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UniProtKB - P97680 (RIN1_RAT)

UniProt

P97680 - RIN1_RAT

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Protein

Ras and Rab interactor 1

Gene

Rin1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Biological processi

Endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Ras and Rab interactor 1
Alternative name(s):
Ras interaction/interference protein 1
Gene namesi
Name:Rin1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620006. Rin1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 774774Ras and Rab interactor 1PRO_0000191319Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei16 – 161PhosphoserineBy similarity
Modified residuei35 – 351Phosphotyrosine; by ABL1 and ABL2By similarity
Modified residuei209 – 2091PhosphoserineBy similarity
Modified residuei257 – 2571PhosphoserineBy similarity
Modified residuei330 – 3301PhosphoserineBy similarity
Modified residuei334 – 3341PhosphoserineBy similarity
Modified residuei351 – 3511Phosphoserine; by PKD/PRKD1By similarity
Modified residuei609 – 6091PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated on tyrosine residues by ABL1 and ABL2. Phosphorylation at Ser-351 by PRKD1 induces interaction with 14-3-3 proteins (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP97680.
PRIDEiP97680.

PTM databases

iPTMnetiP97680.
PhosphoSiteiP97680.

Interactioni

Subunit structurei

Interacts with the GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). This interaction prevents the association between RAF1 and Ras. Interacts with 14-3-3 proteins YWHAB, YWHAE and YWHAZ when phosphorylated on Ser-351. Interacts with the SH3 domain of ABL1 and ABL2. Interacts with RAB5A. The interaction with Ras is probably regulated and antagonized by the interaction with 14-3-3 proteins. The interaction with 14-3-3 proteins is regulated by phosphorylation on Ser-351 (By similarity).By similarity

Protein-protein interaction databases

IntActiP97680. 1 interaction.
STRINGi10116.ENSRNOP00000066064.

Structurei

3D structure databases

ProteinModelPortaliP97680.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 16295SH2PROSITE-ProRule annotationAdd
BLAST
Domaini456 – 598143VPS9PROSITE-ProRule annotationAdd
BLAST
Domaini624 – 70683Ras-associatingPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi258 – 26710Pro-rich
Compositional biasi413 – 612200Leu-richAdd
BLAST

Sequence similaritiesi

Belongs to the RIN (Ras interaction/interference) family.Curated
Contains 1 Ras-associating domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 1 VPS9 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG2320. Eukaryota.
ENOG410ZZW5. LUCA.
HOGENOMiHOG000154128.
HOVERGENiHBG036105.
InParanoidiP97680.
KOiK17638.
PhylomeDBiP97680.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000159. RA_dom.
IPR000980. SH2.
IPR003123. VPS9.
[Graphical view]
PfamiPF02204. VPS9. 1 hit.
[Graphical view]
SMARTiSM00314. RA. 1 hit.
SM00252. SH2. 1 hit.
SM00167. VPS9. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50200. RA. 1 hit.
PS50001. SH2. 1 hit.
PS51205. VPS9. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97680-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDPGETEAH PLGATSLNFV PGYQQEEKPS PDPLYDTPDA RGVQAGGSQQ 
        60         70         80         90        100
PARTVSLRER LLITRPVWLQ LRANAAAALH VLRTEPPGTF LVRKSNTRQC 
       110        120        130        140        150
QTLCVRLPEA SGPSFVSSHY LQESPGGISL EGSELTFPDL VQLICAYCHT 
       160        170        180        190        200
RDILLLPLPL PRAIHQAATH KELEAISHLG MEFWSSSLNT KNQQRPSEAP 
       210        220        230        240        250
QIPRLKARSP QELDQGTGAA LCFFNPLFPG DLGPTKREKF KRSFKVRVST 
       260        270        280        290        300
ETSSPLSPPA VPPPPVPVLP GTSSSQTERL PPRQLLQRES SVGYRVPGSA 
       310        320        330        340        350
SGPSLPPLPS LQEVDCCSPS SSEEEGSSGS PTTSPRLSRP RHRRPLLRSM 
       360        370        380        390        400
SSAFCSLLAP ERQVGRAATM LMQNRYTAVG QLVQDLLTQV RVGPESRELQ 
       410        420        430        440        450
GIRQALSRAR AMLSAELGPE KLLPPERLEL VLEKSLHRSV LKPLRPILAA 
       460        470        480        490        500
RLRRRLSTDG SLGRLAEGFR LARTQGPGAF GSHLNLSSPV EIEPVRQKLL 
       510        520        530        540        550
QLLRAYSPSA QIKWLLQACK LLYTALKTQA GENAGADEFL PLLSLVLAQC 
       560        570        580        590        600
DLPDLLLEAE YMSELLEPTL LTGEGGYYLT SLSASLALLS GLSQAHALPL 
       610        620        630        640        650
SPAQELQRSL ALWEQRRLPA THNFQHLLRV AYQDPSTGCT SKTLAVPPGS 
       660        670        680        690        700
SIATLSQLCA TKFRVTQPDA FGLFLYKDQG YHRLPPEALV HRLPTTGYLI 
       710        720        730        740        750
YRRAERPETQ RAATEKTKTG NERPERGAWE EEKGGLNGEG KSEIAVDQEG 
       760        770 
KDQARGGHMQ LEEQKAEGCP ALEE
Length:774
Mass (Da):84,727
Last modified:February 1, 2003 - v2
Checksum:i33900CEEDBF8E658
GO

Sequence cautioni

The sequence AAB58256 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U80076 mRNA. Translation: AAB58256.1. Different initiation.
RefSeqiNP_620607.1. NM_139038.1.
UniGeneiRn.16006.

Genome annotation databases

GeneIDi207119.
KEGGirno:207119.
UCSCiRGD:620006. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U80076 mRNA. Translation: AAB58256.1. Different initiation.
RefSeqiNP_620607.1. NM_139038.1.
UniGeneiRn.16006.

3D structure databases

ProteinModelPortaliP97680.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP97680. 1 interaction.
STRINGi10116.ENSRNOP00000066064.

PTM databases

iPTMnetiP97680.
PhosphoSiteiP97680.

Proteomic databases

PaxDbiP97680.
PRIDEiP97680.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi207119.
KEGGirno:207119.
UCSCiRGD:620006. rat.

Organism-specific databases

CTDi9610.
RGDi620006. Rin1.

Phylogenomic databases

eggNOGiKOG2320. Eukaryota.
ENOG410ZZW5. LUCA.
HOGENOMiHOG000154128.
HOVERGENiHBG036105.
InParanoidiP97680.
KOiK17638.
PhylomeDBiP97680.

Miscellaneous databases

PROiP97680.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000159. RA_dom.
IPR000980. SH2.
IPR003123. VPS9.
[Graphical view]
PfamiPF02204. VPS9. 1 hit.
[Graphical view]
SMARTiSM00314. RA. 1 hit.
SM00252. SH2. 1 hit.
SM00167. VPS9. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50200. RA. 1 hit.
PS50001. SH2. 1 hit.
PS51205. VPS9. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRIN1_RAT
AccessioniPrimary (citable) accession number: P97680
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 1, 2003
Last modified: June 8, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.