UniProtKB - P97680 (RIN1_RAT)
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Protein
Ras and Rab interactor 1
Gene
Rin1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis (By similarity).By similarity
GO - Molecular functioni
- GTPase activator activity Source: UniProtKB-KW
- Ras GTPase binding Source: RGD
GO - Biological processi
- associative learning Source: RGD
- endocytosis Source: UniProtKB-KW
- memory Source: RGD
- negative regulation of synaptic plasticity Source: RGD
- signal transduction Source: InterPro
Keywordsi
Molecular function | GTPase activation |
Biological process | Endocytosis |
Names & Taxonomyi
Protein namesi | Recommended name: Ras and Rab interactor 1Alternative name(s): Ras interaction/interference protein 1 |
Gene namesi | Name:Rin1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620006. Rin1. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000191319 | 1 – 774 | Ras and Rab interactor 1Add BLAST | 774 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 16 | PhosphoserineBy similarity | 1 | |
Modified residuei | 35 | Phosphotyrosine; by ABL1 and ABL2By similarity | 1 | |
Modified residuei | 209 | PhosphoserineBy similarity | 1 | |
Modified residuei | 257 | PhosphoserineBy similarity | 1 | |
Modified residuei | 330 | PhosphoserineBy similarity | 1 | |
Modified residuei | 334 | PhosphoserineBy similarity | 1 | |
Modified residuei | 351 | Phosphoserine; by PKD/PRKD1By similarity | 1 | |
Modified residuei | 609 | PhosphoserineBy similarity | 1 | |
Modified residuei | 692 | Omega-N-methylarginineBy similarity | 1 |
Post-translational modificationi
Phosphorylated on tyrosine residues by ABL1 and ABL2. Phosphorylation at Ser-351 by PRKD1 induces interaction with 14-3-3 proteins (By similarity).By similarity
Keywords - PTMi
Acetylation, Methylation, PhosphoproteinProteomic databases
PaxDbi | P97680. |
PRIDEi | P97680. |
PTM databases
iPTMneti | P97680. |
PhosphoSitePlusi | P97680. |
Interactioni
Subunit structurei
Interacts with the GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). This interaction prevents the association between RAF1 and Ras. Interacts with 14-3-3 proteins YWHAB, YWHAE and YWHAZ when phosphorylated on Ser-351. Interacts with the SH3 domain of ABL1 and ABL2. Interacts with RAB5A. The interaction with Ras is probably regulated and antagonized by the interaction with 14-3-3 proteins. The interaction with 14-3-3 proteins is regulated by phosphorylation on Ser-351 (By similarity).By similarity
GO - Molecular functioni
- Ras GTPase binding Source: RGD
Protein-protein interaction databases
IntActi | P97680. 1 interactor. |
STRINGi | 10116.ENSRNOP00000066064. |
Structurei
3D structure databases
ProteinModelPortali | P97680. |
SMRi | P97680. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 68 – 162 | SH2PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 456 – 598 | VPS9PROSITE-ProRule annotationAdd BLAST | 143 | |
Domaini | 624 – 706 | Ras-associatingPROSITE-ProRule annotationAdd BLAST | 83 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 258 – 267 | Pro-rich | 10 | |
Compositional biasi | 413 – 612 | Leu-richAdd BLAST | 200 |
Sequence similaritiesi
Belongs to the RIN (Ras interaction/interference) family.Curated
Keywords - Domaini
SH2 domainPhylogenomic databases
eggNOGi | KOG2320. Eukaryota. ENOG410ZZW5. LUCA. |
HOGENOMi | HOG000154128. |
HOVERGENi | HBG036105. |
InParanoidi | P97680. |
KOi | K17638. |
PhylomeDBi | P97680. |
Family and domain databases
CDDi | cd10393. SH2_RIN1. 1 hit. |
Gene3Di | 1.20.1050.80. 1 hit. 3.30.505.10. 1 hit. |
InterProi | View protein in InterPro IPR000159. RA_dom. IPR035867. RIN1_SH2. IPR000980. SH2. IPR036860. SH2_dom_sf. IPR003123. VPS9. IPR037191. VPS9_dom_sf. |
Pfami | View protein in Pfam PF02204. VPS9. 1 hit. |
SMARTi | View protein in SMART SM00314. RA. 1 hit. SM00252. SH2. 1 hit. SM00167. VPS9. 1 hit. |
SUPFAMi | SSF109993. SSF109993. 1 hit. SSF55550. SSF55550. 1 hit. |
PROSITEi | View protein in PROSITE PS50200. RA. 1 hit. PS50001. SH2. 1 hit. PS51205. VPS9. 1 hit. |
i Sequence
Sequence statusi: Complete.
P97680-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEDPGETEAH PLGATSLNFV PGYQQEEKPS PDPLYDTPDA RGVQAGGSQQ
60 70 80 90 100
PARTVSLRER LLITRPVWLQ LRANAAAALH VLRTEPPGTF LVRKSNTRQC
110 120 130 140 150
QTLCVRLPEA SGPSFVSSHY LQESPGGISL EGSELTFPDL VQLICAYCHT
160 170 180 190 200
RDILLLPLPL PRAIHQAATH KELEAISHLG MEFWSSSLNT KNQQRPSEAP
210 220 230 240 250
QIPRLKARSP QELDQGTGAA LCFFNPLFPG DLGPTKREKF KRSFKVRVST
260 270 280 290 300
ETSSPLSPPA VPPPPVPVLP GTSSSQTERL PPRQLLQRES SVGYRVPGSA
310 320 330 340 350
SGPSLPPLPS LQEVDCCSPS SSEEEGSSGS PTTSPRLSRP RHRRPLLRSM
360 370 380 390 400
SSAFCSLLAP ERQVGRAATM LMQNRYTAVG QLVQDLLTQV RVGPESRELQ
410 420 430 440 450
GIRQALSRAR AMLSAELGPE KLLPPERLEL VLEKSLHRSV LKPLRPILAA
460 470 480 490 500
RLRRRLSTDG SLGRLAEGFR LARTQGPGAF GSHLNLSSPV EIEPVRQKLL
510 520 530 540 550
QLLRAYSPSA QIKWLLQACK LLYTALKTQA GENAGADEFL PLLSLVLAQC
560 570 580 590 600
DLPDLLLEAE YMSELLEPTL LTGEGGYYLT SLSASLALLS GLSQAHALPL
610 620 630 640 650
SPAQELQRSL ALWEQRRLPA THNFQHLLRV AYQDPSTGCT SKTLAVPPGS
660 670 680 690 700
SIATLSQLCA TKFRVTQPDA FGLFLYKDQG YHRLPPEALV HRLPTTGYLI
710 720 730 740 750
YRRAERPETQ RAATEKTKTG NERPERGAWE EEKGGLNGEG KSEIAVDQEG
760 770
KDQARGGHMQ LEEQKAEGCP ALEE
Sequence cautioni
The sequence AAB58256 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U80076 mRNA. Translation: AAB58256.1. Different initiation. |
RefSeqi | NP_620607.1. NM_139038.1. |
UniGenei | Rn.16006. |
Genome annotation databases
GeneIDi | 207119. |
KEGGi | rno:207119. |
UCSCi | RGD:620006. rat. |
Similar proteinsi
Entry informationi
Entry namei | RIN1_RAT | |
Accessioni | P97680Primary (citable) accession number: P97680 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | February 1, 2003 | |
Last modified: | March 28, 2018 | |
This is version 119 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |