYV GVRHSLKYPA IMTERKAAAI LALLWAVALV VSVGPLLGWK EPVPPDERFC 

       250        260        270        280        290        300 
GITEEVGYAI FSSVCSFYLP MAVIVVMYCR VYVVARSTTR SLEAGIKREP GKASEVVLRI 

       310        320        330        340        350        360 
HCRGAATSAK GNPGTQSSKG HTLRSSLSVR LLKFSREKKA AKTLAIVVGV FVLCWFPFFF 

       370        380        390        400        410        420 
VLPLGSLFPQ LKPSEGVFKV IFWLGYFNSC VNPLIYPCSS REFKRAFLRL LRCQCRRRRR 

       430        440        450        460        470        480 
RLWPSLRPPL ASLDRRPALR LCPQPAHRTP RGSPSPHCTP RPGLRRHAGG AGFGLRPSKA 

       490        500        510        520        530        540 
SLRLREWRLL GPLQRPTTQL RAKVSSLSHK FRSGGARRAE TACALRSEVE AVSLNVPQDG 

       550        560 
AEAVICQAYE PGDLSNLRET DI

« Hide

References

[1]"Molecular cloning of alpha 1d-adrenergic receptor and tissue distribution of three alpha 1-adrenergic receptor subtypes in mouse."
Alonso-Llamazares A., Zamanillo D., Casanova E., Ovalle S., Calvo P., Chinchetru M.A.
J. Neurochem. 65:2387-2392(1995) [PubMed: 7595531] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Characterization of the mouse alpha1D-adrenergic receptor gene."
Arai K., Tanoue A., Goda N., Takeda M., Takahashi K., Tsujimoto G.
Jpn. J. Pharmacol. 81:271-278(1999) [PubMed: 10622215] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors."
Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I., Copeland N.G., Jenkins N.A.
Genomics 18:175-184(1993) [PubMed: 8288218] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 190-350.
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		S80044 mRNA. Translation: AAB47042.1.
AB030642 Genomic DNA. Translation: BAA90312.1.
L20333 mRNA. Translation: AAA16854.1.
IPIIPI00128833.
PIRD48909.
UniGeneMm.389380.

3D structure databases

ProteinModelPortalP97714.
SMRP97714. Positions 87-413.
ModBaseSearch...

Protein-protein interaction databases

STRINGP97714.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEP97714.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:106673. Adra1d.

Phylogenomic databases

GeneTreeENSGT00600000084087.
HOVERGENHBG106962.

Gene expression databases

ArrayExpressP97714.
BgeeP97714.
CleanExMM_ADRA1A.
MM_ADRA1D.
GenevestigatorP97714.

Family and domain databases

InterProIPR000276. 7TM_GPCR_Rhodpsn.
IPR000363. Adren_rcpt_A1A.
IPR002233. Adrnrgc_rcpt.
IPR017452. GPCR_Rhodpsn_supfam.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01103. ADRENERGICR.
PR00240. ADRENRGCA1DR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameADA1D_MOUSE
AccessionPrimary (citable) accession number: P97714
Secondary accession number(s): Q61619
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: November 16, 2011
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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