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P97691

- FOXM1_RAT

UniProt

P97691 - FOXM1_RAT

Protein

Forkhead box protein M1

Gene

Foxm1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 2 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi234 – 32693Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. sequence-specific DNA binding Source: RGD
    3. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. DNA repair Source: UniProtKB-KW
    2. G2/M transition of mitotic cell cycle Source: UniProtKB
    3. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    4. response to cAMP Source: RGD
    5. response to gonadotropin Source: RGD
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Cell cycle, DNA damage, DNA repair, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein M1
    Alternative name(s):
    INS-1 winged helix
    Winged-helix factor from INS-1 cells
    Gene namesi
    Name:Foxm1
    Synonyms:Win
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi61807. Foxm1.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 759759Forkhead box protein M1PRO_0000091865Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei330 – 3301PhosphoserineBy similarity
    Modified residuei375 – 3751Phosphoserine; by CHEK2By similarity
    Modified residuei608 – 6081Phosphothreonine; by CDK1By similarity
    Modified residuei624 – 6241PhosphothreonineBy similarity
    Modified residuei726 – 7261Phosphoserine; by PLK1By similarity
    Modified residuei735 – 7351Phosphoserine; by PLK1By similarity

    Post-translational modificationi

    Phosphorylated in M (mitotic) phase. Phosphorylation by the checkpoint kinase CHEK2 in response to DNA damage increases the FOXM1 protein stability probably stimulating the transcription of genes involved in DNA repair. Phosphorylated by CDK1 in late S and G2 phases, creating docking sites for the POLO box domains of PLK1. Subsequently, PLK1 binds and phosphorylates FOXM1, leading to activation of transcriptional activity and subsequent enhanced expression of key mitotic regulators By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP97691.
    PRIDEiP97691.

    Expressioni

    Tissue specificityi

    Highly expressed in thymus and testis, but weakly in intestine and lung. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors.

    Developmental stagei

    Expressed from E12 day to neonate in developing pancreas. Also expressed at E14 day in liver, thymus, testis and fat (pregnant mother).

    Inductioni

    Activated in S phase.

    Gene expression databases

    GenevestigatoriP97691.

    Interactioni

    Protein-protein interaction databases

    BioGridi248662. 1 interaction.
    STRINGi10116.ENSRNOP00000008003.

    Structurei

    3D structure databases

    ProteinModelPortaliP97691.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi479 – 51234Glu/Pro/Ser/Thr-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5025.
    HOGENOMiHOG000112633.
    HOVERGENiHBG051652.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    [Graphical view]
    PROSITEiPS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P97691-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRTSPRRPLI LKRRRLPLPI QNAPSETSEE EAKRSPGQQE PTQAQASQDV    50
    AESSSCKFPA GIKIINHPTV PNTQVVAIPN NADIQSIITA LTAKGKESGS 100
    SGPNKFILIS SGGASSHPPD PQSQAQTSTD SKRTELITET LGPKPGAKGV 150
    PVPKPPGALP RQRQESCGGE AAGCTLDNSL TNIQWLGKMS SDGLGRCSIK 200
    QELEEKENCH LEQNRVKVEA PSRASVSWQD SVSERPPYSY MAMIQFAINS 250
    TERKRMTLKD IYTWIEDHFP YFKHIAKPGW KNSIRHNLSL HDMFVRETSA 300
    NGKVSFWTIH PSANRYLTLD QVFKPLEPGS PQSPEHLESQ QKRPNPELRR 350
    NVTIKTELPL GARRKMKPLL PRVSSYLVPI QFPVNQSLVL QPSVKVPLPL 400
    AASLMSSELA RHSKRVRIAP KVLLSNEGIA PLPATEPMKE EKPLLGEGLL 450
    PLLPIQSIKE EVIQPGEDIP HLERPIKVES PPLEEWPSPC ASVKEELSNS 500
    WEDSSCSPTP KPKKSYCGLK SPTRCVSEML VTKRREKREV SRSRRKQHLQ 550
    PPCLDEPELF FSEDSSTFRP AMEILAESSE PAPQLSCPQE EGGPFKTPIK 600
    ETLPVSSTPS KSVLSRDPES WRLTPPAKVG GLDFSPVRTP QGAFGPLPDS 650
    LGLMELNTTP LKSVPLFDSP RELLNSEAFD LASDPFSSSP PPHLEAKPGS 700
    PELQVPSLSA NRSLTEGLVL DTMNDSLSKI LLDISFPGLE EDPLGPDNIN 750
    WSQFIPELR 759
    Length:759
    Mass (Da):83,672
    Last modified:December 1, 2000 - v2
    Checksum:i77231ED495840709
    GO
    Isoform 2 (identifier: P97691-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         325-339: Missing.

    Show »
    Length:744
    Mass (Da):82,087
    Checksum:i0701DB6C6FD3A057
    GO
    Isoform 3 (identifier: P97691-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         281-281: K → KCWHQAYHKLGPQ

    Show »
    Length:771
    Mass (Da):85,122
    Checksum:i98771524E7EB23D4
    GO
    Isoform 4 (identifier: P97691-4)

    Sequence is not available

    Note: Has been shown to exist only in human so far.

    Length:
    Mass (Da):

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei281 – 2811K → KCWHQAYHKLGPQ in isoform 3. 1 PublicationVSP_001549
    Alternative sequencei325 – 33915Missing in isoform 2. 1 PublicationVSP_001550Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U83112 mRNA. Translation: AAC63594.1.
    UniGeneiRn.10665.

    Genome annotation databases

    UCSCiRGD:61807. rat. [P97691-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U83112 mRNA. Translation: AAC63594.1 .
    UniGenei Rn.10665.

    3D structure databases

    ProteinModelPortali P97691.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 248662. 1 interaction.
    STRINGi 10116.ENSRNOP00000008003.

    Proteomic databases

    PaxDbi P97691.
    PRIDEi P97691.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:61807. rat. [P97691-1 ]

    Organism-specific databases

    RGDi 61807. Foxm1.

    Phylogenomic databases

    eggNOGi COG5025.
    HOGENOMi HOG000112633.
    HOVERGENi HBG051652.

    Miscellaneous databases

    NextBioi 611478.

    Gene expression databases

    Genevestigatori P97691.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    [Graphical view ]
    PROSITEi PS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular analysis of a novel winged helix protein, WIN. Expression pattern, DNA binding property, and alternative splicing within the DNA binding domain."
      Yao K.-M., Sha M., Lu Z., Wong G.G.
      J. Biol. Chem. 272:19827-19836(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4).
      Tissue: Insulinoma.

    Entry informationi

    Entry nameiFOXM1_RAT
    AccessioniPrimary (citable) accession number: P97691
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3