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Protein

Mitochondrial 2-oxoglutarate/malate carrier protein

Gene

Slc25a11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism.By similarity

GO - Molecular functioni

  • structural constituent of ribosome Source: GO_Central
  • transporter activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial 2-oxoglutarate/malate carrier protein
Short name:
OGCP
Alternative name(s):
Solute carrier family 25 member 11
Gene namesi
Name:Slc25a11
Synonyms:Slc20a4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708476. Slc25a11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 4219Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei83 – 10119Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei119 – 14022Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei183 – 20220Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei222 – 24019Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei281 – 30020Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 314313Mitochondrial 2-oxoglutarate/malate carrier proteinPRO_0000090627Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei6 – 61PhosphoserineBy similarity
Modified residuei57 – 571N6-succinyllysineBy similarity
Modified residuei73 – 731N6-acetyllysineBy similarity
Modified residuei102 – 1021PhosphotyrosineBy similarity
Modified residuei256 – 2561N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP97700.
PRIDEiP97700.

PTM databases

iPTMnetiP97700.
PhosphoSiteiP97700.

Interactioni

Protein-protein interaction databases

IntActiP97700. 1 interaction.
STRINGi10116.ENSRNOP00000005144.

Structurei

3D structure databases

ProteinModelPortaliP97700.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati23 – 10886Solcar 1Add
BLAST
Repeati117 – 20892Solcar 2Add
BLAST
Repeati217 – 30690Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0759. Eukaryota.
ENOG410XQHU. LUCA.
HOGENOMiHOG000165139.
HOVERGENiHBG009528.
InParanoidiP97700.
KOiK15104.
PhylomeDBiP97700.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97700-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATASPGAG RMDGKPRTSP KSVKFLFGGL AGMGATVFVQ PLDLVXNRMQ
60 70 80 90 100
LSGEGAKTRE YKTSFHALTS ILKAEGLRGI YTGLSAGLLR QATYTTTRLG
110 120 130 140 150
IYTVLFERLT GADGTPPGFL LKALIGMTAG ATGAFVGPPA EVALIRMTAD
160 170 180 190 200
GRLPADQRRG YKNVFNALIR IAREEGVPTL WRGCIPTMAR AVVVNAAQLA
210 220 230 240 250
SYSQSKQFLL DSGYFSDNIL CHFCAIMISG LVTTAASMPV DIVKTRIQNM
260 270 280 290 300
RMIDEKPEYK NGLDVLLKVV RYEGFFSLWK GFTPYYARLG PHTVLTFIFL
310
EQMNKAYKRL FLSG
Length:314
Mass (Da):34,244
Last modified:January 23, 2007 - v3
Checksum:i0DD88F3865E79D04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U84727 mRNA. Translation: AAB41797.1.
RefSeqiNP_071793.1. NM_022398.2.
UniGeneiRn.853.

Genome annotation databases

GeneIDi64201.
KEGGirno:64201.
UCSCiRGD:708476. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U84727 mRNA. Translation: AAB41797.1.
RefSeqiNP_071793.1. NM_022398.2.
UniGeneiRn.853.

3D structure databases

ProteinModelPortaliP97700.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP97700. 1 interaction.
STRINGi10116.ENSRNOP00000005144.

PTM databases

iPTMnetiP97700.
PhosphoSiteiP97700.

Proteomic databases

PaxDbiP97700.
PRIDEiP97700.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi64201.
KEGGirno:64201.
UCSCiRGD:708476. rat.

Organism-specific databases

CTDi8402.
RGDi708476. Slc25a11.

Phylogenomic databases

eggNOGiKOG0759. Eukaryota.
ENOG410XQHU. LUCA.
HOGENOMiHOG000165139.
HOVERGENiHBG009528.
InParanoidiP97700.
KOiK15104.
PhylomeDBiP97700.

Miscellaneous databases

PROiP97700.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Bei D., Lehmann J.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiM2OM_RAT
AccessioniPrimary (citable) accession number: P97700
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.