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P97691

- FOXM1_RAT

UniProt

P97691 - FOXM1_RAT

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Protein

Forkhead box protein M1

Gene
Foxm1, Win
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi234 – 32693Fork-headAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. DNA binding, bending Source: RefGenome
  3. double-stranded DNA binding Source: RefGenome
  4. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: RefGenome
  5. sequence-specific DNA binding Source: RGD
  6. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  7. transcription factor binding Source: RefGenome

GO - Biological processi

  1. DNA repair Source: UniProtKB-KW
  2. G2/M transition of mitotic cell cycle Source: UniProtKB
  3. liver development Source: RefGenome
  4. negative regulation of stress-activated MAPK cascade Source: RefGenome
  5. negative regulation of transcription from RNA polymerase II promoter Source: RefGenome
  6. pattern specification process Source: RefGenome
  7. positive regulation of cell proliferation Source: RefGenome
  8. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  9. regulation of cell cycle arrest Source: RefGenome
  10. regulation of Ras protein signal transduction Source: RefGenome
  11. regulation of sequence-specific DNA binding transcription factor activity Source: RefGenome
  12. response to cAMP Source: RGD
  13. response to gonadotropin Source: RGD
  14. tissue development Source: RefGenome
  15. transcription from RNA polymerase II promoter Source: GOC
  16. vasculogenesis Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Cell cycle, DNA damage, DNA repair, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein M1
Alternative name(s):
INS-1 winged helix
Winged-helix factor from INS-1 cells
Gene namesi
Name:Foxm1
Synonyms:Win
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi61807. Foxm1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. transcription factor complex Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 759759Forkhead box protein M1PRO_0000091865Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei330 – 3301Phosphoserine By similarity
Modified residuei375 – 3751Phosphoserine; by CHEK2 By similarity
Modified residuei608 – 6081Phosphothreonine; by CDK1 By similarity
Modified residuei624 – 6241Phosphothreonine By similarity
Modified residuei726 – 7261Phosphoserine; by PLK1 By similarity
Modified residuei735 – 7351Phosphoserine; by PLK1 By similarity

Post-translational modificationi

Phosphorylated in M (mitotic) phase. Phosphorylation by the checkpoint kinase CHEK2 in response to DNA damage increases the FOXM1 protein stability probably stimulating the transcription of genes involved in DNA repair. Phosphorylated by CDK1 in late S and G2 phases, creating docking sites for the POLO box domains of PLK1. Subsequently, PLK1 binds and phosphorylates FOXM1, leading to activation of transcriptional activity and subsequent enhanced expression of key mitotic regulators By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP97691.
PRIDEiP97691.

Expressioni

Tissue specificityi

Highly expressed in thymus and testis, but weakly in intestine and lung. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors.

Developmental stagei

Expressed from E12 day to neonate in developing pancreas. Also expressed at E14 day in liver, thymus, testis and fat (pregnant mother).

Inductioni

Activated in S phase.

Gene expression databases

GenevestigatoriP97691.

Interactioni

Protein-protein interaction databases

BioGridi248662. 1 interaction.
STRINGi10116.ENSRNOP00000008003.

Structurei

3D structure databases

ProteinModelPortaliP97691.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi479 – 51234Glu/Pro/Ser/Thr-richAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5025.
HOGENOMiHOG000112633.
HOVERGENiHBG051652.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P97691-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRTSPRRPLI LKRRRLPLPI QNAPSETSEE EAKRSPGQQE PTQAQASQDV    50
AESSSCKFPA GIKIINHPTV PNTQVVAIPN NADIQSIITA LTAKGKESGS 100
SGPNKFILIS SGGASSHPPD PQSQAQTSTD SKRTELITET LGPKPGAKGV 150
PVPKPPGALP RQRQESCGGE AAGCTLDNSL TNIQWLGKMS SDGLGRCSIK 200
QELEEKENCH LEQNRVKVEA PSRASVSWQD SVSERPPYSY MAMIQFAINS 250
TERKRMTLKD IYTWIEDHFP YFKHIAKPGW KNSIRHNLSL HDMFVRETSA 300
NGKVSFWTIH PSANRYLTLD QVFKPLEPGS PQSPEHLESQ QKRPNPELRR 350
NVTIKTELPL GARRKMKPLL PRVSSYLVPI QFPVNQSLVL QPSVKVPLPL 400
AASLMSSELA RHSKRVRIAP KVLLSNEGIA PLPATEPMKE EKPLLGEGLL 450
PLLPIQSIKE EVIQPGEDIP HLERPIKVES PPLEEWPSPC ASVKEELSNS 500
WEDSSCSPTP KPKKSYCGLK SPTRCVSEML VTKRREKREV SRSRRKQHLQ 550
PPCLDEPELF FSEDSSTFRP AMEILAESSE PAPQLSCPQE EGGPFKTPIK 600
ETLPVSSTPS KSVLSRDPES WRLTPPAKVG GLDFSPVRTP QGAFGPLPDS 650
LGLMELNTTP LKSVPLFDSP RELLNSEAFD LASDPFSSSP PPHLEAKPGS 700
PELQVPSLSA NRSLTEGLVL DTMNDSLSKI LLDISFPGLE EDPLGPDNIN 750
WSQFIPELR 759
Length:759
Mass (Da):83,672
Last modified:December 1, 2000 - v2
Checksum:i77231ED495840709
GO
Isoform 2 (identifier: P97691-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     325-339: Missing.

Show »
Length:744
Mass (Da):82,087
Checksum:i0701DB6C6FD3A057
GO
Isoform 3 (identifier: P97691-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     281-281: K → KCWHQAYHKLGPQ

Show »
Length:771
Mass (Da):85,122
Checksum:i98771524E7EB23D4
GO
Isoform 4 (identifier: P97691-4)

Sequence is not available

Note: Has been shown to exist only in human so far.

Length:
Mass (Da):

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei281 – 2811K → KCWHQAYHKLGPQ in isoform 3. VSP_001549
Alternative sequencei325 – 33915Missing in isoform 2. VSP_001550Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U83112 mRNA. Translation: AAC63594.1.
UniGeneiRn.10665.

Genome annotation databases

UCSCiRGD:61807. rat. [P97691-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U83112 mRNA. Translation: AAC63594.1 .
UniGenei Rn.10665.

3D structure databases

ProteinModelPortali P97691.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 248662. 1 interaction.
STRINGi 10116.ENSRNOP00000008003.

Proteomic databases

PaxDbi P97691.
PRIDEi P97691.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:61807. rat. [P97691-1 ]

Organism-specific databases

RGDi 61807. Foxm1.

Phylogenomic databases

eggNOGi COG5025.
HOGENOMi HOG000112633.
HOVERGENi HBG051652.

Miscellaneous databases

NextBioi 611478.

Gene expression databases

Genevestigatori P97691.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular analysis of a novel winged helix protein, WIN. Expression pattern, DNA binding property, and alternative splicing within the DNA binding domain."
    Yao K.-M., Sha M., Lu Z., Wong G.G.
    J. Biol. Chem. 272:19827-19836(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4).
    Tissue: Insulinoma.

Entry informationi

Entry nameiFOXM1_RAT
AccessioniPrimary (citable) accession number: P97691
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: July 9, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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