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Reviewed, UniProtKB/Swiss-Prot P97687 (ENTP1_RAT)

Last modified October 13, 2009. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Ectonucleoside triphosphate diphosphohydrolase 1
      Short name=NTPDase 1
    EC=3.6.1.5
Alternative name(s):
    Ecto-ATP diphosphohydrolase
      Short name=ATPDase
    Lymphoid cell activation antigen
    Ecto-apyrase
    CD_antigen=CD39
Gene names
Name: Entpd1
Synonyms: Cd39
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length511 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation. Hydrolyzes ATP and ADP equally well.

Catalytic activity

ATP + 2 H2O = AMP + 2 phosphate.

Cofactor

Calcium.

Magnesium.

Subunit structure

Homodimer; disulfide-linked By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Expressed in primary neurons and astrocytes, kidney, liver, muscle, thymus, lung and spleen.

Post-translational modification

N-glycosylated.

Sequence similarities

Belongs to the GDA1/CD39 NTPase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 511511Ectonucleoside triphosphate diphosphohydrolase 1
PRO_0000209904

Regions

Topological domain1 – 1616Cytoplasmic Potential
Transmembrane17 – 3721 Potential
Topological domain38 – 478441Extracellular Potential
Transmembrane479 – 49921 Potential
Topological domain500 – 51112Cytoplasmic Potential

Amino acid modifications

Modified residue491Phosphotyrosine By similarity
Modified residue651Phosphotyrosine By similarity
Glycosylation731N-linked (GlcNAc...) Potential
Glycosylation2261N-linked (GlcNAc...) Potential
Glycosylation2911N-linked (GlcNAc...) Potential
Glycosylation3331N-linked (GlcNAc...) Potential
Glycosylation3741N-linked (GlcNAc...) Potential
Glycosylation4291N-linked (GlcNAc...) Potential
Glycosylation4581N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict3321F → L Ref.2

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Sequences

Sequence LengthMass (Da)Tools
P97687-1 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 4CC123D3E644C193

FASTA51157,408
        10         20         30         40         50         60 
MEDIKDSKVK RFCSKNILII LGFSSVLAVI ALIAVGLTHN KPLPENVKYG IVLDAGSSHT 

        70         80         90        100        110        120 
NLYIYKWPAE KENDTGVVQL LEECQVKGPG ISKYAQKTDE IAAYLAECMK MSTERIPASK 

       130        140        150        160        170        180 
QHQTPVYLGA TAGMRLLRME SKQSADEVLA AVSRSLKSYP FDFQGAKIIT GQEEGAYGWI 

       190        200        210        220        230        240 
TINYLLGRFT QEQSWLNFIS DSQKQATFGA LDLGGSSTQV TFVPLNQTLE APETSLQFRL 

       250        260        270        280        290        300 
YGTDYTVYTH SFLCYGKDQA LWQKLAQDIQ VSSGGILKDP CFYPGYKKVV NVSELYGTPC 

       310        320        330        340        350        360 
TKRFEKKLPF NQFQVQGTGD YEQCHQSILK FFNNSHCPYS QCAFNGVFLP PLQGSFGAFS 

       370        380        390        400        410        420 
AFYFVMDFFK KMANDSVSSQ EKMTEITKNF CSKPWEEVKA SYPTVKEKYL SEYCFSGTYI 

       430        440        450        460        470        480 
LSLLLQGYNF TGTSWDQIHF MGKIKDSNAG WTLGYMLNLT NMIPAEQPLS PPLPHSTYIS 

       490        500        510 
LMVLFSLVLV AMVITGLFIF SKPSYFWKEA V

« Hide

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References

[1]"Characterization of brain ecto-apyrase: evidence for only one ecto-apyrase (CD39) gene."
Wang T.-F., Rosenberg P.A., Guidotti G.
Brain Res. Mol. Brain Res. 47:295-302(1997) [PubMed: 9221928] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
Strain: Sprague-Dawley.
Tissue: Brain and Hippocampus.
[2]"Evidence for alternative splicing of ecto-ATPase associated with termination of purinergic transmission."
Vlajkovic S.M., Housley G.D., Greenwood D., Thorne P.R.
Brain Res. Mol. Brain Res. 73:85-92(1999) [PubMed: 10581401] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar.
Tissue: Cochlea.
[3]"An ecto-ATPase and an ecto-ATP diphosphohydrolase are expressed in rat brain."
Kegel B., Braun N., Heine P., Maliszewski C.R., Zimmermann H.
Neuropharmacology 36:1189-1200(1997) [PubMed: 9364474] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 432-511.
Strain: Sprague-Dawley.
Tissue: Brain.
+Additional computationally mapped references.

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Cross-references

Sequence databases

U81295 mRNA. Translation: AAC53195.1.
Y15685 mRNA. Translation: CAA75730.1.
IPIIPI00206668.
RefSeqNP_072109.1.
UniGeneRn.17491

3D structure databases

ModBaseSearch...

PTM databases

PhosphoSiteP97687.

Genome annotation databases

GeneID64519.
KEGGrno:64519.
UCSCNM_022587. rat.

Organism-specific databases

CTD64519.
RGD69265. Entpd1.

Phylogenomic databases

HOVERGENP97687.

Enzyme and pathway databases

BRENDA3.6.1.5. 248.

Gene expression databases

GenevestigatorP97687.

Family and domain databases

InterProIPR000407. GDA1_CD39_NTPase.
[Graphical view]
PANTHERPTHR11782. GDA1_CD39_NTPase. 1 hit.
PfamPF01150. GDA1_CD39. 1 hit.
[Graphical view]
PROSITEPS01238. GDA1_CD39_NTPASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio613322.

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Entry information

Entry nameENTP1_RAT
AccessionPrimary (citable) accession number: P97687
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 1997
Last modified: October 13, 2009
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents