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Protein

Interleukin-18

Gene

Il18

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.

GO - Molecular functioni

GO - Biological processi

  • activation of protein kinase B activity Source: RGD
  • angiogenesis Source: UniProtKB
  • cell proliferation Source: RGD
  • cellular response to cAMP Source: RGD
  • cellular response to hydrogen peroxide Source: RGD
  • cellular response to interferon-gamma Source: RGD
  • cellular response to lipopolysaccharide Source: RGD
  • cellular response to mechanical stimulus Source: RGD
  • cellular response to organic cyclic compound Source: RGD
  • cellular response to parathyroid hormone stimulus Source: RGD
  • cellular response to peptide hormone stimulus Source: RGD
  • cellular response to tumor necrosis factor Source: RGD
  • cholesterol homeostasis Source: RGD
  • detection of mechanical stimulus involved in sensory perception of pain Source: RGD
  • digestive tract morphogenesis Source: RGD
  • inflammatory response Source: RGD
  • interferon-gamma biosynthetic process Source: RGD
  • interferon-gamma production Source: RGD
  • interleukin-18-mediated signaling pathway Source: RGD
  • interleukin-6 production Source: RGD
  • learning or memory Source: RGD
  • lipopolysaccharide-mediated signaling pathway Source: RGD
  • lung development Source: RGD
  • MAPK cascade Source: RGD
  • natural killer cell activation Source: RGD
  • natural killer cell mediated cytotoxicity Source: RGD
  • negative regulation of myoblast differentiation Source: RGD
  • negative regulation of neutrophil apoptotic process Source: RGD
  • negative regulation of peptidyl-tyrosine phosphorylation Source: RGD
  • neutrophil activation Source: RGD
  • osteoblast differentiation Source: RGD
  • positive regulation of activated T cell proliferation Source: UniProtKB
  • positive regulation of apoptotic process Source: RGD
  • positive regulation of blood vessel remodeling Source: RGD
  • positive regulation of chemokine production Source: RGD
  • positive regulation of collagen biosynthetic process Source: RGD
  • positive regulation of gene expression Source: RGD
  • positive regulation of granulocyte macrophage colony-stimulating factor production Source: RGD
  • positive regulation of interferon-gamma production Source: RGD
  • positive regulation of interleukin-17 production Source: RGD
  • positive regulation of interleukin-1 beta production Source: RGD
  • positive regulation of interleukin-8 production Source: RGD
  • positive regulation of macrophage derived foam cell differentiation Source: RGD
  • positive regulation of male germ cell proliferation Source: RGD
  • positive regulation of natural killer cell proliferation Source: RGD
  • positive regulation of neuron apoptotic process Source: RGD
  • positive regulation of NF-kappaB import into nucleus Source: RGD
  • positive regulation of NK T cell proliferation Source: RGD
  • positive regulation of phosphatidylinositol 3-kinase signaling Source: RGD
  • positive regulation of protein kinase B signaling Source: RGD
  • positive regulation of smooth muscle cell migration Source: RGD
  • positive regulation of smooth muscle cell proliferation Source: RGD
  • positive regulation of superoxide anion generation Source: RGD
  • positive regulation of T-helper 2 cell differentiation Source: RGD
  • positive regulation of transcription by RNA polymerase II Source: RGD
  • positive regulation of tumor necrosis factor production Source: RGD
  • positive regulation of tyrosine phosphorylation of STAT protein Source: RGD
  • positive regulation of vascular permeability Source: RGD
  • regulation of cell adhesion Source: UniProtKB
  • regulation of circadian sleep/wake cycle, non-REM sleep Source: UniProtKB
  • response to cold Source: RGD
  • response to hyperoxia Source: RGD
  • response to hypoxia Source: RGD
  • response to peptide hormone Source: RGD
  • response to radiation Source: RGD
  • sleep Source: UniProtKB
  • T-helper 1 cell cytokine production Source: RGD
  • T-helper 1 type immune response Source: UniProtKB
  • triglyceride homeostasis Source: RGD

Keywordsi

Molecular functionCytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-18
Short name:
IL-18
Alternative name(s):
Interferon gamma-inducing factor
Short name:
IFN-gamma-inducing factor
Interleukin-1 gamma
Short name:
IL-1 gamma
Gene namesi
Name:Il18
Synonyms:Igif
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2889 Il18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000153491 – 36By similarityAdd BLAST36
ChainiPRO_000001535037 – 194Interleukin-18Add BLAST158

Post-translational modificationi

The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form.By similarity

Proteomic databases

PaxDbiP97636
PRIDEiP97636

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013093

Structurei

3D structure databases

ProteinModelPortaliP97636
SMRiP97636
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410J3U9 Eukaryota
ENOG410ZGS8 LUCA
HOGENOMiHOG000048723
HOVERGENiHBG000388
InParanoidiP97636
KOiK05482
PhylomeDBiP97636
TreeFamiTF336297

Family and domain databases

InterProiView protein in InterPro
IPR015529 IL-18
IPR000975 IL-1_fam
IPR008996 IL1/FGF
PANTHERiPTHR45200 PTHR45200, 1 hit
PfamiView protein in Pfam
PF00340 IL1, 1 hit
PIRSFiPIRSF015162 Interleukin_18, 1 hit
PRINTSiPR01933 INTRLEUKIN18
SUPFAMiSSF50353 SSF50353, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Beta (identifier: P97636-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAMSEEGSC VNFKEMMFID NTLYLIPEDN GDLESDHFGR LHCTTAVIRS
60 70 80 90 100
INDQVLFVDK RNPPVFEDMP DIDRTANESQ TRLIIYMYKD SEVRGLAVTL
110 120 130 140 150
SVKDGRMSTL SCKNKIISFE EMNPPENIDD IKSDLIFFQK RVPGHNKMEF
160 170 180 190
ESSLYEGHFL ACQKEDDAFK LVLKRKDENG DKSVMFTLTN LHQS
Length:194
Mass (Da):22,303
Last modified:May 1, 1997 - v1
Checksum:iE2089AD6F1798450
GO
Isoform Alpha (identifier: P97636-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-139: Missing.

Show »
Length:175
Mass (Da):20,056
Checksum:i360F0E03766AED50
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4 – 5MS → IP in CAA11001 (PubMed:9702748).Curated2
Sequence conflicti4 – 5MS → IP in AAL77211 (PubMed:12787406).Curated2
Sequence conflicti48I → M in CAA11001 (PubMed:9702748).Curated1
Sequence conflicti48I → M in AAL77211 (PubMed:12787406).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002659121 – 139Missing in isoform Alpha. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77776 mRNA Translation: AAC53009.1
U77777 mRNA Translation: AAC53010.1
AJ222813 mRNA Translation: CAA11001.1
AY258448 mRNA Translation: AAP14669.1
AY077842 mRNA Translation: AAL77211.1
RefSeqiNP_062038.1, NM_019165.1 [P97636-1]
UniGeneiRn.11118

Genome annotation databases

GeneIDi29197
KEGGirno:29197
UCSCiRGD:2889 rat [P97636-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiIL18_RAT
AccessioniPrimary (citable) accession number: P97636
Secondary accession number(s): O88749, P97637, Q541E6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: March 28, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health