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Protein
Submitted name:

Colony-stimulating factor 3

Gene

Csf3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-449836. Other interleukin signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
Colony-stimulating factor 3Imported
Submitted name:
Granulocyte colony stimulating factorImported
Gene namesi
Name:Csf3Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi2426. Csf3.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_501050346822 – 214Sequence analysisAdd BLAST193

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi63 ↔ 69UniRule annotation
Disulfide bondi91 ↔ 101UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011509.

Family & Domainsi

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IIM2. Eukaryota.
ENOG4111DA4. LUCA.
GeneTreeiENSGT00390000017328.
HOGENOMiHOG000015371.
HOVERGENiHBG005411.
OMAiKLCHPEE.
OrthoDBiEOG091G0NDU.
TreeFamiTF337698.

Family and domain databases

InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR030474. IL-6/GCSF/MGF.
IPR030473. IL6/GCSF/MGF_CS.
PfamiView protein in Pfam
PF16647. GCSF. 1 hit.
PIRSFiPIRSF001935. IL6_MGF_GCSF. 1 hit.
PRINTSiPR00433. IL6GCSFMGF.
SMARTiView protein in SMART
SM00126. IL6. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiView protein in PROSITE
PS00254. INTERLEUKIN_6. 1 hit.

Sequencei

Sequence statusi: Complete.

P97712-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLMALQLLL WHSALWSGQE AIPLLTVSSL PPSLPLPRSF LLKSLEQVRK
60 70 80 90 100
IQARNTELLE QLCATYKLCH PEELVLFGHS LGIPKASLSS CSSQALQQTK
110 120 130 140 150
CLSQLHSGLF LYQGLLQALA GISSELAPTL DMLHLDVDNF ATTIWQQMES
160 170 180 190 200
LGVAPTVQPT QSTMPIFTSA FQRRAGGVLV TSYLQSFLET AHHALHHLPR
210
PAQKHFPESL FISI
Length:214
Mass (Da):23,660
Last modified:May 1, 1997 - v1
Checksum:i29BB88B17B684C55
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC119462 Genomic DNA. No translation available.
U37101 mRNA. Translation: AAC52915.1.
PIRiJC5043.
UniGeneiRn.53973.

Genome annotation databases

EnsembliENSRNOT00000011509; ENSRNOP00000011509; ENSRNOG00000008525.
UCSCiRGD:2426. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiP97712_RAT
AccessioniPrimary (citable) accession number: P97712
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: July 5, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported