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Protein
Submitted name:

Granulocyte colony stimulating factor

Gene

Csf3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-449147. Signaling by Interleukins.

Names & Taxonomyi

Protein namesi
Submitted name:
Granulocyte colony stimulating factorImported
Submitted name:
Protein Csf3Imported
Gene namesi
Name:Csf3Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi2426. Csf3.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 214193Sequence analysisPRO_5007921954Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi63 ↔ 69UniRule annotation
Disulfide bondi91 ↔ 101UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

PTM databases

PhosphoSiteiP97712.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011509.

Family & Domainsi

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IIM2. Eukaryota.
ENOG4111DA4. LUCA.
GeneTreeiENSGT00390000017328.
HOGENOMiHOG000015371.
HOVERGENiHBG005411.
OMAiLWHSALW.
OrthoDBiEOG091G0NDU.
TreeFamiTF337698.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR030474. IL-6/GCSF/MGF.
IPR030473. IL6/GCSF/MGF_CS.
[Graphical view]
PfamiPF16647. GCSF. 1 hit.
[Graphical view]
PIRSFiPIRSF001935. IL6_MGF_GCSF. 1 hit.
PRINTSiPR00433. IL6GCSFMGF.
SMARTiSM00126. IL6. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00254. INTERLEUKIN_6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97712-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLMALQLLL WHSALWSGQE AIPLLTVSSL PPSLPLPRSF LLKSLEQVRK
60 70 80 90 100
IQARNTELLE QLCATYKLCH PEELVLFGHS LGIPKASLSS CSSQALQQTK
110 120 130 140 150
CLSQLHSGLF LYQGLLQALA GISSELAPTL DMLHLDVDNF ATTIWQQMES
160 170 180 190 200
LGVAPTVQPT QSTMPIFTSA FQRRAGGVLV TSYLQSFLET AHHALHHLPR
210
PAQKHFPESL FISI
Length:214
Mass (Da):23,660
Last modified:May 1, 1997 - v1
Checksum:i29BB88B17B684C55
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC119462 Genomic DNA. No translation available.
U37101 mRNA. Translation: AAC52915.1.
PIRiJC5043.
UniGeneiRn.53973.

Genome annotation databases

EnsembliENSRNOT00000011509; ENSRNOP00000011509; ENSRNOG00000008525.
UCSCiRGD:2426. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC119462 Genomic DNA. No translation available.
U37101 mRNA. Translation: AAC52915.1.
PIRiJC5043.
UniGeneiRn.53973.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011509.

PTM databases

PhosphoSiteiP97712.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011509; ENSRNOP00000011509; ENSRNOG00000008525.
UCSCiRGD:2426. rat.

Organism-specific databases

RGDi2426. Csf3.

Phylogenomic databases

eggNOGiENOG410IIM2. Eukaryota.
ENOG4111DA4. LUCA.
GeneTreeiENSGT00390000017328.
HOGENOMiHOG000015371.
HOVERGENiHBG005411.
OMAiLWHSALW.
OrthoDBiEOG091G0NDU.
TreeFamiTF337698.

Enzyme and pathway databases

ReactomeiR-RNO-449147. Signaling by Interleukins.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR030474. IL-6/GCSF/MGF.
IPR030473. IL6/GCSF/MGF_CS.
[Graphical view]
PfamiPF16647. GCSF. 1 hit.
[Graphical view]
PIRSFiPIRSF001935. IL6_MGF_GCSF. 1 hit.
PRINTSiPR00433. IL6GCSFMGF.
SMARTiSM00126. IL6. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00254. INTERLEUKIN_6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP97712_RAT
AccessioniPrimary (citable) accession number: P97712
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.