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Protein

Melanin-concentrating hormone receptor 1

Gene

Mchr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for melanin-concentrating hormone, coupled to G proteins that inhibit adenylyl cyclase.2 Publications

GO - Molecular functioni

  • hormone binding Source: RGD
  • melanin-concentrating hormone receptor activity Source: RGD
  • neuropeptide receptor activity Source: GO_Central
  • protein C-terminus binding Source: RGD

GO - Biological processi

  • cell surface receptor signaling pathway Source: RGD
  • positive regulation of calcium ion transport Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Melanin-concentrating hormone receptor 1
Short name:
MCH receptor 1
Short name:
MCH-R1
Short name:
MCHR-1
Alternative name(s):
G-protein coupled receptor 24
MCH-1R
Short name:
MCH1R
Short name:
MCHR
SLC-1
Somatostatin receptor-like protein
Gene namesi
Name:Mchr1
Synonyms:Gpr24, Slc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619841. Mchr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini‹1 – 52›52ExtracellularSequence analysisAdd
BLAST
Transmembranei53 – 7321Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini74 – 8613CytoplasmicSequence analysisAdd
BLAST
Transmembranei87 – 10721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini108 – 12518ExtracellularSequence analysisAdd
BLAST
Transmembranei126 – 14621Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini147 – 16822CytoplasmicSequence analysisAdd
BLAST
Transmembranei169 – 18921Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini190 – 21122ExtracellularSequence analysisAdd
BLAST
Transmembranei212 – 23221Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini233 – 26331CytoplasmicSequence analysisAdd
BLAST
Transmembranei264 – 28421Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini285 – 30117ExtracellularSequence analysisAdd
BLAST
Transmembranei302 – 32221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini323 – 36038CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL1075228.
GuidetoPHARMACOLOGYi280.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 360›360Melanin-concentrating hormone receptor 1PRO_0000069739Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi20 – 201N-linked (GlcNAc...)Sequence analysis
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence analysis
Glycosylationi30 – 301N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP97639.

PTM databases

PhosphoSiteiP97639.

Expressioni

Tissue specificityi

High level in the brain, moderate amounts in the eye and skeletal muscle, and small amounts in tongue and pituitary.

Interactioni

Subunit structurei

Interacts with NCDN.By similarity

GO - Molecular functioni

  • protein C-terminus binding Source: RGD

Protein-protein interaction databases

IntActiP97639. 1 interaction.
MINTiMINT-246530.
STRINGi10116.ENSRNOP00000025564.

Chemistry

BindingDBiP97639.

Structurei

3D structure databases

ProteinModelPortaliP97639.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000000704.
HOVERGENiHBG105726.
InParanoidiP97639.
KOiK04320.
OrthoDBiEOG7BKCVQ.
PhylomeDBiP97639.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004047. MCH1_rcpt.
IPR008361. MCH_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01507. MCH1RECEPTOR.
PR01783. MCHRECEPTOR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P97639-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
QATCTGCMDL QTSLLSTGPN ASNISDGQDN LTLPGSPPRT GSVSYINIIM
60 70 80 90 100
PSVFGTICLL GIVGNSTVIF AVVKKSKLHW CSNVPDIFII NLSVVDLLFL
110 120 130 140 150
LGMPFMIHQL MGNGVWHFGE TMCTLITAMD ANSQFTSTYI LTAMTIDRYL
160 170 180 190 200
ATVHPISSTK FRKPSMATLV ICLLWALSFI SITPVWLYAR LIPFPGGAVG
210 220 230 240 250
CGIRLPNPDT DLYWFTLYQF FLAFALPFVV ITAAYVKILQ RMTSSVAPAS
260 270 280 290 300
QRSIRLRTKR VTRTAIAICL VFFVCWAPYY VLQLTQLSIS RPTLTFVYLY
310 320 330 340 350
NAAISLGYAN SCLNPFVYIV LCETFRKRLV LSVKPAAQGQ LRTVSNAQTA
360
DEERTESKGT
Length:360
Mass (Da):39,728
Last modified:August 15, 2003 - v3
Checksum:iB68D3C993E491350
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008650 mRNA. Translation: AAC27977.1.
U77953 Genomic DNA. Translation: AAC14588.1.
RefSeqiNP_113946.1. NM_031758.1.
UniGeneiRn.10822.

Genome annotation databases

GeneIDi83567.
KEGGirno:83567.
UCSCiRGD:619841. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008650 mRNA. Translation: AAC27977.1.
U77953 Genomic DNA. Translation: AAC14588.1.
RefSeqiNP_113946.1. NM_031758.1.
UniGeneiRn.10822.

3D structure databases

ProteinModelPortaliP97639.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP97639. 1 interaction.
MINTiMINT-246530.
STRINGi10116.ENSRNOP00000025564.

Chemistry

BindingDBiP97639.
ChEMBLiCHEMBL1075228.
GuidetoPHARMACOLOGYi280.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP97639.

Proteomic databases

PaxDbiP97639.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi83567.
KEGGirno:83567.
UCSCiRGD:619841. rat.

Organism-specific databases

CTDi2847.
RGDi619841. Mchr1.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000000704.
HOVERGENiHBG105726.
InParanoidiP97639.
KOiK04320.
OrthoDBiEOG7BKCVQ.
PhylomeDBiP97639.

Miscellaneous databases

PROiP97639.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004047. MCH1_rcpt.
IPR008361. MCH_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01507. MCH1RECEPTOR.
PR01783. MCHRECEPTOR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of the rat brain cDNA encoding for the SLC-1 G protein-coupled receptor reveals the presence of an intron in the gene."
    Lakaye B., Minet A., Zorzi W., Grisar T.
    Biochim. Biophys. Acta 1401:216-220(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Characterization of a human gene related to genes encoding somatostatin receptors."
    Kolakowski L.F. Jr., Jung B.P., Nguyen T., Johnson M.P., Lynch K.R., Cheng R., Heng H.H.Q., George S.R., O'Dowd B.F.
    FEBS Lett. 398:253-258(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 150-307.
  3. "The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor."
    Lembo P.M.C., Grazzini E., Cao J., Hubatsch D.A., Pelletier M., Hoffert C., St Onge S., Pou C., Labrecque J., Groblewski T., O'Donnell D., Payza K., Ahmad S., Walker P.
    Nat. Cell Biol. 1:267-271(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Molecular characterization of the melanin-concentrating-hormone receptor."
    Saito Y., Nothacker H.P., Wang Z., Lin S.H., Leslie F., Civelli O.
    Nature 400:265-269(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiMCHR1_RAT
AccessioniPrimary (citable) accession number: P97639
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 15, 2003
Last modified: July 6, 2016
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.