Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ras and Rab interactor 1

Gene

Rin1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation
Biological processEndocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Ras and Rab interactor 1
Alternative name(s):
Ras interaction/interference protein 1
Gene namesi
Name:Rin1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620006 Rin1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001913191 – 774Ras and Rab interactor 1Add BLAST774

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei16PhosphoserineBy similarity1
Modified residuei35Phosphotyrosine; by ABL1 and ABL2By similarity1
Modified residuei209PhosphoserineBy similarity1
Modified residuei257PhosphoserineBy similarity1
Modified residuei330PhosphoserineBy similarity1
Modified residuei334PhosphoserineBy similarity1
Modified residuei351Phosphoserine; by PKD/PRKD1By similarity1
Modified residuei609PhosphoserineBy similarity1
Modified residuei692Omega-N-methylarginineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine residues by ABL1 and ABL2. Phosphorylation at Ser-351 by PRKD1 induces interaction with 14-3-3 proteins (By similarity).By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiP97680
PRIDEiP97680

PTM databases

iPTMnetiP97680
PhosphoSitePlusiP97680

Interactioni

Subunit structurei

Interacts with the GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). This interaction prevents the association between RAF1 and Ras. Interacts with 14-3-3 proteins YWHAB, YWHAE and YWHAZ when phosphorylated on Ser-351. Interacts with the SH3 domain of ABL1 and ABL2. Interacts with RAB5A. The interaction with Ras is probably regulated and antagonized by the interaction with 14-3-3 proteins. The interaction with 14-3-3 proteins is regulated by phosphorylation on Ser-351 (By similarity).By similarity

Protein-protein interaction databases

IntActiP97680, 1 interactor
STRINGi10116.ENSRNOP00000066064

Structurei

3D structure databases

ProteinModelPortaliP97680
SMRiP97680
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 162SH2PROSITE-ProRule annotationAdd BLAST95
Domaini456 – 598VPS9PROSITE-ProRule annotationAdd BLAST143
Domaini624 – 706Ras-associatingPROSITE-ProRule annotationAdd BLAST83

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi258 – 267Pro-rich10
Compositional biasi413 – 612Leu-richAdd BLAST200

Sequence similaritiesi

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG2320 Eukaryota
ENOG410ZZW5 LUCA
HOGENOMiHOG000154128
HOVERGENiHBG036105
InParanoidiP97680
KOiK17638
PhylomeDBiP97680

Family and domain databases

CDDicd10393 SH2_RIN1, 1 hit
Gene3Di1.20.1050.80, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000159 RA_dom
IPR035867 RIN1_SH2
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR003123 VPS9
IPR037191 VPS9_dom_sf
PfamiView protein in Pfam
PF02204 VPS9, 1 hit
SMARTiView protein in SMART
SM00314 RA, 1 hit
SM00252 SH2, 1 hit
SM00167 VPS9, 1 hit
SUPFAMiSSF109993 SSF109993, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50200 RA, 1 hit
PS50001 SH2, 1 hit
PS51205 VPS9, 1 hit

Sequencei

Sequence statusi: Complete.

P97680-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDPGETEAH PLGATSLNFV PGYQQEEKPS PDPLYDTPDA RGVQAGGSQQ
60 70 80 90 100
PARTVSLRER LLITRPVWLQ LRANAAAALH VLRTEPPGTF LVRKSNTRQC
110 120 130 140 150
QTLCVRLPEA SGPSFVSSHY LQESPGGISL EGSELTFPDL VQLICAYCHT
160 170 180 190 200
RDILLLPLPL PRAIHQAATH KELEAISHLG MEFWSSSLNT KNQQRPSEAP
210 220 230 240 250
QIPRLKARSP QELDQGTGAA LCFFNPLFPG DLGPTKREKF KRSFKVRVST
260 270 280 290 300
ETSSPLSPPA VPPPPVPVLP GTSSSQTERL PPRQLLQRES SVGYRVPGSA
310 320 330 340 350
SGPSLPPLPS LQEVDCCSPS SSEEEGSSGS PTTSPRLSRP RHRRPLLRSM
360 370 380 390 400
SSAFCSLLAP ERQVGRAATM LMQNRYTAVG QLVQDLLTQV RVGPESRELQ
410 420 430 440 450
GIRQALSRAR AMLSAELGPE KLLPPERLEL VLEKSLHRSV LKPLRPILAA
460 470 480 490 500
RLRRRLSTDG SLGRLAEGFR LARTQGPGAF GSHLNLSSPV EIEPVRQKLL
510 520 530 540 550
QLLRAYSPSA QIKWLLQACK LLYTALKTQA GENAGADEFL PLLSLVLAQC
560 570 580 590 600
DLPDLLLEAE YMSELLEPTL LTGEGGYYLT SLSASLALLS GLSQAHALPL
610 620 630 640 650
SPAQELQRSL ALWEQRRLPA THNFQHLLRV AYQDPSTGCT SKTLAVPPGS
660 670 680 690 700
SIATLSQLCA TKFRVTQPDA FGLFLYKDQG YHRLPPEALV HRLPTTGYLI
710 720 730 740 750
YRRAERPETQ RAATEKTKTG NERPERGAWE EEKGGLNGEG KSEIAVDQEG
760 770
KDQARGGHMQ LEEQKAEGCP ALEE
Length:774
Mass (Da):84,727
Last modified:February 1, 2003 - v2
Checksum:i33900CEEDBF8E658
GO

Sequence cautioni

The sequence AAB58256 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U80076 mRNA Translation: AAB58256.1 Different initiation.
RefSeqiNP_620607.1, NM_139038.1
UniGeneiRn.16006

Genome annotation databases

GeneIDi207119
KEGGirno:207119
UCSCiRGD:620006 rat

Similar proteinsi

Entry informationi

Entry nameiRIN1_RAT
AccessioniPrimary (citable) accession number: P97680
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 1, 2003
Last modified: May 23, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health