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Protein

Thioredoxin, mitochondrial

Gene

Txn2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity.By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei84Deprotonates C-terminal active site CysBy similarity1
Active sitei90NucleophileBy similarity1
Sitei91Contributes to redox potential valueBy similarity1
Sitei92Contributes to redox potential valueBy similarity1
Active sitei93NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cell redox homeostasis Source: InterPro
  • cellular response to nutrient levels Source: RGD
  • glycerol ether metabolic process Source: InterPro
  • response to axon injury Source: RGD
  • response to drug Source: RGD
  • response to glucose Source: RGD
  • response to hormone Source: RGD
  • response to hypoxia Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to oxidative stress Source: RGD

Keywordsi

Biological processElectron transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-1614558 Degradation of cysteine and homocysteine
R-RNO-3299685 Detoxification of Reactive Oxygen Species

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin, mitochondrial
Short name:
MTRX
Short name:
Mt-Trx
Alternative name(s):
Thioredoxin-2
Gene namesi
Name:Txn2
Synonyms:Trx2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi71040 Txn2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 59MitochondrionBy similarityAdd BLAST59
ChainiPRO_000003415260 – 166Thioredoxin, mitochondrialAdd BLAST107

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi90 ↔ 93Redox-activePROSITE-ProRule annotation
Modified residuei152N6-acetyllysine; alternateBy similarity1
Modified residuei152N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

PaxDbiP97615
PRIDEiP97615

PTM databases

iPTMnetiP97615
PhosphoSitePlusiP97615

Expressioni

Tissue specificityi

Expressed in several tissues with the highest expression levels in heart, muscle, kidney and adrenal gland.1 Publication

Gene expression databases

BgeeiENSRNOG00000005614
GenevisibleiP97615 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060694

Structurei

3D structure databases

ProteinModelPortaliP97615
SMRiP97615
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 166ThioredoxinPROSITE-ProRule annotationAdd BLAST106

Sequence similaritiesi

Belongs to the thioredoxin family.Curated

Keywords - Domaini

Redox-active center, Transit peptide

Phylogenomic databases

eggNOGiKOG0910 Eukaryota
COG0526 LUCA
GeneTreeiENSGT00530000064086
HOGENOMiHOG000292977
HOVERGENiHBG009243
InParanoidiP97615
KOiK03671
OMAiCRMLTPR
OrthoDBiEOG091G0UDG
PhylomeDBiP97615
TreeFamiTF314517

Family and domain databases

InterProiView protein in InterPro
IPR005746 Thioredoxin
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR01068 thioredoxin, 1 hit
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97615-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQRLLLRRF LTSVISRKPP QGVWASLTST SLQTPPYNAG GLTGTPSPAR
60 70 80 90 100
TFHTTRVCST TFNVQDGPDF QDRVVNSETP VVVDFHAQWC GPCKILGPRL
110 120 130 140 150
EKMVAKQHGK VVMAKVDIDD HTDLAIEYEV SAVPTVLAIK NGDVVDKFVG
160
IKDEDQLEAF LKKLIG
Length:166
Mass (Da):18,232
Last modified:May 1, 1997 - v1
Checksum:i27D18DE8B0F8B52B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73525 mRNA Translation: AAC53008.1
BC081760 mRNA Translation: AAH81760.1
RefSeqiNP_445783.1, NM_053331.2
UniGeneiRn.55043

Genome annotation databases

EnsembliENSRNOT00000067483; ENSRNOP00000060694; ENSRNOG00000005614
ENSRNOT00000078528; ENSRNOP00000074086; ENSRNOG00000005614
GeneIDi79462
KEGGirno:79462
UCSCiRGD:71040 rat

Similar proteinsi

Entry informationi

Entry nameiTHIOM_RAT
AccessioniPrimary (citable) accession number: P97615
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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