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Protein

Double-stranded RNA-specific editase B2

Gene

Adarb2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Lacks editing activity. It prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. Capable of binding to dsRNA but also to ssRNA (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi439 – 4391ZincPROSITE-ProRule annotation
Active sitei441 – 4411Proton donorPROSITE-ProRule annotation
Metal bindingi497 – 4971ZincPROSITE-ProRule annotation
Metal bindingi562 – 5621ZincPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Double-stranded RNA-specific editase B2 (EC:3.5.-.-)
Alternative name(s):
RNA-dependent adenosine deaminase 3
RNA-editing deaminase 2
RNA-editing enzyme 2
dsRNA adenosine deaminase B2
Gene namesi
Name:Adarb2
Synonyms:Adar3, Red2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621519. Adarb2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 746746Double-stranded RNA-specific editase B2PRO_0000171784Add
BLAST

Proteomic databases

PaxDbiP97616.
PRIDEiP97616.

Expressioni

Tissue specificityi

Brain specific.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047468.

Structurei

3D structure databases

ProteinModelPortaliP97616.
SMRiP97616. Positions 127-194, 283-351, 355-745.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini126 – 19267DRBM 1PROSITE-ProRule annotationAdd
BLAST
Domaini284 – 34865DRBM 2PROSITE-ProRule annotationAdd
BLAST
Domaini415 – 742328A to I editasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni23 – 3513R-domain (ssRNA-binding)By similarityAdd
BLAST

Sequence similaritiesi

Contains 1 A to I editase domain.PROSITE-ProRule annotation
Contains 2 DRBM (double-stranded RNA-binding) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2777. Eukaryota.
ENOG410XT0Z. LUCA.
HOGENOMiHOG000290164.
HOVERGENiHBG003836.
InParanoidiP97616.
KOiK13194.
PhylomeDBiP97616.

Family and domain databases

Gene3Di3.30.160.20. 2 hits.
InterProiIPR002466. A_deamin.
IPR014720. dsRBD_dom.
[Graphical view]
PfamiPF02137. A_deamin. 1 hit.
PF00035. dsrm. 2 hits.
[Graphical view]
SMARTiSM00552. ADEAMc. 1 hit.
SM00358. DSRM. 2 hits.
[Graphical view]
PROSITEiPS50141. A_DEAMIN_EDITASE. 1 hit.
PS50137. DS_RBD. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97616-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVLGSGRG SGGLSSQLKC KSKRRRRRRS KRKDKVSILS TFLAPFKYLS
60 70 80 90 100
PGTTNTEDED NLSTSSAEVK ENRNVSNLGT RPLPPGDWAR GGSTPSVKRK
110 120 130 140 150
RPLEEGNGGH FCKLQLIWKK LSWSMTPKNA LVQLHELKPG LQYRMVSQTG
160 170 180 190 200
PVHAPVFAVA VEVNGLTFEG TGPTKKKAKM RAAEMALKSF VQFPNAFQAH
210 220 230 240 250
LAMGSSTSPC TDFTSDQADF PDTLFKEFEP SSRNEDFPGC CPVDTEFLSS
260 270 280 290 300
AYRRGRLLYH TLDLMGQALP DRSRLAPGAL GERNPVVVLN ELRSGLRYVC
310 320 330 340 350
LSETAEKPRV KSFVMAVCVD GRTFEGSGRS KKLAKGQAAQ AALQALFDIR
360 370 380 390 400
LPGHIPSRSK SNLLPQDFAD SVSQLVTQKF RELTVGLTSV YARHKTLAGI
410 420 430 440 450
VMTKGLDTKQ AQVIVLSSGT KCISGEHISD QGLVVNDCHA EIVARRAFLH
460 470 480 490 500
FLYTQLELHL SKHQEDPERS IFIRVKEGGY RLRENILFHL YVSTSPCGDA
510 520 530 540 550
RLNSPYEITI DLNSSKHIVR KFRGHLRTKI ESGEGTVPVR GPSAVQTWDG
560 570 580 590 600
ILLGEQLVTM SCTDKIASWN VLGLQGALLC HFIEPVYLHS IIVGSLHHTG
610 620 630 640 650
HLARVMSHRM EGIGQLPASY RQNRPLLSGV SNAEARQPGK SPHFSANWVV
660 670 680 690 700
GSADLEIINA TTGKRSCGGS SRLCKHVFSA RWARLHGRLS TRIPGHGDTP
710 720 730 740
SMYCEAKRGA HTYQSVKQQL FKAFQKAGLG TWVRKPPEQD QFLLSL
Length:746
Mass (Da):82,227
Last modified:May 1, 1997 - v1
Checksum:i6741BA5FDA699077
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U74586 mRNA. Translation: AAB41862.1.
RefSeqiNP_579836.1. NM_133302.2.
UniGeneiRn.10683.

Genome annotation databases

GeneIDi117088.
KEGGirno:117088.
UCSCiRGD:621519. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U74586 mRNA. Translation: AAB41862.1.
RefSeqiNP_579836.1. NM_133302.2.
UniGeneiRn.10683.

3D structure databases

ProteinModelPortaliP97616.
SMRiP97616. Positions 127-194, 283-351, 355-745.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047468.

Proteomic databases

PaxDbiP97616.
PRIDEiP97616.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi117088.
KEGGirno:117088.
UCSCiRGD:621519. rat.

Organism-specific databases

CTDi105.
RGDi621519. Adarb2.

Phylogenomic databases

eggNOGiKOG2777. Eukaryota.
ENOG410XT0Z. LUCA.
HOGENOMiHOG000290164.
HOVERGENiHBG003836.
InParanoidiP97616.
KOiK13194.
PhylomeDBiP97616.

Miscellaneous databases

PROiP97616.

Family and domain databases

Gene3Di3.30.160.20. 2 hits.
InterProiIPR002466. A_deamin.
IPR014720. dsRBD_dom.
[Graphical view]
PfamiPF02137. A_deamin. 1 hit.
PF00035. dsrm. 2 hits.
[Graphical view]
SMARTiSM00552. ADEAMc. 1 hit.
SM00358. DSRM. 2 hits.
[Graphical view]
PROSITEiPS50141. A_DEAMIN_EDITASE. 1 hit.
PS50137. DS_RBD. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRED2_RAT
AccessioniPrimary (citable) accession number: P97616
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: May 1, 1997
Last modified: June 8, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.