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Protein

Sodium channel protein

Gene

Scn7a

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

GO - Molecular functioni

  • sodium channel activity Source: RGD
  • voltage-gated sodium channel activity Source: InterPro

GO - Biological processi

  • muscle contraction Source: InterPro
  • sodium ion transmembrane transport Source: GOC
  • sodium ion transport Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotationSAAS annotation

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
Gene namesi
Name:Scn7aImported
Synonyms:SCL-11Imported, Scn6aImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi61922. Scn7a.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei237 – 25923HelicalUniRule annotationAdd
BLAST
Transmembranei369 – 39325HelicalUniRule annotationAdd
BLAST
Transmembranei528 – 54619HelicalUniRule annotationAdd
BLAST
Transmembranei558 – 57922HelicalUniRule annotationAdd
BLAST
Transmembranei644 – 66522HelicalUniRule annotationAdd
BLAST
Transmembranei729 – 75527HelicalUniRule annotationAdd
BLAST
Transmembranei955 – 97420HelicalUniRule annotationAdd
BLAST
Transmembranei995 – 101319HelicalUniRule annotationAdd
BLAST
Transmembranei1079 – 110224HelicalUniRule annotationAdd
BLAST
Transmembranei1190 – 121425HelicalUniRule annotationAdd
BLAST
Transmembranei1273 – 129119HelicalUniRule annotationAdd
BLAST
Transmembranei1303 – 132119HelicalUniRule annotationAdd
BLAST
Transmembranei1333 – 135422HelicalUniRule annotationAdd
BLAST
Transmembranei1390 – 141829HelicalUniRule annotationAdd
BLAST
Transmembranei1494 – 152027HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiP97706.

PTM databases

iPTMnetiP97706.

Expressioni

Gene expression databases

GenevisibleiP97706. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044385.

Structurei

3D structure databases

ProteinModelPortaliP97706.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini118 – 404287Ion_transInterPro annotationAdd
BLAST
Domaini526 – 751226Ion_transInterPro annotationAdd
BLAST
Domaini764 – 948185Na_trans_assocInterPro annotationAdd
BLAST
Domaini954 – 1221268Ion_transInterPro annotationAdd
BLAST
Domaini1271 – 1518248Ion_transInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410INF4. Eukaryota.
ENOG410Y1Z2. LUCA.
HOGENOMiHOG000231755.
HOVERGENiHBG053100.
KOiK04839.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR028812. Na_channel_a7su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view]
PANTHERiPTHR10037:SF14. PTHR10037:SF14. 1 hit.
PfamiPF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.

Sequencei

Sequence statusi: Complete.

