Reviewed,
UniProtKB/Swiss-Prot P97711 (GRK6_RAT)
Last modified
November 24, 2009.
Version 85.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: G protein-coupled receptor kinase 6 EC=2.7.11.16 Alternative name(s): G protein-coupled receptor kinase GRK6 | ||||
| Gene names |
| ||||
| Organism | Rattus norvegicus (Rat) | ||||
| Taxonomic identifier | 10116 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 576 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Specifically phosphorylates the activated forms of G protein-coupled receptors By similarity. |
| Catalytic activity | ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate. |
| Subcellular location | |
| Sequence similarities | Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 1 protein kinase domain. Contains 1 RGS domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Serine/threonine-protein kinase Transferase |
| PTM | Lipoprotein Palmitate Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | protein amino acid phosphorylation Inferred from direct assay. Source: RGD signal transductionInferred from electronic annotation. Source: InterPro |
| Cellular component | anchored to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW G-protein coupled receptor kinase activityInferred from electronic annotation. Source: EC signal transducer activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 576 | 576 | G protein-coupled receptor kinase 6 | PRO_0000085976 | |||||
Regions | |||||||||
| Domain | 53 – 171 | 119 | RGS | ||||||
| Domain | 186 – 448 | 263 | Protein kinase | ||||||
| Domain | 449 – 514 | 66 | AGC-kinase C-terminal | ||||||
| Nucleotide binding | 192 – 200 | 9 | ATP By similarity | ||||||
| Region | 1 – 185 | 185 | N-terminal | ||||||
Sites | |||||||||
| Active site | 311 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 215 | 1 | ATP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 484 | 1 | Phosphoserine; by autocatalysis By similarity | ||||||
| Modified residue | 485 | 1 | Phosphothreonine; by autocatalysis By similarity | ||||||
| Lipidation | 561 | 1 | S-palmitoyl cysteine By similarity | ||||||
| Lipidation | 562 | 1 | S-palmitoyl cysteine By similarity | ||||||
| Lipidation | 565 | 1 | S-palmitoyl cysteine By similarity | ||||||
Sequences
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References
| [1] | "Molecular cloning of rat G-protein-coupled receptor kinase 6 (GRK6) from brain tissue, and its mRNA expression in different brain regions and peripheral tissues." Fehr C., Fickova M., Hiemke C., Reuss S., Dahmen N. Brain Res. Mol. Brain Res. 49:278-282(1997) [PubMed: 9387888] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | Y09365 mRNA. Translation: CAA70542.1. |
| IPI | IPI00205494. |
| UniGene | Rn.10633 |
3D structure databases | |
| SMR | P97711. Positions 23-532. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P97711. |
PTM databases | |
| PhosphoSite | P97711. |
Genome annotation databases | |
| Ensembl | ENSRNOT00000020214; ENSRNOP00000020214; ENSRNOG00000014615; Rattus norvegicus. [Genome view] ENSRNOT00000047958; ENSRNOP00000050134; ENSRNOG00000014615; Rattus norvegicus. [Genome view] |
| UCSC | NM_031657. rat. |
Organism-specific databases | |
| RGD | 61986. Gprk6. |
Phylogenomic databases | |
| HOVERGEN | P97711. |
Enzyme and pathway databases | |
| BRENDA | 2.7.11.16. 248. |
Gene expression databases | |
| ArrayExpress | P97711. |
| Genevestigator | P97711. |
| GermOnline | ENSRNOG00000014615. Rattus norvegicus. |
Family and domain databases | |
| InterPro | IPR000961. AGC-kinase_C. IPR000239. GPCR_kinase. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR000342. Regulat_G_prot_signal. IPR016137. Regulat_G_prot_signal_superfam. IPR017442. Se/Thr_prot_kinase-like_dom. IPR008271. Ser/Thr_prot_kinase_AS. IPR002290. Ser/Thr_prot_kinase_dom. [Graphical view] |
| Pfam | PF00069. Pkinase. 1 hit. PF00615. RGS. 1 hit. [Graphical view] |
| PRINTS | PR00717. GPCRKINASE. |
| SMART | SM00315. RGS. 1 hit. SM00133. S_TK_X. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view] |
| PROSITE | PS51285. AGC_KINASE_CTER. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. PS50132. RGS. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GRK6_RAT | ||||||||
| Accession | Primary (citable) accession number: P97711 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

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