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P97698

- SMO_RAT

UniProt

P97698 - SMO_RAT

Protein

Smoothened homolog

Gene

Smo

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia By similarity.By similarity

    GO - Molecular functioni

    1. drug binding Source: UniProtKB
    2. G-protein coupled receptor activity Source: UniProtKB-KW
    3. PDZ domain binding Source: RefGenome
    4. Wnt-activated receptor activity Source: RefGenome
    5. Wnt-protein binding Source: RefGenome

    GO - Biological processi

    1. adenohypophysis development Source: RefGenome
    2. axon extension involved in axon guidance Source: RGD
    3. canonical Wnt signaling pathway Source: RefGenome
    4. cardioblast differentiation Source: RefGenome
    5. central nervous system neuron differentiation Source: RefGenome
    6. cerebellar cortex morphogenesis Source: RefGenome
    7. ciliary receptor clustering involved in smoothened signaling pathway Source: RefGenome
    8. determination of left/right asymmetry in lateral mesoderm Source: UniProtKB
    9. determination of left/right symmetry Source: RefGenome
    10. dorsal/ventral neural tube patterning Source: RefGenome
    11. embryonic camera-type eye development Source: RefGenome
    12. embryonic digestive tract morphogenesis Source: RefGenome
    13. embryonic neurocranium morphogenesis Source: RefGenome
    14. embryonic viscerocranium morphogenesis Source: RefGenome
    15. exocrine pancreas development Source: RefGenome
    16. facial nerve development Source: RGD
    17. floor plate formation Source: RefGenome
    18. forebrain morphogenesis Source: UniProtKB
    19. gonad development Source: RefGenome
    20. heart looping Source: UniProtKB
    21. heart morphogenesis Source: RefGenome
    22. mesenchymal to epithelial transition involved in metanephric renal vesicle formation Source: UniProtKB
    23. midgut development Source: UniProtKB
    24. muscle cell fate commitment Source: RefGenome
    25. negative regulation of apoptotic process Source: RefGenome
    26. negative regulation of DNA binding Source: UniProtKB
    27. negative regulation of gene expression Source: UniProtKB
    28. neural crest cell migration Source: RefGenome
    29. neuron fate commitment Source: RefGenome
    30. neuron projection regeneration Source: RGD
    31. odontogenesis of dentin-containing tooth Source: RefGenome
    32. osteoblast differentiation Source: RGD
    33. osteoblast proliferation Source: RGD
    34. otolith morphogenesis Source: RefGenome
    35. positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
    36. positive regulation of epithelial cell proliferation Source: RefGenome
    37. positive regulation of gene expression Source: UniProtKB
    38. positive regulation of hh target transcription factor activity Source: UniProtKB
    39. positive regulation of mesenchymal cell proliferation Source: RefGenome
    40. positive regulation of neuroblast proliferation Source: RefGenome
    41. positive regulation of smoothened signaling pathway Source: RefGenome
    42. response to organic substance Source: RGD
    43. response to wounding Source: RGD
    44. semicircular canal morphogenesis Source: RefGenome
    45. smoothened signaling pathway Source: UniProtKB
    46. smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation Source: RefGenome
    47. smoothened signaling pathway involved in ventral spinal cord patterning Source: RefGenome
    48. somite development Source: UniProtKB
    49. spermatogenesis Source: RGD
    50. vasculogenesis Source: RefGenome

    Keywords - Molecular functioni

    Developmental protein, G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Smoothened homolog
    Short name:
    SMO
    Gene namesi
    Name:Smo
    Synonyms:Smoh
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi3726. Smo.

    Subcellular locationi

    GO - Cellular componenti

    1. axonal growth cone Source: RGD
    2. cilium Source: RefGenome
    3. cytoplasm Source: RGD
    4. dendrite Source: RGD
    5. dendritic growth cone Source: RGD
    6. integral component of membrane Source: UniProtKB-KW
    7. neuronal cell body Source: RGD
    8. plasma membrane Source: UniProtKB
    9. postsynaptic density Source: RGD

    Keywords - Cellular componenti

    Cell projection, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 793763Smoothened homologPRO_0000013017Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi38 – 381N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi74 ↔ 138PROSITE-ProRule annotation
    Disulfide bondi82 ↔ 131PROSITE-ProRule annotation
    Disulfide bondi122 ↔ 158PROSITE-ProRule annotation
    Disulfide bondi151 ↔ 173PROSITE-ProRule annotation
    Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi197 ↔ 217PROSITE-ProRule annotation
    Disulfide bondi221 ↔ 299PROSITE-ProRule annotation
    Disulfide bondi318 ↔ 394PROSITE-ProRule annotation
    Disulfide bondi494 ↔ 511PROSITE-ProRule annotation
    Glycosylationi497 – 4971N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP97698.
    PRIDEiP97698.

    PTM databases

    PhosphoSiteiP97698.

    Expressioni

    Tissue specificityi

    In embryo, found in the early neural folds and neural tube, pre-somitic mesoderm and somites, developing limb bud, gut, eye, testes, cartilage, muscle, lung, epiglottis, thymus, tongue, jaw, taste buds, teeth, and skin. In adult, found in multiple tissues including heart, brain, liver, lung, skeletal muscle, kidney and testis.

    Gene expression databases

    GenevestigatoriP97698.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with ARRB2. Interacts with KIF7. Interacts with BBS5 and BBS7; the interactions are indicative for the association of SMO with the BBsome complex to facilitate ciliary localization of SMO By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000011356.

