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Protein

Melanin-concentrating hormone receptor 1

Gene

Mchr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for melanin-concentrating hormone, coupled to G proteins that inhibit adenylyl cyclase.2 Publications

GO - Molecular functioni

  • hormone binding Source: RGD
  • melanin-concentrating hormone receptor activity Source: RGD
  • neuropeptide receptor activity Source: GO_Central
  • protein C-terminus binding Source: RGD
  • receptor binding Source: RGD

GO - Biological processi

  • cell surface receptor signaling pathway Source: RGD
  • chemical synaptic transmission Source: GO_Central
  • feeding behavior Source: GO_Central
  • neuropeptide signaling pathway Source: GO_Central
  • positive regulation of calcium ion transport Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-416476. G alpha (q) signalling events.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Melanin-concentrating hormone receptor 1
Short name:
MCH receptor 1
Short name:
MCH-R1
Short name:
MCHR-1
Alternative name(s):
G-protein coupled receptor 24
MCH-1R
Short name:
MCH1R
Short name:
MCHR
SLC-1
Somatostatin receptor-like protein
Gene namesi
Name:Mchr1
Synonyms:Gpr24, Slc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componentsi: Chromosome 7, Unplaced

Organism-specific databases

RGDi619841. Mchr1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 45ExtracellularCuratedAdd BLAST45
Transmembranei46 – 66Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini67 – 79CytoplasmicCuratedAdd BLAST13
Transmembranei80 – 100Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini101 – 116ExtracellularCuratedAdd BLAST16
Transmembranei117 – 139Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini140 – 161CytoplasmicCuratedAdd BLAST22
Transmembranei162 – 182Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini183 – 204ExtracellularCuratedAdd BLAST22
Transmembranei205 – 225Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini226 – 256CytoplasmicCuratedAdd BLAST31
Transmembranei257 – 277Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini278 – 294ExtracellularCuratedAdd BLAST17
Transmembranei295 – 315Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini316 – 353CytoplasmicCuratedAdd BLAST38

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075228.
GuidetoPHARMACOLOGYi280.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000697391 – 353Melanin-concentrating hormone receptor 1Add BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi13N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi16N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi23N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP97639.

PTM databases

PhosphoSitePlusiP97639.

Expressioni

Tissue specificityi

High level in the brain, moderate amounts in the eye and skeletal muscle, and small amounts in tongue and pituitary.

Interactioni

Subunit structurei

Interacts with NCDN.By similarity

GO - Molecular functioni

  • protein C-terminus binding Source: RGD
  • receptor binding Source: RGD

Protein-protein interaction databases

IntActiP97639. 1 interactor.
MINTiMINT-246530.
STRINGi10116.ENSRNOP00000025564.

Chemistry databases

BindingDBiP97639.

Structurei

3D structure databases

ProteinModelPortaliP97639.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000000704.
HOVERGENiHBG105726.
InParanoidiP97639.
KOiK04320.
OMAiTSTYILT.
PhylomeDBiP97639.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004047. MCH1_rcpt.
IPR008361. MCH_rcpt.
PANTHERiPTHR44627. PTHR44627. 1 hit.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR01507. MCH1RECEPTOR.
PR01783. MCHRECEPTOR.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P97639-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLQTSLLST GPNASNISDG QDNLTLPGSP PRTGSVSYIN IIMPSVFGTI
60 70 80 90 100
CLLGIVGNST VIFAVVKKSK LHWCSNVPDI FIINLSVVDL LFLLGMPFMI
110 120 130 140 150
HQLMGNGVWH FGETMCTLIT AMDANSQFTS TYILTAMTID RYLATVHPIS
160 170 180 190 200
STKFRKPSMA TLVICLLWAL SFISITPVWL YARLIPFPGG AVGCGIRLPN
210 220 230 240 250
PDTDLYWFTL YQFFLAFALP FVVITAAYVK ILQRMTSSVA PASQRSIRLR
260 270 280 290 300
TKRVTRTAIA ICLVFFVCWA PYYVLQLTQL SISRPTLTFV YLYNAAISLG
310 320 330 340 350
YANSCLNPFV YIVLCETFRK RLVLSVKPAA QGQLRTVSNA QTADEERTES

KGT
Length:353
Mass (Da):39,063
Last modified:November 22, 2017 - v4
Checksum:iF6EEB2DF381084A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008650 mRNA. Translation: AAC27977.1.
AABR07058532 Genomic DNA. No translation available.
CH473950 Genomic DNA. Translation: EDM15736.1.
U77953 Genomic DNA. Translation: AAC14588.1.
RefSeqiNP_113946.1. NM_031758.1.
UniGeneiRn.10822.

Genome annotation databases

EnsembliENSRNOT00000025564; ENSRNOP00000025564; ENSRNOG00000018895.
GeneIDi83567.
KEGGirno:83567.
UCSCiRGD:619841. rat.

Similar proteinsi

Entry informationi

Entry nameiMCHR1_RAT
AccessioniPrimary (citable) accession number: P97639
Secondary accession number(s): A0A140TAD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 22, 2017
Last modified: November 22, 2017
This is version 127 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families