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Protein

Interleukin-3

Gene

Il3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.UniRule annotation
This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

CytokineUniRule annotation, Growth factorUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-3UniRule annotation
Short name:
IL-3UniRule annotation
Alternative name(s):
Hematopoietic growth factorUniRule annotation
Mast cell growth factorUniRule annotation
Multipotential colony-stimulating factorUniRule annotation
P-cell-stimulating factorUniRule annotation
Gene namesi
Name:Il3Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi2897. Il3.

Subcellular locationi

  • Secreted UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 169143Interleukin-3Sequence analysisPRO_5004161745Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi43 ↔ 109UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Proteomic databases

PaxDbiP97688.

Expressioni

Gene expression databases

GenevisibleiP97688. RN.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030704.

Structurei

3D structure databases

ProteinModelPortaliP97688.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-3 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

HOGENOMiHOG000113051.
HOVERGENiHBG006148.
KOiK04736.
PhylomeDBiP97688.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002183. IL-3.
[Graphical view]
PANTHERiPTHR10079. PTHR10079. 1 hit.
PfamiPF02059. IL3. 1 hit.
[Graphical view]
PIRSFiPIRSF001939. IL-3. 1 hit.
PRINTSiPR00430. INTERLEUKIN3.
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

P97688-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLASSTTSI LCMLLPLLML FHQGLQISDR GSDAHHLLRT LDCRTIALEI
60 70 80 90 100
LVKLPYPQVS GLNNSDDKAN LRNSTLRRVN LDEFLKSQEE FDSQDTTDIK
110 120 130 140 150
SKLQKLKCCI PAAASDSVLP GVYNKDLDDF KKKLRFYVIH LKDLQPVSVS
160
RPPQPTSSSD NFRPMTVEC
Length:169
Mass (Da):19,019
Last modified:May 1, 1997 - v1
Checksum:i728FD1DCF18DACD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81492 mRNA. Translation: AAC17704.1.
PIRiJC6566.
RefSeqiNP_113701.1. NM_031513.1.
UniGeneiRn.10652.

Genome annotation databases

GeneIDi24495.
KEGGirno:24495.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81492 mRNA. Translation: AAC17704.1.
PIRiJC6566.
RefSeqiNP_113701.1. NM_031513.1.
UniGeneiRn.10652.

3D structure databases

ProteinModelPortaliP97688.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030704.

Proteomic databases

PaxDbiP97688.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24495.
KEGGirno:24495.

Organism-specific databases

CTDi3562.
RGDi2897. Il3.

Phylogenomic databases

HOGENOMiHOG000113051.
HOVERGENiHBG006148.
KOiK04736.
PhylomeDBiP97688.

Gene expression databases

GenevisibleiP97688. RN.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002183. IL-3.
[Graphical view]
PANTHERiPTHR10079. PTHR10079. 1 hit.
PfamiPF02059. IL3. 1 hit.
[Graphical view]
PIRSFiPIRSF001939. IL-3. 1 hit.
PRINTSiPR00430. INTERLEUKIN3.
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiP97688_RAT
AccessioniPrimary (citable) accession number: P97688
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: June 8, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.