    Structurei

    3D structure databases

    ProteinModelPortaliP97698.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini31 – 237207ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini259 – 2668CytoplasmicSequence Analysis
    Topological domaini288 – 31831ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini340 – 36223CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini384 – 40623ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini428 – 45528CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini477 – 52852ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini550 – 793244CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei238 – 25821Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei267 – 28721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei319 – 33921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei363 – 38321Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei407 – 42721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei456 – 47621Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei529 – 54921Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini69 – 185117FZPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni542 – 57332Interaction with BBS5 and BBS7By similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG312505.
    HOGENOMiHOG000252964.
    HOVERGENiHBG000352.
    InParanoidiP97698.
    KOiK06226.
    PhylomeDBiP97698.

    Family and domain databases

    Gene3Di1.10.2000.10. 1 hit.
    InterProiIPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR017981. GPCR_2-like.
    IPR026544. SMO.
    [Graphical view]
    PANTHERiPTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF35. PTHR11309:SF35. 1 hit.
    PfamiPF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view]
    PRINTSiPR00489. FRIZZLED.
    SMARTiSM00063. FRI. 1 hit.
    [Graphical view]
    SUPFAMiSSF63501. SSF63501. 1 hit.
    PROSITEiPS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P97698-1 [UniParc]FASTAAdd to Basket

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    MAAGRPVRGP ELAPRRLLQL LLLVLLGGRG RGAALSGNVT GPGPRSAGGS    50
    ARRNAPVTSP PPPLLSHCGR AAHCEPLRYN VCLGSALPYG ATTTLLAGDS 100
    DSQEEAHSKL VLWSGLRNAP RCWAVIQPLL CAVYMPKCEN DRVELPSRTL 150
    CQATRGPCAI VERERGWPDF LRCTPDHFPE GCPNEVQNIK FNSSGQCEAP 200
    LVRTDNPKSW YEDVEGCGIQ CQNPLFTEAE HQDMHSYIAA FGAVTGLCTL 250
    FTLATFVADW RNSNRYPAVI LFYVNACFFV GSIGWLAQFM DGARREIVCR 300
    ADGTMRFGEP TSSETLSCVI IFVIVYYALM AGVVWFVVLT YAWHTSFKAL 350
    GTTYQPLSGK TSYFHLLTWS LPFVLTVAIL AVAQVDGDSV SGICFVGYKN 400
    YRYRAGFVLA PIGLVLIVGG YFLIRGVMTL FSIKSNHPGL LSEKAASKIN 450
    ETMLRLGIFG FLAFGFVLIT FSCHFYDFFN QAEWERSFRD YVLCQANVTI 500
    GLPTKKPIPD CEIKNRPSLL VEKINLFAMF GTGIAMSTWV WTKATLLIWR 550
    RTWCRLTGHS DDEPKRIKKS KMIAKAFSKR RELLQNPGQE LSFSMHTVSH 600
    DGPVAGLAFE LNEPSADVSS AWAQHVTKMV ARRGAILPQD VSVTPVATPV 650
    PPEEQANLWL VEAEISPELE KRLGRKKKRR KRKKEVCPLG PAPELHHSAP 700
    VPATSAVPRL PQLPRQKCLV AANAWGTGEP CRQGAWTVVS NPFCPEPSPH 750
    QDPFLPGASA PRVWAQGRLQ GLGSIHSRTN LMEAELLDAD SDF 793
    Length:793
    Mass (Da):87,376
    Last modified:May 1, 1997 - v1
    Checksum:i27B88178B2565FB9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U84402 mRNA. Translation: AAB41789.1.
    RefSeqiNP_036939.1. NM_012807.1.
    UniGeneiRn.44429.

    Genome annotation databases

    GeneIDi25273.
    KEGGirno:25273.
    UCSCiRGD:3726. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U84402 mRNA. Translation: AAB41789.1 .
    RefSeqi NP_036939.1. NM_012807.1.
    UniGenei Rn.44429.

    3D structure databases

    ProteinModelPortali P97698.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000011356.

    Chemistry

    ChEMBLi CHEMBL1795175.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P97698.

    Proteomic databases

    PaxDbi P97698.
    PRIDEi P97698.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 25273.
    KEGGi rno:25273.
    UCSCi RGD:3726. rat.

    Organism-specific databases

    CTDi 6608.
    RGDi 3726. Smo.

    Phylogenomic databases

    eggNOGi NOG312505.
    HOGENOMi HOG000252964.
    HOVERGENi HBG000352.
    InParanoidi P97698.
    KOi K06226.
    PhylomeDBi P97698.

    Miscellaneous databases

    NextBioi 605965.
    PROi P97698.

    Gene expression databases

    Genevestigatori P97698.

    Family and domain databases

    Gene3Di 1.10.2000.10. 1 hit.
    InterProi IPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR017981. GPCR_2-like.
    IPR026544. SMO.
    [Graphical view ]
    PANTHERi PTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF35. PTHR11309:SF35. 1 hit.
    Pfami PF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view ]
    PRINTSi PR00489. FRIZZLED.
    SMARTi SM00063. FRI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63501. SSF63501. 1 hit.
    PROSITEi PS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiSMO_RAT
    AccessioniPrimary (citable) accession number: P97698
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3