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Protein

Interleukin-18

Gene

Il18

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: UniProtKB
  • cellular response to cAMP Source: RGD
  • cellular response to hydrogen peroxide Source: RGD
  • cellular response to interferon-gamma Source: RGD
  • cellular response to lipopolysaccharide Source: RGD
  • cellular response to mechanical stimulus Source: RGD
  • cellular response to parathyroid hormone stimulus Source: RGD
  • cellular response to peptide hormone stimulus Source: RGD
  • cellular response to tumor necrosis factor Source: RGD
  • detection of mechanical stimulus involved in sensory perception of pain Source: RGD
  • digestive tract morphogenesis Source: RGD
  • inflammatory response Source: GO_Central
  • learning or memory Source: RGD
  • lung development Source: RGD
  • negative regulation of neutrophil apoptotic process Source: RGD
  • negative regulation of peptidyl-tyrosine phosphorylation Source: RGD
  • osteoblast differentiation Source: RGD
  • positive regulation of activated T cell proliferation Source: UniProtKB
  • positive regulation of apoptotic process Source: RGD
  • positive regulation of blood vessel remodeling Source: RGD
  • positive regulation of chemokine production Source: RGD
  • positive regulation of collagen biosynthetic process Source: RGD
  • positive regulation of interleukin-1 beta production Source: RGD
  • positive regulation of interleukin-8 production Source: RGD
  • positive regulation of male germ cell proliferation Source: RGD
  • positive regulation of neuron apoptotic process Source: RGD
  • positive regulation of smooth muscle cell migration Source: RGD
  • positive regulation of smooth muscle cell proliferation Source: RGD
  • positive regulation of superoxide anion generation Source: RGD
  • positive regulation of tumor necrosis factor production Source: RGD
  • positive regulation of vascular permeability Source: RGD
  • regulation of cell adhesion Source: UniProtKB
  • regulation of circadian sleep/wake cycle, non-REM sleep Source: UniProtKB
  • response to cold Source: RGD
  • response to hyperoxia Source: RGD
  • response to hypoxia Source: RGD
  • response to peptide hormone Source: RGD
  • response to radiation Source: RGD
  • sleep Source: UniProtKB
  • T-helper 1 type immune response Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-18
Short name:
IL-18
Alternative name(s):
Interferon gamma-inducing factor
Short name:
IFN-gamma-inducing factor
Interleukin-1 gamma
Short name:
IL-1 gamma
Gene namesi
Name:Il18
Synonyms:Igif
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2889. Il18.

Subcellular locationi

GO - Cellular componenti

  • apical plasma membrane Source: RGD
  • cytoplasm Source: RGD
  • extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000153491 – 36By similarityAdd BLAST36
ChainiPRO_000001535037 – 194Interleukin-18Add BLAST158

Post-translational modificationi

The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form.By similarity

Proteomic databases

PaxDbiP97636.
PRIDEiP97636.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013093.

Structurei

3D structure databases

ProteinModelPortaliP97636.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410J3U9. Eukaryota.
ENOG410ZGS8. LUCA.
HOGENOMiHOG000048723.
HOVERGENiHBG000388.
InParanoidiP97636.
KOiK05482.
PhylomeDBiP97636.
TreeFamiTF336297.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR015529. IL-18.
IPR000975. IL-1_fam.
[Graphical view]
PANTHERiPTHR11326. PTHR11326. 1 hit.
PfamiPF00340. IL1. 1 hit.
[Graphical view]
PIRSFiPIRSF015162. Interleukin_18. 1 hit.
PRINTSiPR01933. INTRLEUKIN18.
SUPFAMiSSF50353. SSF50353. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Beta (identifier: P97636-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAMSEEGSC VNFKEMMFID NTLYLIPEDN GDLESDHFGR LHCTTAVIRS
60 70 80 90 100
INDQVLFVDK RNPPVFEDMP DIDRTANESQ TRLIIYMYKD SEVRGLAVTL
110 120 130 140 150
SVKDGRMSTL SCKNKIISFE EMNPPENIDD IKSDLIFFQK RVPGHNKMEF
160 170 180 190
ESSLYEGHFL ACQKEDDAFK LVLKRKDENG DKSVMFTLTN LHQS
Length:194
Mass (Da):22,303
Last modified:May 1, 1997 - v1
Checksum:iE2089AD6F1798450
GO
Isoform Alpha (identifier: P97636-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-139: Missing.

Show »
Length:175
Mass (Da):20,056
Checksum:i360F0E03766AED50
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4 – 5MS → IP in CAA11001 (PubMed:9702748).Curated2
Sequence conflicti4 – 5MS → IP in AAL77211 (PubMed:12787406).Curated2
Sequence conflicti48I → M in CAA11001 (PubMed:9702748).Curated1
Sequence conflicti48I → M in AAL77211 (PubMed:12787406).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002659121 – 139Missing in isoform Alpha. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77776 mRNA. Translation: AAC53009.1.
U77777 mRNA. Translation: AAC53010.1.
AJ222813 mRNA. Translation: CAA11001.1.
AY258448 mRNA. Translation: AAP14669.1.
AY077842 mRNA. Translation: AAL77211.1.
RefSeqiNP_062038.1. NM_019165.1. [P97636-1]
UniGeneiRn.11118.

Genome annotation databases

GeneIDi29197.
KEGGirno:29197.
UCSCiRGD:2889. rat. [P97636-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77776 mRNA. Translation: AAC53009.1.
U77777 mRNA. Translation: AAC53010.1.
AJ222813 mRNA. Translation: CAA11001.1.
AY258448 mRNA. Translation: AAP14669.1.
AY077842 mRNA. Translation: AAL77211.1.
RefSeqiNP_062038.1. NM_019165.1. [P97636-1]
UniGeneiRn.11118.

3D structure databases

ProteinModelPortaliP97636.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013093.

Proteomic databases

PaxDbiP97636.
PRIDEiP97636.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29197.
KEGGirno:29197.
UCSCiRGD:2889. rat. [P97636-1]

Organism-specific databases

CTDi3606.
RGDi2889. Il18.

Phylogenomic databases

eggNOGiENOG410J3U9. Eukaryota.
ENOG410ZGS8. LUCA.
HOGENOMiHOG000048723.
HOVERGENiHBG000388.
InParanoidiP97636.
KOiK05482.
PhylomeDBiP97636.
TreeFamiTF336297.

Miscellaneous databases

PROiP97636.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR015529. IL-18.
IPR000975. IL-1_fam.
[Graphical view]
PANTHERiPTHR11326. PTHR11326. 1 hit.
PfamiPF00340. IL1. 1 hit.
[Graphical view]
PIRSFiPIRSF015162. Interleukin_18. 1 hit.
PRINTSiPR01933. INTRLEUKIN18.
SUPFAMiSSF50353. SSF50353. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIL18_RAT
AccessioniPrimary (citable) accession number: P97636
Secondary accession number(s): O88749, P97637, Q541E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: October 5, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.