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Protein

Thioredoxin, mitochondrial

Gene

Txn2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential (By similarity). Possesses a dithiol-reducing activity.By similarity1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei84 – 841Deprotonates C-terminal active site CysBy similarity
Active sitei90 – 901NucleophileBy similarity
Sitei91 – 911Contributes to redox potential valueBy similarity
Sitei92 – 921Contributes to redox potential valueBy similarity
Active sitei93 – 931NucleophileBy similarity

GO - Molecular functioni

  • protein complex binding Source: RGD
  • protein disulfide oxidoreductase activity Source: InterPro

GO - Biological processi

  • cell redox homeostasis Source: GO_Central
  • cellular response to nutrient levels Source: RGD
  • cellular response to oxidative stress Source: GO_Central
  • glycerol ether metabolic process Source: InterPro
  • protein folding Source: GO_Central
  • response to axon injury Source: RGD
  • response to drug Source: RGD
  • response to glucose Source: RGD
  • response to hormone Source: RGD
  • response to hypoxia Source: RGD
  • response to nutrient Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to oxidative stress Source: RGD
  • sulfate assimilation Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-3299685. Detoxification of Reactive Oxygen Species.

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin, mitochondrial
Short name:
MTRX
Short name:
Mt-Trx
Alternative name(s):
Thioredoxin-2
Gene namesi
Name:Txn2
Synonyms:Trx2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi71040. Txn2.

Subcellular locationi

GO - Cellular componenti

  • dendrite Source: RGD
  • mitochondrion Source: RGD
  • neuronal cell body Source: RGD
  • nucleolus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 5959MitochondrionBy similarityAdd
BLAST
Chaini60 – 166107Thioredoxin, mitochondrialPRO_0000034152Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi90 ↔ 93Redox-activePROSITE-ProRule annotation
Modified residuei152 – 1521N6-acetyllysine; alternateBy similarity
Modified residuei152 – 1521N6-succinyllysine; alternateBy similarity

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

PaxDbiP97615.
PRIDEiP97615.

PTM databases

iPTMnetiP97615.

Expressioni

Tissue specificityi

Expressed in several tissues with the highest expression levels in heart, muscle, kidney and adrenal gland.1 Publication

Gene expression databases

GenevisibleiP97615. RN.

Interactioni

GO - Molecular functioni

  • protein complex binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060694.

Structurei

3D structure databases

ProteinModelPortaliP97615.
SMRiP97615. Positions 59-166.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 166106ThioredoxinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the thioredoxin family.Curated
Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center, Transit peptide

Phylogenomic databases

eggNOGiKOG0910. Eukaryota.
COG0526. LUCA.
GeneTreeiENSGT00530000064086.
HOGENOMiHOG000292977.
HOVERGENiHBG009243.
InParanoidiP97615.
KOiK03671.
OMAiDYEVGSV.
OrthoDBiEOG7VTDQP.
PhylomeDBiP97615.
TreeFamiTF314517.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01068. thioredoxin. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97615-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQRLLLRRF LTSVISRKPP QGVWASLTST SLQTPPYNAG GLTGTPSPAR
60 70 80 90 100
TFHTTRVCST TFNVQDGPDF QDRVVNSETP VVVDFHAQWC GPCKILGPRL
110 120 130 140 150
EKMVAKQHGK VVMAKVDIDD HTDLAIEYEV SAVPTVLAIK NGDVVDKFVG
160
IKDEDQLEAF LKKLIG
Length:166
Mass (Da):18,232
Last modified:May 1, 1997 - v1
Checksum:i27D18DE8B0F8B52B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73525 mRNA. Translation: AAC53008.1.
BC081760 mRNA. Translation: AAH81760.1.
RefSeqiNP_445783.1. NM_053331.2.
UniGeneiRn.55043.

Genome annotation databases

EnsembliENSRNOT00000067483; ENSRNOP00000060694; ENSRNOG00000005614.
ENSRNOT00000078528; ENSRNOP00000074086; ENSRNOG00000005614.
GeneIDi79462.
KEGGirno:79462.
UCSCiRGD:71040. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73525 mRNA. Translation: AAC53008.1.
BC081760 mRNA. Translation: AAH81760.1.
RefSeqiNP_445783.1. NM_053331.2.
UniGeneiRn.55043.

3D structure databases

ProteinModelPortaliP97615.
SMRiP97615. Positions 59-166.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060694.

PTM databases

iPTMnetiP97615.

Proteomic databases

PaxDbiP97615.
PRIDEiP97615.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000067483; ENSRNOP00000060694; ENSRNOG00000005614.
ENSRNOT00000078528; ENSRNOP00000074086; ENSRNOG00000005614.
GeneIDi79462.
KEGGirno:79462.
UCSCiRGD:71040. rat.

Organism-specific databases

CTDi25828.
RGDi71040. Txn2.

Phylogenomic databases

eggNOGiKOG0910. Eukaryota.
COG0526. LUCA.
GeneTreeiENSGT00530000064086.
HOGENOMiHOG000292977.
HOVERGENiHBG009243.
InParanoidiP97615.
KOiK03671.
OMAiDYEVGSV.
OrthoDBiEOG7VTDQP.
PhylomeDBiP97615.
TreeFamiTF314517.

Enzyme and pathway databases

ReactomeiR-RNO-3299685. Detoxification of Reactive Oxygen Species.

Miscellaneous databases

PROiP97615.

Gene expression databases

GenevisibleiP97615. RN.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01068. thioredoxin. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Heart.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiTHIOM_RAT
AccessioniPrimary (citable) accession number: P97615
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: July 6, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.