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Protein

Endothelial cell-specific molecule 1

Gene

Esm1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Angiogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelial cell-specific molecule 1
Short name:
ESM-1
Alternative name(s):
PG25
Gene namesi
Name:Esm1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi71013. Esm1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 184163Endothelial cell-specific molecule 1PRO_0000014396Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi157 – 1571O-linked (Xyl...) (chondroitin sulfate)By similarity

Post-translational modificationi

O-glycosylated; contains chondroitin sulfate and dermatan sulfate.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP97682.
PRIDEiP97682.

Expressioni

Tissue specificityi

Pineal gland specific.

Gene expression databases

GenevisibleiP97682. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014559.

Structurei

3D structure databases

ProteinModelPortaliP97682.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 10279IGFBP N-terminalPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1218. Eukaryota.
ENOG410XQWV. LUCA.
GeneTreeiENSGT00390000018810.
HOGENOMiHOG000273901.
HOVERGENiHBG005610.
InParanoidiP97682.
OMAiSTKYAVD.
OrthoDBiEOG7BW0M2.
PhylomeDBiP97682.

Family and domain databases

InterProiIPR009030. Growth_fac_rcpt_.
IPR000867. IGFBP-like.
[Graphical view]
PfamiPF00219. IGFBP. 1 hit.
[Graphical view]
SMARTiSM00121. IB. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS51323. IGFBP_N_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97682-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSLLLLTTL LIPLHLGMAW SAKYAVDCPE HCDNTECRSS LRCKRTVLDD
60 70 80 90 100
CGCCQVCAAG PGETCYRTVS GMDGVKCGPG LKCHFYSEED DFGDEFGVCK
110 120 130 140 150
DCPYGTFGMD CKETCNCQSG ICDRVTGRCL DFPFFQYAAA KSPSRTSASQ
160 170 180
TERDAASGDG NAVREEIGDR NAARPSVMKW LNPR
Length:184
Mass (Da):20,075
Last modified:May 1, 1997 - v1
Checksum:i58549D713E88E189
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U80818 mRNA. Translation: AAB39192.1.
BC070888 mRNA. Translation: AAH70888.1.
RefSeqiNP_072126.1. NM_022604.2.
UniGeneiRn.6376.

Genome annotation databases

EnsembliENSRNOT00000014559; ENSRNOP00000014559; ENSRNOG00000010797.
GeneIDi64536.
KEGGirno:64536.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U80818 mRNA. Translation: AAB39192.1.
BC070888 mRNA. Translation: AAH70888.1.
RefSeqiNP_072126.1. NM_022604.2.
UniGeneiRn.6376.

3D structure databases

ProteinModelPortaliP97682.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014559.

Proteomic databases

PaxDbiP97682.
PRIDEiP97682.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000014559; ENSRNOP00000014559; ENSRNOG00000010797.
GeneIDi64536.
KEGGirno:64536.

Organism-specific databases

CTDi11082.
RGDi71013. Esm1.

Phylogenomic databases

eggNOGiKOG1218. Eukaryota.
ENOG410XQWV. LUCA.
GeneTreeiENSGT00390000018810.
HOGENOMiHOG000273901.
HOVERGENiHBG005610.
InParanoidiP97682.
OMAiSTKYAVD.
OrthoDBiEOG7BW0M2.
PhylomeDBiP97682.

Miscellaneous databases

PROiP97682.

Gene expression databases

GenevisibleiP97682. RN.

Family and domain databases

InterProiIPR009030. Growth_fac_rcpt_.
IPR000867. IGFBP-like.
[Graphical view]
PfamiPF00219. IGFBP. 1 hit.
[Graphical view]
SMARTiSM00121. IB. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS51323. IGFBP_N_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "PG25, a pineal-specific cDNA, cloned by differential display PCR (DDPCR) and rapid amplification of cDNA ends (RACE)."
    Wang X., Brownstein M.J., Young W.S.
    J. Neurosci. Methods 73:187-191(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Pineal gland.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiESM1_RAT
AccessioniPrimary (citable) accession number: P97682
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1997
Last modified: June 8, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.