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Protein

Voltage-dependent calcium channel gamma-1 subunit

Gene

Cacng1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This protein is a subunit of the dihydropyridine (DHP) sensitive calcium channel. Plays a role in excitation-contraction coupling. The skeletal muscle DHP-sensitive Ca2+ channel may function only as a multiple subunit complex.

GO - Molecular functioni

  • voltage-gated calcium channel activity Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-1 subunit
Alternative name(s):
Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma
Gene namesi
Name:Cacng1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2249. Cacng1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 2919HelicalSequence analysisAdd
BLAST
Transmembranei106 – 13025HelicalSequence analysisAdd
BLAST
Transmembranei141 – 15616HelicalSequence analysisAdd
BLAST
Transmembranei181 – 20525HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223Voltage-dependent calcium channel gamma-1 subunitPRO_0000164672Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi43 – 431N-linked (GlcNAc...)Sequence analysis
Glycosylationi80 – 801N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP97707.

Expressioni

Tissue specificityi

Skeletal muscle.

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004349.

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH0I. Eukaryota.
ENOG4111J5G. LUCA.
HOGENOMiHOG000293219.
HOVERGENiHBG003868.
InParanoidiP97707.
KOiK04866.
PhylomeDBiP97707.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR005421. VDCC_g1su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF13903. Claudin_2. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01601. VDCCGAMMA1.

Sequencei

Sequence statusi: Complete.

P97707-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQTKTAKVR VTLFFILAGG VLAMVAVVTD HWAVLSPHLE HHNETCVAAH
60 70 80 90 100
FGLWRICTTW VAMHNQDKNC DGTIPAGEKN CSYFRHFNPG ESSEIFEFTT
110 120 130 140 150
QKEYSISAAA IAIFSLGFII IGSICAFLSF GNKRDYLLRP ASMFYAFAGL
160 170 180 190 200
CLIVSVEVMR QSVKRMIDSE DTVWIEYYYS WSFACACAGF TLLFLGGLFL
210 220
LLFSLPRMPQ NPWESCMDTE SEH
Length:223
Mass (Da):25,119
Last modified:May 1, 1997 - v1
Checksum:iA9EA30B625E41CCC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09453 mRNA. Translation: CAA70602.1.
RefSeqiNP_062128.1. NM_019255.1.
UniGeneiRn.24079.

Genome annotation databases

GeneIDi29658.
KEGGirno:29658.
UCSCiRGD:2249. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09453 mRNA. Translation: CAA70602.1.
RefSeqiNP_062128.1. NM_019255.1.
UniGeneiRn.24079.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004349.

Proteomic databases

PaxDbiP97707.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29658.
KEGGirno:29658.
UCSCiRGD:2249. rat.

Organism-specific databases

CTDi786.
RGDi2249. Cacng1.

Phylogenomic databases

eggNOGiENOG410IH0I. Eukaryota.
ENOG4111J5G. LUCA.
HOGENOMiHOG000293219.
HOVERGENiHBG003868.
InParanoidiP97707.
KOiK04866.
PhylomeDBiP97707.

Miscellaneous databases

PROiP97707.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR005421. VDCC_g1su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF13903. Claudin_2. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01601. VDCCGAMMA1.
ProtoNetiSearch...

Entry informationi

Entry nameiCCG1_RAT
AccessioniPrimary (citable) accession number: P97707
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 1997
Last modified: June 8, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.