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Protein

Melanin-concentrating hormone receptor 1

Gene

Mchr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for melanin-concentrating hormone, coupled to G proteins that inhibit adenylyl cyclase.2 Publications

GO - Molecular functioni

  • hormone binding Source: RGD
  • melanin-concentrating hormone receptor activity Source: RGD
  • neuropeptide receptor activity Source: GO_Central
  • protein C-terminus binding Source: RGD

GO - Biological processi

  • cell surface receptor signaling pathway Source: RGD
  • chemical synaptic transmission Source: GO_Central
  • feeding behavior Source: GO_Central
  • neuropeptide signaling pathway Source: GO_Central
  • positive regulation of calcium ion transport Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Melanin-concentrating hormone receptor 1
Short name:
MCH receptor 1
Short name:
MCH-R1
Short name:
MCHR-1
Alternative name(s):
G-protein coupled receptor 24
MCH-1R
Short name:
MCH1R
Short name:
MCHR
SLC-1
Somatostatin receptor-like protein
Gene namesi
Name:Mchr1
Synonyms:Gpr24, Slc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619841. Mchr1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini‹1 – 52ExtracellularSequence analysisAdd BLAST›52
Transmembranei53 – 73Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini74 – 86CytoplasmicSequence analysisAdd BLAST13
Transmembranei87 – 107Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini108 – 125ExtracellularSequence analysisAdd BLAST18
Transmembranei126 – 146Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini147 – 168CytoplasmicSequence analysisAdd BLAST22
Transmembranei169 – 189Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini190 – 211ExtracellularSequence analysisAdd BLAST22
Transmembranei212 – 232Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini233 – 263CytoplasmicSequence analysisAdd BLAST31
Transmembranei264 – 284Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini285 – 301ExtracellularSequence analysisAdd BLAST17
Transmembranei302 – 322Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini323 – 360CytoplasmicSequence analysisAdd BLAST38

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075228.
GuidetoPHARMACOLOGYi280.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000069739‹1 – 360Melanin-concentrating hormone receptor 1Add BLAST›360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi20N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi23N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi30N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP97639.

PTM databases

PhosphoSitePlusiP97639.

Expressioni

Tissue specificityi

High level in the brain, moderate amounts in the eye and skeletal muscle, and small amounts in tongue and pituitary.

Interactioni

Subunit structurei

Interacts with NCDN.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ZMYND19Q96E353EBI-8522179,EBI-746595From Homo sapiens.

GO - Molecular functioni

  • protein C-terminus binding Source: RGD

Protein-protein interaction databases

IntActiP97639. 1 interactor.
MINTiMINT-246530.
STRINGi10116.ENSRNOP00000025564.

Chemistry databases

BindingDBiP97639.

Structurei

3D structure databases

ProteinModelPortaliP97639.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000000704.
HOVERGENiHBG105726.
InParanoidiP97639.
KOiK04320.
PhylomeDBiP97639.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004047. MCH1_rcpt.
IPR008361. MCH_rcpt.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR01507. MCH1RECEPTOR.
PR01783. MCHRECEPTOR.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Fragment.

P97639-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
QATCTGCMDL QTSLLSTGPN ASNISDGQDN LTLPGSPPRT GSVSYINIIM
60 70 80 90 100
PSVFGTICLL GIVGNSTVIF AVVKKSKLHW CSNVPDIFII NLSVVDLLFL
110 120 130 140 150
LGMPFMIHQL MGNGVWHFGE TMCTLITAMD ANSQFTSTYI LTAMTIDRYL
160 170 180 190 200
ATVHPISSTK FRKPSMATLV ICLLWALSFI SITPVWLYAR LIPFPGGAVG
210 220 230 240 250
CGIRLPNPDT DLYWFTLYQF FLAFALPFVV ITAAYVKILQ RMTSSVAPAS
260 270 280 290 300
QRSIRLRTKR VTRTAIAICL VFFVCWAPYY VLQLTQLSIS RPTLTFVYLY
310 320 330 340 350
NAAISLGYAN SCLNPFVYIV LCETFRKRLV LSVKPAAQGQ LRTVSNAQTA
360
DEERTESKGT
Length:360
Mass (Da):39,728
Last modified:August 15, 2003 - v3
Checksum:iB68D3C993E491350
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008650 mRNA. Translation: AAC27977.1.
U77953 Genomic DNA. Translation: AAC14588.1.
RefSeqiNP_113946.1. NM_031758.1.
UniGeneiRn.10822.

Genome annotation databases

GeneIDi83567.
KEGGirno:83567.
UCSCiRGD:619841. rat.

Similar proteinsi

Entry informationi

Entry nameiMCHR1_RAT
AccessioniPrimary (citable) accession number: P97639
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 15, 2003
Last modified: September 27, 2017
This is version 125 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families