P97706-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTSPEPKGL VPFTAESLEL IKNHIAKKCN EEHEEEDLKP SRDIEAGKKL
60 70 80 90 100
PFAYGTLPQG TVSEPLEDVD PYYYVKRNTF MVLNRNRVIF RFNAVSILCT
110 120 130 140 150
LSPLSSLRRA VIKVLVHPLL RLLILISVLT DSILMCMSNL PEWILAVENT
160 170 180 190 200
CLGIYTFEIL VKVIARGIWA GSFSFLGDLW NWLDFSVTLF ELITRSSPLS
210 220 230 240 250
SLPMFKTIRT LRILKIIPLN HGLQSIVVTL VQCLKKLLGA IALALFFLTV
260 270 280 290 300
SSLFGMGLFM GNLKHKCVRW PQEDGNDVMY SGTGSQYHIL ERENFYYMEG
310 320 330 340 350
ARYALLCGNK TDAGLCPEGY MCVKEGSNPD NGFTSFDNFG WALLAMFRLM
360 370 380 390 400
TQDYPELLYH QILYASGKIY MIFFVLISFW FAFYMASLFL GILTMAYEQE
410 420 430 440 450
KQRASEESRD MDSKCHQTVK EFEEEHEGAE LQCIWFYEEV LDLLGLELCI
460 470 480 490 500
KEMETTQIEM KKRSPTSINT TLDILEDTAL GHKEEPETSR KECPLCWYKF
510 520 530 540 550
TKTCFIWKCS PCWIKLNEFA DRIITHPLFD LFLVICIILN ICFLALEHFP
560 570 580 590 600
MSEELMSLLA IGNLVFIGIY TIEMILKIIA MHPYGYFQIS WHIFDSILVV
610 620 630 640 650
LGLTEMLLAD IEEITVFILV PLIFIKLGKY APPFKNLMRI LGRALVALKD
660 670 680 690 700
LVLLVSIFIY FSAVFGMKLF GRSYKDCVCH VDQDCQRQRW HMSDFLHAYV
710 720 730 740 750
TVFRILCGEW IETLWECMEV AGEAWCIPFY MMVILIGNLL ILYLFVGLVS
760 770 780 790 800
SFASYDATTE VSKEAKNLQL AVAWIKMVIN CVLLKILCKE KTVSTEATDQ
810 820 830 840 850
TCDPSVKENI SGHTLSELSN TQTFLRYKDQ SSGTEKTPVT ESESQSLIAS
860 870 880 890 900
PSVSETVPIA SGESDIENLD NKETRSKSAN GSSKEKMKQS SSSECSTVDI
910 920 930 940 950
AISEEEEMVY EHEKSKLHKN GYERKSSAGQ VSRESRNGKI WRNIRKTCCK
960 970 980 990 1000
IVENSWFECF IGLVTLLCTG TLALEDIYIH QRKTIKIFLE YGDMIFAYIF
1010 1020 1030 1040 1050
ILEMLLKWVA YGFKAYFSNN WYKLDFMVVI VLCLSLKGKT REDLNPLPSI
1060 1070 1080 1090 1100
KFLRALRVLS QFERMKVVLR ALIKTTLPAV SVFLVCLMIW LLFSVMGVFL
1110 1120 1130 1140 1150
FAGKFYECID PTRGERFSVF EVMNKSQCEN LVFNESMPWE NAKLNFDNVG
1160 1170 1180 1190 1200
NGFLSLFQVA TFNGWISIMN SAIDSVGVYM QPSFEHSLHM YTYFIIFVVF
1210 1220 1230 1240 1250
GLFLPLCMLI GVIIRNFNKQ KIKQGGSNIF ITVKQKKQYR ALKKLLYADS
1260 1270 1280 1290 1300
QKPAARPRNK FQGFICDVVT HRVFNVVVVL LICFQATTIM IQNDEQSPQI
1310 1320 1330 1340 1350
ETAVFWMNSL FTMLFTLECI LKLTAFRCHY FTSAWNVHDF MVVVFSITGL
1360 1370 1380 1390 1400
LLPLSIGQYF VPPSLVQLLL LSRIIHVLRP GKGPKVFHDL MLPLMLSLPA
1410 1420 1430 1440 1450
LLNIGLLIFL VMFIYAIFGM YNFAYVKKEA GINDVSNFET FGSSMLCLFQ
1460 1470 1480 1490 1500
VTTFSGWDGM LDAIFNSQWS DCDPDKINPG TQVRGDCGSP SVGIFYFVSY
1510 1520 1530 1540 1550
ILISWLIIVN MYVVLIMEFL SIPSKRKNRT LSEDDFRRFF KVWNRFDPDR
1560 1570 1580 1590 1600
TQYIDSTKLS DFAAALDPPL FMAKPNKGQL VAMDLPMAAG DRIHCLDILL
1610 1620 1630 1640 1650
AFTKRVMGKD ERVEKILSEI ESGFMLANPF KITYEPITTT LKRKQEAVSA
1660 1670 1680 1690 1700
TIIQRAYKSY RLRQSDKKIQ DIPEIDDGRE DPNSKGVHSG QIEEKASIQT

QI
Length:1,702
Mass (Da):194,738
Last modified:May 1, 1997 - v1
Checksum:iF123DB9ADA2FFCE3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09164 mRNA. Translation: CAA70364.1.
RefSeqiNP_113874.1. NM_031686.1.
UniGeneiRn.54541.

Genome annotation databases

GeneIDi64155.
KEGGirno:64155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09164 mRNA. Translation: CAA70364.1.
RefSeqiNP_113874.1. NM_031686.1.
UniGeneiRn.54541.

3D structure databases

ProteinModelPortaliP97706.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044385.

PTM databases

iPTMnetiP97706.

Proteomic databases

PaxDbiP97706.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi64155.
KEGGirno:64155.

Organism-specific databases

CTDi6332.
RGDi61922. Scn7a.

Phylogenomic databases

eggNOGiENOG410INF4. Eukaryota.
ENOG410Y1Z2. LUCA.
HOGENOMiHOG000231755.
HOVERGENiHBG053100.
KOiK04839.

Gene expression databases

GenevisibleiP97706. RN.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR028812. Na_channel_a7su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view]
PANTHERiPTHR10037:SF14. PTHR10037:SF14. 1 hit.
PfamiPF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
ProtoNetiSearch...

Publicationsi

  1. "Structure and distribution of a broadly expressed atypical sodium channel."
    Akopian A., Souslova V., Sivilotti L., Wood J.N.
    Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiP97706_RAT
AccessioniPrimary (citable) accession number: P97706
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: June 8, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.